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Nexium (esomeprazole) Drug Interactions

A total of 303 drugs are known to interact with Nexium (esomeprazole).

  • 21 major drug interactions
  • 186 moderate drug interactions
  • 96 minor drug interactions

Show all medications in the database that may interact with Nexium (esomeprazole).

Check for interactions with Nexium (esomeprazole)

Type in a drug name and select a drug from the list.

Common medications checked in combination with Nexium (esomeprazole)

  • aspirin (Aspir 81, Ecotrin, Acetylsalicylic Acid, Aspirin Low Strength, Bayer Aspirin, Aspir-Low, Ascriptin, Ecotrin Adult Low Strength, Bufferin, Aspiritab, Arthritis Pain, Fasprin, Halfprin, Easprin, Durlaza, Aspirtab, St. Joseph 81 mg Chewable Aspirin, Aspergum, Low Dose ASA, Buffered Aspirin, Ecotrin Maximum Strength, Ascriptin Enteric, Acuprin 81, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Aspirin Lite Coat, Bayer Aspirin Regimen, Aspi-Cor, Empirin, Bayer Children's Aspirin, Bufferin Extra Strength, St. Joseph Aspirin, Bayer Women's Aspirin With Calcium, Miniprin, Migralex, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Bufferin Low Dose, Medi-Seltzer, Sloprin, ZORprin, Bayer Aspirin Extra Strength Plus, Buffex, Entercote, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Minitabs, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Therapy Bayer, Stanback Analgesic, Norwich Aspirin, Ecpirin, Zero-Order Release, YSP Aspirin, Heartline, Bayer Advanced Aspirin, Buffasal)
  • Aspirin Low Strength (aspirin)
  • azithromycin (Zithromax, Azithromycin Dose Pack, Z-Pak, Zmax)
  • Cipro (ciprofloxacin)
  • clindamycin (Cleocin, Cleocin Pediatric, Cleocin HCl, Cleocin Phosphate, Cleocin Phosphate ADD-Vantage)
  • Crestor (rosuvastatin)
  • Cymbalta (duloxetine)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • hydrochlorothiazide (HydroDIURIL, Microzide, Esidrix, Oretic, Aquazide H, Hydro Par, Ezide, Carozide, Diaqua, Loqua)
  • ibuprofen (Advil, Motrin, IBU, Advil Liqui-Gels, Proprinal, Motrin IB, Children's Motrin, IBU-200, Advil Migraine, Ibu-8, Motrin Childrens, Nuprin, Motrin Migraine Pain, Ibuprofen PMR, NeoProfen, Caldolor, Advil Children's, Addaprin, Motrin Infant Drops, Advil Infant's Concentrated Drops, Rufen, Genpril, A-G Profen, Ibu-Tab, Haltran, Menadol, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Actiprofen, Childrens Ibuprofen Berry, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Cap-Profen, Motrin Pediatric, Advil Film-Coated)
  • levothyroxine (Synthroid, Levoxyl, Tirosint, Levothroid, Eltroxin, Unithroid, Levothyrox, Euthyrox, Levo-T, L Thyroxine Roche, Eutroxsig, Novothyrox, Oroxine, Tirosint-Sol, Levotabs, Levotec, Evotrox)
  • Lexapro (escitalopram)
  • Lipitor (atorvastatin)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • Lyrica (pregabalin)
  • Macrobid (nitrofurantoin)
  • metformin (Glucophage, Glucophage XR, Glumetza, Riomet, Fortamet)
  • metoprolol (Metoprolol Tartrate, Metoprolol Succinate ER, Toprol-XL, Lopressor, Kapspargo Sprinkle)
  • Plavix (clopidogrel)
  • prednisone (Deltasone, Rayos, Sterapred, Sterapred DS, Prednicot, Meticorten, Orasone, Liquid Pred, Prednicen-M)
  • Prilosec (omeprazole)
  • Protonix (pantoprazole)
  • simvastatin (Zocor, FloLipid)
  • Singulair (montelukast)
  • Synthroid (levothyroxine)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, Larapam SR, Tramedo, Ryzolt, GenRx Tramadol, ConZip, Zydol, Tramal SR, Tramahexal, Zamadol, Tramahexal SR, Zydol XL, Rybix ODT, Ultram ODT)
  • trazodone (Desyrel, Oleptro, Desyrel Dividose)
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)
  • Zantac (ranitidine)

Nexium (esomeprazole) alcohol/food interactions

There is 1 alcohol/food interaction with Nexium (esomeprazole)

Nexium (esomeprazole) disease interactions

There are 4 disease interactions with Nexium (esomeprazole) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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