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Prevpac Side Effects

Generic name: amoxicillin / clarithromycin / lansoprazole

Medically reviewed by Last updated on Jul 25, 2023.

Note: This document contains side effect information about amoxicillin / clarithromycin / lansoprazole. Some dosage forms listed on this page may not apply to the brand name Prevpac.

Applies to amoxicillin / clarithromycin / lansoprazole: oral capsule, oral capsule delayed release, oral tablet.

Serious side effects of Prevpac

Along with its needed effects, amoxicillin / clarithromycin / lansoprazole may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amoxicillin / clarithromycin / lansoprazole:

Incidence not known

Other side effects of Prevpac

Some side effects of amoxicillin / clarithromycin / lansoprazole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to amoxicillin / clarithromycin / lansoprazole: oral kit.


The most commonly reported side effects included diarrhea, headache, and taste perversion.

Amoxicillin: The most commonly reported side effects included nausea, diarrhea, rash, and vomiting.

Clarithromycin: The most commonly reported side effects included abdominal pain, diarrhea, nausea/vomiting, and dysgeusia.

Lansoprazole: The most commonly reported side effects included abdominal pain, diarrhea, and nausea.[Ref]

Nervous system

Common (1% to 10%): Headache, taste perversion

Frequency not reported: Dizziness


Common (1% to 10%): Headache, taste perversion

Frequency not reported: Dizziness, hyperactivity/reversible hyperactivity


Common (1% to 10%): Dysgeusia, headache

Frequency not reported: Dizziness, dyskinesia, loss of consciousness, somnolence, tremor, vertigo

Postmarketing reports: Ageusia, anosmia, convulsion, paresthesia, parosmia


Frequency not reported: Amnesia, cerebrovascular accident/cerebral infarction, convulsion, dementia, dizziness, headache, hemiplegia, hyperkinesia, hypertonia, hypesthesia, migraine, paresthesia, parosmia, somnolence, syncope, taste loss/perversion, tremor, vertigo

Postmarketing reports: Speech disorder[Ref]


Common (1% to 10%): Diarrhea

Frequency not reported: Abdominal pain, dark stools, dry mouth, glossitis, nausea, oral moniliasis, rectal itching, stomatitis, tongue discoloration/disorder, vomiting


Common (1% to 10%): Diarrhea, nausea, vomiting

Frequency not reported: Black hairy tongue, hemorrhagic/pseudomembranous colitis, tooth discoloration/brown, yellow or gray staining of teeth


Common (1% to 10%): Abdominal pain, diarrhea, dyspepsia, nausea, vomiting

Frequency not reported: Abdominal distension, constipation, dry mouth, eructation, esophagitis, flatulence, gastritis, gastroenteritis, gastroesophageal reflux disease, glossitis, proctalgia, stomatitis

Postmarketing reports: Acute pancreatitis, pseudomembranous colitis, tongue/tooth discoloration


Common (1% to 10%): Abdominal pain, constipation, diarrhea, nausea

Frequency not reported: Abnormal stools, bezoar, cardiospasm, colitis, dry mouth, dyspepsia, dysphagia, enlarged abdomen, enteritis, eructation, esophageal stenosis, esophageal ulcer, esophagitis, fecal discoloration, flatulence, gastric nodules/fundic gland polyps, gastritis, gastroenteritis, gastrointestinal anomaly, gastrointestinal disorder, gastrointestinal hemorrhage, gastrointestinal moniliasis, glossitis, gum hemorrhage, halitosis, hematemesis, increased salivation, melena, mouth ulceration, rectal disorder/hemorrhage, stomatitis, tenesmus, tongue disorder, ulcerative colitis/stomatitis, vomiting

Postmarketing reports: Clostridium difficile-associated diarrhea, pancreatitis, positive fecal occult blood[Ref]


Frequency not reported: Vaginal moniliasis, vaginitis


Frequency not reported: Crystalluria


Frequency not reported: Vaginal infection

Postmarketing reports: Abnormal urine color


Frequency not reported: Abnormal menses, breast enlargement/pain/tenderness, dysmenorrhea, dysuria, impaired urination, impotence, leukorrhea, menorrhagia, menstrual disorder, pelvic pain, penis disorder, polyuria, testis disorder, urethral pain, urinary frequency, urinary retention, urinary tract infection, urinary urgency, vaginitis

Postmarketing reports: Albuminuria, hematuria, presence of crystal urine, urine abnormalities[Ref]


Frequency not reported: Skin reactions


Common (1% to 10%): Rash

Frequency not reported: Acute generalized exanthematous pustulosis, erythematous maculopapular rashes, erythema multiforme, exfoliative dermatitis, hypersensitivity vasculitis, mucocutaneous candidiasis, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria


Common (1% to 10%): Rash

Frequency not reported: Cellulitis, dermatitis bollus, hyperhidrosis, maculopapular rash, pruritus, urticaria

Postmarketing reports: Acne, drug rash with eosinophilia and systemic symptoms (DRESS), Henoch-Schonlein purpura, Stevens-Johnson syndrome, toxic epidermal necrolysis


Frequency not reported: Acne, alopecia, contact dermatitis, dry skin, fixed eruption, hair disorder, maculopapular rash, nail disorder, pruritus, rash, skin disorder, sweating, urticaria

Postmarketing reports: Cutaneous lupus erythematosus, erythema multiforme, severe dermatologic reactions, Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN)/fatal TEN[Ref]


Frequency not reported: Confusion


Frequency not reported: Agitation, anxiety, behavioral change, confusion, insomnia


Common (1% to 10%): Insomnia

Frequency not reported: Anxiety, nervousness

Postmarketing reports: Abnormal behavior/dreams, confusion, confusional state, depersonalization, depression, disorientation, hallucination, manic behavior, psychotic disorder


Frequency not reported: Abnormal dreams/thinking, aggravated hostility, agitation, anxiety, apathy, confusion, depersonalization, depression, emotional lability, hallucinations, insomnia, increased/decreased libido, nervousness, neurosis, sleep disorders[Ref]


Frequency not reported: Myalgia


Frequency not reported: Muscle spasms, myalgia, nuchal rigidity

Postmarketing reports: Myopathy, rhabdomyolysis


Frequency not reported: Arthralgia, arthritis, back pain, bone disorder, joint disorder, leg cramps, musculoskeletal pain, myalgia, myasthenia, neck pain/rigidity, synovitis

Postmarketing reports: Bone fracture, myositis, systemic lupus erythematosus[Ref]


Frequency not reported: Thirst


Frequency not reported: Chills, fatigue, hearing loss, malaise, pyrexia, tinnitus

Postmarketing reports: Deafness, death


Frequency not reported: Asthenia, chills, deafness, ear disorder, fever, malaise, otitis media, pain, thirst, tinnitus

Postmarketing reports: Increased globulins[Ref]


Frequency not reported: Respiratory disorders


Frequency not reported: Asthma, epistaxis, pulmonary embolism


Frequency not reported: Asthma, bronchitis, cough increased, dyspnea, epistaxis, hemoptysis, hiccup, lung fibrosis, pharyngitis, pleural disorder, pneumonia, respiratory disorder, upper respiratory inflammation/infection, rhinitis, sinusitis, stridor[Ref]



Frequency not reported: Agranulocytosis, anemia, eosinophilia, hemolytic anemia, leukopenia, thrombocytopenia, thrombocytopenic purpura


Frequency not reported: Abnormal albumin globulin ratio, eosinophilia, leukopenia, neutropenia, thrombocythemia

Postmarketing reports: Agranulocytosis, decreased white blood cell count, increased INR, prolonged prothrombin time, thrombocytopenia


Frequency not reported: Anemia, hemolysis, lymphadenopathy

Postmarketing reports: Abnormal AG ratio/red blood cells, abnormal/increased/decreased white blood cells/platelets, agranulocytosis, aplastic anemia, decreased hemoglobin, eosinophilia, hemolytic anemia, leukopenia, neutropenia, pancytopenia, thrombocytopenia, thrombotic thrombocytopenic purpura[Ref]



Frequency not reported: Acute cytolytic hepatitis, cholestatic jaundice, hepatic dysfunction/cholestasis, moderate AST/ALT elevation


Common (1% to 10%): Abnormal liver function tests

Frequency not reported: Cholestasis, hepatitis, increased blood bilirubin

Postmarketing reports: Hepatic dysfunction/failure, hepatocellular jaundice


Frequency not reported: Cholelithiasis

Postmarketing reports: Abnormal liver function tests, bilirubinemia, hepatotoxicity, increased AST/ALT/gamma glutamyl transpeptidase[Ref]



Frequency not reported: Anaphylaxis, hypersensitivity phenomena


Common (1% to 10%): Anaphylactoid reaction

Frequency not reported: Hypersensitivity

Postmarketing reports: Anaphylactic reaction


Frequency not reported: Allergic reaction

Postmarketing reports: Anaphylactic/anaphylactoid reactions[Ref]



Frequency not reported: Anorexia, decreased appetite, increased blood alkaline phosphatase/lactate dehydrogenase

Postmarketing reports: Hypoglycemia


Frequency not reported: Anorexia, avitaminosis, dehydration, diabetes mellitus, gout, hyperglycemia, hypoglycemia, increased appetite, weight gain/loss

Postmarketing reports: Hyperlipemia, hypomagnesemia, increased alkaline phosphatase/blood potassium/lactate dehydrogenase, increased/decreased electrolytes/cholesterol[Ref]



Frequency not reported: Atrial fibrillation, cardiac arrest, chest pains, electrocardiogram QT prolonged, extrasystoles, palpitations

Postmarketing reports: Hemorrhage, torsade de pointes, ventricular arrhythmia/tachycardia


Frequency not reported: Angina, arrhythmia, bradycardia, chest pain (not otherwise specified), edema, hypertension/hypotension, myocardial infarction, palpitations, peripheral edema, shock/circulatory failure, tachycardia, vasodilation[Ref]



Frequency not reported: Increased blood creatinine/urea

Postmarketing reports: Interstitial nephritis, renal failure


Frequency not reported: Kidney calculus, kidney pain

Postmarketing reports: Glycosuria, increased creatinine/blood urea, interstitial nephritis[Ref]



Frequency not reported: Abnormal vision, amblyopia, blepharitis, blurred vision, cataracts, conjunctivitis, diplopia, dry eyes, eye disorder, eye pain, glaucoma, photophobia, ptosis, retinal degeneration/disorder, visual field defect[Ref]



Frequency not reported: Goiter, gynecomastia, hypothyroidism

Postmarketing reports: Increased glucocorticoids/gastrin levels[Ref]



Frequency not reported: Carcinoma, laryngeal neoplasia, skin carcinoma[Ref]



Frequency not reported: Serum sickness-like reaction


Common (1% to 10%): Candidiasis

Frequency not reported: Infection


Frequency not reported: Candidiasis, flu syndrome, infection (not otherwise specified)[Ref]


1. Product Information. Prevpac (amoxicillin / clarithromycin / lansoprazole). TAP Pharmaceuticals Inc. 2001;PROD.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.