Skip to main content

Tirzepatide User Reviews & Ratings

Brand names: Mounjaro, Zepbound

Tirzepatide has an average rating of 8.5 out of 10 from a total of 918 reviews on Drugs.com. 80% of reviewers reported a positive experience, while 8% reported a negative experience.

Reviews for Tirzepatide

  • Senagal
  • Taken for 1 to 6 months
  • February 27, 2023

Mounjaro (tirzepatide) for Weight Loss (Obesity/Overweight) "I am an African American female 58yrs old 5’8” weighed an unbelievable 270lbs 12/30/22 I asked my doctor could I take this medication and now here we are. 8 weeks later. I currently weigh 244.6 lbs , I lost 16lbs in the first 3 weeks . I was extremely shocked and a little worried. My health is constant concern, I suffer from chronic allergies and frequently took steroids shots to manage the problem but, brought on weight gain. I am feeling better about my self I am honestly trying to make this a life change. As far as the first day after each shot I am exceptionally tired and I experienced redness at the injection sight once not sure why but, so far so good. No headaches, no vomiting slight constipation. I am attempting to make this a life change better food selections and exercise regiments to keep me on track."

9 / 10
Was this helpful?YesNo
510 Report
  • SeaJa...
  • Taken for less than 1 month
  • February 7, 2024

Zepbound (tirzepatide) for Weight Loss (Obesity/Overweight) "Started Zepbound 2 days ago. Ate normally the day of the first injection (2.5mg/0.5ml)... boy, did I make a mistake. I ate 3 meals, my last around 6 PM. That night I felt like a rock was in my stomach, and you could hear the sloshing of water and food as I moved in bed. I started dry heaving and gagging in my sleep. Woke up Tuesday morning feeling sicker than I did when I had morning sickness from pregnancy... and my morning sickness was bad. Was sick all day. Ate nothing on Tuesday. Not a thing. All I could stomach was water and 7up to ease the nausea. Today is Wednesday, diarrhea started this morning and still nauseous, but not hungry. Just drinking my water and some 7up to help with nausea. I was told the nausea will subside after my body gets used to it. Hoping that's true. But honestly, if I have to deal with some nausea to lose the 70 lbs I would like to lose, I'll do it. Will update more once I've been on it for a while."

8 / 10
Was this helpful?YesNo
151 Report
  • Ava
  • Taken for 1 to 6 months
  • March 9, 2023

Mounjaro (tirzepatide) for Weight Loss (Obesity/Overweight) "I have learned to manage side effects (constipation) with probiotics. This is the only thing that has allowed me to lose the weight I gained post-menopause. I was a size 22 and am now almost a size 10. My BMI went from 39 to just over 30, and I have about 25 more pounds to go. I lost 45 pounds currently. I am no longer taking medication for migraines, asthma, and chronic edema, and my BP medication has been reduced by half."

10 / 10
Was this helpful?YesNo
432 Report

Frequently asked questions

  • Nimrod
  • Taken for 1 to 6 months
  • June 29, 2023

Mounjaro (tirzepatide) for Weight Loss (Obesity/Overweight) "315-pound man, 64 heavy drinker, quit all booze, gained weight. Began rowing machine daily, gained weight. Counted all calories, 2500/day, no loss. A1C not bad 7, went on Mounjaro lowest dose 2.5. Have lost 40 pounds (!) in two months, eat anything and everything just way less and no desire to snack between. Still losing a bit, but feel plateau, may ask for larger dose. A miracle, has changed my life mentally and physically. Also, no desire to drink, a side benefit? I didn't do anything, this is all science. I pray it continues to work. Great delivery system. As long as I don't grow a third arm or have something fall off, I'm riding this thing as long as possible. Magic, feel strong, energetic."

10 / 10
Was this helpful?YesNo
331 Report
  • Lori
  • Taken for less than 1 month
  • December 30, 2023

Zepbound (tirzepatide) for Weight Loss (Obesity/Overweight) "Thank you Zepbound for showing me what being full was. It's a whole new feeling. I have more pep in my step. Four weeks in, over 20 pounds lost. Bring on the 2024 weight loss journey!! (2.5 dose, going up next shot)"

10 / 10
Was this helpful?YesNo
169 Report

Are you taking this medicine?

  • Fairy...
  • Taken for less than 1 month
  • February 3, 2024

Zepbound (tirzepatide) for Weight Loss (Obesity/Overweight) "Just took my third shot. I am 60 yrs old, female, 5'7" and weigh 295. I lost 5 pounds by the 2nd shot. Maybe that's not terribly impressive, but I don't want to lose quickly. Here's what I think is an absolute miracle with Zapbound: NO HEAD HUNGER! For the first time (probably in my life), I don't think about food. I don't crave junk food, I get full very quickly and can only eat small amounts. I had a gastric sleeve 6 years ago (at that time was 350 pounds) and it did a rotten job. It stretched out very quickly and never got rid of the obsessive food thoughts. This Zapbound is something else. I wonder if this is how thin people eat? lol I have had a bit of stomach upset once in awhile, but for the most part am excited to start my higher dose next week. Even if I never lose what I want to, I am so grateful for this drug because I am eating all healthy foods. Nothing less than a miracle if you ask me!"

10 / 10
Was this helpful?YesNo
113 Report
  • Shana...
  • Taken for 1 to 6 months
  • July 14, 2023

Mounjaro (tirzepatide) for Weight Loss (Obesity/Overweight) "I started Mounjaro 5/26/23 weighing 200.5 lbs. I work out 3-5 days per week but was not losing weight. I am down 15 lbs and have lost all cravings. I listen to my body and eat when I am hungry. I have zero side effects."

10 / 10
Was this helpful?YesNo
255 Report

More FAQ

  • Dee
  • Taken for less than 1 month
  • February 29, 2024

Zepbound (tirzepatide) for Weight Loss (Obesity/Overweight) "I started Zepbound 2 weeks ago, so ready for my third injection tomorrow. I’ve lost 4 lbs in the first 2 weeks. I’ve had no side effects whatsoever so far. I’m on the 2.5 initial dose. I am 64 yo and need to lose 50 lbs. I think it’s an amazing drug. I don’t feel hungry all the time, no thoughts of eating or snacking, NO MORE CARB CRAVINGS, and find it’s very easy now to eat super healthy foods. I am eating very small portions, and I think that makes a big difference as far as having side effects. I’ll check back in after I increase my dose, but I want others to hear that not everyone has side effects. Don’t be afraid to try it and don’t let some reviews scare you so much that you refuse it. It’s a fantastic experience so far, for me."

10 / 10
Was this helpful?YesNo
85 Report
  • TBelle
  • Taken for 6 months to 1 year
  • April 1, 2023

Mounjaro (tirzepatide) for Weight Loss (Obesity/Overweight) "I started using Mounjaro (tirzepatide) in July 2022 and weighed 206 lbs. 63 years old and 5'3. It is now March 2023 and I now weigh 130 lbs. The Mounjaro eliminated the desire to eat. I never felt hungry and nothing sounded good so was easy to make myself eat only very light meals, more like snacks of fruit, throughout the day. When I say "make myself" eat I am being literal and could easily have gone without eating at all but know that isn't healthy. I have experienced a little hair loss likely due to a lack of nutrients but it is now growing back. There is an adjustment period to the oddity of food no longer be appealing. No cravings or temptations at all. I believe tirzepatide is the most amazing weight loss medication ever made. I had no side effects other than mild constipation but nothing that dried prunes couldn't cure. I had tried Ozempic quite sometime before the Mounjaro but the side effects of fatigue and nausea prevented me from continuing."

10 / 10
Was this helpful?YesNo
277 Report
  • Amazing
  • Taken for 6 months to 1 year
  • May 1, 2023

Mounjaro (tirzepatide) for Weight Loss (Obesity/Overweight) "I have been on the 15 mg/0.5 mL for the last four months and on mounjaro for a total of ten months starting with the 2.5 mg dosage. Well, I have to say I love it. I had a bit of nausea in the beginning but that’s it never had it again. I have lost a total of 115 lbs. I don’t just eat whatever I want though I have mainly been eating chicken and eggs and Turkey with things like cauliflower rice and once-a-week regular rice. I have gone from being 455 lbs to my current weight of 340 lbs. Also, something awesome I have gone from a size 62 waist in paints to now a 52. I am so happy with it."

10 / 10
Was this helpful?YesNo
247 Report
  • Pam
  • Taken for 1 to 6 months
  • April 11, 2023

Mounjaro (tirzepatide) for Weight Loss (Obesity/Overweight) "This medication was a life changer for me. I’m a 49 year old female. I never had a problem with my weight until after the age of 45. Then during Covid I gained 30 pounds and got up to 189. I was exercising regularly and trying to eat healthy, but could not lose any weight. I started Mounjaro and lost 12 pounds the first month. I had very little side effects. The only thing I experienced was fatigue, a slight headache and I felt very cold. Once I became used to the medication, after a couple of months, those side effects diminished. I’ve been on the medication for 6 months and have lost a total of 56 pounds. I’m now at 133 pounds. My goal weight is 130. I feel better than I did when I was in my 20’s and 30’s. This medication was life changing for me. It not only helped me to lose weight, but it also lowered my A1C, lowered my triglycerides and blood pressure."

10 / 10
Was this helpful?YesNo
250 Report
  • Miracle...
  • Taken for 1 to 2 years
  • April 16, 2024

Mounjaro (tirzepatide) for Weight Loss (Obesity/Overweight) "I am a 38-year-old female who began taking Mounjaro almost a year and a half ago. My beginning weight was 300 pounds. I had high blood pressure and type two diabetes. My doctor started me on the lowest dose possible, and we only increased the dose to 5 mg when I hit a plateau after losing about 70 pounds. I never had to increase after that. In the last 18 months, I have lost 130 pounds! My current weight is 170 pounds which surpassed my goal weight! My blood pressure is within normal range and my type two diabetes is controlled! In addition to using the medication, I used portion control and dancing as a form of exercise. The weight just melted off. The first three months were the most difficult for my body to adjust to the medication. Once I learned what foods my body needed and which ones to avoid, things got easier! I definitely recommend this product for anyone looking to lose weight. I am beyond satisfied with this medication!"

Was this helpful?YesNo
34 Report
  • Donna
  • Taken for 6 months to 1 year
  • April 14, 2023

Mounjaro (tirzepatide) for Weight Loss (Obesity/Overweight) "I’m 58 years old and weighed 176 lbs. I started on mounjaro at the end of last August. I had tried several different ways to lose weight and if I lost I would gain back plus some. I was taking 2 kinds of blood pressure pills a day and having hip, leg, and foot pain. I’m on the 5 mg and have currently lost 56 lbs now weighing 120 lbs. I’m down to one blood pressure pill a day and the dosage has been lowered. My hip, leg, and foot pain is 95% better. I feel amazing and have more confidence in myself. Even my husband calls me his skinny wife. Hope this helps someone and best of luck. This is an amazing med and I hope they will approve it for weight loss! Would love it to help someone as well as it has me!!!"

10 / 10
Was this helpful?YesNo
218 Report
  • Misery
  • Taken for less than 1 month
  • September 13, 2022

Mounjaro (tirzepatide) for Diabetes, Type 2 "I usually don’t share reviews but felt this was warranted. I took my first 2.5 mg shot on 9/4, felt fine until 9/7 when the terrible sulfur burps started followed by sour stomach and nausea. Around 10 pm that night I began 5 days of severe vomiting and diarrhea which culminated yesterday at the ER getting fluids, CT scans, and IV nausea meds. I will not be taking this shot again I have not thrown up anymore but the diarrhea will just not stop. I can’t eat or take any of my other medication properly. Beware. When something sounds too good to be true it usually it is. I’m a past user of byetta, victoza, ozempic, trulicity, rybellsus, bydureon, all the pills, and and about every homeopathic treatment ever made. I didn’t take this shot like a blind fool but I have never had a side effect as terrible as this case. I’ll stick with my insulin. At least I can function like a normal human being!"

1 / 10
Was this helpful?YesNo
286 Report
  • TGMW
  • Taken for 1 to 6 months
  • January 1, 2023

Mounjaro (tirzepatide) "Was prescribed 2.5 , 8 weeks ago, for weight loss. Had never heard of this drug. No issue giving the injection. I was excited to be taking this after research. Have lost a total of 43 lbs and dropped several sizes. This drug has been a miracle for me. I’ve struggled with weight for my entire life and have gained/lost 80+ many times. Never have I had anything to take away my desire to eat like this. Food tastes totally different. Even morning coffee doesn’t taste good anymore. I am thrilled with the results. Sometimes I do have a slight headache and constipation was terrible the 1st week but subsided. In 3 days, I start on the 5 dosage. For me, a slight headache is worth the weight I’ve lost and the lack of hip pain now that I’ve lost the weight. I’ve gone from a size 24 to a 16. I am a 60 year old female, 5’2”..current weight 198-want to lose another 35-40 and will be content for my age. I feel happy and healthy! I take a multivitamin everyday. Had labwork on 12/06/22-perfect!"

10 / 10
Was this helpful?YesNo
242 Report
  • Gia
  • Taken for less than 1 month
  • February 16, 2024

Zepbound (tirzepatide) for Weight Loss (Obesity/Overweight) "39-year-old female, starting weight okay. So, I am on my 3rd shot of the lowest dose of 2.5mg. I have had very minimal side effects. My stool is a bit tacky at times, which I combat with fiber gummies. I have lost 14 pounds in less than three weeks!! My appetite is minimal at best, and I've been walking 10k steps a day. I no longer feel ravenous. I can go 12+ hours without eating and feel just fine. I have also simultaneously quit smoking (or greatly reduced) as well as cutting caffeine, and I was afraid that I would be compelled to eat more to compensate, but nope! That urge to bored eat is completely gone!! Like people have said, this is no miracle drug. You have to want to change, but this can help you significantly. My energy is soooo much better. I'm sleeping better. I feel amazing, and it's only week 3!!"

10 / 10
Was this helpful?YesNo
66 Report
  • Vincy
  • Taken for 1 to 6 months
  • March 15, 2023

Mounjaro (tirzepatide) for Weight Loss (Obesity/Overweight) "I took Monjaro for 10 weeks and lost 7 pounds. Each week I would have a day or so of mild nausea, but no other side effects. In the 10th week, I thought I had a stomach virus but was not throwing up or having diarrhea. After a night of no sleep, I was in severe pain, my heart rate was spiking, and I was very dizzy. I ended up in the ER. All tests were negative so they did an abdominal CAT scan which showed paralysis of the small intestines...(paralytic ileum). Nothing was moving through my bowels so everything backed up into the stomach. No wonder I could not eat. It was the worst "stomach bug" I ever had. I am glad this works for some, but there are potentially serious side effects."

1 / 10
Was this helpful?YesNo
209 Report
  • Anonymous
  • Taken for 1 to 6 months
  • February 14, 2024

Zepbound (tirzepatide) for Weight Loss (Obesity/Overweight) "65, 5' 6'' inches, who weighed 305 lbs 2.5 years ago. Needless to say, I needed to lose weight for more than cosmetic reasons. I started on a medically managed weight loss plan under the direction of a great NP who is well-versed in treating obesity. My insurance won't cover weight loss drugs, so all drugs have been out of pocket. I started on Contrave while following WW and lost 60 lbs. I then went on compounded semaglutide (I know, don't do that) and lost another 40 lbs for a total of 100 lbs, again sticking with WW along with the meds. When Zepbound was approved, I switched to Zepbound using the Lilly savings card ($550/mo) and have lost another 22 lbs so far (a total of 122 lbs) (on 12.5 mg shots now). I am still following WW, and it is so much easier to stick to the food plan with the help of the weight loss drugs. I am a believer and advocate for using these drugs if you need them with a healthy nutrition plan. Mild side effects that diminish over time. Stick with it! It works!"

10 / 10
Was this helpful?YesNo
62 Report
  • Nicole
  • Taken for 1 to 6 months
  • January 31, 2024

Zepbound (tirzepatide) for Weight Loss (Obesity/Overweight) "I love Zepbound! I started on the low dose and now I'm on the 7.5, and I have lost over 25 lbs. There are side effects, not bad enough to make me not use it. They include nausea, cramping, and loose dark stool. I am totally disabled and can't exercise, so this was a great way for me to get lighter on my feet. Thank you. Good luck if you're starting."

Was this helpful?YesNo
69 Report
  • Anonymous
  • Taken for 1 to 6 months
  • March 19, 2024

Zepbound (tirzepatide) for Weight Loss (Obesity/Overweight) "This medication works beyond all my expectations!! I am a 40-year-old female and was at a starting weight of 226 when I began the 2.5 mg dose. Immediately, I noticed I could not finish more than a few bites of food, and the thought of chewing meat was repulsive. But for some reason, I could eat fish and fresh fruit. The mental food noise is gone. It's so nice to go grocery shopping and not look twice at foods that, in the past, I could easily binge eat. Now everything has side effects, so I will say they are manageable. My doctor gave me a script for Zofran for the nausea, and that helps tremendously. For constipation, I take Senna, and at times when it was really bad, I used a pediatric suppository (Pedia-Lax), peppermints for sulfur burps! Don't eat too much; this med delays stomach emptying, so eat slowly and in small portions. I only drink water and want water!! I have so much energy! I have lost 27 pounds in 6 weeks. I am on 7.5 mg and can't wait to reach my goal!"

10 / 10
Was this helpful?YesNo
43 Report
  • Female...
  • Taken for less than 1 month
  • September 1, 2022

Mounjaro (tirzepatide) "Lost 5 lbs in one week. First 2 days after injection I am spacey & can't think clearly; just feel a little odd mentally. Also EXTREMELY tired/run down feeling. Otherwise, mild headache & constipation the rest of the week. Overall, would say it's worth it as I no longer binge or even eat much. Never in my life did I think I could stop obsessing over food and dieting. Maybe one day this drug could be reverse engineered for anorexia or bulemia. Definitely took care of that awful desire and craving to eat all day and night."

8 / 10
Was this helpful?YesNo
254 Report
  • cpoole
  • Taken for less than 1 month
  • December 20, 2023

Zepbound (tirzepatide) for Weight Loss (Obesity/Overweight) "57 years old female, 5'7", and 200 pounds. Tried to get on Mounjaro for 13 months, but cost was $1,200-1,300. I am not diabetic. In 2022, I had normal cholesterol, and BMI was 30. When Zepbound came out, I went to three doctors. One doctor had never heard of Zepbound, acted like GLP-1 was cheating and that I needed to try more exercise and food control. One doctor said maybe I should try diet and exercise first. An Online doctor, Plushcare, agreed after blood work showed high cholesterol, high blood sugar, and other indicators heading up from the prior year. After five blood tests, each worsening, thirteen months of waiting, and spending $800 on visits, I was written a prescription for Zepbound, which cost me $550 for four 2.5 injections. My insurance will not cover the drug, even though they turned down Mounjaro because it was off-label, and Zepbound is for weight loss. Hope insurance companies will pay for Zepbound, but not today. Thanks Ely Lilly for savings card. I'll post results."

10 / 10
Was this helpful?YesNo
86 Report
  • Miracle...
  • Taken for 1 to 6 months
  • March 27, 2024

Zepbound (tirzepatide) for Weight Loss (Obesity/Overweight) "No side effects whatsoever (except lack of hunger!). My stomach has not growled in months and I am satisfied with half the amount of food I used to eat. Love it! I hope insurance will cover this for the rest of my life. Thank you to the makers and doctors pushing to help others realize that obesity is not a choice, and we are not weak, lazy, stupid, etc. It is genetics and a medical condition."

10 / 10
Was this helpful?YesNo
37 Report
  • sandra
  • Taken for less than 1 month
  • February 4, 2024

Zepbound (tirzepatide) for Weight Loss (Obesity/Overweight) "I just started Zepbound 2.5mg two days ago and OMG, I cannot eat ANYTHING! I keep having waves of nausea that feels like I have a stomach virus! OMG people TRY THIS MEDICATION! My insurance wouldn't cover it, so I paid $1292 cash for the month's supply. I have been overweight my entire life, but THIS METHOD IS THE EASIEST WAY TO LOSE WEIGHT! I did weigh myself (after only 2 days), and I lost 8 lbs so far. Next week I am only going to take a half dose (1.25mg) because the nausea has been really awful. I am an actual patient and just wanted to share my progress... THIS MEDICATION IS TRIED AND TRUE! Good luck!"

10 / 10
Was this helpful?YesNo
58 Report
  • Mikey
  • March 30, 2023

Mounjaro (tirzepatide) for Weight Loss (Obesity/Overweight) "So far I have been on mounjaro for a little short of two months. I started at 404 lbs and currently weigh 345 lbs. I've been on 5mg and will move to 7.5 mg after the last shot of 5mg. This has been an absolute game-changer for me. I did make the necessary changes though for the first time in my life. I'm working out 3-4 times a week and I've drastically changed my diet as well. Did blood work and everything is looking great. I didn't get the $25 coupon so I'm roughly paying $525 a month. It is worth every single penny. Going to reevaluate at 6 months but would like to run it for a year and build those healthy habits and go from there. No serious side effects so far and I'm feeling fantastic."

10 / 10
Was this helpful?YesNo
166 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.