Prilosec Side Effects
Generic name: omeprazole
Medically reviewed by Drugs.com. Last updated on Oct 24, 2022.
Note: This document contains side effect information about omeprazole. Some dosage forms listed on this page may not apply to the brand name Prilosec.
Applies to omeprazole: oral capsule delayed release, oral packet, oral powder for suspension, oral tablet disintegrating delayed release, oral tablet delayed release.
Serious side effects of Prilosec
Along with its needed effects, omeprazole (the active ingredient contained in Prilosec) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking omeprazole:
- Back, leg, or stomach pain
- bleeding or crusting sores on the lips
- bloody or cloudy urine
- continuing ulcers or sores in the mouth
- difficult, burning, or painful urination
- frequent urge to urinate
- general feeling of discomfort or illness
- itching, skin rash
- joint pain
- loss of appetite
- muscle aches or cramps
- red or irritated eyes
- redness, tenderness, itching, burning, or peeling of the skin
- sore throat
- sores, ulcers, or white spots on the lips, in the mouth, or on the genitals
- unusual bleeding or bruising
- unusual tiredness or weakness
Incidence not known
- Black, tarry stools
- bleeding gums
- blistering, peeling, or loosening of the skin
- bloating or swelling of the face, arms, hands, lower legs, or feet
- blurred or decreased vision
- chest pain or tightness
- dark urine
- decreased urine
- difficulty swallowing
- eye pain
- fast, racing, or uneven heartbeat
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- light-colored stools
- lower back or side pain
- mood or mental changes
- muscle cramps in the hands, arms, feet, legs, or face
- muscle spasms (tetany) or twitching seizures
- numbness and tingling around the mouth , fingertips, or feet
- pain or swelling in the arms or legs without any injury
- pains in the stomach, side, or abdomen, possibly radiating to the back
- pale skin
- pinpoint red spots on the skin
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- rapid weight gain
- red skin lesions, often with a purple center
- red, irritated eyes
- stomach pain
- swollen glands
- unpleasant breath odor
- vomiting of blood
- yellow eyes or skin
Get emergency help immediately if any of the following symptoms of overdose occur while taking omeprazole:
Symptoms of overdose
- Blurred vision
- dryness of the mouth
- increased sweating
Other side effects of Prilosec
Some side effects of omeprazole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Body aches or pain
- diarrhea or loose stools
- difficulty with breathing
- ear congestion
- loss of voice
- muscle pain
- runny or stuffy nose
- unusual drowsiness
Incidence not known
- Bloody nose
- continuing ringing or buzzing or other unexplained noise in the ears
- dry mouth
- hearing loss
- increased sensitivity of the skin to sunlight
- increased sweating
- redness or other discoloration of the skin
- severe sunburn
- swelling of the breasts or breast soreness in both females and males
- trouble sleeping
For Healthcare Professionals
Applies to omeprazole: compounding powder, oral delayed release capsule, oral delayed release tablet, oral powder for reconstitution, oral powder for reconstitution delayed release, oral suspension, oral tablet disintegrating delayed release.
The most commonly reported side effects included headache, abdominal pain, nausea, and diarrhea.[Ref]
Otitis media occurred most frequently in patients 1 month to less than 1 year of age.
Fever most commonly occurred in patients 1 to less than 2 years of age.
Accidental injury most commonly occurred in patients 2 to 16 years of age.[Ref]
Very common (10% or more): Fever (up to 33%), otitis media (up to 22%)
Common (1% to 10%): Accidental injury, asthenia
Uncommon (0.1% to 1%): Malaise
Very rare (less than 0.01%): Elevated body temperature
Postmarketing reports: Pain, fatigue, tinnitus[Ref]
Patients 1 to less than 2 years of age had the highest frequency of adverse reactions of the respiratory system, followed by patients 1 month to less than 1 year and patients 2 to 16 years of age.[Ref]
Very common (10% or more): Respiratory system reactions (up to 75%)
Common (1% to 10%): Cough, pharyngitis/pharyngeal pain, rhinitis, upper respiratory infection
Rare (0.01% to 0.1%): Bronchospasm
Very rare (less than 0.01%): Dyspnea
Postmarketing reports: Epistaxis[Ref]
Lightheadedness occurred predominantly in severely ill or elderly patients.
Taste disturbance usually resolved when treatment was stopped.
Taste perversion most commonly occurred in patients given concomitant treatment with clarithromycin.
Hepatic encephalopathy occurred in patients with preexisting liver disease.[Ref]
Very common (10% or more): Taste perversion (up to 15%)
Common (1% to 10%): Dizziness, drowsiness, headache, somnolence
Uncommon (0.1% to 1%): Paresthesia, taste disturbances, vertigo
Rare (0.01% to 0.1%): Hepatic encephalopathy, lightheadedness
Postmarketing reports: Tremor[Ref]
Hemorrhagic necrotic gastritis has been reported in pediatric patients.
Diarrhea most commonly occurred in patients given concomitant treatment with clarithromycin and amoxicillin.
Benign gastric fundic gland polyps appeared to be reversible when omeprazole (the active ingredient contained in Prilosec) was discontinued.[Ref]
Very common (10% or more): Diarrhea (Up to 14%)
Common (1% to 10%): Abdominal pain, acid regurgitation, benign fundic gland polyps, constipation, flatulence, nausea, tongue discoloration, vomiting
Rare (0.01% to 0.1%): Dry mouth, gastrointestinal candidiasis, microscopic colitis, stomatitis
Very rare (less than 0.01%): Dyspepsia, hemorrhagic necrotic gastritis
Postmarketing reports: Abdominal swelling, Clostridium difficile associated diarrhea, esophageal candidiasis, fecal discoloration, fundic gland polyps, irritable colon, mucosal atrophy of the tongue, pancreatitis (sometimes fatal)[Ref]
Common (1% to 10%): Rash
Uncommon (0.1% to 1%): Alopecia, dermatitis, erythema multiforme, increased sweating, pruritus, photosensitivity, skin eruptions, urticaria
Rare (0.01% to 0.1%): Allergic vasculitis, Stevens-Johnson syndrome, toxic epidermal necrolysis (some fatal)
Frequency not reported: Subacute cutaneous lupus erythematosus
Postmarketing reports: Cutaneous lupus erythematosus, dry skin, hyperhidrosis, petechia, skin inflammation, severe generalized skin reactions, systemic lupus erythematosus[Ref]
Common (1% to 10%): Back pain
Uncommon (0.1% to 1%): Fracture of the hip/wrist/spine
Rare (0.01% to 0.1%): Arthralgia, joint pain, muscular weakness, myalgia
Postmarketing reports: Bone fracture, leg pain, muscle cramps[Ref]
Confusion, agitation, aggression, depression, and hallucinations occurred predominantly in severely ill or elderly patients.[Ref]
Common (1% to 10%): Insomnia
Rare (0.01% to 0.1%): Aggression, agitation, confusion/reversible mental confusion, depression, hallucinations
Postmarketing reports: Anxiety, apathy, dream abnormalities, nervousness, psychiatric and sleep disturbances[Ref]
Common (1% to 10%): Flu syndrome[Ref]
Uncommon (0.1% to 1%): Increased liver enzymes (ALT, alkaline phosphatase, AST, bilirubin, gamma glutamyl transferase)
Rare (0.01% to 0.1%): Hepatic failure, hepatitis with/without jaundice
Postmarketing reports: Cholestatic disease, fatal hepatic failure, hepatocellular disease, jaundice, liver disease, liver necrosis (some fatal), mixed hepatitis[Ref]
Uncommon (0.1% to 1%): Peripheral edema
Postmarketing reports: Bradycardia, chest pain/angina, elevated blood pressure/hypertension, palpitations, tachycardia[Ref]
Peripheral edema usually resolved when treatment was stopped.[Ref]
Rare (0.01% to 0.1%): Agranulocytosis, hypochromic/microcytic anemia, leukopenia, pancytopenia, thrombocytopenia
Postmarketing reports: Anemia, fatal agranulocytosis, hemolytic anemia, leukocytosis, neutropenia, purpura[Ref]
Rare (0.01% to 0.1%): Anaphylactic reaction/shock, angioedema, hypersensitivity reactions
Postmarketing reports: Anaphylaxis[Ref]
Rare (0.01% to 0.1%): Hyponatremia
Very rare (less than 0.01%): Hypocalcemia, hypokalemia, hypomagnesemia with/without hypocalcemia and/or hypokalemia, weight increase
Postmarketing reports: Anorexia, cyanocobalamin (vitamin B12) deficiency, hypoglycemia[Ref]
Severe hypomagnesemia may result in hypocalcemia, and this condition may be associated with hypokalemia.
Hypokalemia was reported in pediatric patients.[Ref]
Rare (0.01% to 0.1%): Interstitial nephritis
Very rare (less than 0.01%): Impaired renal function, nephrosis
Postmarketing reports: Elevated serum creatinine, glycosuria[Ref]
Rare (0.01% to 0.1%): Blurred vision
Frequency not reported: Irreversible visual impairment
Postmarketing reports: Anterior ischemic optic neuropathy, double vision, dry eye syndrome, ocular irritation, optic atrophy, optic neuritis[Ref]
Irreversible visual impairment has been reported in critically ill patients who generally received high doses of the IV formulation as a bolus; however, no causal relationship has been established.[Ref]
Rare (0.01% to 0.1%): Gynecomastia[Ref]
Very rare (less than 0.01%): Impotence
Postmarketing reports: Hematuria, microscopic pyuria, proteinuria, testicular pain, urinary frequency, urinary tract infection[Ref]
A causal relationship between this drug and impotence has not been established.[Ref]
Postmarketing reports: Gastroduodenal carcinoids[Ref]
Gastroduodenal carcinoids have been reported in patients with Zollinger-Ellison syndrome on long-term therapy. This condition may be a manifestation of the underlying condition, which is known to be associated with tumors.[Ref]
Frequently asked questions
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More about Prilosec (omeprazole)
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Related treatment guides
1. "Product Information. PriLOSEC (omeprazole)." Merck & Co., Inc (2022):
2. "Product Information. Omeprazole (omeprazole)." Mylan Pharmaceuticals Inc (2003):
3. "Product Information. Zegerid (omeprazole)." Santarus Inc (2004):
4. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
5. Cerner Multum, Inc. "Australian Product Information." O 0
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.