Lansoprazole Dosage
Medically reviewed by Drugs.com. Last updated on Feb 2, 2024.
Applies to the following strengths: 15 mg; 30 mg; 3 mg/mL
Usual Adult Dose for:
- Erosive Esophagitis
- Duodenal Ulcer
- Duodenal Ulcer Prophylaxis
- Duodenal Ulcer Maintenance
- Gastroesophageal Reflux Disease
- Gastric Ulcer
- Multiple Endocrine Adenomas
- Systemic Mastocytosis
- Zollinger-Ellison Syndrome
- Helicobacter pylori Infection
- NSAID-Induced Gastric Ulcer
- NSAID-Induced Ulcer Prophylaxis
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Erosive Esophagitis
Treatment: 30 mg orally once a day
- Duration of therapy: Up to 8 weeks
Maintenance: 15 mg orally once a day
Comments:
- Controlled maintenance studies did not extend beyond 12 months.
- If patients are not healed after 8 weeks OR if erosive esophagitis recurs, treatment for another 8 weeks may be considered.
Uses:
- Short-term treatment for healing and symptom relief of all grades of erosive esophagitis
- Maintain healing of erosive esophagitis
Usual Adult Dose for Duodenal Ulcer
Treatment: 15 mg orally once a day
- Duration of therapy: Up to 4 weeks
Maintenance: 15 mg orally once a day
Comment: Controlled maintenance studies did not extend beyond 12 months.
Uses:
- Short-term treatment for healing and symptom relief of active duodenal ulcers
- Maintain healing of duodenal ulcers
Usual Adult Dose for Duodenal Ulcer Prophylaxis
Treatment: 15 mg orally once a day
- Duration of therapy: Up to 4 weeks
Maintenance: 15 mg orally once a day
Comment: Controlled maintenance studies did not extend beyond 12 months.
Uses:
- Short-term treatment for healing and symptom relief of active duodenal ulcers
- Maintain healing of duodenal ulcers
Usual Adult Dose for Duodenal Ulcer Maintenance
Treatment: 15 mg orally once a day
- Duration of therapy: Up to 4 weeks
Maintenance: 15 mg orally once a day
Comment: Controlled maintenance studies did not extend beyond 12 months.
Uses:
- Short-term treatment for healing and symptom relief of active duodenal ulcers
- Maintain healing of duodenal ulcers
Usual Adult Dose for Gastroesophageal Reflux Disease
15 mg orally once a day
- Duration of therapy: 14 days (over-the-counter [OTC] formulations); up to 8 weeks (prescription formulations)
Comments:
- Treatment may take 1 to 4 days for full effect; this drug should not be used for immediate heartburn relief.
- Patients may repeat an OTC course of treatment every 4 months.
Uses:
- Treatment of frequent heartburn occurring at least 2 days a week (OTC formulations)
- Short-term treatment of heartburn and other symptoms associated with gastroesophageal reflux disease (GERD)
Usual Adult Dose for Gastric Ulcer
30 mg orally once a day
- Duration of therapy: Up to 8 weeks
Use: Short-term treatment for healing and symptom relief of active benign gastric ulcers
Usual Adult Dose for Multiple Endocrine Adenomas
Initial dose: 60 mg orally once a day
Maintenance dose: 60 to 180 mg/day
Comments:
- A daily dose higher than 120 mg should be given as divided doses.
- Doses should be patient-specific and should continue as long as clinically necessary. Some patients with Zollinger-Ellison syndrome (ZES) have been on treatment for longer than 4 years.
Use: Long-term treatment of pathological hypersecretory conditions, including ZES with/without multiple endocrine adenomas
Usual Adult Dose for Systemic Mastocytosis
Initial dose: 60 mg orally once a day
Maintenance dose: 60 to 180 mg/day
Comments:
- A daily dose higher than 120 mg should be given as divided doses.
- Doses should be patient-specific and should continue as long as clinically necessary. Some patients with Zollinger-Ellison syndrome (ZES) have been on treatment for longer than 4 years.
Use: Long-term treatment of pathological hypersecretory conditions, including ZES with/without multiple endocrine adenomas
Usual Adult Dose for Zollinger-Ellison Syndrome
Initial dose: 60 mg orally once a day
Maintenance dose: 60 to 180 mg/day
Comments:
- A daily dose higher than 120 mg should be given as divided doses.
- Doses should be patient-specific and should continue as long as clinically necessary. Some patients with Zollinger-Ellison syndrome (ZES) have been on treatment for longer than 4 years.
Use: Long-term treatment of pathological hypersecretory conditions, including ZES with/without multiple endocrine adenomas
Usual Adult Dose for Helicobacter pylori Infection
Triple Therapy: 30 mg orally 2 times a day, taken concomitantly with amoxicillin and clarithromycin
- Duration of therapy: 10 to 14 days
Dual Therapy: 30 mg orally 3 times a day, taken concomitantly with amoxicillin
- Duration of therapy: 14 days
Comments:
- Refer to the manufacturer product information for dosing for amoxicillin and/or clarithromycin.
- Eradication of Helicobacter pylori has been shown to reduce duodenal ulcer recurrence, and may result in duodenal/gastric ulcer healing without the need for continued therapy.
Uses:
- Triple therapy: In combination with amoxicillin and clarithromycin for the treatment of patients with H pylori infection and duodenal ulcer disease (active/1-year history of a duodenal ulcer) to eradicate H pylori
- Dual therapy: In combination with amoxicillin for the treatment of patients with H pylori infection and duodenal ulcer disease (active/1-year history of a duodenal ulcer) who are either allergic/intolerant to clarithromycin OR in whom resistance to clarithromycin is known/suspected
Usual Adult Dose for NSAID-Induced Gastric Ulcer
30 mg orally once a day
- Duration of therapy: Up to 8 weeks
Comment: Treatment studies did not extend beyond 8 weeks.
Use: Treatment of NSAID-associated gastric ulcer in patients who continue NSAID use
Usual Adult Dose for NSAID-Induced Ulcer Prophylaxis
15 mg orally once a day
- Duration of therapy: Up to 12 weeks
Comment: Prophylaxis studies did not extend beyond 12 weeks.
Use: Reducing the risk of NSAID-associated gastric ulcers in patients with a history of a documented gastric ulcer who require the use of an NSAID
Usual Pediatric Dose for Gastroesophageal Reflux Disease
1 to 11 years:
- Less than or equal to 30 kg: 15 mg orally once a day
- Greater than 30 kg: 30 mg orally once a day
- Duration of therapy: Up to 12 weeks
12 years and older: 15 mg orally once a day
- Duration of therapy: Up to 8 weeks
Uses:
- Short-term treatment of GERD and other symptoms associated with GERD
- Short-term treatment of symptomatic, non-erosive GERD
Usual Pediatric Dose for Erosive Esophagitis
1 to 11 years:
- Less than or equal to 30 kg: 15 mg orally once a day
- Greater than 30 kg: 30 mg orally once a day
- Duration of therapy: Up to 12 weeks
12 to 17 years: 30 mg orally once a day
- Duration of therapy: Up to 8 weeks
Use: Short-term treatment for healing and symptom relief of all grades of erosive esophagitis
Renal Dose Adjustments
No adjustment recommended.
Liver Dose Adjustments
Mild to moderate liver dysfunction (Child-Pugh Class A to B): No adjustment recommended.
Severe liver dysfunction (Child-Pugh Class C): 15 mg orally once a day
Dose Adjustments
Patients receiving high-dose methotrexate: Temporary withdrawal of this drug should be considered.
Precautions
CONTRAINDICATIONS:
- Known severe hypersensitivity to the active component or any of the ingredients
- Use with rilpivirine-containing products
For the treatment of H pylori (as combination therapy): Refer to the contraindications section of the other antibacterial agents for further information.
Safety and efficacy of prescription formulations have not been established in patients younger than 1 year.
Safety and efficacy of over-the-counter formulations have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
- This drug should be taken prior to eating and should not be crushed/chewed. Ideally, this drug should be taken in the morning, 30 minutes prior to breakfast.
- The oral dissolvable tablet should be placed on the tongue and allowed to disintegrate.
- The delayed-release capsule may be opened and sprinkled onto a tablespoon of applesauce, pudding, cottage cheese, yogurt, or strained pears and swallowed immediately. Do not chew or crush granules. Alternatively, it may also be emptied into a small volume (60 mL) of either apple juice, orange juice or tomato juice and swallowed immediately. Rinse glass with more juice and swallow immediately.
- This drug may be mixed with apple juice and administered via nasogastric tube.
Storage requirements:
- The manufacturer product information should be consulted.
Reconstitution/preparation techniques:
- The manufacturer product information should be consulted.
General:
- Children younger than 1 year of age did not show beneficial effects when treated for gastroesophageal reflux disease.
- H pylori eradication rates reach 90% when this drug is combined with clarithromycin and amoxicillin/metronidazole. Lower eradication rates were seen in the combination of this drug, amoxicillin, and metronidazole.
- Treatment should be given at least an hour prior to sucralfate or antacids.
- A single, 30 mg dose inhibited stimulated acid secretion by 30%; after repeated dosing over 7 days, 90% of stimulated acid secretion was inhibited.
Monitoring:
- METABOLIC: Magnesium levels, especially in patients taking other drugs that could result in hypomagnesemia or those on long-term therapy
- METABOLIC: Vitamin B12 levels, especially in patients on long-term therapy
- MUSCULOSKELETAL: Bone fractures, especially in patients at high risk for osteoporosis-related events
Patient advice:
- If using this drug to treat H pylori, tell patients that it is important to complete the full regimen.
- Instruct patients to seek medical attention if signs/symptoms of hypersensitivity, Clostridium difficile, or systemic cutaneous lupus erythematosus occur.
- Inform patients that this drug may cause drowsiness, somnolence, dizziness, vertigo, and/or visual disturbances. They should avoid driving or operating machinery until the full effects of the drug are seen.
- Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.
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