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Prevpac Side Effects

Generic Name: amoxicillin / clarithromycin / lansoprazole

Note: This page contains side effects data for the generic drug amoxicillin / clarithromycin / lansoprazole. It is possible that some of the dosage forms included below may not apply to the brand name Prevpac.

For the Consumer

Applies to amoxicillin / clarithromycin / lansoprazole: oral capsule, oral capsule delayed release, oral tablet

As well as its needed effects, amoxicillin / clarithromycin / lansoprazole may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking amoxicillin / clarithromycin / lansoprazole, check with your doctor immediately:

Incidence not known:
  • Abdominal or stomach pain or tenderness
  • blistering, peeling, or loosening of the skin
  • clay colored stools
  • dark urine
  • diarrhea
  • difficulty with swallowing
  • dizziness or fainting
  • fast, slow, or irregular heartbeat
  • fever or chills
  • headache
  • hives, itching, or skin rash
  • joint or muscle pain
  • loss of appetite
  • nausea and vomiting
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • sores, ulcers, or white spots in the mouth or on the lips
  • swelling of the body, feet, and ankles
  • tightness in the chest
  • unusual tiredness or weakness
  • unusual weight gain
  • watery and severe diarrhea, which may also be bloody
  • yellow eyes or skin

Minor Side Effects

Some amoxicillin / clarithromycin / lansoprazole side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common:
  • Bad, unusual or unpleasant (after) taste
  • change in taste
Less common or rare:
  • Confusion
  • discoloration of the tongue
  • itching of the vagina or genital area
  • pain during sexual intercourse
  • redness, swelling, or soreness of the tongue
  • sore mouth or tongue
  • thick, white vaginal discharge with no odor or with a mild odor
  • white patches in the mouth, tongue, or throat

For Healthcare Professionals

Applies to amoxicillin / clarithromycin / lansoprazole: oral kit


Gastrointestinal side effects have included diarrhea (7%) and taste perversion (5%). Dark stools, dry mouth/thirst, glossitis, rectal itching, nausea, oral moniliasis, stomatitis, tongue discoloration, tongue disorder, and vomiting have also been reported. Other side effects associated with the use of lansoprazole have included: abnormal stools, anorexia, bezoar, cardiospasm, cholelithiasis, colitis, dry mouth, dyspepsia, dysphagia, enteritis, gastric nodules/fundic gland polyps, gastritis, gastroenteritis, GI anomaly, GI disorder, GI hemorrhage, glossitis, gum hemorrhage, hematemesis, increased appetite, increased salivation, melena, mouth ulceration, nausea and vomiting, nausea and vomiting and diarrhea, oral moniliasis, rectal disorder, rectal hemorrhage, stomatitis, tenesmus, thirst, tongue disorder, ulcerative colitis, and ulcerative stomatitis. Hemorrhagic/pseudomembranous colitis has been reported with nearly all antibacterial agents, including amoxicillin and clarithromycin. Therefore, it is important to consider this diagnosis in patients who present with diarrhea subsequent to the administration of antibacterial agents. Mild cases of pseudomembranous colitis usually respond to drug discontinuation alone.[Ref]


Musculoskeletal side effects have rarely included myalgia. Arthralgia, arthritis, bone disorder, joint disorder, leg cramps, musculoskeletal pain, myalgia, myasthenia, and synovitis have been reported with the use of lansoprazole.[Ref]

Nervous system

Nervous system side effects have included confusion and dizziness. Abnormal dreams, agitation, amnesia, anxiety, apathy, confusion, convulsion, depersonalization, depression, diplopia, dizziness, emotional lability, hallucinations, hemiplegia, hostility aggravated, hyperkinesia, hypertonia, hypesthesia, insomnia, libido decreased/increased, nervousness, neurosis, paresthesia, sleep disorder, somnolence, thinking abnormality, tremor, and vertigo have been reported with the use of lansoprazole.[Ref]


Respiratory side effects have included respiratory disorders. Asthma, bronchitis, cough increased, dyspnea, epistaxis, hemoptysis, hiccup, laryngeal neoplasia, pharyngitis, pleural disorder, pneumonia, respiratory disorder, upper respiratory inflammation/infection, rhinitis, sinusitis, and stridor have been reported with the use lansoprazole.[Ref]


Dermatologic side effects have included skin reactions. Acne, alopecia, contact dermatitis, dry skin, fixed eruption, hair disorder, maculopapular rash, nail disorder, pruritus, rash, skin carcinoma, skin disorder, sweating, and urticaria have been reported during the use of lansoprazole. Severe dermatologic reactions including erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis, with some fatal cases, have been reported during the postmarketing of lansoprazole. Drug rash with eosinophilia and systemic symptoms (DRESS) and Henoch-Schonlein Purpura have been reported postmarketing for clarithromycin.[Ref]


Genitourinary side effects have included vaginitis and vaginal moniliasis. Abnormal menses, breast enlargement, breast pain, breast tenderness, dysmenorrhea, dysuria, gynecomastia, impotence, leukorrhea, menorrhagia, menstrual disorder, penis disorder, polyuria, testis disorder, urethral pain, urinary frequency, urinary tract infection, urinary urgency, and urination impaired have been reported with the use of lansoprazole. Urinary retention has been reported during the postmarketing period of lansoprazole, although a direct relationship has not been established.[Ref]


Hematologic side effects have included anemia, hemolysis, and lymphadenopathy with the use of lansoprazole. Agranulocytosis, aplastic anemia, hemolytic anemia, leukopenia, neutropenia, pancytopenia, thrombocytopenia, and thrombotic thrombocytopenic purpura have been reported during the postmarketing of lansoprazole. Although a direct relationship has not been established. Hemorrhaging has been reported postmarketing with clarithromycin.[Ref]


Hepatic side effects have included moderate elevations of AST (SGOT) and/or ALT (SGPT) levels with the use of amoxicillin and lansoprazole. Cholestatic jaundice, hepatic cholestasis, and acute cytolytic hepatitis with the use of amoxicillin. Abnormal liver function tests, increased alkaline phosphatase, bilirubinemia have also been reported with the use of lansoprazole.[Ref]


Metabolic side effects have included gout, dehydration, hyperglycemia/hypoglycemia, peripheral edema, and weight gain/loss with the use of lansoprazole.[Ref]


Ocular side effects have included abnormal vision, blurred vision, conjunctivitis, dry eyes, eye pain, photophobia, retinal degeneration, and visual field defect.[Ref]


Cardiovascular side effects have included angina, arrhythmia, bradycardia, cerebrovascular accident/cerebral infarction, hypertension/hypotension, migraine, myocardial infarction, palpitations, shock (circulatory failure), syncope, tachycardia, and vasodilation with the use of lansoprazole.[Ref]


Hypersensitivity side effects associated with amoxicillin / clarithromycin / lansoprazole including anaphylactic and anaphylactoid reactions have been reported in postmarketing experience.


Other side effects have included abdominal pain, abdomen enlarged, asthenia, chills, edema, fever, flu syndrome, infection (not otherwise specified), malaise, neck pain, neck rigidity, pain, and pelvic pain with the use of lansoprazole.[Ref]


Endocrine side effects have included diabetes mellitus, goiter, and hypothyroidism with the use of lansoprazole.[Ref]


Other side effects have included changes in laboratory parameters with the use of lansoprazole. These have included increased creatinine, increased alkaline phosphatase, increased globulins, increased/decreased/abnormal WBC, abnormal AG ratio, abnormal RBC, eosinophilia, hyperlipemia, increased/decreased electrolyte, increased/decreased cholesterol, increased glucocorticoids, increased LDH, increased/decreased/abnormal platelets, and increased gastrin levels. Urine abnormalities such as albuminuria, glycosuria, and hematuria were also reported.[Ref]


Amoxicillin can be removed from the body by hemodialysis.[Ref]

Renal side effects have included kidney calculus and kidney pain. Crystalluria, in some cases leading to renal failure, has also been reported after amoxicillin overdose. Renal side effects associated with clarithromycin, including interstitial nephritis, have been reported in postmarketing experience.[Ref]


Tooth discoloration (brown, yellow, or gray staining) has been reported rarely with amoxicillin use. Discoloration was reduced or eliminated with brushing or dental cleaning in most cases.[Ref]


Psychiatric side effects have included depression for clarithromycin postmarketing.


1. "Product Information. Prevpac (amoxicillin / clarithromycin / lansoprazole)." Tap Pharmaceuticals Inc, Dearfield, IL.

It is possible that some side effects of Prevpac may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.