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Omeprazole Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Omeprazole Remove Omeprazole from your drug comparison Pantoprazole Remove Pantoprazole from your drug comparison Nexium Remove Nexium from your drug comparison
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Omeprazole Remove Omeprazole from your drug comparison Pantoprazole Remove Pantoprazole from your drug comparison Nexium esomeprazole Remove Nexium from your drug comparison

Omeprazole decreases stomach acid production which promotes the healing of gastric and duodenal ulcers and other inflamed gastrointestinal tissue areas. The risk of interactions with omeprazole is... View more

Pantoprazole is a proton pump inhibitor that decreases acid secretion in the stomach and may be given to relieve the symptoms of heartburn or to allow inflamed tissue in the gastrointestinal tract to... View more

Nexium effectively heals inflamed tissue in the gastrointestinal tract and relieves symptoms of heartburn. Nexium is available orally and as an IV preparation that may be used in adults and children... View more

Prescription and OTC

Prescription only

Prescription only

Ratings & Reviews

View all 288 reviews

View all 272 reviews

View all 168 reviews

Drug Class

Side Effects

See the full omeprazole side effects document.

See the full pantoprazole side effects document.

See the full Nexium side effects document.

Pricing and Coupons

* Prices are without insurance
Quantity 5 delayed release capsule
Dosage 20 mg
Per Unit* $2.84
Cost* $14.20

View all omeprazole prices

Quantity 50 each
Dosage 40 mg
Per Unit* $0.80 - $1.24
Cost* $39.75 - $61.75

View all pantoprazole prices

Quantity 15 delayed release capsule
Dosage 40 mg
Per Unit* $8.13
Cost* $122.01

View all Nexium prices and generic prices

Get free Discount Card

Get free Discount Card

Get free Discount Card

Generic Availability

Yes (this medicine)

Yes (this medicine)

Yes

Dosage Form(s) Available
  • Oral delayed release capsule
  • Oral delayed release tablet
  • Intravenous powder for injection
  • Oral delayed release tablet
  • Oral granule, enteric coated
  • Oral delayed release capsule
  • Oral powder for reconstitution, delayed release

Brand Names
Omesec, Prilosec, Prilosec OTC Protonix, Protonix IV Other esomeprazole brands include: Nexium 24HR, Nexium IV

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

1.5 hours

1 hour

1.5 hours

CSA Schedule**

View glossary of terms.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category
C
Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.
B
Category B No proven risk in humans

See the full Pregnancy Warnings document.
C
Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

FDA Alerts

FDA Alerts (6)

FDA Alerts (4)

FDA Alerts (5)

Drug Interactions

A total of 196 drugs are known to interact with omeprazole:

  • 16 major drug interactions (42 brand and generic names)
  • 134 moderate drug interactions (1220 brand and generic names)
  • 46 minor drug interactions (263 brand and generic names)

A total of 145 drugs are known to interact with pantoprazole:

  • 12 major drug interactions (31 brand and generic names)
  • 114 moderate drug interactions (1147 brand and generic names)
  • 19 minor drug interactions (139 brand and generic names)

A total of 170 drugs are known to interact with Nexium:

  • 15 major drug interactions (40 brand and generic names)
  • 122 moderate drug interactions (1184 brand and generic names)
  • 33 minor drug interactions (181 brand and generic names)

Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
  • Food may interfere with the absorption of esomeprazole. Esomeprazole should be taken at least one... View more

Disease Interactions

First Approval Date

June 20, 2003

February 02, 2000

N/A

WADA Class

View World Anti-Doping Agency classifications.

N/A

N/A

N/A

More Information

Consumer Resources

Professional Resources

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer