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Amoxicillin, clarithromycin, and omeprazole

Generic Name: amoxicillin, clarithromycin, and omeprazole (a MOX i SIL in, kla RITH roe MYE sin, oh MEP ra zole)
Brand Name: Omeclamox-Pak

Medically reviewed on June 26, 2018

What is amoxicillin, clarithromycin, and omeprazole?

Amoxicillin is a penicillin antibiotic. Clarithromycin is a macrolide antibiotic. These antibiotics fight bacteria in the body.

Omeprazole decreases the amount of acid produced in the stomach.

Amoxicillin, clarithromycin, and omeprazole is a combination medicine used to prevent stomach ulcer caused by infection with Helicobacter pylori (H. pylori).

Amoxicillin, clarithromycin, and omeprazole may also be used for purposes not listed in this medication guide.

Important Information

You should not take amoxicillin, clarithromycin, and omeprazole if you've ever had a severe allergic reaction to certain antibiotics.

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

Before taking this medicine

You should not take this medicine if you are allergic to amoxicillin (Amoxil), clarithromycin (Biaxin), or omeprazole (Prevacid), or if:

Taking any of the following medicines together with amoxicillin, clarithromycin, and omeprazole can cause a life-threatening side effect on your heart:

Tell your doctor if you have ever had:

You may be more likely to have a broken bone while taking this medicine long term or more than once per day. Talk with your doctor about ways to keep your bones healthy.

This medicine may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.

Amoxicillin can make birth control pills less effective. Ask your doctor about using a non-hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy.

You should not breast-feed while taking amoxicillin, clarithromycin, and omeprazole. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby.

This medicine is not approved for use by anyone younger than 18 years old.

How should I take amoxicillin, clarithromycin, and omeprazole?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Each dose of this combination medication contains 4 pills (3 capsules and 1 tablet). Take all 4 pills twice daily before you eat, unless your doctor tells you otherwise.

Swallow each pill whole and do not crush, chew, break, or open it.

Use amoxicillin, clarithromycin, and omeprazole for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. This medicine will not treat a viral infection such as the flu or a common cold.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using amoxicillin, clarithromycin, and omeprazole.

Store at room temperature, away from moisture, heat, and light.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking amoxicillin, clarithromycin, and omeprazole?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

Amoxicillin, clarithromycin, and omeprazole side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;

  • fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);

  • liver problems--upper stomach pain, itching, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes);

  • kidney problems--urinating more or less than usual, blood in your urine, swelling, rapid weight gain; or

  • new or worsening symptoms of lupus--joint pain, and a skin rash on your cheeks or arms that worsens in sunlight.

Serious side effects may be more likely in older adults.

Taking amoxicillin, clarithromycin, and omeprazole long-term may cause you to develop stomach growths called fundic gland polyps. Talk with your doctor about this risk.

Common side effects may include:

  • diarrhea;

  • headache; or

  • unusual or unpleasant taste in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Amoxicillin, clarithromycin, and omeprazole dosing information

Usual Adult Dose for Duodenal Ulcer:

Amoxicillin 500 mg-clarithromycin 500 mg-omeprazole 20 mg orally 2 times a day
-Duration of therapy: 10 days

Comments:
-Doses should be given in the morning and evening before eating a meal.
-An additional 18 days of treatment with omeprazole 20 mg orally once a day is recommended for patients with an ulcer at initiation of treatment.

Use: Eradication of Helicobacter pylori in patients with active duodenal ulcer of a history of duodenal ulcer disease

Usual Adult Dose for Helicobacter pylori Infection:

Amoxicillin 500 mg-clarithromycin 500 mg-omeprazole 20 mg orally 2 times a day
-Duration of therapy: 10 days

Comments:
-Doses should be given in the morning and evening before eating a meal.
-An additional 18 days of treatment with omeprazole 20 mg orally once a day is recommended for patients with an ulcer at initiation of treatment.

Use: Eradication of Helicobacter pylori in patients with active duodenal ulcer of a history of duodenal ulcer disease

What other drugs will affect amoxicillin, clarithromycin, and omeprazole?

A gout medication called colchicine (Colcrys) can interact with clarithromycin and cause serious or life-threatening medical problems. You should not take colchicine during your treatment with amoxicillin, clarithromycin, and omeprazole, especially if you are an older adult with kidney disease.

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Clarithromycin can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Tell your doctor about all your current medicines. Many drugs can affect amoxicillin, clarithromycin, and omeprazole, especially:

This list is not complete and many other drugs may affect amoxicillin, clarithromycin, and omeprazole. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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