Sunosi Side Effects

Generic name: solriamfetol

Medically reviewed by Philip Thornton, DipPharm. Last updated on Jun 16, 2024.

Note: This document provides detailed information about Sunosi.

Applies to solriamfetol: oral tablet Side Effects associated with solriamfetol. Some dosage forms listed on this page may not apply specifically to the brand name Sunosi.

Applies to solriamfetol: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

This medicine does not take the place of getting enough sleep. It should not be used for occasional sleepiness that has not been diagnosed as narcolepsy or sleep apnea. Ask your doctor for advice about good sleep habits.

Do not use this medicine if you are using or have used an MAO inhibitor (MAOI), such as isocarboxazid (Marplan®), linezolid (Zyvox®), phenelzine (Nardil®), selegiline (Eldepryl®), tranylcypromine (Parnate®) within the past 14 days.

Your blood pressure might get too high while you are using this medicine. It may also increase your heat rate. This may cause headaches, dizziness, lightheadedness, fainting, or blurred vision. You might need to measure your blood pressure at home. If you think your blood pressure is too high, call your doctor right away.

This medicine may cause some people to be agitated, irritable, or display other abnormal behaviors. Make sure the doctor knows if you have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. Also tell the doctor if you have sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. If you or your caregiver notice any of these side effects, tell your doctor right away.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Sunosi

Along with its needed effects, solriamfetol (the active ingredient contained in Sunosi) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking solriamfetol:

Other side effects of Sunosi

Some side effects of solriamfetol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to solriamfetol: oral tablet.

General adverse events

The more commonly reported adverse reactions have included headache, nausea, decreased appetite, insomnia, and anxiety.^[Ref]

Cardiovascular

• Common (1% to 10%): Palpitations, chest discomfort/pain
• Frequency not reported: Increased blood pressure and heart rate

Increased systolic and diastolic blood pressure and heart rate occurred in a dose-dependent manner during clinical trials.

Psychiatric

• Common (1% to 10%): Insomnia, anxiety (includes nervousness and panic attacks), irritability, jittery
• Frequency not reported: Agitation, restlessness

Anxiety was more commonly reported at higher doses. Agitation and restlessness were reported in less than 2% of patients.

Gastrointestinal

• Common (1% to 10%): Nausea (includes nausea and vomiting), dry mouth, constipation, diarrhea, abdominal pain
• Frequency not reported: Bruxism, thirst

Nausea, including vomiting, dry mouth, and vomiting were more common at higher doses. Bruxism and thirst were reported in less than 2% of patients.

Metabolic

• Common (1% to 10%): Decreased appetite
• Frequency not reported: Decreased weight

Decreased appetite was more common at higher doses. Decreased weight was reported in less than 2% of patients.

Respiratory

• Frequency not reported: Cough, dyspnea

Cough and dyspnea were reported in less than 2% of patients.

Nervous system

• Very common (10% or more): Headache (16%)
• Common (1% to 10%): Dizziness
• Frequency not reported: Disturbances in attention, tremor

Headache was more common with higher doses. Disturbances in attention and tremor were reported in less than 2% of patients.

Dermatologic

• Common (1% to 10%): Hyperhidrosis

See also:

Frequently asked questions

• Is Sunosi (solriamfetol) a controlled substance?

Further information

Sunosi side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer