Skip to Content

Medications for Narcolepsy

Other names: Daytime sleep disorder; Excessive Sleepiness

About Narcolepsy:  Narcolepsy is a sleep disorder associated with uncontrollable sleepiness and frequent daytime sleeping.

Drugs Used to Treat Narcolepsy

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
Adderall C 2 X 39 reviews
8.0

Generic name: amphetamine / dextroamphetamine systemic

Drug class: CNS stimulants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Provigil C 4 79 reviews
7.0

Generic name: modafinil systemic

Drug class: CNS stimulants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

Nuvigil C 4 79 reviews
6.0

Generic name: armodafinil systemic

Drug class: CNS stimulants

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

modafinil C 4 105 reviews
7.0

Generic name: modafinil systemic

Brand name:  Provigil

Drug class: CNS stimulants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Ritalin C 2 X 21 reviews
7.0

Generic name: methylphenidate systemic

Drug class: CNS stimulants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Adderall XR C 2 X 7 reviews
8.0

Generic name: amphetamine / dextroamphetamine systemic

Drug class: CNS stimulants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Xyrem B 3 X 68 reviews
8.0

Generic name: sodium oxybate systemic

Drug class: miscellaneous anxiolytics, sedatives and hypnotics

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

methylphenidate C 2 X 42 reviews
7.0

Generic name: methylphenidate systemic

Brand names:  Ritalin, Concerta, Ritalin-SR, Methylin, Methylin ER …show all

Drug class: CNS stimulants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Concerta C 2 X 7 reviews
7.0

Generic name: methylphenidate systemic

Drug class: CNS stimulants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Dexedrine C 2 X 12 reviews
9.0

Generic name: dextroamphetamine systemic

Drug class: CNS stimulants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

amphetamine / dextroamphetamine C 2 X 54 reviews
8.0

Generic name: amphetamine / dextroamphetamine systemic

Brand names:  Adderall, Adderall XR

Drug class: CNS stimulants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

dextroamphetamine C 2 X 20 reviews
9.0

Generic name: dextroamphetamine systemic

Brand names:  Dexedrine, Dextrostat, ProCentra, Zenzedi …show all

Drug class: CNS stimulants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Ritalin-SR C 2 X 1 review
9.0

Generic name: methylphenidate systemic

Drug class: CNS stimulants

For consumers: dosage, interactions, side effects

Methylin C 2 X 4 reviews
8.0

Generic name: methylphenidate systemic

Drug class: CNS stimulants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

armodafinil C 4 93 reviews
6.0

Generic name: armodafinil systemic

Brand name:  Nuvigil

Drug class: CNS stimulants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

amphetamine C 2 X 2 reviews
7.0

Generic name: amphetamine systemic

Brand name:  Evekeo

Drug class: CNS stimulants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts

Dextrostat C 2 X 1 review
8.0

Generic name: dextroamphetamine systemic

Drug class: CNS stimulants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Methylin ER C 2 X 1 review
8.0

Generic name: methylphenidate systemic

Drug class: CNS stimulants

For consumers: dosage, interactions, side effects

sodium oxybate B 3 X 70 reviews
8.0

Generic name: sodium oxybate systemic

Brand name:  Xyrem

Drug class: miscellaneous anxiolytics, sedatives and hypnotics

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph

desvenlafaxine Off Label C N X 1 review
9.0

Generic name: desvenlafaxine systemic

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

ProCentra C 2 X Add review Rate

Generic name: dextroamphetamine systemic

Drug class: CNS stimulants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Evekeo C 2 X 1 review
4.0

Generic name: amphetamine systemic

Drug class: CNS stimulants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

lisdexamfetamine Off Label C 2 X 7 reviews
8.0

Generic name: lisdexamfetamine systemic

Drug class: CNS stimulants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph

Off Label: Yes

Zenzedi C 2 X Add review
9.0

Generic name: dextroamphetamine systemic

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

ephedrine Off Label C N 2 reviews
8.0

Generic name: ephedrine systemic

Drug class: vasopressors, decongestants

For consumers: dosage, interactions,

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

Topics under Narcolepsy

Learn more about Narcolepsy

Micromedex® Care Notes

Symptoms and treatments

Mayo Clinic Reference

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Browse Drugs by Condition

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Hide