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Omeprazole Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Omeprazole Pantoprazole Nexium
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Omeprazole Pantoprazole Nexium esomeprazole

Omeprazole decreases stomach acid production which promotes the healing of gastric and duodenal ulcers and other inflamed gastrointestinal tissue areas. The risk of interactions with omeprazole is... View more

Pantoprazole is a proton pump inhibitor that decreases acid secretion in the stomach and may be given to relieve the symptoms of heartburn or to allow inflamed tissue in the gastrointestinal tract to... View more

Nexium effectively heals inflamed tissue in the gastrointestinal tract and relieves symptoms of heartburn. Nexium is available orally and as an IV preparation that may be used in adults and children... View more

More about Omeprazole More about Pantoprazole More about Nexium (esomeprazole)
Generic Status

Lower-cost generic is available

Lower-cost generic is available

Lower-cost generic is available
Availability

Prescription and OTC

Prescription only

Prescription only
Ratings & Reviews

Omeprazole has an average rating of 4.8 out of 10 from a total of 413 ratings on Drugs.com. 33% of reviewers reported a positive effect, while 50% reported a negative effect.

Pantoprazole has an average rating of 5.0 out of 10 from a total of 377 ratings on Drugs.com. 36% of reviewers reported a positive effect, while 48% reported a negative effect.

Nexium has an average rating of 6.0 out of 10 from a total of 195 ratings on Drugs.com. 51% of reviewers reported a positive effect, while 36% reported a negative effect.

View all 413 reviews

View all 377 reviews

View all 195 reviews

Drug Class
Side Effects

See the full omeprazole side effects document.

See the full pantoprazole side effects document.

See the full Nexium side effects document.
Pricing and Coupons * Prices are without insurance
Quantity 50 each
Dosage 20 mg
Per Unit* $1.22
Cost* $60.85

View all omeprazole prices

Quantity 50 each
Dosage 40 mg
Per Unit* $1.31
Cost* $65.52

View all pantoprazole prices

Quantity 30 delayed release capsule
Dosage 40 mg
Per Unit* $9.98
Cost* $299.40

View all Nexium prices and generic prices

Get free Discount Card

Get free Discount Card

Get free Discount Card

Dosage Form(s) Available
  • Oral delayed release capsule
  • Oral delayed release tablet
  • Intravenous powder for injection
  • Oral delayed release tablet
  • Oral granule, enteric coated
  • Oral delayed release capsule
  • Oral powder for reconstitution, delayed release
Brand Names
Omesec, Prilosec, Prilosec OTC Protonix, Protonix IV Other esomeprazole brands include: Nexium 24HR, Nexium IV
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

1.5 hours

1 hour

1.5 hours
CSA Schedule** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
C
Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.
B
Category B No proven risk in humans

See the full Pregnancy Warnings document.
C
Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.
Drug Interactions

A total of 208 drugs are known to interact with omeprazole:

  • 20 major drug interactions (50 brand and generic names)
  • 141 moderate drug interactions (1247 brand and generic names)
  • 47 minor drug interactions (267 brand and generic names)

A total of 153 drugs are known to interact with pantoprazole:

  • 15 major drug interactions (37 brand and generic names)
  • 119 moderate drug interactions (1167 brand and generic names)
  • 19 minor drug interactions (141 brand and generic names)

A total of 181 drugs are known to interact with Nexium:

  • 19 major drug interactions (48 brand and generic names)
  • 128 moderate drug interactions (1206 brand and generic names)
  • 34 minor drug interactions (185 brand and generic names)
Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
  • Food may interfere with the absorption of esomeprazole. Esomeprazole should be taken at least one... View more
Disease Interactions
First Approval Date

June 20, 2003

February 02, 2000

N/A
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources
Professional Resources
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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