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Lansoprazole Patient Tips

Written by C. Fookes, BPharm on May 29, 2017

How it works

  • Lansoprazole reduces the production of stomach acid by irreversibly blocking the actions of an enzyme responsible for acid production, called H+/K+ ATPase (also known as the gastric proton pump). The proton pump is located in the parietal cells of the stomach wall. Both baseline gastric acid secretion and stimulated gastric acid secretion are affected; the degree that they are affected to depends on the dose of lansoprazole.
  • This allows damaged tissue in the esophagus, stomach, and duodenum to heal, and reduces the risk of new ulcers from forming. PPIs are also used to treat other gastrointestinal disorders characterized by excessive acid secretion.
  • Lansoprazole belongs to the class of medicines known as proton pump inhibitors (PPIs).

Upsides

  • Used for the short-term treatment of duodenal ulcers (up to four weeks) and gastric ulcers (up to eight weeks).
  • May also be used to heal ulcers associated with NSAID use and to reduce the risk of ulcer occurrence in people using NSAIDs.
  • May be considered for the short-term treatment of gastroesophageal reflux disease (GERD) (also known as heartburn) and erosive esophagitis (a severe inflammation of the lining of the esophagus- the tube that carries food from the mouth to the stomach).
  • Lansoprazole capsules may be used to maintain healing of duodenal ulcers and erosive esophagitis.
  • May be used in addition to antibiotics to eradicate Helicobacter pylori (a bacteria found in the gut that is linked to gastric ulcers).
  • Useful in the treatment of hypersecretory conditions such as Zollinger-Ellison syndrome.
  • No dosage adjustment is needed in people with kidney disease; however, a dosage reduction should be considered in those with severe liver disease.
  • Lansoprazole is available as a delayed-release capsule, in a 15mg and 30mg strength.

Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

  • Diarrhea, abdominal pain, nausea, headache, and constipation have been the most common side effects reported. May also interfere with some laboratory tests.
  • PPIs (including lansoprazole) have been associated with an increased risk of osteoporosis-related fractures of the hip, wrist, or spine. People on high-dose or long-term therapy are more at risk.
  • Has also been associated with other conditions such as lupus erythematosus and magnesium deficiency.
  • Prolonged treatment (greater than 24-36 months) may cause vitamin B12 deficiency. The risk is greater in women, people aged less than 30, and with higher dosages.
  • Administration of PPIs (such as lansoprazole) has been associated with acute interstitial nephritis, a severe inflammation of the kidneys. May occur on medication initiation or at any point of therapy. Symptoms include fever, rash and generalized aches and pains. Discontinue lansoprazole and seek medical advice.
  • Has been associated with a greater risk of Clostridium difficile-associated diarrhea. See your doctor if you develop diarrhea that does not improve.
  • May interact with some other medications including methotrexate and sometimes warfarin. Lansoprazole can also reduce the absorption of drugs that are dependant on a certain gastric pH for their absorption.

Notes: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. For a complete list of all side effects, click here.

Bottom Line

Lansoprazole decreases stomach acid production which promotes the healing of gastric and duodenal ulcers and other inflamed gastrointestinal tissue areas. Lansoprazole, like other PPIs, should only be used short-term.

Tips

  • Take as directed by your doctor (usually once or twice daily).
  • Take lansoprazole capsules before eating (usually 30 minutes before food).
  • Swallow delayed-release lansoprazole capsules whole; do not crush or chew.
  • Delayed-release capsules may be opened and the contents sprinkled on a tablespoon of applesauce, ENSURE pudding, cottage cheese, yogurt, or strained pears and swallowed immediately. Alternatively, 60mL of apple, orange, or tomato juice may be used.
  • See your doctor if you develop any unexplained fever, rash (particularly one that gets worse after you have been in the sun), new or worsening joint pain, persistent diarrhea or generalized aches and pains.
  • Also see your doctor if you develop any muscle cramps, spasms, or weakness; jitteriness; abnormal heartbeat; dizziness; seizures; or any other symptoms of concern.

Response and Effectiveness

  • Peak plasma levels of lansoprazole are reached within 1.7 hours of oral administration. Lansoprazole does not accumulate with multiple dosing.

References

Lansoprazole [Package Insert]. Revised 02/2017. Breckenridge Pharmaceutical, Inc. https://www.drugs.com/pro/lansoprazole.html

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use lansoprazole only for the indication prescribed.

  • Disclaimer: Every effort has been made to ensure that this information is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This drug information does not endorse drugs, diagnose patients or recommend therapy. It is an informational resource designed as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of this information. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2017 Drugs.com. Revision Date: 2017-05-30 22:02:22

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