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Pantoprazole Drug Interactions

A total of 261 drugs are known to interact with pantoprazole.

  • 17 major drug interactions
  • 174 moderate drug interactions
  • 70 minor drug interactions

Show all medications in the database that may interact with pantoprazole.

Check for interactions

Type in a drug name to check for interactions with pantoprazole.

Most frequently checked interactions

View interaction reports for pantoprazole and the medicines listed below.

  • amoxicillin (Amoxil, Trimox, Apo-Amoxi, Amoxicot, Moxatag, DisperMox, Moxilin, Wymox, Biomox)
  • Aspirin Low Strength (aspirin)
  • azithromycin (Zithromax, Azithromycin Dose Pack, Z-Pak, Zmax)
  • ciprofloxacin (Cipro, Cipro XR, Cipro I.V., Cipro Cystitis Pack, Proquin XR)
  • Cymbalta (duloxetine)
  • famotidine (Pepcid, Pepcid AC, Acid Reducer-Famotidine, Heartburn Relief, Pepcid AC Maximum Strength, Pepcid AC Chewable Tablets, Pepcid Oral Suspension, Fluxid, Acid Control, Acid Reducer Original Strength, Acid Reducer Maximum Strength, Heartburn Relief Maximum Strength, Acid Controller Original Strength, Pepcid RPD, Mylanta AR, Pepcid AC Maximum Strength Tablets, Acid Controller Maximum Strength)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • ibuprofen (Advil, Motrin, IBU, Children's Motrin, Proprinal, Advil Liqui-Gels, Ibu-8, Motrin IB, Motrin Childrens, Rufen, Childrens Ibuprofen Berry, IBU-200, Ibuprofen PMR, Advil Migraine, Ibu-Tab, Genpril, Menadol, Advil Children's, Midol Maximum Strength Cramp Formula, Motrin Migraine Pain, Addaprin, Motrin Infant Drops, NeoProfen, Caldolor, Motrin Pediatric, Haltran, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Nuprin, Advil Junior Strength, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Advil Infant's Concentrated Drops, Cap-Profen, Advil Film-Coated)
  • levothyroxine (Synthroid, Levoxyl, Tirosint, Levothroid, Eltroxin, Euthyrox, Unithroid, Levothyrox, Eutroxsig, Levo-T, Oroxine, L Thyroxine Roche, Levotabs, Novothyrox, Tirosint-Sol, Levotec, Evotrox)
  • Lyrica (pregabalin)
  • Metoprolol Succinate ER (metoprolol)
  • Metoprolol Tartrate (metoprolol)
  • naproxen (Aleve, Naprosyn, Anaprox, Naproxen Sodium DS, EC-Naprosyn, Anaprox-DS, Naprelan, Comfort Pac with Naproxen, Leader Naproxen Sodium, Aflaxen, Midol Extended Relief, Flanax Pain Reliever, Pamprin All Day Relief, All Day Pain Relief, All Day Relief)
  • Nexium (esomeprazole)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • ondansetron (Zofran, Zofran ODT, Zuplenz)
  • Plavix (clopidogrel)
  • ranitidine (Zantac, Zantac 150, Zantac 75, Zantac 300, Acid Reducer, Zantac 150 EFFERdose, Taladine, Zantac 25 mg EFFERdose, Berkley and Jensen Acid Reducer Maximum Strength, Deprizine, Zantac GELdose, Zantac 300 GELdose, Zantac EFFERdose, Acid Reducer Non-Prescription Strength, Zantac Injection, Acid Relief, Sunmark Acid Reducer Maximum Strength, Acid Control 75, Careone Acid Reducer, Equaline Heartburn Relief, Acid Control 150)
  • Synthroid (levothyroxine)
  • Tylenol (acetaminophen)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)
  • Zantac (ranitidine)

Pantoprazole disease interactions

There are 4 disease interactions with pantoprazole which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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