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Pylera for Helicobacter Pylori Infection User Reviews

Pylera has an average rating of 5.8 out of 10 from a total of 195 reviews for the treatment of Helicobacter Pylori Infection. 36% of reviewers reported a positive experience, while 26% reported a negative experience.

Pylera rating summary

5.8/10 average rating

195 ratings from 245 user reviews.

Compare all 49 medications used in the treatment of Helicobacter Pylori Infection.

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Reviews for Pylera

  • Half...
  • Taken for less than 1 month
  • July 6, 2021

"On my fifth day taking this med. I have all the side effects from nausea to bad stomach spasms very dry and swollen lips. I can't even see or smell food. I'm taking emprazole twice a day. I don't know how I will be able to get through the last 5 days. I feel like Im going mentally crazy. I live in Syria and we don't have this med here so I ordered it from France. I was given local meds but they didn't work so I got it from France. Even if no one sees my review typing this is really helping me with my anxiety."

4 / 10
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93 Report
  • GSano
  • Taken for less than 1 month
  • December 17, 2019

"On Pylera for H pylori, Days 1-3 were ok but days 4-7 were the worst. Loss of appetite, heartburn, acidic reflux, belching (lots of it!), general discomfort, nausea and vomiting were the worst side effects. Found a way to overcome these: DRINK LOTS OF WATER! Like 2L a day, it'll help out a lot. Recommended food: broth/soup/mashed vegetables, the less solid the better. Try probiotics 15min before breakfast, so that your intestinal flora stays balanced. Days 8-10 were much better once I drank a lot and ate (semi-)liquid food, I felt almost normal (still acidic reflux in the morning). General discomfort disappeared around day 13. Daily schedule: 9.15 probiotic; 9.30-10.15 breakfast; 12.30-13.15 lunch; 16.30-16.50 snack; 20.00-20.45 dinner. LOTS OF WATER (BUT NO DAIRY) ALL DAY LONG! Don't panic if you're feeling nauseous, stay calm. I tried to meditate and do yoga so that my mind isn't focused on the treatment, it helped psychologically but also physically. Breathe and don't stress yourself!"

7 / 10
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107 Report
  • Abesko
  • Taken for less than 1 month
  • April 2, 2019

"I was diagnosed with IBS syndrome with very bad diarrhea and bloating but went for blood test (and gastro test) for Helicobacter. They found massive infection in my stomach and I got Pylera and PPI (omeprazole). Today is day 10 of my procedure and I have to say starting day first I have no symptoms of IBS so it looks it works very well! Zero side effects (just black stool but this is normal during Pylera treatment) You can find many negative comments here but typically people are writing these only if something goes wrong. My advice is don't be scared (don't panic :) ) of Pylera treatment, I was lucky for no side effects and never feel that good (after 3 years of problems). Every body is different.."

10 / 10
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106 Report
  • No HP...
  • August 27, 2019

"Due to H Pylori, I had bloating, indigestion, gas, nausea, some change in bowel movements, stomach pain/cramping/gnawing, acid reflux/heartburn, etc. With Pylera, I had terrible nausea and trouble eating, my whole body was very achy, and felt totally drained while on Pylera. I took some sick leave and teleworked on worst days. I was regimented about taking the medication on time: 7-7:15 am, 12:15-12:30 pm, 5:15-5:30 pm, 10:15-10:30 pm. That definitely helped. I re-tested 1 month later and no longer have H Pylori. After Pylera, I still had burning/gnawing in my stomach, heartburn, bloating, and trapped gas. Damage done by H Pylori can take at least 2-3 months to heal. I went the natural remedy route: 1) acupuncture; 2) Slippery elm; 3) fresh cabbage juice (this was most helpful). I also decided to temporarily remove coffee, alcohol, spicy food, citrus, tomatoes, chocolate, red meat, and dairy from my diet."

6 / 10
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81 Report
  • Jill
  • Taken for less than 1 month
  • November 5, 2019

"Just took my last 3 pills of Pylera...woohoo! Contrary to what I read about this treatment, it was not as bad as I thought. I believe what made it easier was drinking at least 10 ounces of water and taking pills after eating. I also tried to eat as clean as possible. The cons were eating more than usual for me and keeping to the schedule. I also had some headaches in the morning but nothing intolerable."

7 / 10
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55 Report

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  • sickt...
  • October 30, 2014

"Had hard time pretty much since second day. Some people stated you should eat first. Unfortunately, that makes me want to vomit after taking it. No diarrhea (I took probiotics and ate activia), but weird stools (very dark and frequent). I think my bowels are empty at this point. Appetite gone. Lost almost 10 pds. Difficulty sleeping due to nausea and gas pains. Threw up twice. Little energy. Headaches. Feeling stressed and somewhat depressed at times. Crying bouts in middle of night. What I described wasn't constant. It came and went throughout the day, but nights were hardest for some reason. Tomorrow is final day. Can you survive it? Yes. Is it hard? For sure. If h.pylori is gone, then it's worth it. Be strong."

3 / 10
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93 Report
  • Nikki
  • Taken for less than 1 month
  • May 20, 2014

"I stated that I would come back to this site with the results of my endoscopy after taking Pylera and the bacteria has been eradicated. Pylera worked for me!! I am a very satisfied customer. I hope this review will be helpful to others. Hang in there if you are taking it and having a rough time."

10 / 10
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93 Report
  • Babyg...
  • July 23, 2019

"I'm on day 8 of taking pylera and it hasn't been bad surprisingly. My only complaint is taking so many pills for 10 days can be frustrating and exhausting. I did experience a slight headache and nausea. The nausea didn't start till day 7 but it wasn't bad. Had a headache the first couple days. I have been fine. It was hard to find things to eat as I did not want to eat anything I was not supposed to. I ate at 7, 12, 4, and 8. Took meds at 10, 2, 6 and 10. Also I ate very little as there is hardly anything you can eat while taking this. I had trouble finding what to eat so I hope this helps out for people finding something to eat. I ate hummus, apples, chicken, tuna, eggs, guacamole, spam(all spam is gluten free)! Gluten free oatmeal. Dukes mayo is also gluten free and diary free! Mustard is also. Black olives and i got organic vegetable broth to drink also for my late snack. I drink a 16oz bottle of water with taking pylera instead of 8oz recommended and it's all good!"

9 / 10
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49 Report
  • Mals...
  • January 14, 2017

"I was very hesitant to take this medicine based on reviews. I had taken the amoxicillin, claromyicin treatment a year before but it did not work. I tried Black Seed Oil, Mastic Gum and Manila Honey. They made my stomach feel better for a while but then the pain started again and my stool sample came back positive again. So I started Plyera. I took a strong probiotic twice a day, ate a good amount of food with each dose and took omeprazole twice a day. I eliminated any foods or drinks with dairy or alcohol. I pretty much ate oatmeal, eggs, peanut butter sandwiches and veggies. I did not have any problems with Plyera. About day 5 I had some stomach pains and was really tired but was fine otherwise and now my stool test was negative!"

10 / 10
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65 Report
  • Puff
  • October 3, 2018

"I know so many people have posted about how terrible the medication is. I had a hard time the first 5 days and almost stopped it. I finally figured out the secret to getting through it. Drink tons of water and eat food between each capsule. It might take 10-15 minutes to take the dose but it makes a huge difference. I still did get the black stools which were gross but now they are back to normal. Since finishing the 10 days a week ago, I am feeling great, no pain, and so glad I got through it. Now I'm just waiting to go in for the breath test hoping that all is good. My advice to everyone is to stick it out. You can do it!!"

9 / 10
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52 Report
  • Mehanna
  • Taken for less than 1 month
  • April 24, 2019

"Read all the reviews here and started to think whether I will take it or not since I'm very anxious person. I decided to take it since its the only way to kill this strong bacteria that can cause stomach cancer! I'm on day 6 now, my only side effects are feeling so tired, dizzy all day and dark stool. Advice for everyone drink a lot of water and eat proper food without gluten, eat soups, chicken, lentils, avocado, bananas as well eat Oat (Gluten Free) in the morning before u take your first pills, it will make you full and relaxed for a while. 4 days to go! Just feeling anxious all time, hope this will kill this bacteria, I will come back here to update everyone if its gone."

4 / 10
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41 Report
  • anony...
  • April 6, 2015

"Don't be afraid to take this medication. If you don't suffer from side effects from antibiotics, you will be fine with this one too. The only problem is that 10 days taking 12 pills a days is a long time and by the 8th days it feels that it would never end, but it was worth it . I am H pillory free now."

9 / 10
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61 Report
  • AIM
  • Taken for less than 1 month
  • January 8, 2022

"I’m not a big person when it comes to taking a constant medication but I finished it 2 weeks ago and I’m waiting to take the breath test, but my symptoms have came back. I do not feel good at all. I don’t want to go anywhere or do anything. The Zofran hasn’t really be helping either. Has anyone else still been feeling sick after taking the medication?"

4 / 10
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21 Report
  • TumGERD
  • Taken for less than 1 month
  • August 29, 2015

"Was prescribed this after positive ID of h.pylori from endoscopy biopsy. 10 days / 12 pills a day. Not gonna lie it was rough. Side effects included dizziness, upset stomach, nausea for me. Within 10mins of ingestion the effects could be felt. I made sure to eat a full meal to help lessen the effects. Even at bedtime. Sometimes no effects other times strong effects. But got through the 10 days. After taking it still had residual side effects for another 2 days on/off. Then finally on day 3 returned to normal. Need to do the re-test in 1mo so not sure if it worked to kill the bacteria for good. I won't lie I almost stopped taking it in the middle of treatment but kept telling myself this has to be done and I cannot stop!"

7 / 10
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56 Report
  • Emi
  • September 27, 2018

"I had a positive experience with Pylera. As with any other antibiotic, you MUST eat before taking the medication. Moreover, drink water copiously throughout the day and with your meals. The instructions say 8 ounces: double this! Avoid foods that are high in calcium: calcium prevents the medication from working, making you feel worse. This includes ALL dairy but also many replacements like soy milk etc. Read labels carefully. Unless explicitly told so by your doctor, stop multivitamins/supplements. NO ALCOHOL! Regular intervals will help. Taking the medication right after meals at 7am, noon, 5:30pm, and 10pm worked for me. Regularity is key. I took the full course of Pylera and had minimal side effects. I was rigorous about eating and drinking. I was somewhat tired. But I experienced none of the nausea, headaches, etc that others describe. And I ascribe that to being regimental about intake of food and water, and timing. Please do not be afraid of Pylera."

10 / 10
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39 Report
  • Nikki
  • Taken for less than 1 month
  • May 21, 2014

"*UPDATE* The Pylera worked! The bacteria has been eradicated! I completed my 10 day treatment on April 7, 2014. The only side effect was some mild nausea (I just ate a little more) and a bad taste in my mouth (lots of sugar-free gum). I am waiting 30 says to test to see if the bug is gone. I will come back on here with the results of the endoscopy."

10 / 10
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59 Report
  • Redrinx
  • June 20, 2015

"Pylera eradicated my H Pylori infection. Apparently, I had a horrible case for many years, and this worked. I had tried other drugs in the past, and nothing worked until this. It's rough though! I think I had every side effect and the 9th day was the worst, but you have to push through! My tricks - eating larger meals before taking it, and yes, you will always feel bloated and full. Also, sucking on fruit flavored Tic Tacs helped the nausea. Something I learned - sugar, caffeine, chocolate and salt feed this bacteria, so I tried to steer clear of these things. I heard vitamin C, grapefruit, and a probiotic, keep it away so I incorporated these into my diet -while taking Pylera. I had a pretty aggressive case, but it's gone!!"

7 / 10
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51 Report
  • HPisT...
  • Taken for less than 1 month
  • April 6, 2013

"After reading message boards, I became so freaked out at the thought of going on Pylera, I waited 5 days before starting the regimen, but boy am I glad that I did because on day 4 my brain came back and by day 6 I was really feeling a lot better. I'm not going to lie. It was very intense. It was almost like I could feel the war going on inside of me between the pills and the bacteria, but knowing the medicine was eradicating this hideous thing made it palpable. "

9 / 10
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58 Report
  • Efultz
  • June 9, 2017

"Just finished pylera last night and still have the symptoms as if I was still taking the meds. I'm so happy I'm finished and can't believe I got through it...it was really tough. Good luck everyone and remember it's light at the end of the tunnel"

9 / 10
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40 Report
  • Knoxv...
  • Taken for less than 1 month
  • March 2, 2013

"I was on a ten day treatment taking three pills four times a day. I was also taking Omeprazole twice daily. It helped a lot as far as the sickness and nausea go. Dark urine and stool was about the only side effect I experienced except for dry mouth during the night. The key is to make sure you eat plenty before each dose. Do NOT eat or drink dairy while taking it. I made that mistake one time and that's all it took. Other than that I felt pretty good. I will also suggest a good brand of probiotic to take daily as well. It was a tough ten days but I believe it's well worth it."

9 / 10
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57 Report
  • Its...
  • September 19, 2019

"I've been taking pylera for 6 days. Its the worst experience I've had with taking this medication. I have all the side affect symptoms. Nausea and the bitter taste are the worst ones. I cant hardly eat and I've thought about just giving up. This suppose to be a good medicine but the side affect will have you second guessing yourself. I don't think I could make it to day 10. 12 pills a day is too much meds to take in for anyone. I'm praying that I could get through this. At least they should be able to prescribe you something for nausea. On top of that I stay sleepy all the time. This med sucks!!"

9 / 10
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29 Report
  • Calo
  • Taken for less than 1 month
  • October 14, 2019

"I am on day 7 of this Pylera pill. I really hope it works because I don’t think I can do it again. The headaches, the nausea, the weird taste started after day 4. It’s hard to find things to eat so if anyone has ideas please share. Full meals are helpful and lots of water. Fresh fruits, no dairy. It’s very draining so lots of rest is needed. Glad I found this site. Stay strong."

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28 Report
  • Anonymous
  • July 16, 2015

"This is my fourth time trying to eradicate the bacteria and had never been given pylera. after reading people's stories I was horrified to take this medication. Let me tell you it has been the hardest medication I have ever taken. I had vomiting, diharrea, and every side effect. I am now on day 10 and could not be any happier.The mind is powerful so keep positive and finish. I will update if it worked."

7 / 10
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46 Report
  • Healt...
  • September 8, 2018

"So I am currently on Pylera for Pylori. This is Day 8 & I can honestly say this is the worst, the first 5-6 days was fine! I was upbeat then day 7 I started feeling pregnant. I can smell everything I can’t eat anything at all! I have no appetite. I throw up every morning, the nasty metal taste in my mouth, so tired & feel like I never get any sleep. I don’t know what to do since I have to take the medication after meals and I can’t eat & I can’t miss a dose. I have to force myself to eat but the nausea is horrible. I have mood swings, fast heart rate.... BASICALLY FEEL LIKE I AM DYING SLOWLY. but I have to stick this through If I want to recover."

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33 Report
  • Anonym
  • Taken for less than 1 month
  • January 24, 2024

"I wanted to share my review, as this review page helped me a lot. I took Pylera in December 2023 for 10 days, as I had pains in my stomach for the past several months. I recently took a test, which came back negative! The 10 days with Pylera were hard, as I had continuous strong (sometimes even stronger than before) pains in my stomach and back, which made it difficult for me to sleep well. I was exhausted. I experienced heart pain at night on day 6, which made me wonder if I should call an ambulance. I wasn't sure if the bacteria had gone by the time I finished Pylera. However, the test showed negative, and I started feeling normal only around 2-3 weeks after finishing Pylera. During this time, my diet consisted mainly of vegetables, bananas, white bread, rice, and eggs. I avoided caffeine, alcohol, sour fruits, chocolates, and dairy products. I took the tablets at 6am, 11am, 4pm, and 9pm. So, when taking Pylera, be prepared for some side effects. But it is worth finishing, unless there are extreme adverse effects."

8 / 10
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3 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

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