Skip to Content

Lansoprazole Dosage

Applies to the following strength(s): 15 mg30 mg3 mg/mL

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for Erosive Esophagitis

Treatment:
-Recommended dose: 30 mg orally once a day
-Duration of therapy: Up to 8 weeks

Maintenance:
-Recommended dose: 15 mg orally once a day

Comments:
-Controlled studies did not extend beyond 12 months.
-If patients are not healed after 8 weeks or erosive esophagitis recurs, treatment for another 8 weeks may be considered.

Use:
-Short-term treatment for healing and symptom relief of all grades of erosive esophagitis
-Maintain healing of erosive esophagitis

Usual Adult Dose for Duodenal Ulcer

Recommended dose: 15 mg orally once a day
Duration of therapy: Up to 4 weeks

Use:
-Short-term treatment for healing and symptom relief of active duodenal ulcers

Usual Adult Dose for Gastroesophageal Reflux Disease

Recommended dose: 15 mg orally once a day
Duration of therapy: Up to 8 weeks

Use:
-Treatment of heartburn and other symptoms associated with gastroesophageal reflux disease (GERD)

Usual Adult Dose for Gastric Ulcer

Recommended dose: 30 mg orally once a day
Duration of therapy: Up to 8 weeks

Use:
-Short-term treatment for healing and symptom relief of active benign gastric ulcers

Usual Adult Dose for Multiple Endocrine Adenomas

Recommended initial dose: 60 mg orally once a day
Maintenance dose: 60 to 180 mg/day

Comments:
-A daily dose higher than 120 mg should be given as divided doses.
-Dosage should be patient-specific and should continue as long as clinically necessary. Some patients with Zollinger-Ellison syndrome (ZES) have been on treatment for longer than 4 years.

Use:
-Long-term treatment of pathological hypersecretory conditions, including ZES

Usual Adult Dose for Systemic Mastocytosis

Recommended initial dose: 60 mg orally once a day
Maintenance dose: 60 to 180 mg/day

Comments:
-A daily dose higher than 120 mg should be given as divided doses.
-Dosage should be patient-specific and should continue as long as clinically necessary. Some patients with Zollinger-Ellison syndrome (ZES) have been on treatment for longer than 4 years.

Use:
-Long-term treatment of pathological hypersecretory conditions, including ZES

Usual Adult Dose for Zollinger-Ellison Syndrome

Recommended initial dose: 60 mg orally once a day
Maintenance dose: 60 to 180 mg/day

Comments:
-A daily dose higher than 120 mg should be given as divided doses.
-Dosage should be patient-specific and should continue as long as clinically necessary. Some patients with Zollinger-Ellison syndrome (ZES) have been on treatment for longer than 4 years.

Use:
-Long-term treatment of pathological hypersecretory conditions, including ZES

Usual Adult Dose for Helicobacter pylori Infection

Triple Therapy:
-Recommended dose: 30 mg orally 2 times a day, taken concomitantly with amoxicillin and clarithromycin
-Duration of therapy: 10 to 14 days

Dual Therapy:
-Recommended dose: 30 mg orally 3 times a day, taken concomitantly with amoxicillin
-Duration of therapy: 14 days

Comments:
-Refer to the manufacturer product information for dosing for amoxicillin and clarithromycin.
-Eradication of Helicobacter pylori (H pylori) has been shown to reduce duodenal ulcer recurrence, and may result in duodenal/gastric ulcer healing without the need for continued therapy.

Uses:
-Triple therapy: Treatment of patients with H pylori infection and duodenal ulcer disease (active/1 year history of a duodenal ulcer) to eradicate H pylori
-Dual therapy: Treatment of patients with H pylori infection and duodenal ulcer disease (active/1 year history of a duodenal ulcer) who is either allergic/intolerant to clarithromycin or in whom resistance to clarithromycin is known/suspected

Usual Adult Dose for Duodenal Ulcer Prophylaxis

Recommended dose: 15 mg orally once a day

Comment:
-Studies did not extend beyond 12 months.

Use:
-Maintain healing of duodenal ulcers

Usual Adult Dose for NSAID-Induced Gastric Ulcer

Recommended dose: 30 mg orally once a day
Duration of therapy: Up to 8 weeks

Comment:
-Studies did not extend beyond 8 weeks.

Use:
-Treatment of NSAID-associated gastric ulcer in patients who continue NSAID use

Usual Adult Dose for NSAID-Induced Ulcer Prophylaxis

Recommended dose: 15 mg orally once a day
Duration of therapy: Up to 12 weeks

Comment:
-Studies did not extend beyond 12 weeks.

Use:
-Reduce the risk of NSAID-associated gastric ulcers in patients with a history of a documented gastric ulcer who require the use of an NSAID

Usual Pediatric Dose for Gastroesophageal Reflux Disease

1 to 11 years:
-Less than or equal to 30 kg: 15 mg orally once a day
-Greater than 30 kg: 30 mg orally once a day
-Duration of therapy: Up to 12 weeks

12 to 17 years:
-Recommended dose: 15 mg orally once a day
-Duration of therapy: Up to 8 weeks

Comment:
-The dose was increased (up to 30 mg 2 times a day) in some patients who remained symptomatic after at least 2 weeks of treatment.

Use:
-Short-term treatment of gastroesophageal reflux disease (GERD) and other symptoms associated with GERD

Usual Pediatric Dose for Erosive Esophagitis

1 to 11 years:
-Less than or equal to 30 kg: 15 mg orally once a day
-Greater than 30 kg: 30 mg orally once a day
-Duration of therapy: Up to 12 weeks

12 to 17 years:
Recommended dose: 30 mg orally once a day
Duration of therapy: Up to 8 weeks

Comments:
-The dose was increased (up to 30 mg 2 times a day) in some patients who remained symptomatic after at least 2 weeks of treatment.

Use:
-Short-term treatment for healing and symptom relief of all grades of erosive esophagitis

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Mild to Moderate Liver Impairment: No adjustment recommended.
Severe Liver Impairment: Dose adjustments may be required; however, no specific guidelines have been suggested. Caution is recommended.

Dose Adjustments

Daily doses above 120 mg should be administered in 2 equally divided doses.

Precautions

Safety and efficacy have not been established in patients younger than 1 year.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-This drug should be taken prior to eating and should not be crushed/chewed. Ideally, this drug should be taken in the morning, 30 minutes prior to breakfast.
-The oral dissolvable tablet should be placed on the tongue and allowed to disintegrate.
-The delayed-release capsule may be opened and sprinkled onto a tablespoon of applesauce, pudding, cottage cheese, yogurt, or strained pears and swallowed immediately. Do not chew or crush granules. Alternatively, it may also be emptied into a small volume (60 mL) of either apple juice, orange juice or tomato juice and swallowed immediately. Rinse glass with more juice and swallow immediately.
-This drug may be mixed with apple juice and administered via nasogastric tube.

Storage requirements:
-The manufacturer product information should be consulted.

Reconstitution/preparation techniques:
-The manufacturer product information should be consulted.

General:
-Children younger than 1 year of age did not show beneficial effects when treated for gastroesophageal reflux disease.
-Helicobacter pylori (H pylori) eradication rates reach 90% when this drug is combined with clarithromycin and amoxicillin/metronidazole. Lower eradication rates were seen in the combination of this drug, amoxicillin, and metronidazole.
-Treatment should be given at least an hour prior to sucralfate or antacids.
-A single, 30 mg dose inhibited stimulated acid secretion by 30%; after repeated dosing over 7 days, 90% of stimulated acid secretion was inhibited.

Monitoring:
-Magnesium levels, especially in patients taking other drugs that could result in hypomagnesemia or those on long-term therapy
-Vitamin B12 levels, especially in patients on long-term therapy
-Bone fractures, especially in patients at high risk for osteoporosis-related events

Patient advice:
-If using this drug to treat H pylori, tell patients that it is important to complete the full regimen.
-Instruct patients to seek medical attention if signs/symptoms of hypersensitivity, Clostridium difficile, or systemic cutaneous lupus erythematosus occur.
-Inform patients that this drug may cause drowsiness, dizziness, vertigo, and/or visual disturbances. They should avoid driving or operating machinery until the full effects of the drug are seen.
-Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.

Hide