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Flurbiprofen Side Effects

Medically reviewed by Drugs.com. Last updated on Jul 15, 2023.

Applies to flurbiprofen: oral tablet.

Warning

Oral route (Tablet)

NSAIDs cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. This risk may occur early in treatment and may increase with duration of use. Flurbiprofen is contraindicated in the setting of CABG surgery. NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events.

Serious side effects of Flurbiprofen

Along with its needed effects, flurbiprofen may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking flurbiprofen:

Less common

Rare

Get emergency help immediately if any of the following symptoms of overdose occur while taking flurbiprofen:

Symptom of overdose

Other side effects of Flurbiprofen

Some side effects of flurbiprofen may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Rare

For Healthcare Professionals

Applies to flurbiprofen: compounding powder, oral tablet.

General

The most frequently reported side effects were gastrointestinal (GI) in nature and included abdominal pain, constipation, diarrhea, dyspepsia/heartburn, flatulence, GI bleeding, nausea, and vomiting.[Ref]

Gastrointestinal

Common (1% to 10%): Abdominal pain, constipation, diarrhea, dyspepsia/heartburn, flatulence, GI bleeding, nausea, vomiting

Frequency not reported: Bloody diarrhea, esophageal disease, gastric/peptic ulcer disease, gastritis, hematemesis, stomatitis, glossitis, colitis, dry mouth, exacerbation of inflammatory bowel disease, exacerbation of Crohn's disease, exacerbation of ulcerative colitis, small intestine inflammation with blood and protein loss, GI perforation, duodenal ulcer, pancreatitis, ulcerative stomatitis[Ref]

Nervous system

Common (1% to 10%): Headache, reflexes increased, tremor, central nervous system (CNS) stimulation, CNS inhibition, amnesia, somnolence

Frequency not reported: Ataxia, cerebrovascular ischemia, paresthesia, convulsion, cerebrovascular accident, hypertonia, subarachnoid hemorrhage, dizziness/vertigo, parosmia, taste changed, retrobulbar neuritis, optic neuritis[Ref]

Other

Common (1% to 10%): Edema, asthenia, malaise, tinnitus

Frequency not reported: Chills, fever, periodontal abscess, meningitis, aseptic meningitis, herpes simples, herpes zoster, ear disease, transient hearing loss, fatigue[Ref]

Respiratory

Common (1% to 10%): Rhinitis

Frequency not reported: Asthma, epistaxis, bronchitis, dyspnea, hyperventilation, laryngitis, pulmonary embolism, pulmonary infarct, bronchospasm[Ref]

Hepatic

Common (1% to 10%): Elevated liver enzymes

Frequency not reported: Cholestatic jaundice, noncholestatic jaundice, hepatitis, cholecystitis, liver failure, abnormal liver function[Ref]

Renal

Frequency not reported: Interstitial nephritis, renal failure, nephrotic syndrome[Ref]

Dermatologic

Common (1% to 10%): Rash

Frequency not reported: Ecchymosis, purpura, angioedema, eczema, exfoliative dermatitis, photosensitivity, pruritus, toxic epidermal necrolysis, urticaria, alopecia, dry skin, nail disorder, sweating, bullous dermatoses, Stevens-Johnson syndrome, erythema multiforme[Ref]

Ocular

Common (1% to 10%): Vision changes

Frequency not reported: Conjunctivitis, corneal opacity, glaucoma, retinal hemorrhage, visual disturbance[Ref]

Psychiatric

Common (1% to 10%): Nervousness, anxiety, insomnia, depression

Frequency not reported: Confusion, emotional lability, hallucinations[Ref]

Hypersensitivity

Frequency not reported: Hypersensitivity reaction[Ref]

Hematologic

Frequency not reported: Aplastic anemia, agranulocytosis, pancytopenia, hemoglobin decreased, hematocrit decreased, eosinophilia, hemolytic anemia, iron deficiency anemia, leukopenia, thrombocytopenia, lymphadenopathy, anemia, bleeding time increased, neutropenia[Ref]

Cardiovascular

Frequency not reported: Congestive heart failure, hypertension, vascular diseases, vasodilation, angina pectoris, arrhythmias, myocardial infarction, cardiac failure[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection

Frequency not reported: Hematuria, menstrual disturbances, vaginal hemorrhage, uterine hemorrhage, vulvovaginitis, prostate disease[Ref]

Immunologic

Frequency not reported: Anaphylactic reaction[Ref]

Metabolic

Common (1% to 10%): Body weight changes

Frequency not reported: Appetite changes, hyperuricemia, hyperkalemia[Ref]

Musculoskeletal

Frequency not reported: Twitching, myasthenia[Ref]

Frequently asked questions

References

1. Product Information. Ansaid (flurbiprofen). Pharmacia and Upjohn. 2001;PROD.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

3. Cerner Multum, Inc. Australian Product Information.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.