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User Reviews for Omeprazole

Also known as: Prilosec, Prilosec OTC, Omesec

Omeprazole has an average rating of 4.8 out of 10 from a total of 413 ratings on Drugs.com. 33% of reviewers reported a positive experience, while 50% reported a negative experience.

Condition Avg. Rating Reviews Compare
GERD  
4.9
241 reviews 225 medications
Indigestion  
4.1
43 reviews 252 medications
Gastritis/Duodenitis  Off-label
3.2
37 reviews 4 medications
Stomach Ulcer  
3.8
26 reviews 98 medications
Barrett's Esophagus  
8.0
17 reviews 13 medications
Hiatal Hernia  Off-label
3.9
13 reviews 6 medications
Erosive Esophagitis  
8.8
11 reviews 102 medications
Laryngopharyngeal Reflux  Off-label
3.9
9 reviews 7 medications
Duodenal Ulcer  
5.2
7 reviews 129 medications
Helicobacter Pylori Infection  
3.1
7 reviews 64 medications
Multiple Endocrine Adenomas  
10.0
1 reviews 6 medications
Zollinger-Ellison Syndrome  
10.0
1 reviews 45 medications
Summary of Omeprazole reviews 4.8 413 reviews

Reviews may be edited to correct grammar/spelling, or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published.

Reviews for Omeprazole

SJ · July 23, 2021

For GERD: “On omeprazole for 11 days, which 5 years ago & I had all side effects mentioned-anxiety, stomach pain, severe brain fog, etc. I had 3 trips to ER with heart pounding & racing numerous tests to try to diagnose. It took 6 months to feel 100%. Upped nutrition & made my own rehydration liquid (coconut water, fresh oranges & lemons,etc). I used organic products when possible, wanted as few toxins in my body) exercised, increased vitamins & supplements B12 & magnesium & started yoga. Symptoms slowly decreased over next 6 months - symptoms didn’t cease immediately after stopping. PLEASE don’t lose hope if you are still experiencing symptoms! Stay on a regimen of optimum nutrition & hydration & symptoms will slowly subside over several months. I feel like the poison got into every crevice of my body & invaded tissue & muscles, so took time to flush out. Do NOT let doctors tell you that it’s all in your head, that medication can’t cause these side effects! Wishing everyone hope for recovery & encouragement for a return to normal. It WILL get better:)”

1 / 10
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Deano · May 25, 2020

For GERD: “I was left on this medication omeprazole for around 6 years by my doctor for stomach acid. I am from the UK so although we have a national health service it’s a common occurrence not to receive a sufficient level of care. Anyway I managed to replace the benefits that these tablets did assist with by instead taking vitamins. Stopped taking 5 months ago and I can not put into words how amazing I have felt ever since. Anxiety and depression have lifted enormously! I used to get anxious about the smallest things, such as driving my car, having type of certain juice in the house. Just the daftest things ever. I’m sleeping better then I ever was. No brain fog, memory/concentration have increased significantly. I can not recall a time when my mood was been constantly high throughout my life (32) I truly believe these tablets severely impacted my mental health for all those years so I strongly advise anyone either taking or thinking about taking them to not bother. Look into natural aids instead!!”

1 / 10
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TLC · Taken for less than 1 month · September 28, 2021

For GERD: “Started a short treatment of Prilosec for an acid reflux flare up. 40mg a day. Took for 16 days before we realized what was happening! I’m generally in great health, fit, healthy weight, on no medications, and have never experienced depression. This medication caused me to have anxiety, heart palpitations, loss of appetite, weight loss, extreme depression, tingling in the hands and feet, and worsened my acid reflux symptoms! Once we realized these symptoms were actually side effects of the medication I stopped taking it! That was 2 weeks ago. The depression has very slowly lifted, the anxiety keeps coming and going, the acid reflux is cleared up, and appetite is improving every day. No degree of acid reflux is worth going through what I’ve been going through the past month! DON”T TAKE IT!”

1 / 10
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Need help for my wife · Taken for less than 1 month · March 27, 2021

For GERD: “My wife has been off this stuff for about 3 weeks now and is still plagued with the anxiety, insomnia, pins and needles etc. Can anyone tell me how long it took for them to be free of this misery? Thanks so much...we hope everyday that these horrible side effect subside...please give me some good news!! Thanks so much!”

1 / 10
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Mark · Taken for 1 to 2 years · March 28, 2022

For GERD: “Evil drug!!! Do not take it took me over 4 months to get over the side effects and I still have little lapses to this day a year later. Not sure what they have done but like they put my whole nervous system on overdrive horrible drug. Honestly I'd rather the gastric acid do the max damage then ever go through that again. Dizziness, brain fog, eye twitches, muscle spasms randomly all over more slightly left shoulder and arm. Made me nervous about everything. I was horrible to people getting very aggressive over nothing, burning and itching of the skin, pins and needles in feet and hands, non stop congestion and ear ache, waking up during sleep feeling like I'd stop breathing.This probably around half of what I went through, the list is endless.”

1 / 10
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Jimmie · Taken for less than 1 month · March 14, 2022

For GERD: “I don’t even know where to start. I will say this medicine did work but the side effects are absolutely horrible! The anxiety, depression, and impending doom I felt all day long was terrible! I was on 40mg a day for 14 days along with famotodine for an ulcer. I just finished my 14 days and the symptoms (Anxiety and feel like something bad is going to happen) are still there. Can anyone please tell me if this anxiety will eventually go away and how long? This is terrible I feel like I’m going nuts!”

1 / 10
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Don · Taken for less than 1 month · September 3, 2020

For GERD: “I started experiencing tightness in the middle of my chest with constant belching and a pinching stomach pain in my upper right abdomen. Dr diagnosed me with acid reflux and put me on prilosec otc 20mg for 14 days. I just started taking the pills and man... my anxiety was 10x worst. I was anxious, heart racing, nauseated, stomach pain, brain fog, blurred vision and overall I felt like crying and just so awful. Please talk to your dr for other alternative medicine. I don’t recommend taking these.”

1 / 10
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Frequently asked questions

Asia · Taken for less than 1 month · January 10, 2020

For GERD: “My acid reflux came back recently so I went to see a doctor. She prescribed me to take 20mg omeprazole every morning. 3 days had passed and I noticed dizziness, unable to focus, my eyes couldn’t focus on one thing...they always dilated, diarrhea, fatigue, paranoid, anxiety spiked! I took it for exactly 6 days. My dad told me not to take it anymore and we’ll soon be headed to the doctor. It works for some but the reviews that I have been reading are exactly how I feel...if you experience any one of these symptoms stop taking them immediately! I read that someone had seizures! I wish you all well and will be taking the natural way suggested...baking soda+water, apple cider vinegar, and ginger tea!”

1 / 10
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Mich73 · Taken for less than 1 month · December 14, 2021

For GERD: “My daughter was put on these for 14 days, I’ve never seen someone change so dramatically. By her last day of taking them she was pacing her room saying she felt like she was going to die and that something bad was going to happen. She has never suffered with anxiety before or panic attacks. Brain fog, shooting pains in her head, can't stop crying. It’s been 4 weeks since she stopped these and she is really struggling. She is taking extra vitamins and eating but is desperate to know how long this is going to last. She has gone from being an outgoing girl to not leaving the house. Any advice appreciated. Her doctor has prescribed antidepressants but she’s reluctant to take these as she has never needed them before.”

1 / 10
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Fam · Taken for less than 1 month · March 13, 2021

For GERD: “I been taking this pill for 3 weeks. Started to feel dizziness, headache, and lightheaded. Loss appetite, chills, tingling, brain fog, and feels like being drunk all the time. Has been hit hard. Off the meds for 3 weeks. And still feel whoozy and drunk. The meds haven't wear off yet. Anyone know what to do at the moment?”

10 / 10
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Presley · Taken for less than 1 month · September 25, 2019

Prilosec (omeprazole) for GERD: “DO NOT TAKE THIS MEDICINE!!!!! This medicine has ripped the life out from inside me. I went from being my totally normal happy self to having serious panic attack’s, constant anxiety/depression and a general feel of hopelessness. The symptoms started on my 12th day and I stopped taking the pill on my 13th day. It is a week later and the panic attacks, anxiety, depression, and hopelessness still remain. This drug is poison to me and many others!!!”

1 / 10
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ANXIETY · March 3, 2021

For Gastritis/Duodenitis: “This medication will drag you to a place where you really don't want to be. What I'm feeling is chest heaviness, dizziness, severe anxiety, panic episodes, shakiness, sweating, diarrhea shortness of breath. It is nothing to worry about, my symptoms got better after a few weeks. However the doctor made me start it again and I now know that everything that just randomly started going wrong with me is all linked to this medication. And when I say anxiety I mean severe amplified anxiety. Like the kind were you can't sleep at night because you panic thinking tonight is the night. Do not take this medication. Ever. You don't know anxiety until you take this. I'm not sure why this is even a med to begin with. Keep your head up and read my review. I promise you'll be ok after a few weeks. You're not dying. Just going through a bad side effect that will subside.”

1 / 10
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Georgie · August 29, 2020

For GERD: “Hey guys! One night I had too much wine and woke up with stabbing pain between my breasts in the middle; I went to dr got diagnosed with GERD. Prescribed me 40mg omeprazole. I started taking it, it helped and a few days later the stabbing pain was gone. Then I started feeling rib pain and lower sternum pain. Dr told me it was because of GERD. Nope. The more I took it the worse it got and 3 weeks after taking this stuff I was in horrendous rib pain, all over my upper body, chest wall pain I could not move. Had to go to ER, Xrays, blood test they found nothing. I lost a bunch of weight too, I had blurry vision, terrible brain fog, warm arms and swollen toes, insomnia, horrendous body pain, I could not move. My poop looked like it came out the same way it went in, food junks etc.. I stopped taking it and now I am a month off of it, rib pain and all other side effects are going away, still have a tiny pain left but feel better. Seriously, what is this med? Avoid it if you can”

1 / 10
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Marieski858 · September 6, 2021

For Gastritis/Duodenitis: “DO. NOT. TAKE. HORRIFIC side effects. Took this for only 5 days due to gastritis, ulcer symptoms on and off for about a year. Decided to take Omeprazole for a few weeks after repeated recommendations by my doc to heal the ulcer once and for all. An enormous mistake. 5 days in, suddenly panicky, dizzy, faint, heart beating painfully hard for hours, pulse sky high, numb hands and legs and an ambulance ride to the ER, I thought I was having a heart attack! Released the next day, they basically found nothing. Night after night, waking up in a panicked sweat feeling claustrophobic like I was losing it, unable to sleep due to the fear and pounding heartbeat. (And 2 kids to care for!)I was a complete mental and physical wreck. I have NEVER had anxiety or had a panic attack ever in my life so it was obvious these pills had done me in. Been off for 2 weeks, acupuncture and herbs to detox hopefully as quick as I can. DON’T TAKE this stuff!!!!”

1 / 10
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J R · Taken for 1 to 6 months · October 7, 2021

For GERD: “Absolutely awful, dangerous, one of the worst experiences of my life. It is finally time to share my story in hopes it helps others not go through this. I waited until the nightmare was 100% over and that garbage was out of my system. I was prescribed 80mg per day of Omeprazole on June 11, 2021 and took that amount daily for 7 weeks. In late July, I had severe mental fog, insane anxiety, near impossible ability to drive, often felt like I would pass out driving. This nightmare continued for exactly 2 months after going cold turkey off that garbage. 2 months of being terrified to drive feeling awful, hugging the berm, going under the speed limit, fearing for my life. If your doctor tells you there are no side effects with this drug like mine did, they are full of you know what. Please think of alternate solutions. This can wreck your life and others, literally. Big pharma wont want you to know that. I highly recommend you do not go through this and finds healthy solutions.”

1 / 10
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Jack · Taken for less than 1 month · January 12, 2021

For GERD: “Took 40mg once a day before breakfast. Noticed some anxiety on Day 5. By Day 11 I was completely toasted, I had brain fog, weight loss, nausea, blurry vision, and extreme anxiety. It has been 3 weeks since I quit this medicine. Brain fog has subsided however, anxiety keeps crawling in and out. Hang in there, stay tough. This medicine will take its course and time to wash out completely from your system. I am hoping to fully recover in near future. Exercise, and stay positive.”

1 / 10
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Anonymous · Taken for less than 1 month · May 4, 2020

Prilosec OTC (omeprazole) for GERD: “After 12 days of taking this medicine, I feel crazy! Sudden head rushes when I stand up. A feeling of my ears being full. Heart palpitations, chest tightness etc..it did help with my acid reflux but I had to stop taking it. I can't deal with the side effects. Going to lose weight and cut off certain foods.”

8 / 10
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More FAQ

Smudgetootsie · Taken for 2 to 5 years · March 10, 2021

For Indigestion: “Omg I have just read these omeprazole reviews I just thank each and everyone of you for sharing your experiences as you have solved my health issues that I have been suffering for a year and a half probably longer. I even went to see my cardiologist and went through an angiogram as I felt so bad. Pains in my chest going through to my back and down my arms. My cardiologist said my arteries were all clear and these feelings must have been down to your sotalol beta blockers giving you side effects. I have just spent 4 nights in hospital trying to get to the bottom of these horrendous feelings. And by reading your reviews on Omeprazole I'm sure that's whats wrong with me. As you say it is one awful drug as its ruined my life for the past 2 years I would say. THANK YOU FOR SHARING”

1 / 10
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toby b · Taken for 6 months to 1 year · March 18, 2021

For Hiatal Hernia: “DO NOT TAKE UNDER ANY CIRCUMSTANCES!!!!! I have lost 7 months of my life to this drug, I was at a loose end and wanted everything to be over!! I went from a man enjoying his life to a severely depressed and unhappy person. The omeprazole prescribed for my heartburn unknowing to me gave me crippling anxiety, depression, dizziness, brain fog, feeling like I was going to blackout constantly, helplessness, crying.. you name it!! I stopped the Omeprazole 4 days ago and wow I feel like a new man back to my old self! No depression, no anxiety... WOW!! Please avoid this awful drug at all costs!!!”

1 / 10
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satchelmuffin · Taken for less than 1 month · February 5, 2021

For GERD: “I complained about having sharp pains occasionally just below the breasts and the Dr. told me it was acid build up and that I should take an omeprazole every morning. On day 5 I got very lightheaded and dizzy every time I stood up, felt my heart racing, and felt anxious. I stopped taking the pills that day and three days later I'm still feeling lightheaded, a general feeling of heaviness in my chest, and, most concerning, a tidal wave of depression. I am wondering how long it will take this to get out of my system because I feel so wonky.”

1 / 10
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PC · January 10, 2021

For GERD: “This omeprazole stuff is horrible. Sure, it got rid of the heartburn issues I was having, but the side effects are horrific and scary. Even more scary is they don't include the litany of scary side effects. While on this retched drug, I had pain in my thighs, slightly swollen lower legs, increased blood pressure, tingling in my hands and feet, lethargic legs, water retention, and a painful right testicle. Of course, none of these side effects, which can be found online on sites, but aren't mentioned on the packaging. So, while taking this dangerous drug, I was having these issues and not realizing it was the drug because these side effects weren't mentioned. I thought I was having some other type of horrible medical condition(s). Luckily, I realized all these conditions cropped up after I started the drug. Once stopped, my conditions all began to improve and go away. Beware of this cursed drug. It can screw you up big time. Never again.”

1 / 10
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Royalrider · Taken for 1 to 6 months · August 13, 2020

For Indigestion: “I have had heartburn for years. I was put on this omeprazole medication and it worked well for my heartburn. However after about 2 months or so I began to feel symptoms that I couldn't pin to one thing or another. Back aches, light headedness, fatigue, anxiety, shoulder pain and my rib cage felt like I got beat up. Also if felt like a basket ball was in my stomach. So I started chasing down side effects with the meds I take and started to see ALL these side effects tied to this drug. I am now on day 2 of not taking them. I just hope it is not too long before the side effects start to subside.”

3 / 10
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Derek · Taken for less than 1 month · December 31, 2019

For GERD: “Does anyone know how long these horrible side effects last??? I’ve took them two weeks and now been off them two weeks so far. Brain fog has lessened but still getting anxiety and depression/emotionless/soul less feeling from time to time. I could sleep the first week off of them now the second week I’m having hard time sleeping , snapping awake, muscle jerking, needles in my skin feeling. This pill is awful . I’ve heard it could take a month or two to normalize”

1 / 10
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loilen · June 11, 2021

For Gastritis/Duodenitis: “Got diagnosed with Gastritis and was prescribed omeprazole for 5 weeks. Got the full package side effects - tingling in my arms and feet, buzzing in my back, buzzing in my left calf, weakness to the point where i was barely able to lift it, extreme anxiety, waking up during the night with my heart racing, pain and burning on the left under the ribs, lost 14 kilos in 3 weeks. Today it is 3 weeks since I stopped taking it, anxiety lifted 3 days ago and is no longer there, tingling in my arms and feet is gone, burning the stomach too, the only thing left is slight weakness in my left calf still, but that's improving slowly. I have an appetite, weight is going up steady. If you are reading this, hang in there, stay tough, it takes a while for that poison to wear off, keep yourself hydrated and take vitamins and electrolytes, probiotics help with anxiety, it gets better. I honestly thought this nightmare will never end. PPI - never again !”

1 / 10
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Anonymous · November 7, 2020

For GERD: “I went to the ENT doctor because I was having trouble swallowing my saliva so she stuck the tube up my nose and after she was done and told me the back of my throat was red and I have severe acid reflux before I even came to the ENT doctor I suffer from anxiety & depression already. Not knowing the drugs she prescribed me was going to make that worse I took omeprazole for 6 days and the side effects I couldn't deal with - my anxiety got worse I got more depressed, eyes felt dilated, I got a headache, diarrhea, woke up and my arms was slightly aching without me doing anything also having to clear my throat with nothing in my throat to be cleared and lose of appetite I will never take omeprazole again I'm going try the hopefully it leaves my systems soon I'm going to try the natural way”

1 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.