Omeprazole Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Omeprazole	Pantoprazole	Famotidine	Enter another drug to compare

Omeprazole

Pantoprazole

Famotidine

Prescription and OTC

Omeprazole decreases stomach acid production which promotes the healing of gastric and duodenal ulcers and other inflamed areas of gastrointestinal tissue. The risk of interactions with omeprazole... View more

Prescription only

Pantoprazole is a proton pump inhibitor that decreases acid secretion in the stomach and may be given to relieve the symptoms of heartburn or to allow inflamed tissue in the gastrointestinal tract to... View more

Prescription and OTC

Famotidine is an acid-suppressing agent that may be used to treat a wide range of gastric-acid-related disorders including gastric ulcers, heartburn, and GERD. A headache is the most common side... View more

More about Omeprazole

More about Pantoprazole

More about Famotidine

Ratings & Reviews

Omeprazole has an average rating of 4.7 out of 10 from a total of 501 ratings on Drugs.com. 32% of reviewers reported a positive effect, while 51% reported a negative effect.

Pantoprazole has an average rating of 5.0 out of 10 from a total of 433 ratings on Drugs.com. 37% of reviewers reported a positive effect, while 47% reported a negative effect.

Famotidine has an average rating of 4.5 out of 10 from a total of 177 ratings on Drugs.com. 34% of reviewers reported a positive effect, while 56% reported a negative effect.

View all 501 reviews

View all 433 reviews

View all 177 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Anxiety (25.3%)
Dizziness (16.0%)
Nausea (12.0%)
Headaches (9.0%)
Brain fog (8.6%)
Depression (8.2%)
Panic attacks (7.2%)

View all Omeprazole side effects

Headaches (16.6%)
Anxiety (11.5%)
Dizziness (11.1%)
Nausea (10.9%)
Stomach pain (7.9%)
Bloating (7.2%)
Gas (6.5%)

View all Pantoprazole side effects

Anxiety (26.0%)
Headaches (10.7%)
Nausea (10.7%)
Insomnia (9.6%)
Chest pain (8.5%)
Diarrhea (8.5%)
Dizziness (7.3%)

View all Famotidine side effects

Drug Class

Proton pump inhibitors

Proton pump inhibitors

H2 antagonists

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	50 each
Strength	20 mg
Per unit^*	$0.39
Cost^*	$19.42

View all Omeprazole prices

Quantity	50 each
Strength	40 mg
Per unit^*	$0.38 - $0.52
Cost^*	$19.17 - $25.80

View all Pantoprazole prices

Quantity	6 tablet
Strength	20 mg
Per unit^*	$2.22
Cost^*	$13.34

View all Famotidine prices

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Dosage Forms

Oral delayed release capsule
Oral delayed release tablet
Oral tablet, disintegrating, delayed release

Intravenous powder for injection
Intravenous solution
Oral delayed release tablet
Oral granule, enteric coated

Intravenous solution
Oral powder for reconstitution
Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

1.5 hours

1 hour

4 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category B No proven risk in humans

See the full pregnancy warnings document.

Category B No proven risk in humans

See the full pregnancy warnings document.

Drug Interactions

A total of 244 drugs are known to interact with Omeprazole:

25 major drug interactions (66 brand and generic names)
171 moderate drug interactions (1327 brand and generic names)
48 minor drug interactions (273 brand and generic names)

A total of 184 drugs are known to interact with Pantoprazole:

17 major drug interactions (44 brand and generic names)
148 moderate drug interactions (1238 brand and generic names)
19 minor drug interactions (142 brand and generic names)

A total of 315 drugs are known to interact with Famotidine:

14 major drug interactions (36 brand and generic names)
255 moderate drug interactions (834 brand and generic names)
46 minor drug interactions (296 brand and generic names)

Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Disease Interactions

First Approval Date

June 20, 2003

February 02, 2000

October 15, 1986

WADA Class View classifications

N/A

More Information

Patient Resources

Omeprazole uses

Famotidine uses

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Omeprazole Alternatives Compared

See also:

Protonix

Nexium

Botox

Prilosec

Dexilant

Prevacid

Aciphex

Dexlansoprazole

Rabeprazole

Lansoprazole

Further information

Omeprazole Alternatives Compared

See also:

Further information

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