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Prilosec Side Effects

Generic name: omeprazole

Medically reviewed by Drugs.com. Last updated on Feb 5, 2024.

Note: This document provides detailed information about Prilosec Side Effects associated with omeprazole. Some dosage forms listed on this page may not apply specifically to the brand name Prilosec.

Applies to omeprazole: oral capsule delayed release, oral packet, oral powder for suspension, oral tablet disintegrating delayed release, oral tablet delayed release.

Common side effects of Prilosec

Some side effects of omeprazole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

  • body aches or pain
  • diarrhea or loose stools
  • difficulty with breathing
  • dizziness
  • ear congestion
  • gas
  • heartburn
  • loss of voice
  • muscle pain
  • runny or stuffy nose
  • sneezing
  • unusual drowsiness

Incidence not known

  • bloody nose
  • continuing ringing or buzzing or other unexplained noise in the ears
  • decreased interest in sexual intercourse
  • dry mouth
  • hearing loss
  • inability to have or keep an erection
  • increased sensitivity of the skin to sunlight
  • increased sweating
  • loss in sexual ability, desire, drive, or performance
  • redness or other discoloration of the skin
  • severe sunburn
  • swelling of the breasts or breast soreness in both females and males
  • trouble sleeping

Serious side effects of Prilosec

Along with its needed effects, omeprazole (the active ingredient contained in Prilosec) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking omeprazole:

Rare side effects

  • back, leg, or stomach pain
  • bleeding or crusting sores on the lips
  • blisters
  • bloody or cloudy urine
  • chills
  • continuing ulcers or sores in the mouth
  • difficult, burning, or painful urination
  • fever
  • frequent urge to urinate
  • general feeling of discomfort or illness
  • itching, skin rash
  • joint pain
  • loss of appetite
  • muscle aches or cramps
  • pain
  • red or irritated eyes
  • redness, tenderness, itching, burning, or peeling of the skin
  • sore throat
  • sores, ulcers, or white spots on the lips, in the mouth, or on the genitals
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Incidence not known

  • black, tarry stools
  • bleeding gums
  • blindness
  • blistering, peeling, or loosening of the skin
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blurred or decreased vision
  • chest pain or tightness
  • confusion
  • constipation
  • cough
  • dark urine
  • decreased urine
  • difficulty swallowing
  • dizziness
  • drowsiness
  • eye pain
  • fast, racing, or uneven heartbeat
  • indigestion
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • light-colored stools
  • lower back or side pain
  • mood or mental changes
  • muscle cramps in the hands, arms, feet, legs, or face
  • muscle spasms (tetany) or twitching seizures
  • numbness and tingling around the mouth , fingertips, or feet
  • nausea
  • pain or swelling in the arms or legs without any injury
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • pale skin
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid weight gain
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • seizures
  • stomach pain
  • swollen glands
  • trembling
  • unpleasant breath odor
  • vomiting
  • vomiting of blood
  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking omeprazole:

Symptoms of overdose

For healthcare professionals

Applies to omeprazole: compounding powder, oral delayed release capsule, oral delayed release tablet, oral powder for reconstitution, oral powder for reconstitution delayed release, oral suspension, oral tablet disintegrating delayed release.

General adverse events

The most commonly reported side effects included headache, abdominal pain, nausea, and diarrhea.[Ref]

Other

Otitis media occurred most frequently in patients 1 month to less than 1 year of age.

Fever most commonly occurred in patients 1 to less than 2 years of age.

Accidental injury most commonly occurred in patients 2 to 16 years of age.[Ref]

Respiratory

Patients 1 to less than 2 years of age had the highest frequency of adverse reactions of the respiratory system, followed by patients 1 month to less than 1 year and patients 2 to 16 years of age.[Ref]

Nervous system

Lightheadedness occurred predominantly in severely ill or elderly patients.

Taste disturbance usually resolved when treatment was stopped.

Taste perversion most commonly occurred in patients given concomitant treatment with clarithromycin.

Hepatic encephalopathy occurred in patients with preexisting liver disease.[Ref]

Gastrointestinal

Hemorrhagic necrotic gastritis has been reported in pediatric patients.

Diarrhea most commonly occurred in patients given concomitant treatment with clarithromycin and amoxicillin.

Benign gastric fundic gland polyps appeared to be reversible when omeprazole was discontinued.[Ref]

Dermatologic

Musculoskeletal

Psychiatric

Confusion, agitation, aggression, depression, and hallucinations occurred predominantly in severely ill or elderly patients.[Ref]

Immunologic

Hepatic

Cardiovascular

Peripheral edema usually resolved when treatment was stopped.[Ref]

Hematologic

Hypersensitivity

Metabolic

Severe hypomagnesemia may result in hypocalcemia, and this condition may be associated with hypokalemia.

Hypokalemia was reported in pediatric patients.[Ref]

Renal

Ocular

Irreversible visual impairment has been reported in critically ill patients who generally received high doses of the IV formulation as a bolus; however, no causal relationship has been established.[Ref]

Endocrine

Genitourinary

A causal relationship between this drug and impotence has not been established.[Ref]

Oncologic

Gastroduodenal carcinoids have been reported in patients with Zollinger-Ellison syndrome on long-term therapy. This condition may be a manifestation of the underlying condition, which is known to be associated with tumors.[Ref]

References

1. (2022) "Product Information. PriLOSEC (omeprazole)." Merck & Co., Inc

2. (2003) "Product Information. Omeprazole (omeprazole)." Mylan Pharmaceuticals Inc

3. Cerner Multum, Inc. "UK Summary of Product Characteristics."

4. Cerner Multum, Inc. "Australian Product Information."

Frequently asked questions

Further information

Prilosec side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.