Amoxicillin / Clarithromycin / Omeprazole Dosage
Medically reviewed by Drugs.com. Last updated on Sep 4, 2024.
Applies to the following strengths: 500 mg-500 mg-20 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Duodenal Ulcer
Amoxicillin 500 mg-clarithromycin 500 mg-omeprazole 20 mg orally 2 times a day
- Duration of therapy: 10 days
Comments:
- Doses should be given in the morning and evening before eating a meal.
- An additional 18 days of treatment with omeprazole 20 mg orally once a day is recommended for patients with an ulcer at initiation of treatment.
Use: Eradication of Helicobacter pylori in patients with active duodenal ulcer of a history of duodenal ulcer disease
Usual Adult Dose for Helicobacter pylori Infection
Amoxicillin 500 mg-clarithromycin 500 mg-omeprazole 20 mg orally 2 times a day
- Duration of therapy: 10 days
Comments:
- Doses should be given in the morning and evening before eating a meal.
- An additional 18 days of treatment with omeprazole 20 mg orally once a day is recommended for patients with an ulcer at initiation of treatment.
Use: Eradication of Helicobacter pylori in patients with active duodenal ulcer of a history of duodenal ulcer disease
Renal Dose Adjustments
- Mild to moderate renal dysfunction No adjustment recommended.
- Severe renal dysfunction: Consider longer dosage intervals.
Liver Dose Adjustments
Hepatic dysfunction: Not recommended.
Dose Adjustments
Asian patients: Use is not recommended unless clearly needed.
Patients with severe renal dysfunction and hepatic dysfunction: Prolonged dose intervals should be considered.
Precautions
Safety and efficacy have not been established in children.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
- This drug should be swallowed whole; chewing or crushing should be avoided.
- The regimen should be given before meals.
Storage requirements:
- Protect from light and moisture.
General:
- Eradication of H pylori reduces the risk of duodenal ulcer recurrence.
- This drug may be used in patients with active or a one-year history of duodenal ulcer.
Monitoring:
- Hepatic: Hepatic function tests
- Hematologic: Hematopoietic function tests
- Renal: Renal function tests
Patient advice:
- Tell patients that it is important to complete the full regimen.
- Instruct patients to seek medical attention if signs/symptoms of hypersensitivity, Clostridium difficile-associated diarrhea, hypomagnesemia, or systemic cutaneous lupus erythematosus occur.
More about amoxicillin / clarithromycin / omeprazole
- Check interactions
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- Reviews (2)
- Side effects
- During pregnancy
- Drug class: H. pylori eradication agents
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Patient resources
- Amoxicillin, clarithromycin, and omeprazole drug information
- Omeprazole, clarithromycin, and amoxicillin (Advanced Reading)
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.