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Flurbiprofen Side Effects

For the Consumer

Applies to flurbiprofen: oral capsule extended release, oral tablet

Along with its needed effects, flurbiprofen may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking flurbiprofen:

Less common
  • Abdominal or stomach pain
  • bladder pain
  • bloody or black, tarry stools
  • bloody or cloudy urine
  • constipation
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain
  • rash
  • severe stomach pain
  • swelling
  • vomiting of blood or material that looks like coffee grounds
Rare
  • Back or leg pains
  • bleeding gums
  • blistering, peeling, or loosening of the skin
  • bloody diarrhea
  • bloody nose
  • blurred vision
  • burning feeling in the chest or stomach
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • chills
  • clay-colored stools
  • cough
  • cracks in the skin
  • dark urine
  • decreased urine output
  • difficulty breathing
  • difficulty swallowing
  • dilated neck veins
  • dizziness
  • extreme fatigue
  • fast heartbeat
  • feeling faint, dizzy, or lightheaded
  • feeling of warmth or heat
  • fever with or without chills
  • flushing or redness of the skin, especially on the face and neck
  • general feeling of tiredness or weakness
  • greatly decreased frequency of urination
  • headache
  • high fever
  • hives or itching
  • hoarseness
  • increased blood pressure
  • increased sensitivity of the skin to sunlight
  • increased thirst
  • indigestion
  • irregular breathing
  • irregular heartbeat
  • joint pain, stiffness, or swelling
  • large, flat, blue, or purplish patches in the skin
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • light-colored stools
  • loss of appetite
  • loss of heat from the body
  • muscle pain
  • nausea
  • nervousness
  • noisy breathing
  • nosebleeds
  • pale skin
  • pinpoint red or purple spots on the skin
  • pounding in the ears
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • red, swollen skin
  • redness or other discoloration of the skin
  • redness, swelling, or soreness of the tongue
  • scaly skin
  • severe or continuing stomach pain
  • severe sunburn
  • shakiness and unsteady walk
  • skin rash, encrusted, scaly and oozing
  • slow or fast heartbeat
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stomach bloating or cramping
  • stomach upset
  • sweating
  • swelling of the face, fingers, feet, or lower legs
  • swelling or inflammation of the mouth
  • swollen or painful glands
  • tenderness in the stomach area
  • tightness in the chest
  • troubled breathing
  • unpleasant breath odor
  • unsteadiness, trembling, or other problems with muscle control or coordination
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • upper right abdominal or stomach pain
  • vomiting
  • weight gain
  • weight loss
  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking flurbiprofen:

Symptom of overdose
  • Change in consciousness
  • fast or slow, or shallow breathing
  • heartburn
  • loss of consciousness
  • pain or discomfort in the chest, upper stomach, or throat
  • pale or blue lips, fingernails, or skin
  • unusual drowsiness, dullness, or feeling of sluggishness

Some side effects of flurbiprofen may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Acid or sour stomach
  • belching
  • changes in vision
  • continuing ringing or buzzing or other unexplained noise in the ear
  • diarrhea
  • discouragement
  • excess air or gas in the stomach or intestines
  • fear
  • feeling of constant movement of self or surroundings
  • feeling sad or empty
  • full feeling
  • general feeling of discomfort or illness
  • hearing loss
  • irritability
  • lack of appetite
  • lack or loss of strength
  • lightheadedness
  • loss of interest or pleasure
  • loss of memory
  • passing gas
  • problems with memory
  • runny nose
  • sensation of spinning
  • sleepiness
  • sneezing
  • stomach discomfort
  • stuffy nose
  • tremor
  • trouble concentrating
  • trouble sleeping
Rare
  • Burning, dry, or itching eyes
  • confusion
  • discharge or excessive tearing
  • redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid
  • transient, mild, pleasant aromatic odor
  • twitching

For Healthcare Professionals

Applies to flurbiprofen: compounding powder, oral tablet

General

The most frequently reported side effects were gastrointestinal (GI) in nature and included abdominal pain, constipation, diarrhea, dyspepsia/heartburn, flatulence, GI bleeding, nausea, and vomiting.[Ref]

Gastrointestinal

Common (1% to 10%): Abdominal pain, constipation, diarrhea, dyspepsia/heartburn, flatulence, GI bleeding, nausea, vomiting
Frequency not reported: Bloody diarrhea, esophageal disease, gastric/peptic ulcer disease, gastritis, hematemesis, stomatitis, glossitis, colitis, dry mouth, exacerbation of inflammatory bowel disease, exacerbation of Crohn's disease, exacerbation of ulcerative colitis, small intestine inflammation with blood and protein loss, GI perforation, duodenal ulcer, pancreatitis, ulcerative stomatitis[Ref]

Nervous system

Common (1% to 10%): Headache, reflexes increased, tremor, central nervous system (CNS) stimulation, CNS inhibition, amnesia, somnolence
Frequency not reported: Ataxia, cerebrovascular ischemia, paresthesia, convulsion, cerebrovascular accident, hypertonia, subarachnoid hemorrhage, dizziness/vertigo, parosmia, taste changed, retrobulbar neuritis, optic neuritis[Ref]

Other

Common (1% to 10%): Edema, asthenia, malaise, tinnitus
Frequency not reported: Chills, fever, periodontal abscess, meningitis, aseptic meningitis, herpes simples, herpes zoster, ear disease, transient hearing loss, fatigue[Ref]

Respiratory

Common (1% to 10%): Rhinitis
Frequency not reported: Asthma, epistaxis, bronchitis, dyspnea, hyperventilation, laryngitis, pulmonary embolism, pulmonary infarct, bronchospasm[Ref]

Hepatic

Common (1% to 10%): Elevated liver enzymes
Frequency not reported: Cholestatic jaundice, noncholestatic jaundice, hepatitis, cholecystitis, liver failure, abnormal liver function[Ref]

Renal

Frequency not reported: Interstitial nephritis, renal failure, nephrotic syndrome[Ref]

Dermatologic

Common (1% to 10%): Rash
Frequency not reported: Ecchymosis, purpura, angioedema, eczema, exfoliative dermatitis, photosensitivity, pruritus, toxic epidermal necrolysis, urticaria, alopecia, dry skin, nail disorder, sweating, bullous dermatoses, Stevens-Johnson syndrome, erythema multiforme[Ref]

Ocular

Common (1% to 10%): Vision changes
Frequency not reported: Conjunctivitis, corneal opacity, glaucoma, retinal hemorrhage, visual disturbance[Ref]

Psychiatric

Common (1% to 10%): Nervousness, anxiety, insomnia, depression
Frequency not reported: Confusion, emotional lability, hallucinations[Ref]

Hypersensitivity

Frequency not reported: Hypersensitivity reaction[Ref]

Hematologic

Frequency not reported: Aplastic anemia, agranulocytosis, pancytopenia, hemoglobin decreased, hematocrit decreased, eosinophilia, hemolytic anemia, iron deficiency anemia, leukopenia, thrombocytopenia, lymphadenopathy, anemia, bleeding time increased, neutropenia[Ref]

Cardiovascular

Frequency not reported: Congestive heart failure, hypertension, vascular diseases, vasodilation, angina pectoris, arrhythmias, myocardial infarction, cardiac failure[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection
Frequency not reported: Hematuria, menstrual disturbances, vaginal hemorrhage, uterine hemorrhage, vulvovaginitis, prostate disease[Ref]

Immunologic

Frequency not reported: Anaphylactic reaction[Ref]

Metabolic

Common (1% to 10%): Body weight changes
Frequency not reported: Appetite changes, hyperuricemia, hyperkalemia[Ref]

Musculoskeletal

Frequency not reported: Twitching, myasthenia[Ref]

References

1. "Product Information. Ansaid (flurbiprofen)." Pharmacia and Upjohn, Kalamazoo, MI.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Some side effects of flurbiprofen may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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