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Pylera Dosage

Generic name: BISMUTH SUBCITRATE POTASSIUM 140mg, METRONIDAZOLE 125mg, TETRACYCLINE HYDROCHLORIDE 125mg
Dosage form: capsule
Drug class: H. pylori eradication agents

Medically reviewed by Drugs.com. Last updated on Apr 7, 2025.

Administer three PYLERA capsules 4 times a day (after meals and at bedtime) for 10 days. One omeprazole 20 mg capsule should be taken twice a day with PYLERA after the morning and evening meal for 10 days (Table 1).

Table 1: Daily Dosing Schedule for PYLERA
Time of dose Number of capsules of PYLERA Number of capsules of omeprazole 20 mg
After morning meal 3 1
After lunch 3 0
After evening meal 3 1
At bedtime 3 0

Instruct patients to swallow the PYLERA capsules whole with a full glass of water (8 ounces). Ingestion of adequate amounts of fluid, particularly with the bedtime dose, is recommended to reduce the risk of esophageal irritation and ulceration by tetracycline hydrochloride.

If a dose is missed, patients should continue the normal dosing schedule until medication is gone. Patients should not take double doses. If more than 4 doses are missed, the prescriber should be contacted.

Further information

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