Prilosec Dosage

Generic name: OMEPRAZOLE MAGNESIUM 2.5mg
Dosage forms: capsule, delayed release, granule, delayed release
Drug class: Proton pump inhibitors

Medically reviewed by Drugs.com. Last updated on Mar 19, 2024.

Recommended Adult Dosage Regimen by Indication

Table 1 shows the recommended dosage of PRILOSEC in adult patients by indication.

Table 1: Recommended Dosage Regimen of PRILOSEC in Adults by Indication
Indication	Dosage of PRILOSEC	Treatment Duration
* Most patients heal within 4 weeks; some patients may require an additional 4 weeks of therapy to achieve healing † The efficacy of PRILOSEC used for longer than 8 weeks in patients with EE has not been established. If a patient does not respond to 8 weeks of treatment, an additional 4 weeks of treatment may be given. If there is recurrence of EE or GERD symptoms (e.g., heartburn), additional 4 to 8 week courses of PRILOSEC may be considered. ‡ Dosage reduction to 10 mg once daily is recommended for patients with hepatic impairment (Child-Pugh Class A, B or C) and Asian patients when used for the maintenance of healing of EE [see Use in Specific Populations (8.6, 8.7) and Clinical Pharmacology (12.3, 12.5)].
Treatment of Active Duodenal Ulcer	20 mg once daily	4 weeks*
Helicobacter pylori Eradication to Reduce the Risk of Duodenal Ulcer Recurrence	Triple Therapy PRILOSEC 20 mg Amoxicillin 1000 mg Clarithromycin 500 mg Take all three drugs twice daily	10 days In patients with an ulcer present at the time of initiation of therapy, continue PRILOSEC 20 mg once daily for an additional 18 days for ulcer healing and symptom relief.
	Dual Therapy PRILOSEC 40 mg once daily Clarithromycin 500 mg three times daily	14 days In patients with an ulcer present at the time of initiation of therapy, an additional 14 days of PRILOSEC 20 mg once daily is recommended for ulcer healing and symptom relief.
Active Benign Gastric Ulcer	40 mg once daily	4 to 8 weeks
Treatment of Symptomatic GERD	20 mg once daily	Up to 4 weeks
Treatment of EE due to Acid-Mediated GERD	20 mg once daily	4 to 8 weeks†
Maintenance of Healing of EE due to Acid-Mediated GERD	20 mg once daily‡	Controlled studies do not extend beyond 12 months.
Pathological Hypersecretory Conditions	Starting dose is 60 mg once daily; adjust to patient needs Daily dosages of greater than 80 mg should be administered in divided doses. Dosages up to 120 mg three times daily have been administered.	As long as clinically indicated. Some patients with Zollinger-Ellison syndrome have been treated continuously for more than 5 years.

Recommended Pediatric Dosage Regimen by Indication

Table 2 shows the recommended dosage of PRILOSEC in pediatric patients by indication.

Table 2: Recommended Dosage Regimen of PRILOSEC in Pediatric Patients by Indication
* The efficacy of PRILOSEC used for longer than 8 weeks in patients with EE has not been established. If a patient does not respond to 8 weeks of treatment, an additional 4 weeks of treatment may be given. If there is recurrence of EE or GERD symptoms (e.g., heartburn), additional 4 to 8 week courses of PRILOSEC may be considered.
Indication	PRILOSEC Dosage Regimen and Duration
	Patient Age	Weight-Based Dose (mg)	Regimen and Duration
Treatment of Symptomatic GERD	1 to 16 years	5 to less than 10 kg: 5 mg	Once daily for up to 4 weeks
		10 to less than 20 kg: 10 mg
		20 kg and greater: 20 mg
Treatment of EE due to Acid-Mediated GERD	1 to 16 years	5 to less than 10 kg: 5 mg	Once daily for 4 to 8 weeks*
		10 to less than 20 kg: 10 mg
		20 kg and greater: 20 mg
	1 month to less than 1 year	3 to less than 5 kg: 2.5 mg	Once daily up to 6 weeks
		5 to less than 10 kg: 5 mg
		10 kg and greater: 10 mg
Maintenance of Healing of EE due to Acid-Mediated GERD	1 to 16 years	5 to less than 10 kg: 5 mg	Once daily. Controlled studies do not extend beyond 12 months
		10 to less than 20 kg: 10 mg
		20 kg and greater: 20 mg

Administration Instructions

•: PRILOSEC is intended to be prepared in water and administered orally or via a nasogastric (NG) or gastric tube.
•: Take PRILOSEC before meals.
•: Antacids may be used concomitantly with PRILOSEC.
•: Missed doses: If a dose is missed, administer as soon as possible. However, if the next scheduled dose is due, do not take the missed dose, and take the next dose on time. Do not take two doses at one time to make up for a missed dose.

Oral Administration in Water

1.: Empty the contents of a 2.5 mg packet into a container containing 5 mL of water.
2.: Empty the contents of a 10 mg packet into a container containing 15 mL of water.
3.: Stir.
4.: Leave 2 to 3 minutes to thicken.
5.: Stir and drink within 30 minutes.
6.: If any material remains after drinking, add more water, stir and drink immediately.

Administration with Water via a NG or Gastric Tube (Size 6 or Larger)

1.: Add 5 mL of water to a catheter tipped syringe and then add the contents of a 2.5 mg packet (or 15 mL of water for the 10 mg packet). It is important to only use a catheter tipped syringe when administering through a nasogastric tube or gastric tube.
2.: Immediately shake the syringe and leave 2 to 3 minutes to thicken.
3.: Shake the syringe and inject through the nasogastric or gastric tube into the stomach within 30 minutes.
4.: Refill the syringe with an equal amount of water.
5.: Shake and flush any remaining contents from the nasogastric or gastric tube into the stomach.