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Prevpac Side Effects

Generic Name: amoxicillin / clarithromycin / lansoprazole

Note: This document contains side effect information about amoxicillin / clarithromycin / lansoprazole. Some of the dosage forms listed on this page may not apply to the brand name Prevpac.

For the Consumer

Applies to amoxicillin / clarithromycin / lansoprazole: oral capsule, oral capsule delayed release, oral tablet

Along with its needed effects, amoxicillin/clarithromycin/lansoprazole may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amoxicillin / clarithromycin / lansoprazole:

Incidence not known
  • Blistering, peeling, or loosening of the skin
  • chills
  • clay colored stools
  • dark urine
  • diarrhea
  • difficulty with swallowing
  • dizziness or fainting
  • fast, slow, or irregular heartbeat
  • fever
  • headache
  • hives, itching, or skin rash
  • joint or muscle pain
  • loss of appetite
  • nausea
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • sores, ulcers, or white spots in the mouth or on the lips
  • stomach pain or tenderness
  • swelling of the body, feet, and ankles
  • tightness in the chest
  • unusual tiredness or weakness
  • unusual weight gain
  • vomiting
  • watery and severe diarrhea, which may also be bloody
  • yellow eyes or skin

Some side effects of amoxicillin / clarithromycin / lansoprazole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Bad, unusual or unpleasant (after) taste
  • change in taste
Less common
  • Confusion
  • discoloration of the tongue
  • itching of the vagina or genital area
  • pain during sexual intercourse
  • redness, swelling, or soreness of the tongue
  • sore mouth or tongue
  • thick, white vaginal discharge with no odor or with a mild odor
  • white patches in the mouth, tongue, or throat

For Healthcare Professionals

Applies to amoxicillin / clarithromycin / lansoprazole: oral kit


The most commonly reported side effects included diarrhea, headache, and taste perversion.

Amoxicillin: The most commonly reported side effects included nausea, diarrhea, rash, and vomiting.

Clarithromycin: The most commonly reported side effects included abdominal pain, diarrhea, nausea/vomiting, and dysgeusia.

Lansoprazole: The most commonly reported side effects included abdominal pain, diarrhea, and nausea.[Ref]

Nervous system

Common (1% to 10%): Headache, taste perversion
Frequency not reported: Dizziness

Frequency not reported: Dizziness, hyperactivity/reversible hyperactivity

Frequency not reported: Dizziness, dysgeusia, dyskinesia, headache, loss of consciousness, somnolence, tremor, vertigo
Postmarketing reports: Ageusia, anosmia, convulsion, paresthesia, parosmia

Frequency not reported: Amnesia, cerebrovascular accident/cerebral infarction, convulsion, dementia, dizziness, headache, hemiplegia, hyperkinesia, hypertonia, hypesthesia, migraine, paresthesia, parosmia, somnolence, syncope, taste loss/perversion, tremor, vertigo
Postmarketing reports: Speech disorder[Ref]


Common (1% to 10%): Diarrhea
Frequency not reported: Abdominal pain, dark stools, dry mouth, glossitis, nausea, oral moniliasis, rectal itching, stomatitis, tongue discoloration/disorder, vomiting

Common (1% to 10%): Diarrhea, nausea, vomiting
Frequency not reported: Black hairy tongue, hemorrhagic/pseudomembranous colitis, tooth discoloration/brown, yellow or gray staining of teeth

Frequency not reported: Abdominal distension/pain, constipation, diarrhea, dry mouth, dyspepsia, eructation, esophagitis, flatulence, gastritis, gastroenteritis, gastroesophageal reflux disease, glossitis, nausea, proctalgia, stomatitis, vomiting
Postmarketing reports: Acute pancreatitis, pseudomembranous colitis, tongue/tooth discoloration

Common (1% to 10%): Abdominal pain, constipation, diarrhea, nausea
Frequency not reported: Abnormal stools, bezoar, cardiospasm, colitis, dry mouth, dyspepsia, dysphagia, enlarged abdomen, enteritis, eructation, esophageal stenosis, esophageal ulcer, esophagitis, fecal discoloration, flatulence, gastric nodules/fundic gland polyps, gastritis, gastroenteritis, gastrointestinal anomaly, gastrointestinal disorder, gastrointestinal hemorrhage, gastrointestinal moniliasis, glossitis, gum hemorrhage, halitosis, hematemesis, increased salivation, melena, mouth ulceration, rectal disorder/hemorrhage, stomatitis, tenesmus, tongue disorder, ulcerative colitis/stomatitis, vomiting
Postmarketing reports: Clostridium difficile-associated diarrhea, pancreatitis, positive fecal occult blood[Ref]


Frequency not reported: Vaginal moniliasis, vaginitis

Frequency not reported: Crystalluria

Frequency not reported: Vaginal infection
Postmarketing reports: Abnormal urine color

Frequency not reported: Abnormal menses, breast enlargement/pain/tenderness, dysmenorrhea, dysuria, impaired urination, impotence, leukorrhea, menorrhagia, menstrual disorder, pelvic pain, penis disorder, polyuria, testis disorder, urethral pain, urinary frequency, urinary retention, urinary tract infection, urinary urgency, vaginitis
Postmarketing reports: Albuminuria, hematuria, presence of crystal urine, urine abnormalities[Ref]


Frequency not reported: Skin reactions

Common (1% to 10%): Rash
Frequency not reported: Acute generalized exanthematous pustulosis, erythematous maculopapular rashes, erythema multiforme, exfoliative dermatitis, hypersensitivity vasculitis, mucocutaneous candidiasis, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria

Frequency not reported: Cellulitis, dermatitis bollus, hyperhidrosis, maculopapular rash, pruritus, rash, urticaria
Postmarketing reports: Acne, drug rash with eosinophilia and systemic symptoms (DRESS), Henoch-Schonlein purpura, Stevens-Johnson syndrome, toxic epidermal necrolysis

Frequency not reported: Acne, alopecia, contact dermatitis, dry skin, fixed eruption, hair disorder, maculopapular rash, nail disorder, pruritus, rash, skin disorder, sweating, urticaria
Postmarketing reports: Cutaneous lupus erythematosus, erythema multiforme, severe dermatologic reactions, Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN)/fatal TEN[Ref]


Frequency not reported: Confusion

Frequency not reported: Agitation, anxiety, behavioral change, confusion, insomnia

Frequency not reported: Anxiety, insomnia, nervousness
Postmarketing reports: Abnormal behavior/dreams, confusion, confusional state, depersonalization, depression, disorientation, hallucination, manic behavior, psychotic disorder

Frequency not reported: Abnormal dreams/thinking, aggravated hostility, agitation, anxiety, apathy, confusion, depersonalization, depression, emotional lability, hallucinations, insomnia, increased/decreased libido, nervousness, neurosis, sleep disorders[Ref]


Frequency not reported: Myalgia

Frequency not reported: Muscle spasms, myalgia, nuchal rigidity
Postmarketing reports: Myopathy, rhabdomyolysis

Frequency not reported: Arthralgia, arthritis, back pain, bone disorder, joint disorder, leg cramps, musculoskeletal pain, myalgia, myasthenia, neck pain/rigidity, synovitis
Postmarketing reports: Bone fracture, myositis, systemic lupus erythematosus[Ref]


Frequency not reported: Thirst

Frequency not reported: Chills, fatigue, hearing loss, malaise, pyrexia, tinnitus
Postmarketing reports: Deafness, death

Frequency not reported: Asthenia, chills, deafness, ear disorder, fever, malaise, otitis media, pain, thirst, tinnitus
Postmarketing reports: Increased globulins[Ref]


Frequency not reported: Respiratory disorders

Frequency not reported: Asthma, epistaxis, pulmonary embolism

Frequency not reported: Asthma, bronchitis, cough increased, dyspnea, epistaxis, hemoptysis, hiccup, lung fibrosis, pharyngitis, pleural disorder, pneumonia, respiratory disorder, upper respiratory inflammation/infection, rhinitis, sinusitis, stridor[Ref]


Frequency not reported: Agranulocytosis, anemia, eosinophilia, hemolytic anemia, leukopenia, thrombocytopenia, thrombocytopenic purpura

Frequency not reported: Abnormal albumin globulin ratio, eosinophilia, leukopenia, neutropenia, thrombocythemia
Postmarketing reports: Agranulocytosis, decreased white blood cell count, increased INR, prolonged prothrombin time, thrombocytopenia

Frequency not reported: Anemia, hemolysis, lymphadenopathy
Postmarketing reports: Abnormal AG ratio/red blood cells, abnormal/increased/decreased white blood cells/platelets, agranulocytosis, aplastic anemia, decreased hemoglobin, eosinophilia, hemolytic anemia, leukopenia, neutropenia, pancytopenia, thrombocytopenia, thrombotic thrombocytopenic purpura[Ref]


Frequency not reported: Acute cytolytic hepatitis, cholestatic jaundice, hepatic dysfunction/cholestasis, moderate AST/ALT elevation

Frequency not reported: Abnormal liver function tests, cholestasis, hepatitis, increased blood bilirubin
Postmarketing reports: Hepatic dysfunction/failure, hepatocellular jaundice

Frequency not reported: Cholelithiasis
Postmarketing reports: Abnormal liver function tests, bilirubinemia, hepatotoxicity, increased AST/ALT/gamma glutamyl transpeptidase[Ref]


Frequency not reported: Anaphylaxis, hypersensitivity phenomena

Frequency not reported: Anaphylactoid reaction, hypersensitivity
Postmarketing reports: Anaphylactic reaction

Frequency not reported: Allergic reaction
Postmarketing reports: Anaphylactic/anaphylactoid reactions[Ref]


Frequency not reported: Anorexia, decreased appetite, increased blood alkaline phosphatase/lactate dehydrogenase
Postmarketing reports: Hypoglycemia

Frequency not reported: Anorexia, avitaminosis, dehydration, diabetes mellitus, gout, hyperglycemia, hypoglycemia, increased appetite, weight gain/loss
Postmarketing reports: Hyperlipemia, hypomagnesemia, increased alkaline phosphatase/blood potassium/lactate dehydrogenase, increased/decreased electrolytes/cholesterol[Ref]


Frequency not reported: Atrial fibrillation, cardiac arrest, chest pains, electrocardiogram QT prolonged, extrasystoles, palpitations
Postmarketing reports: Hemorrhage, torsade de pointes, ventricular arrhythmia/tachycardia

Frequency not reported: Angina, arrhythmia, bradycardia, chest pain (not otherwise specified), edema, hypertension/hypotension, myocardial infarction, palpitations, peripheral edema, shock/circulatory failure, tachycardia, vasodilation[Ref]


Frequency not reported: Increased blood creatinine/urea
Postmarketing reports: Interstitial nephritis, renal failure

Frequency not reported: Kidney calculus, kidney pain
Postmarketing reports: Glycosuria, increased creatinine/blood urea, interstitial nephritis[Ref]


Frequency not reported: Abnormal vision, amblyopia, blepharitis, blurred vision, cataracts, conjunctivitis, diplopia, dry eyes, eye disorder, eye pain, glaucoma, photophobia, ptosis, retinal degeneration/disorder, visual field defect[Ref]


Frequency not reported: Goiter, gynecomastia, hypothyroidism
Postmarketing reports: Increased glucocorticoids/gastrin levels[Ref]


Frequency not reported: Carcinoma, laryngeal neoplasia, skin carcinoma[Ref]


Frequency not reported: Serum sickness-like reaction

Frequency not reported: Candidiasis, infection

Frequency not reported: Candidiasis, flu syndrome, infection (not otherwise specified)[Ref]


1. "Product Information. Prevpac (amoxicillin / clarithromycin / lansoprazole)." Tap Pharmaceuticals Inc, Dearfield, IL.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.