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Amoxicillin / Clarithromycin / Omeprazole Dosage

Medically reviewed by Drugs.com. Last updated on Sep 14, 2021.

Applies to the following strengths: 500 mg-500 mg-20 mg

Usual Adult Dose for Duodenal Ulcer

Amoxicillin 500 mg-clarithromycin 500 mg-omeprazole 20 mg orally 2 times a day

  • Duration of therapy: 10 days

Comments:
  • Doses should be given in the morning and evening before eating a meal.
  • An additional 18 days of treatment with omeprazole 20 mg orally once a day is recommended for patients with an ulcer at initiation of treatment.

Use: Eradication of Helicobacter pylori in patients with active duodenal ulcer of a history of duodenal ulcer disease

Usual Adult Dose for Helicobacter pylori Infection

Amoxicillin 500 mg-clarithromycin 500 mg-omeprazole 20 mg orally 2 times a day

  • Duration of therapy: 10 days

Comments:
  • Doses should be given in the morning and evening before eating a meal.
  • An additional 18 days of treatment with omeprazole 20 mg orally once a day is recommended for patients with an ulcer at initiation of treatment.

Use: Eradication of Helicobacter pylori in patients with active duodenal ulcer of a history of duodenal ulcer disease

Renal Dose Adjustments

  • Mild to moderate renal dysfunction No adjustment recommended.
  • Severe renal dysfunction: Consider longer dosage intervals.

Liver Dose Adjustments

Hepatic dysfunction: Not recommended.

Dose Adjustments

Asian patients: Use is not recommended unless clearly needed.

Patients with severe renal dysfunction and hepatic dysfunction: Prolonged dose intervals should be considered.

Precautions

Safety and efficacy have not been established in children.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

  • This drug should be swallowed whole; chewing or crushing should be avoided.
  • The regimen should be given before meals.

Storage requirements:
  • Protect from light and moisture.

General:
  • Eradication of H pylori reduces the risk of duodenal ulcer recurrence.
  • This drug may be used in patients with active or a one-year history of duodenal ulcer.

Monitoring:
  • Hepatic: Hepatic function tests
  • Hematologic: Hematopoietic function tests
  • Renal: Renal function tests

Patient advice:
  • Tell patients that it is important to complete the full regimen.
  • Instruct patients to seek medical attention if signs/symptoms of hypersensitivity, Clostridium difficile-associated diarrhea, hypomagnesemia, or systemic cutaneous lupus erythematosus occur.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.