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Sunosi Side Effects

Generic name: solriamfetol

Medically reviewed by Philip Thornton, DipPharm. Last updated on Apr 4, 2022.

Note: This document contains side effect information about solriamfetol. Some of the dosage forms listed on this page may not apply to the brand name Sunosi.

For the Consumer

Applies to solriamfetol: oral tablet

Side effects requiring immediate medical attention

Along with its needed effects, solriamfetol (the active ingredient contained in Sunosi) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking solriamfetol:

More common

Less common

  • Agitation
  • chest pain or discomfort
  • cough
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling jittery
  • irritability
  • restlessness
  • tightness of the chest
  • tremor
  • trouble breathing
  • trouble sleeping

Side effects not requiring immediate medical attention

Some side effects of solriamfetol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to solriamfetol: oral tablet


The more commonly reported adverse reactions have included headache, nausea, decreased appetite, insomnia, and anxiety.[Ref]


Increased systolic and diastolic blood pressure and heart rate occurred in a dose-dependent manner during clinical trials.

Common (1% to 10%): Palpitations, chest discomfort/pain

Frequency not reported: Increased blood pressure and heart rate


Common (1% to 10%): Insomnia, anxiety (includes nervousness and panic attacks), irritability, jittery

Frequency not reported: Agitation, restlessness

Anxiety was more commonly reported at higher doses. Agitation and restlessness were reported in less than 2% of patients.


Nausea, including vomiting, dry mouth, and vomiting were more common at higher doses. Bruxism and thirst were reported in less than 2% of patients.

Common (1% to 10%): Nausea (includes nausea and vomiting), dry mouth, constipation, diarrhea, abdominal pain

Frequency not reported: Bruxism, thirst


Decreased appetite was more common at higher doses. Decreased weight was reported in less than 2% of patients.

Common (1% to 10%): Decreased appetite

Frequency not reported: Decreased weight


Frequency not reported: Cough, dyspnea

Cough and dyspnea were reported in less than 2% of patients.

Nervous system

Headache was more common with higher doses. Disturbances in attention and tremor were reported in less than 2% of patients.

Very common (10% or more): Headache (16%)

Common (1% to 10%): Dizziness

Frequency not reported: Disturbances in attention, tremor


Common (1% to 10%): Hyperhidrosis

Frequently asked questions


1. "Product Information. Sunosi (solriamfetol)." Jazz Pharmaceuticals (2019):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.