Medically reviewed by Drugs.com. Last updated on Apr 25, 2022.
Commonly used brand name(s)
In the U.S.
- Protonix IV
Available Dosage Forms:
- Powder for Solution
Therapeutic Class: Gastric Acid Secretion Inhibitor
Pharmacologic Class: Proton Pump Inhibitor
Uses for pantoprazole
Pantoprazole injection is used to treat certain conditions in which there is too much acid in the stomach. It is used for short-term treatment (7 to 10 days) of gastroesophageal reflux disease (GERD) with a history of erosive esophagitis. GERD is a condition in which the acid in the stomach washes back up into the esophagus. Pantoprazole may also be used to treat Zollinger-Ellison syndrome or other conditions (eg, cancer) in which the stomach produces too much acid.
Pantoprazole is a proton pump inhibitor (PPI). It works by decreasing the amount of acid produced by the stomach.
Pantoprazole is given only by or under the direct supervision of your doctor.
Before using pantoprazole
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For pantoprazole, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to pantoprazole or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of pantoprazole injection in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of pantoprazole injection in the elderly. However, elderly patients are more sensitive to the effects of pantoprazole than younger adults.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving pantoprazole, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using pantoprazole with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using pantoprazole with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Eslicarbazepine Acetate
- Mycophenolate Mofetil
- Secretin Human
Using pantoprazole with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using pantoprazole with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use pantoprazole, or give you special instructions about the use of food, alcohol, or tobacco.
Other medical problems
The presence of other medical problems may affect the use of pantoprazole. Make sure you tell your doctor if you have any other medical problems, especially:
- Diarrhea or
- Hypomagnesemia (low magnesium in the blood), history of or
- Kidney disease or
- Osteoporosis (thinning of the bones) or
- Systemic lupus erythematosus (SLE) or
- Zinc deficiency—Use with caution. May make these conditions worse.
- Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Proper use of pantoprazole
A nurse or other trained health professional will give you pantoprazole in a medical facility. It is given through a needle placed into one of your veins.
It may take several days before pantoprazole begins to relieve stomach pain. To help relieve this pain, antacids may be taken with pantoprazole, unless your doctor tells you otherwise.
Tell your doctor if you have had problems with your zinc levels in your body. Your doctor may want you to take zinc supplements.
Your doctor will give you a few doses of pantoprazole until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.
Precautions while using pantoprazole
It is important that your doctor check your progress at regular visits to make sure pantoprazole is working properly. Blood and urine tests may be needed to check for unwanted effects. If your condition does not improve, or if it becomes worse, check with your doctor.
You should not receive pantoprazole together with medicines containing rilpivirine (eg, Complera®, Edurant®, Odefsey®). Using these medicines together may cause unwanted side effects.
Pantoprazole may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing or swallowing, or any swelling of your hands, face, or mouth after you receive the medicine.
Pantoprazole may cause serious skin reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, and drug reaction with eosinophilia and systemic symptoms (DRESS). Check with your doctor right away if you have black, tarry stools, blistering, peeling, or loosening of the skin, chest pain, chills, cough, diarrhea, itching, joint or muscle pain, painful or difficult urination, red irritated eyes, red skin lesions, often with a purple center, sore throat, sores, ulcers, or white spots in the mouth or on the lips, swollen glands, unusual bleeding or bruising, or unusual tiredness or weakness.
Pantoprazole may cause an injection site reaction called thrombophlebitis. Check with your doctor right away if you notice any of these side effects at the injection site: changes in skin color, pain, tenderness, or swelling of the foot or leg.
Check with your doctor right away if you have a change in frequency of urination or amount of urine, blood in the urine, fever, joint pain, loss of appetite, nausea, skin rash, swelling of the body, feet, or ankles, unusual tiredness or weakness, or unusual weight gain after receiving pantoprazole. These could be symptoms of a serious kidney problem called acute tubulointerstitial nephritis.
Serious stomach conditions may occur while taking pantoprazole. Check with your doctor immediately if you or your child has stomach cramps, bloated feeling, watery and severe diarrhea which may also be bloody sometimes, fever, nausea or vomiting, or unusual tiredness or weakness.
Pantoprazole injection may increase your risk of having fractures of the hip, wrist, and spine. This is more likely if you are 50 years of age and older, if you receive high doses of pantoprazole, or use it for one year or more. Call your doctor right away if you have severe bone pain or are unable to walk or sit normally.
Pantoprazole may cause hypomagnesemia (low magnesium in the blood). This is more likely to occur if you are using pantoprazole for more than 1 year, or if you are using pantoprazole together with digoxin (Lanoxin®) or certain diuretics (water pills). Check with your doctor right away if you have convulsions (seizures), fast, racing, or uneven heartbeat, muscle spasms (tetany), tremors, or unusual tiredness or weakness.
Cutaneous or systemic lupus erythematosus may occur or get worse in patients receiving a PPI. Call your doctor right away if you have joint pain or a skin rash on your cheeks or arms that gets worse when exposed to the sun.
Pantoprazole may increase your risk for fundic gland polyps (abnormal tissue growth in the upper part of your stomach). This is more likely if you are receiving pantoprazole for more than 1 year. Talk ti your doctor if you have concerns.
Make sure any doctor or dentist who treats you knows that you are using pantoprazole. Pantoprazole may affect the results of certain medical tests.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription (eg, atazanavir, nelfinavir, Reyataz®, Viracept®) or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Pantoprazole side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
- Accumulation of pus
- bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- changes in skin color
- pain, tenderness, or swelling of the foot or leg
- stomach pain
- swollen, red, tender area of infection
- loss of appetite
- mood or mental changes
- muscle spasms (tetany) or twitching
- unusual tiredness or weakness
Incidence not known
- Absence of or decrease in body movement
- black, tarry stools
- blistering, peeling, or loosening of the skin
- bloating of the stomach
- bloody or cloudy urine
- bloody, black, or tarry stools
- blurred vision
- chest pain or tightness
- continuing ringing or buzzing or other unexplained noise in the ears
- dark urine
- decreased urine output
- decreased vision
- difficulty with speaking
- difficulty with swallowing
- dizziness or lightheadedness
- dry mouth
- fast heartbeat
- feeling of constant movement of self or surroundings
- greatly decreased frequency of urination or amount of urine
- hearing loss
- hives, itching, or rash
- increased thirst
- increased watering of the mouth
- joint or muscle pain
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
- light-colored stools
- muscle cramps, pain, or stiffness
- numbness and tingling around the mouth, fingertips, or feet
- painful or difficult urination
- pains in the stomach, side, or abdomen, possibly radiating to the back
- pale skin
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- red skin lesions, often with a purple center
- red, irritated eyes
- sensation of spinning
- severe stomach cramps or pain
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- stomach cramps or tenderness
- swelling of the feet or lower legs
- swollen glands
- trouble breathing
- unexplained bleeding or bruising
- watery and severe diarrhea, which may also be bloody
- yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- excess air or gas in the stomach or bowels
- full feeling
- passing gas
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Frequently asked questions
- Can you take pantoprazole 40 mg twice a day?
- How long can I take pantoprazole?
- Does pantoprazole cause bloating?
More about pantoprazole
- Side effects
- Drug interactions
- Dosage information
- During pregnancy or Breastfeeding
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- Drug class: proton pump inhibitors
- Drug Information
- Pantoprazole (Advanced Reading)
- Pantoprazole Delayed-Release Granules
- Pantoprazole Delayed-Release Tablets
- Pantoprazole Injection
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