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Omeprazole for GERD User Reviews

Brand names: Prilosec, Prilosec OTC, Omesec

Omeprazole has an average rating of 4.7 out of 10 from a total of 254 reviews for the treatment of GERD. 32% of reviewers reported a positive experience, while 51% reported a negative experience.

Omeprazole rating summary

4.7/10 average rating

254 ratings from 279 user reviews.

Compare all 121 medications used in the treatment of GERD.

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Reviews for Omeprazole

  • SJano
  • July 23, 2021

"On omeprazole for 11 days, which 5 years ago & I had all side effects mentioned-anxiety, stomach pain, severe brain fog, etc. I had 3 trips to ER with heart pounding & racing numerous tests to try to diagnose. It took 6 months to feel 100%. Upped nutrition & made my own rehydration liquid (coconut water, fresh oranges & lemons,etc). I used organic products when possible, wanted as few toxins in my body) exercised, increased vitamins & supplements B12 & magnesium & started yoga. Symptoms slowly decreased over next 6 months - symptoms didn’t cease immediately after stopping. PLEASE don’t lose hope if you are still experiencing symptoms! Stay on a regimen of optimum nutrition & hydration & symptoms will slowly subside over several months. I feel like the poison got into every crevice of my body & invaded tissue & muscles, so took time to flush out. Do NOT let doctors tell you that it’s all in your head, that medication can’t cause these side effects! Wishing everyone hope for recovery & encouragement for a return to normal. It WILL get better:)"

1 / 10
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  • Deano
  • May 25, 2020

"I was left on this medication omeprazole for around 6 years by my doctor for stomach acid. I am from the UK so although we have a national health service it’s a common occurrence not to receive a sufficient level of care. Anyway I managed to replace the benefits that these tablets did assist with by instead taking vitamins. Stopped taking 5 months ago and I can not put into words how amazing I have felt ever since. Anxiety and depression have lifted enormously! I used to get anxious about the smallest things, such as driving my car, having type of certain juice in the house. Just the daftest things ever. I’m sleeping better then I ever was. No brain fog, memory/concentration have increased significantly. I can not recall a time when my mood was been constantly high throughout my life (32) I truly believe these tablets severely impacted my mental health for all those years so I strongly advise anyone either taking or thinking about taking them to not bother. Look into natural aids instead!!"

1 / 10
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  • Need...
  • Taken for less than 1 month
  • March 27, 2021

"My wife has been off this stuff for about 3 weeks now and is still plagued with the anxiety, insomnia, pins and needles etc. Can anyone tell me how long it took for them to be free of this misery? Thanks so much...we hope everyday that these horrible side effect subside...please give me some good news!! Thanks so much!"

1 / 10
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Frequently asked questions

  • Presley
  • Taken for less than 1 month
  • September 25, 2019

Prilosec (omeprazole) "DO NOT TAKE THIS MEDICINE!!!!! This medicine has ripped the life out from inside me. I went from being my totally normal happy self to having serious panic attack’s, constant anxiety/depression and a general feel of hopelessness. The symptoms started on my 12th day and I stopped taking the pill on my 13th day. It is a week later and the panic attacks, anxiety, depression, and hopelessness still remain. This drug is poison to me and many others!!!"

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  • TLC
  • Taken for less than 1 month
  • September 28, 2021

"Started a short treatment of Prilosec for an acid reflux flare up. 40mg a day. Took for 16 days before we realized what was happening! I’m generally in great health, fit, healthy weight, on no medications, and have never experienced depression. This medication caused me to have anxiety, heart palpitations, loss of appetite, weight loss, extreme depression, tingling in the hands and feet, and worsened my acid reflux symptoms! Once we realized these symptoms were actually side effects of the medication I stopped taking it! That was 2 weeks ago. The depression has very slowly lifted, the anxiety keeps coming and going, the acid reflux is cleared up, and appetite is improving every day. No degree of acid reflux is worth going through what I’ve been going through the past month! DON”T TAKE IT!"

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Are you taking this medicine?

  • Asia
  • Taken for less than 1 month
  • January 10, 2020

"My acid reflux came back recently so I went to see a doctor. She prescribed me to take 20mg omeprazole every morning. 3 days had passed and I noticed dizziness, unable to focus, my eyes couldn’t focus on one thing...they always dilated, diarrhea, fatigue, paranoid, anxiety spiked! I took it for exactly 6 days. My dad told me not to take it anymore and we’ll soon be headed to the doctor. It works for some but the reviews that I have been reading are exactly how I feel...if you experience any one of these symptoms stop taking them immediately! I read that someone had seizures! I wish you all well and will be taking the natural way suggested...baking soda+water, apple cider vinegar, and ginger tea!"

1 / 10
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  • Don
  • Taken for less than 1 month
  • September 3, 2020

"I started experiencing tightness in the middle of my chest with constant belching and a pinching stomach pain in my upper right abdomen. Dr diagnosed me with acid reflux and put me on prilosec otc 20mg for 14 days. I just started taking the pills and man... my anxiety was 10x worst. I was anxious, heart racing, nauseated, stomach pain, brain fog, blurred vision and overall I felt like crying and just so awful. Please talk to your dr for other alternative medicine. I don’t recommend taking these."

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More FAQ

  • Georgie
  • August 29, 2020

"Hey guys! One night I had too much wine and woke up with stabbing pain between my breasts in the middle; I went to dr got diagnosed with GERD. Prescribed me 40mg omeprazole. I started taking it, it helped and a few days later the stabbing pain was gone. Then I started feeling rib pain and lower sternum pain. Dr told me it was because of GERD. Nope. The more I took it the worse it got and 3 weeks after taking this stuff I was in horrendous rib pain, all over my upper body, chest wall pain I could not move. Had to go to ER, Xrays, blood test they found nothing. I lost a bunch of weight too, I had blurry vision, terrible brain fog, warm arms and swollen toes, insomnia, horrendous body pain, I could not move. My poop looked like it came out the same way it went in, food junks etc.. I stopped taking it and now I am a month off of it, rib pain and all other side effects are going away, still have a tiny pain left but feel better. Seriously, what is this med? Avoid it if you can"

1 / 10
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131 Report
  • Fam
  • Taken for less than 1 month
  • March 13, 2021

"I been taking this pill for 3 weeks. Started to feel dizziness, headache, and lightheaded. Loss appetite, chills, tingling, brain fog, and feels like being drunk all the time. Has been hit hard. Off the meds for 3 weeks. And still feel whoozy and drunk. The meds haven't wear off yet. Anyone know what to do at the moment?"

10 / 10
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  • Mark
  • Taken for 1 to 2 years
  • March 28, 2022

"Evil drug!!! Do not take it took me over 4 months to get over the side effects and I still have little lapses to this day a year later. Not sure what they have done but like they put my whole nervous system on overdrive horrible drug. Honestly I'd rather the gastric acid do the max damage then ever go through that again. Dizziness, brain fog, eye twitches, muscle spasms randomly all over more slightly left shoulder and arm. Made me nervous about everything. I was horrible to people getting very aggressive over nothing, burning and itching of the skin, pins and needles in feet and hands, non stop congestion and ear ache, waking up during sleep feeling like I'd stop breathing.This probably around half of what I went through, the list is endless."

1 / 10
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  • Mich
  • Taken for less than 1 month
  • December 14, 2021

"My daughter was put on these for 14 days, I’ve never seen someone change so dramatically. By her last day of taking them she was pacing her room saying she felt like she was going to die and that something bad was going to happen. She has never suffered with anxiety before or panic attacks. Brain fog, shooting pains in her head, can't stop crying. It’s been 4 weeks since she stopped these and she is really struggling. She is taking extra vitamins and eating but is desperate to know how long this is going to last. She has gone from being an outgoing girl to not leaving the house. Any advice appreciated. Her doctor has prescribed antidepressants but she’s reluctant to take these as she has never needed them before."

1 / 10
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  • Anonymous
  • Taken for less than 1 month
  • May 4, 2020

Prilosec OTC (omeprazole) "After 12 days of taking this medicine, I feel crazy! Sudden head rushes when I stand up. A feeling of my ears being full. Heart palpitations, chest tightness etc..it did help with my acid reflux but I had to stop taking it. I can't deal with the side effects. Going to lose weight and cut off certain foods."

8 / 10
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  • Jack
  • Taken for less than 1 month
  • January 12, 2021

"Took 40mg once a day before breakfast. Noticed some anxiety on Day 5. By Day 11 I was completely toasted, I had brain fog, weight loss, nausea, blurry vision, and extreme anxiety. It has been 3 weeks since I quit this medicine. Brain fog has subsided however, anxiety keeps crawling in and out. Hang in there, stay tough. This medicine will take its course and time to wash out completely from your system. I am hoping to fully recover in near future. Exercise, and stay positive."

1 / 10
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  • PCano
  • January 10, 2021

"This omeprazole stuff is horrible. Sure, it got rid of the heartburn issues I was having, but the side effects are horrific and scary. Even more scary is they don't include the litany of scary side effects. While on this retched drug, I had pain in my thighs, slightly swollen lower legs, increased blood pressure, tingling in my hands and feet, lethargic legs, water retention, and a painful right testicle. Of course, none of these side effects, which can be found online on sites, but aren't mentioned on the packaging. So, while taking this dangerous drug, I was having these issues and not realizing it was the drug because these side effects weren't mentioned. I thought I was having some other type of horrible medical condition(s). Luckily, I realized all these conditions cropped up after I started the drug. Once stopped, my conditions all began to improve and go away. Beware of this cursed drug. It can screw you up big time. Never again."

1 / 10
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  • Derek
  • Taken for less than 1 month
  • December 31, 2019

"Does anyone know how long these horrible side effects last??? I’ve took them two weeks and now been off them two weeks so far. Brain fog has lessened but still getting anxiety and depression/emotionless/soul less feeling from time to time. I could sleep the first week off of them now the second week I’m having hard time sleeping , snapping awake, muscle jerking, needles in my skin feeling. This pill is awful . I’ve heard it could take a month or two to normalize"

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  • satch...
  • Taken for less than 1 month
  • February 5, 2021

"I complained about having sharp pains occasionally just below the breasts and the Dr. told me it was acid build up and that I should take an omeprazole every morning. On day 5 I got very lightheaded and dizzy every time I stood up, felt my heart racing, and felt anxious. I stopped taking the pills that day and three days later I'm still feeling lightheaded, a general feeling of heaviness in my chest, and, most concerning, a tidal wave of depression. I am wondering how long it will take this to get out of my system because I feel so wonky."

1 / 10
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  • Jimmie
  • Taken for less than 1 month
  • March 14, 2022

"I don’t even know where to start. I will say this medicine did work but the side effects are absolutely horrible! The anxiety, depression, and impending doom I felt all day long was terrible! I was on 40mg a day for 14 days along with famotodine for an ulcer. I just finished my 14 days and the symptoms (Anxiety and feel like something bad is going to happen) are still there. Can anyone please tell me if this anxiety will eventually go away and how long? This is terrible I feel like I’m going nuts!"

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  • J R
  • Taken for 1 to 6 months
  • October 7, 2021

"Absolutely awful, dangerous, one of the worst experiences of my life. It is finally time to share my story in hopes it helps others not go through this. I waited until the nightmare was 100% over and that garbage was out of my system. I was prescribed 80mg per day of Omeprazole on June 11, 2021 and took that amount daily for 7 weeks. In late July, I had severe mental fog, insane anxiety, near impossible ability to drive, often felt like I would pass out driving. This nightmare continued for exactly 2 months after going cold turkey off that garbage. 2 months of being terrified to drive feeling awful, hugging the berm, going under the speed limit, fearing for my life. If your doctor tells you there are no side effects with this drug like mine did, they are full of you know what. Please think of alternate solutions. This can wreck your life and others, literally. Big pharma wont want you to know that. I highly recommend you do not go through this and finds healthy solutions."

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  • sumguy
  • Taken for 6 months to 1 year
  • February 10, 2020

"I suffer from extreme chest pain related to GERDs induced esophageal spasms. Omeprazole is the only medicine that I've been given that can even come close to alleviating my reflux and therefore my pain. The problem though is that this medication makes me so sick I can hardly function. It causes nausea, dizziness, brain fog, muscle fatigue, and eventually leads to a kind of painful swelling lump feeling at the base of my throat that can be highly distracting. It's horrible but so is the chest pain from reflux. So, when the pain gets unbearable I take the Omeprazole and stop when it makes me sick (usually around day 8 or 9), then I quit the medication until the chest pain again becomes unbearable. It's a vicious, awful, horrible cycle between pain and illness. If you can avoid this medication, do!"

2 / 10
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95 Report
  • justme
  • July 24, 2015

Prilosec (omeprazole) "I have taken Prilosec for over 15yrs. It works great for the heartburn/reflux/gerd. But let me tell you what it took away from me! It dropped my iron and my iron stores to the bottom, it also took my B12 to the bottom. It also after years of taking it gave me anxiety, cramping of muscles and lead to my potassium being low as well. Then most recently I kept having a horrible burning in my stomach, well guess what Prilosec gave me most of all! A stomach full of gastric polyps!! So now I have weaned myself off this horrible medicine cause gastric polyps are a side effect of it and no one tells you! And if you keep taking it , well guess what it makes even more in your stomach once it starts!! So I weaned myself off it, took over a month"

7 / 10
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  • Wendy
  • Taken for less than 1 month
  • November 17, 2019

"I took this for 5 days for acid reflux. I experienced extreme anxiety and panic attacks. I couldn’t sleep, at all as every time I was dropping off I had a huge adrenaline rush. I couldn’t function and had 4 weeks off work sick. I realised in the 5th day that these tablets must be the cause so I researched it only to find other people had similar symptoms . I stopped taking them straight away. The doctor had to prescribe anxiety tablets Duloxetine as I was in such a state of anxiety . The doctor would not believe that the tablets have these side effects. I tackled the acid reflux with an alkaline only diet and a year later I am now back to normal and off the anxiety tablets. I would advise anyone to not take these tablets, they caused me to literally have a break down . Thank god I stopped taking them when I did."

1 / 10
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  • Keegan
  • Taken for less than 1 month
  • May 4, 2020

"I've given by MD this worst medicine! 2 weeks consumed it. On the 10th or 11th days, I feels brain fogs, my upper and lower back feels so painfully. Anxiety got higher. It is a month already since I stopped it, the side effects are still in my body. Seriously, what ever PPI kinda med... Do not ever take it. "

1 / 10
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  • Rachel
  • March 27, 2023

"I can second all the other anxiety-related issues to this drug. I was a perfectly happy and healthy 28-year-old. Starting taking omeprazole for some nasty silent reflux symptoms and anxiety came out of nowhere. I had never in my life experienced anxiety, depression, or panic attacks until I started taking this awful drug. After 2 months I started deep diving into the research and quit taking them. Instantly felt better and started recovering, started taking supplements to restore the acid in my stomach that this drug had depleted along with many other vitamins it prohibits your body from absorbing!!! I'm on my road to recovery now and encourage you to do your own research before taking."

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  • Anonymous
  • November 7, 2020

"I went to the ENT doctor because I was having trouble swallowing my saliva so she stuck the tube up my nose and after she was done and told me the back of my throat was red and I have severe acid reflux before I even came to the ENT doctor I suffer from anxiety & depression already. Not knowing the drugs she prescribed me was going to make that worse I took omeprazole for 6 days and the side effects I couldn't deal with - my anxiety got worse I got more depressed, eyes felt dilated, I got a headache, diarrhea, woke up and my arms was slightly aching without me doing anything also having to clear my throat with nothing in my throat to be cleared and lose of appetite I will never take omeprazole again I'm going try the hopefully it leaves my systems soon I'm going to try the natural way"

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  • Susie
  • October 23, 2019

"I started to have problem with swallowing and felt like I had a lump in my throat. Constantly had to clear it in order to complete a sentence. I was experiencing heartburn. I went to an ENT, who put a camera up my nose and into my throat and said all was good but I have GERD. Had never heard of this until now. He suggested I take 40mg of Omperazole everyday and see how it works. So, it did help with the issue with my throat but the side effects from it are horrible . I have been nauseous, feel like I am going to vomit, dizzy, shakes, chill, panic attack, rapid heart beat, severe anxiety and severe insomnia. I have tried taking it for three weeks and as the days go by the side effects make me feel so bad I can not function. IAM NOT GOING TO CONTINUE WITH THIS PILL!!! IT IS HORRIBLE!!!!! It literally has ruined me . I am hoping it clears my system quick. I feel horrible"

1 / 10
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Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.