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Medications for Sciatica

The medications listed below are related to or used in the treatment of this condition.

Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
cyclobenzaprine 6.0 75 reviews for cyclobenzaprine to treat Sciatica Rx B N X
Generic name:
cyclobenzaprine systemic
Brand name:
Amrix
Drug class:
skeletal muscle relaxants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
naproxen 5.9 54 reviews for naproxen to treat Sciatica Rx/OTC C N X
Generic name:
naproxen systemic
Brand names:
Aleve, Naprelan, Naprosyn, Aflaxen, All Day Pain Relief, All Day Relief, Anaprox-DS, EC-Naprosyn, Flanax Pain Reliever, Midol Extended Relief
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
diclofenac 7.3 33 reviews for diclofenac to treat Sciatica Rx D N X
Generic name:
diclofenac systemic
Brand names:
Voltaren, Cataflam
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
ibuprofen 6.7 15 reviews for ibuprofen to treat Sciatica Rx/OTC C N X
Generic name:
ibuprofen systemic
Brand names:
Advil, Motrin, A-G Profen, Addaprin, Genpril, IBU-200, Midol IB, Motrin IB, Nuprin, Proprinal
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
acetaminophen 4.9 15 reviews for acetaminophen to treat Sciatica Rx/OTC C N X
Generic name:
acetaminophen systemic
Brand names:
Tylenol, Paracetamol, Tylenol Arthritis Pain, Tylenol 8 Hour, Acephen, Actamin, Altenol, Aminofen, Anacin Aspirin Free, Apra, Cetafen, Dolono, Febrol Solution, Feverall, Genapap, Genebs, Leader 8 Hour Pain Reliever, Mapap, Mapap Arthritis Pain, Tactinal, Tempra Quicklets, Tycolene, Tylophen, Vitapap
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Tylenol 5.8 6 reviews for Tylenol to treat Sciatica Rx/OTC C N X
Generic name:
acetaminophen systemic
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects
Paracetamol Rate Add review Rx/OTC C N X
Generic name:
acetaminophen systemic
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects
Tylenol Arthritis Pain Rate Add review Rx/OTC C N X
Generic name:
acetaminophen systemic
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Amrix 9.0 2 reviews for Amrix to treat Sciatica Rx B N X
Generic name:
cyclobenzaprine systemic
Drug class:
skeletal muscle relaxants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Voltaren 7.4 8 reviews for Voltaren to treat Sciatica Rx D N X
Generic name:
diclofenac systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Arthrotec Off-label 8.8 6 reviews for Arthrotec to treat Sciatica Rx X N X
Generic name:
diclofenac / misoprostol systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Off-label:
Yes
Advil 8.5 4 reviews for Advil to treat Sciatica Rx/OTC C N X
Generic name:
ibuprofen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Aleve 7.2 13 reviews for Aleve to treat Sciatica Rx/OTC C N X
Generic name:
naproxen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
diclofenac / misoprostol Off-label 8.5 8 reviews for diclofenac / misoprostol to treat Sciatica Rx X N X
Generic name:
diclofenac / misoprostol systemic
Brand name:
Arthrotec
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Off-label:
Yes
aspirin 7.3 3 reviews for aspirin to treat Sciatica Rx/OTC N N X
Generic name:
aspirin systemic
Brand names:
Bayer Aspirin, Arthritis Pain, Ascriptin, Aspergum, Aspirtab, Bayer Aspirin Extra Strength Plus, Easprin, Ecotrin, Ecpirin, Entercote, Genacote, Halfprin, Norwich Aspirin, Vazalore
Drug class:
salicylates, platelet aggregation inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Motrin Rate Add review Rx/OTC C N X
Generic name:
ibuprofen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Naprelan 9.0 3 reviews for Naprelan to treat Sciatica Rx/OTC C N X
Generic name:
naproxen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Tylenol 8 Hour Rate Add review Rx/OTC C N X
Generic name:
acetaminophen systemic
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects
Acephen Rate Add review Rx/OTC C N X
Generic name:
acetaminophen systemic
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects
Actamin Rate Add review Rx/OTC C N X
Generic name:
acetaminophen systemic
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects
Altenol Rate Add review Rx/OTC C N X
Generic name:
acetaminophen systemic
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects
Aminofen Rate Add review Rx/OTC C N X
Generic name:
acetaminophen systemic
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects
Anacin Aspirin Free Rate Add review Rx/OTC C N X
Generic name:
acetaminophen systemic
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects
Apra Rate Add review Rx/OTC C N X
Generic name:
acetaminophen systemic
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects
Bayer Aspirin Rate Add review Rx/OTC N N X
Generic name:
aspirin systemic
Drug class:
salicylates, platelet aggregation inhibitors
For consumers:
dosage, interactions, side effects
Cetafen Rate Add review Rx/OTC C N X
Generic name:
acetaminophen systemic
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects
Dolono Rate Add review Rx/OTC C N X
Generic name:
acetaminophen systemic
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects
Febrol Solution Rate Add review Rx/OTC C N X
Generic name:
acetaminophen systemic
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects
Feverall Rate Add review Rx/OTC C N X
Generic name:
acetaminophen systemic
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects
Genapap Rate Add review Rx/OTC C N X
Generic name:
acetaminophen systemic
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects
Genebs Rate Add review Rx/OTC C N X
Generic name:
acetaminophen systemic
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects
Leader 8 Hour Pain Reliever Rate Add review Rx/OTC C N X
Generic name:
acetaminophen systemic
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects
Mapap Rate Add review Rx/OTC C N X
Generic name:
acetaminophen systemic
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects
Mapap Arthritis Pain Rate Add review Rx/OTC C N X
Generic name:
acetaminophen systemic
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects
Tactinal Rate Add review Rx/OTC C N X
Generic name:
acetaminophen systemic
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects
Tempra Quicklets Rate Add review Rx/OTC C N X
Generic name:
acetaminophen systemic
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects
Tycolene Rate Add review Rx/OTC C N X
Generic name:
acetaminophen systemic
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects
Tylophen Rate Add review Rx/OTC C N X
Generic name:
acetaminophen systemic
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects
Vitapap Rate Add review Rx/OTC C N X
Generic name:
acetaminophen systemic
Drug class:
miscellaneous analgesics
For consumers:
dosage, interactions, side effects
A-G Profen Rate Add review Rx/OTC C N X
Generic name:
ibuprofen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
Addaprin Rate Add review Rx/OTC C N X
Generic name:
ibuprofen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
Arthritis Pain Rate Add review Rx/OTC N N X
Generic name:
aspirin systemic
Drug class:
salicylates, platelet aggregation inhibitors
For consumers:
dosage, interactions, side effects
Ascriptin Rate Add review Rx/OTC N N X
Generic name:
aspirin systemic
Drug class:
salicylates, platelet aggregation inhibitors
For consumers:
dosage, interactions, side effects
Aspergum Rate Add review Rx/OTC N N X
Generic name:
aspirin systemic
Drug class:
salicylates, platelet aggregation inhibitors
For consumers:
dosage, interactions, side effects
Aspirtab Rate Add review Rx/OTC N N X
Generic name:
aspirin systemic
Drug class:
salicylates, platelet aggregation inhibitors
For consumers:
dosage, interactions, side effects
Bayer Aspirin Extra Strength Plus Rate Add review Rx/OTC N N X
Generic name:
aspirin systemic
Drug class:
salicylates, platelet aggregation inhibitors
For consumers:
dosage, interactions, side effects
Easprin Rate Add review Rx N N X
Generic name:
aspirin systemic
Drug class:
salicylates, platelet aggregation inhibitors
For consumers:
dosage, interactions, side effects
Ecotrin Rate Add review Rx/OTC N N X
Generic name:
aspirin systemic
Drug class:
salicylates, platelet aggregation inhibitors
For consumers:
dosage, interactions, side effects
Ecpirin Rate Add review Rx/OTC N N X
Generic name:
aspirin systemic
Drug class:
salicylates, platelet aggregation inhibitors
For consumers:
dosage, interactions, side effects
Entercote Rate Add review Rx/OTC N N X
Generic name:
aspirin systemic
Drug class:
salicylates, platelet aggregation inhibitors
For consumers:
dosage, interactions, side effects
Genacote Rate Add review Rx/OTC N N X
Generic name:
aspirin systemic
Drug class:
salicylates, platelet aggregation inhibitors
For consumers:
dosage, interactions, side effects
Genpril Rate Add review Rx/OTC C N X
Generic name:
ibuprofen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
Halfprin Rate Add review Rx/OTC N N X
Generic name:
aspirin systemic
Drug class:
salicylates, platelet aggregation inhibitors
For consumers:
dosage, interactions, side effects
IBU-200 Rate Add review Rx/OTC C N X
Generic name:
ibuprofen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
Midol IB Rate Add review Rx/OTC C N X
Generic name:
ibuprofen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
Motrin IB Rate Add review Rx/OTC C N X
Generic name:
ibuprofen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Naprosyn 6.0 2 reviews for Naprosyn to treat Sciatica Rx/OTC C N X
Generic name:
naproxen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Norwich Aspirin Rate Add review Rx/OTC N N X
Generic name:
aspirin systemic
Drug class:
salicylates, platelet aggregation inhibitors
For consumers:
dosage, interactions, side effects
Nuprin Rate Add review Rx/OTC C N X
Generic name:
ibuprofen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
Proprinal Rate Add review Rx/OTC C N X
Generic name:
ibuprofen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
Vazalore Rate Add review Rx/OTC N N X
Generic name:
aspirin systemic
Drug class:
salicylates, platelet aggregation inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Cataflam 7.0 1 review for Cataflam to treat Sciatica Rx D N X
Generic name:
diclofenac systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
nabumetone Off-label 4.1 7 reviews for nabumetone to treat Sciatica Rx C N X
Generic name:
nabumetone systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
Aflaxen Rate Add review Rx/OTC C N X
Generic name:
naproxen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
All Day Pain Relief Rate Add review Rx/OTC C N X
Generic name:
naproxen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
All Day Relief Rate Add review Rx/OTC C N X
Generic name:
naproxen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Anaprox-DS Rate Add review Rx/OTC C N X
Generic name:
naproxen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
EC-Naprosyn Rate Add review Rx/OTC C N X
Generic name:
naproxen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
Flanax Pain Reliever Rate Add review Rx/OTC C N X
Generic name:
naproxen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
flurbiprofen 10 1 review for flurbiprofen to treat Sciatica Rx C N X
Generic name:
flurbiprofen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
indomethacin 8.4 5 reviews for indomethacin to treat Sciatica Rx C N X
Generic name:
indomethacin systemic
Brand names:
Indocin, Indocin SR
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Midol Extended Relief Rate Add review Rx/OTC C N X
Generic name:
naproxen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
Indocin 6.0 1 review for Indocin to treat Sciatica Rx C N X
Generic name:
indomethacin systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
ketoprofen Rate Add review Rx/OTC C N X
Generic name:
ketoprofen systemic
Brand name:
Kiprofen
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Indocin SR Rate Add review Rx C N X
Generic name:
indomethacin systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
Kiprofen Rate Add review Rx/OTC C N X
Generic name:
ketoprofen systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Tolectin DS Rate Add review Rx C N X
Generic name:
tolmetin systemic
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
tolmetin Rate Add review Rx C N X
Generic name:
tolmetin systemic
Brand name:
Tolectin DS
Drug class:
Nonsteroidal anti-inflammatory drugs
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information

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Frequently asked questions

View more FAQ

Alternative treatments for Sciatica

The following products are considered to be alternative treatments or natural remedies for Sciatica. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However, there may be historical, cultural or anecdotal evidence linking their use to the treatment of Sciatica.

Learn more about Sciatica

Care guides

Symptoms and treatments

Medicine.com guides (external)

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription only.
OTC Over-the-counter.
Rx/OTC Prescription or Over-the-counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Expanded Access Expanded Access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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