Flurbiprofen Dosage
Medically reviewed by Drugs.com. Last updated on Aug 2, 2023.
Applies to the following strengths: 50 mg; 100 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Osteoarthritis
200 mg to 300 mg orally per day in 2 to 4 divided doses
Maximum single dose: 100 mg
Comments:
- Once response to therapy is determined, dose and frequency should be adjusted to the lowest effective dose for the shortest duration possible to suit individual patient treatment goals.
Uses: For the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis
Usual Adult Dose for Rheumatoid Arthritis
200 mg to 300 mg orally per day in 2 to 4 divided doses
Maximum single dose: 100 mg
Comments:
- Once response to therapy is determined, dose and frequency should be adjusted to the lowest effective dose for the shortest duration possible to suit individual patient treatment goals.
Uses: For the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis
Renal Dose Adjustments
Advanced Renal Disease: Not recommended; if treatment is necessary, close monitoring of renal function is advised.
Liver Dose Adjustments
- Dosage adjustments may be required in hepatic disease; however, no specific guidelines have been suggested. Caution recommended.
- Patients who have an abnormal liver test or who develop signs or symptoms of liver dysfunction should be evaluated for hepatic dysfunction.
- If liver disease develops or if systemic manifestations such as eosinophilia or rash occur, this drug should be discontinued.
Dose Adjustments
- Elderly: Elderly patients may require lower doses due to increased risk for adverse effects and increased likelihood of concomitant hepatic and/or renal impairment.
- Poor Metabolizers of CYP450 2C9: Use with caution.
Precautions
US BOXED WARNINGS: RISK OF SERIOUS CARDIOVASCULAR AND GASTROINTESTINAL EVENTS:
- Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular (CV) thrombotic events, myocardial infarction and stroke, which can be fatal. This risk may occur early in treatment and may increase with duration of use.
- This drug is contraindicated in the setting of coronary artery bypass graft (CABG) surgery.
- NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at a greater risk for serious GI events.
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
- Take with food
General:
- Prior to initiating treatment, the potential benefits and risks of this drug should be weighed against other treatment options.
- The lowest effective dose for the shortest duration consistent with individual patient treatment goals should be used.
- There is an increased risk of heart attack, heart failure, and stroke when taking nonsteroidal anti-inflammatory drugs (NSAIDs); these events may occur at any time during treatment and risk increases with long term use, a history of cardiovascular (CV) disease or risk factors for CV disease, and higher doses.
Monitoring:
- Cardiovascular: Monitor blood pressure closely during initiation and throughout course of therapy.
- Gastrointestinal: Monitor for signs/symptoms of gastrointestinal bleeding.
- Renal function: Monitor renal status, especially in patients with conditions where renal prostaglandins have a supportive role in the maintenance of renal perfusion.
- Monitor blood counts, renal, and hepatic function periodically for patients receiving long-term therapy.
Patient advice:
- Patients should seek medical advice for signs and symptoms of gastrointestinal events, adverse skin reactions, allergic reactions, hepatotoxicity, or unexplained weight gain or edema.
- Patients should seek medical attention immediately if signs/symptoms of cardiovascular events occur including, shortness of breath, slurred speech, chest pain, or weakness on one side of the body.
- Patients should talk to their health care provider if they are pregnant, planning to become pregnant, or breastfeeding; NSAIDs should not be used at 20 weeks or later in pregnancy unless specifically advised to do so by their health care professional.
Frequently asked questions
More about flurbiprofen
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (10)
- Drug images
- Latest FDA alerts (5)
- Side effects
- During pregnancy
- Drug class: Nonsteroidal anti-inflammatory drugs
- Breastfeeding
- En español
Patient resources
Other brands
Professional resources
Other brands
Related treatment guides
See also:
Methylprednisolone
Methylprednisolone is used to treat conditions such as allergies, arthritis, lupus and ulcerative ...
Oxycodone
Oxycodone is an opioid analgesic used to treat moderate to severe pain; it has a high potential for ...
Botox
Botox is used for cosmetic purposes and to treat overactive bladder symptoms, urinary incontinence ...
Tylenol
Tylenol is a pain reliever and a fever reducer used to treat many conditions such as headaches ...
Naproxen
Naproxen is a nonsteroidal anti-inflammatory drug used to treat pain or inflammation caused by ...
Diclofenac
Diclofenac is a nonsteroidal anti-inflammatory drug used to treat pain and inflammation associated ...
Tramadol
Tramadol is an opioid medication that may be used to treat moderate to moderately severe chronic ...
Paracetamol
Paracetamol (Panadol, Calpol, Alvedon) is a widely used over-the-counter painkiller and fever ...
Duloxetine
Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor antidepressant used to ...
Hydroxyzine
Hydroxyzine is an antihistamine used to treat itching, hives, and anxiety. It also acts as a ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.