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Prevpac Side Effects

Generic Name: amoxicillin / clarithromycin / lansoprazole

Note: This page contains side effects data for the generic drug amoxicillin / clarithromycin / lansoprazole. It is possible that some of the dosage forms included below may not apply to the brand name Prevpac.

For the Consumer

Applies to amoxicillin / clarithromycin / lansoprazole: oral capsule, oral capsule delayed release, oral tablet

As well as its needed effects, amoxicillin / clarithromycin / lansoprazole may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking amoxicillin / clarithromycin / lansoprazole, check with your doctor immediately:

Incidence not known:
  • Abdominal or stomach pain or tenderness
  • blistering, peeling, or loosening of the skin
  • clay colored stools
  • dark urine
  • diarrhea
  • difficulty with swallowing
  • dizziness or fainting
  • fast, slow, or irregular heartbeat
  • fever or chills
  • headache
  • hives, itching, or skin rash
  • joint or muscle pain
  • loss of appetite
  • nausea and vomiting
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • sores, ulcers, or white spots in the mouth or on the lips
  • swelling of the body, feet, and ankles
  • tightness in the chest
  • unusual tiredness or weakness
  • unusual weight gain
  • watery and severe diarrhea, which may also be bloody
  • yellow eyes or skin

Minor Side Effects

Some amoxicillin / clarithromycin / lansoprazole side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common:
  • Bad, unusual or unpleasant (after) taste
  • change in taste
Less common or rare:
  • Confusion
  • discoloration of the tongue
  • itching of the vagina or genital area
  • pain during sexual intercourse
  • redness, swelling, or soreness of the tongue
  • sore mouth or tongue
  • thick, white vaginal discharge with no odor or with a mild odor
  • white patches in the mouth, tongue, or throat

For Healthcare Professionals

Applies to amoxicillin / clarithromycin / lansoprazole: oral kit

General

The most commonly reported side effects included diarrhea, headache, and taste perversion.

Amoxicillin: The most commonly reported side effects included nausea, diarrhea, rash, and vomiting.

Clarithromycin: The most commonly reported side effects included abdominal pain, diarrhea, nausea/vomiting, and dysgeusia.

Lansoprazole: The most commonly reported side effects included abdominal pain, diarrhea, and nausea.[Ref]

Nervous system

Common (1% to 10%): Headache, taste perversion
Frequency not reported: Dizziness

Amoxicillin:
Frequency not reported: Dizziness, hyperactivity

Clarithromycin:
Frequency not reported: Dizziness, dysgeusia, dyskinesia, headache, loss of consciousness, somnolence, tremor, vertigo
Postmarketing reports: Ageusia, anosmia, convulsion, paresthesia, parosmia

Lansoprazole:
Frequency not reported: Amnesia, cerebrovascular accident/cerebral infarction, convulsion, dementia, dizziness, headache, hemiplegia, hyperkinesia, hypertonia, hypesthesia, migraine, paresthesia, parosmia, somnolence, syncope, taste loss/perversion, vertigo
Postmarketing reports: Speech disorder[Ref]

Gastrointestinal

Common (1% to 10%): Diarrhea
Frequency not reported: Dark stools, dry mouth, glossitis, nausea, oral moniliasis, rectal itching, stomatitis, tongue discoloration/disorder, vomiting

Amoxicillin:
Common (1% to 10%): Diarrhea, nausea, vomiting
Frequency not reported: Black hairy tongue, hemorrhagic/pseudomembranous colitis, tooth discoloration/brown, yellow or gray staining of teeth

Clarithromycin:
Frequency not reported: Abdominal distension/pain, constipation, diarrhea, dry mouth, dyspepsia, eructation, esophagitis, flatulence, gastritis, gastroenteritis, gastroesophageal reflux disease, glossitis, nausea, proctalgia, stomatitis, vomiting
Postmarketing reports: Acute pancreatitis, pseudomembranous colitis, tongue/tooth discoloration

Lansoprazole:
Common (1% to 10%): Abdominal pain, constipation, diarrhea, nausea
Frequency not reported: Abnormal stools, bezoar, cardiospasm, colitis, dry mouth, dyspepsia, dysphagia, enlarged abdomen, enteritis, eructation, esophageal stenosis, esophageal ulcer, esophagitis, fecal discoloration, flatulence, gastric nodules/fundic gland polyps, gastritis, gastroenteritis, gastrointestinal anomaly, gastrointestinal disorder, gastrointestinal hemorrhage, gastrointestinal moniliasis, glossitis, gum hemorrhage, halitosis, hematemesis, increased salivation, melena, mouth ulceration, rectal disorder/hemorrhage, stomatitis, tenesmus, tongue disorder, ulcerative colitis/stomatitis, vomiting
Postmarketing reports: Clostridium difficile-associated diarrhea, pancreatitis, positive fecal occult blood[Ref]

Genitourinary

Frequency not reported: Vaginitis, vaginal moniliasis

Amoxicillin:
Frequency not reported: Crystalluria

Clarithromycin:
Frequency not reported: Vaginal infection
Postmarketing reports: Abnormal urine color

Lansoprazole:
Frequency not reported: Abnormal menses, breast enlargement/pain/tenderness, dysmenorrhea, dysuria, impaired urination, impotence, leukorrhea, menorrhagia, menstrual disorder, pelvic pain, penis disorder, polyuria, testis disorder, urethral pain, urinary frequency, urinary retention, urinary tract infection, urinary urgency, vaginitis
Postmarketing reports: Albuminuria, hematuria, presence of crystal urine[Ref]

Dermatologic

Frequency not reported: Skin reactions

Amoxicillin:
Common (1% to 10%): Rash
Frequency not reported: Acute generalized exanthematous pustulosis, erythematous maculopapular rashes, erythema multiforme, exfoliative dermatitis, hypersensitivity vasculitis, mucocutaneous candidiasis, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria

Clarithromycin:
Frequency not reported: Cellulitis, dermatitis bollus, hyperhidrosis, maculopapular rash, pruritus, urticaria
Postmarketing reports: Acne, drug rash with eosinophilia and systemic symptoms (DRESS), Henoch-Schonlein purpura, Stevens-Johnson syndrome, toxic epidermal necrolysis

Lansoprazole:
Frequency not reported: Acne, alopecia, contact dermatitis, dry skin, fixed eruption, hair disorder, maculopapular rash, nail disorder, pruritus, skin disorder, sweating, urticaria
Postmarketing reports: Cutaneous lupus erythematosus, erythema multiforme, severe dermatologic reactions, Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN)/fatal TEN[Ref]

Psychiatric

Frequency not reported: Confusion

Amoxicillin:
Frequency not reported: Agitation, anxiety, behavioral change, confusion, insomnia

Clarithromycin:
Frequency not reported: Anxiety, insomnia, nervousness
Postmarketing reports: Abnormal behavior/dreams, confusional state, depersonalization, depression, disorientation, hallucination, manic behavior, psychotic disorder

Lansoprazole:
Frequency not reported: Abnormal dreams/thinking, aggravated hostility, agitation, anxiety, apathy, confusion, depersonalization, depression, emotional lability, hallucinations, insomnia, increased/decreased libido, nervousness, neurosis, sleep disorders[Ref]

Musculoskeletal

Frequency not reported: Myalgia

Clarithromycin:
Frequency not reported: Muscle spasms, myalgia, nuchal rigidity
Postmarketing reports: Myopathy, rhabdomyolysis

Lansoprazole:
Frequency not reported: Arthralgia, arthritis, back pain, bone disorder, joint disorder, leg cramps, musculoskeletal pain, myalgia, myasthenia, neck pain/rigidity, synovitis
Postmarketing reports: Bone fracture, myositis, systemic lupus erythematosus[Ref]

Other

Frequency not reported: Thirst

Clarithromycin:
Frequency not reported: Candidiasis, chills, fatigue, hearing loss, infection, malaise, pyrexia, tinnitus
Postmarketing reports: Deafness

Lansoprazole:
Frequency not reported: Asthenia, candidiasis, chills, deafness, ear disorder, fever, flu syndrome, infection (not otherwise specified), malaise, otitis media, pain, thirst, tinnitus
Postmarketing reports: Increased globulins[Ref]

Respiratory

Frequency not reported: Respiratory disorders

Clarithromycin:
Very rare (less than 0.01%): Asthma, epistaxis, pulmonary embolism

Lansoprazole:
Frequency not reported: Asthma, bronchitis, cough, increased dyspnea, epistaxis, hemoptysis, hiccup, lung fibrosis, pharyngitis, pleural disorder, pneumonia, respiratory disorder, upper respiratory inflammation/infection, rhinitis, sinusitis, stridor[Ref]

Hematologic

Amoxicillin:
Frequency not reported: Agranulocytosis, anemia, eosinophilia, hemolytic anemia, leukopenia, thrombocytopenia, thrombocytopenic purpura

Clarithromycin:
Frequency not reported: Abnormal albumin globulin ratio, eosinophilia, leukopenia, neutropenia, thrombocythemia
Postmarketing reports: Agranulocytosis, decreased white blood cell count, increased INR, prolonged prothrombin time, thrombocytopenia

Lansoprazole:
Frequency not reported: Anemia, hemolysis, lymphadenopathy
Postmarketing reports: Abnormal AG ratio/red blood cells, abnormal/increased/decreased white blood cells/platelets, agranulocytosis, aplastic anemia, decreased hemoglobin, eosinophilia, hemolytic anemia, leukopenia, neutropenia, pancytopenia, thrombocytopenia, thrombotic thrombocytopenic purpura[Ref]

Hepatic

Amoxicillin:
Frequency not reported: Acute cytolytic hepatitis, cholestatic jaundice, hepatic dysfunction/cholestasis, moderate AST/ALT elevation

Clarithromycin:
Frequency not reported: Abnormal liver function tests, cholestasis, hepatitis, increased blood bilirubin,
Postmarketing reports: Hepatic dysfunction/failure, hepatocellular jaundice

Lansoprazole:
Frequency not reported: Cholelithiasis
Postmarketing reports: Abnormal liver function tests, bilirubinemia, hepatotoxicity, increased AST/ALT/gamma glutamyl transpeptidase[Ref]

Hypersensitivity

Amoxicillin:
Frequency not reported: Anaphylaxis

Clarithromycin:
Frequency not reported: Anaphylactoid reaction, hypersensitivity
Postmarketing reports: Anaphylactic reaction

Lansoprazole:
Frequency not reported: Allergic reaction
Postmarketing reports: Anaphylactic/anaphylactoid reactions[Ref]

Metabolic

Clarithromycin:
Frequency not reported: Anorexia, decreased appetite, increased blood alkaline phosphatase/lactate dehydrogenase
Postmarketing reports: Hypoglycemia

Lansoprazole:
Frequency not reported: Anorexia, avitaminosis, dehydration, diabetes mellitus, gout, hyperglycemia, hypoglycemia, increased appetite, weight gain/loss
Postmarketing reports: Hyperlipidemia, hypomagnesemia, increased alkaline phosphatase/blood potassium/lactate dehydrogenase, increased/decreased electrolytes/cholesterol[Ref]

Cardiovascular

Clarithromycin:
Frequency not reported: Atrial fibrillation, cardiac arrest, chest pains, extrasystole, palpitations, QT prolongation
Postmarketing reports: Hemorrhage, torsade de pointes, ventricular arrhythmia/tachycardia

Lansoprazole:
Frequency not reported: Angina, arrhythmia, bradycardia, chest pain (not otherwise specified), edema, hypertension/hypotension, myocardial infarction, palpitations, peripheral edema, shock/circulatory failure, tachycardia, vasodilation[Ref]

Renal

Clarithromycin:
Frequency not reported: Increased blood creatinine/urea
Postmarketing reports: Interstitial nephritis, renal failure

Lansoprazole:
Frequency not reported: Kidney calculus, kidney pain
Postmarketing reports: Glycosuria, increased creatinine/urea, interstitial nephritis[Ref]

Ocular

Lansoprazole:
Frequency not reported: Abnormal vision, amblyopia, blepharitis, blurred vision, cataracts, conjunctivitis, diplopia, dry eyes, eye disorder, eye pain, glaucoma, photophobia, ptosis, retinal degeneration/disorder, visual field defect[Ref]

Endocrine

Lansoprazole:
Frequency not reported: Goiter, gynecomastia, hypothyroidism
Postmarketing reports: Increased glucocorticoids/gastrin levels[Ref]

Oncologic

Lansoprazole:
Frequency not reported: Carcinoma, laryngeal neoplasia, skin carcinoma[Ref]

Immunologic

Amoxicillin:
Frequency not reported: Serum sickness-like reaction[Ref]

References

1. "Product Information. Prevpac (amoxicillin / clarithromycin / lansoprazole)." Tap Pharmaceuticals Inc, Dearfield, IL.

It is possible that some side effects of Prevpac may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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