Tirzepatide and Nausea: What Users Say

• Ama...
• Taken for 6 months to 1 year
• May 1, 2023

For Weight Loss (Obesity/Overweight) "I have been on the 15 mg/0.5 mL for the last four months and on Mounjaro for a total of ten months starting with the 2.5 mg dosage. Well, I have to say I love it. I had a bit of nausea in the beginning but that’s it, never had it again. I have lost a total of 115 lbs. I don’t just eat whatever I want though, I have mainly been eating chicken, eggs, and turkey with things like cauliflower rice and once a week regular rice. I have gone from being 455 lbs to my current weight of 340 lbs. Also, something awesome, I have gone from a size 62 waist in pants to now a 52. I am so happy with it."

• DRo...
• Taken for 1 to 6 months
• February 8, 2025

For Weight Loss (Obesity/Overweight) "I started on Zepbound 2.5 back in Dec 2024. No major issues in the beginning. It definitely helps control your appetite, and you feel sick if you eat too much. After going to 5.0, I got a little more nauseated and started noticing more dizziness, lightheadedness, and fatigue. But I was losing the weight, so I just kept going. After going to 7.5, that's when my horror stories started. I have taken only two doses but am stopping this stuff altogether. It has truly caused me extreme dizziness, shortness of breath, fatigue, terrible stomach pains, and diarrhea that won't stop. I have lost 37 pounds... great... but the suffering and pain that comes with this medicine... no thanks. I'd rather be a little overweight and be happy than the constant nausea, stomach pain, and diarrhea. Best of luck to you all, but I'm going to accept me for me."

• Vin...
• Taken for 1 to 6 months
• March 15, 2023

For Weight Loss (Obesity/Overweight) "I took Mounjaro for 10 weeks and lost 7 pounds. Each week I would have a day or so of mild nausea, but no other side effects. In the 10th week, I thought I had a stomach virus but was not throwing up or having diarrhea. After a night of no sleep, I was in severe pain, my heart rate was spiking, and I was very dizzy. I ended up in the ER. All tests were negative so they did an abdominal CAT scan which showed paralysis of the small intestines...(paralytic ileus). Nothing was moving through my bowels so everything backed up into the stomach. No wonder I could not eat. It was the worst 'stomach bug' I ever had. I am glad this works for some, but there are potentially serious side effects."

• Mis...
• Taken for less than 1 month
• September 13, 2022

For Type 2 Diabetes "I usually don’t share reviews but felt this was warranted. I took my first 2.5 mg shot on 9/4, felt fine until 9/7 when the terrible sulfur burps started followed by sour stomach and nausea. Around 10 pm that night, I began 5 days of severe vomiting and diarrhea, which culminated yesterday at the ER getting fluids, CT scans, and IV nausea meds. I will not be taking this shot again. I have not thrown up anymore, but the diarrhea will just not stop. I can’t eat or take any of my other medication properly. Beware. When something sounds too good to be true, it usually is. I’m a past user of Byetta, Victoza, Ozempic, Trulicity, Rybelsus, Bydureon, all the pills, and about every homeopathic treatment ever made. I didn’t take this shot like a blind fool, but I have never had a side effect as terrible as this one. I’ll stick with my insulin. At least I can function like a normal human being!"

• My ...
• Taken for 6 months to 1 year
• September 3, 2024

For Weight Loss (Obesity/Overweight) "I am 64, 5'7" and weighed 245. Started Zepbound the second week of February, and as of September 1, have lost 65 lbs and went from a 42 waist to a 34 and never walked into a gym. Had some morning sickness at first, but got over it. You have to ask yourself, is the juice worth the squeeze? And yes, it is. Do the math: that’s between 2 to 3 lbs a week. My doctor discontinued my blood pressure medication, and my gout has gone away, not to mention how great I feel and look. You owe it to yourself if you are in need of losing weight. My BMI went from 39% to 25% as well."

• Nic...
• Taken for 1 to 6 months
• January 31, 2024

For Weight Loss (Obesity/Overweight) "I love Zepbound ❣️ I started on the low dose, and now I’m on the 7.5, and I have lost over 25 lbs. There are side effects, not bad enough to make me not use it, they include nausea, cramping, and loose dark stool. I am totally disabled and can’t exercise, so this was a great way for me to get lighter on my feet. Thank you. Good luck if you’re starting."

• SdS...
• Taken for 1 to 2 years
• February 13, 2025

For Weight Loss (Obesity/Overweight) "I have been on Zepbound for almost a full year. I lost weight quickly: 90 pounds. I was at my goal in 6 months. I had to go back 2 doses to maintain and stop losing weight. The nausea has not stopped. It’s better than in the beginning, but I still get it every time for 1 or 2 days after a shot. The diarrhea is terrible. It has never stopped. I get it on day 2, and it is uncontrollable. It’s been almost a year, so I would think some of these side effects would have stopped, but they haven’t. I also get sulfur burps for a day or 2 after a shot. I’m at the point where I might have to stop taking it due to the side effects. I love the weight loss, and I sure don’t want to gain it back, though."

• cla...
• Taken for 1 to 6 months
• December 26, 2022

For Type 2 Diabetes "I completed 4 weeks on 2.5 mg with zero side effects, other than the intended appetite suppression and lost 10 pounds. HOWEVER, after my second week at 5mg, I'm not sure I can continue. I've had awful nausea, vomiting, sulfur burps, and diarrhea, to the point I had to go to the ER for IV fluids and potassium. Zofran, Phenergan, Tums, and Pepto have zero effect. I can barely function, but hey, I'm down a total of 17 lbs in 6 weeks, so at least I'll look skinny for my next trip to the ER."

• ibd...
• Taken for less than 1 month
• January 28, 2025

For Weight Loss (Obesity/Overweight) "Started the shot on Wednesday, was kind of nervous. Ate small portions, so I wouldn't get nausea. Didn't really think it was working, didn't feel any different. It is now Monday, I have lost eight pounds. I'm never hungry, have to remember to eat, don't think about food really except fruit, it always sounds good. Absolutely no negative side effects. Started at 187, am now at 179. This is on my first shot! This stuff is amazing, looking forward to that second shot! It's expensive since state insurance doesn't cover it, and I only work part-time, but worth every cent!"

• fat...
• Taken for 1 to 6 months
• April 13, 2023

For Weight Loss (Obesity/Overweight) "I started taking this medication for weight loss. My first round of the 4 injections was 2.5 mg, and it had no negative side effects at all. I just had no appetite. I lost 10 lbs within that 4 weeks. I then moved up to the 0.5 mg. The day after taking the first injection, nausea hit like a train. I never threw up but was just nauseous. I called my doctor, and she prescribed medication for the nausea which helped immensely. By the time I took my second injection, the nausea had gone away, and I had lost another 5 lbs. I still have so much more to go and I'm very optimistic. I literally have had no appetite; nothing sounds good or tastes good. I do drink as much water as I can throughout the day. I've had no problems with constipation but as a precaution, I take a couple of stool softeners once a week and I'm good to go. I used to have a sweet tooth, but not now. Great benefits, has tolerable side effects, and is very easy to use."

• APB...
• Taken for 6 months to 1 year
• March 10, 2023

For Weight Loss (Obesity/Overweight) "Good results. Immediate appetite suppression starting with the lowest dose. More importantly, my food cravings went away. It takes a couple of weeks, at most, to get through the psychological part of less appetite/less food. You get full quickly, and yet you feel like you still want to eat because your mind is telling you, 'how can you be full already, you've only had 4 bites?' It only takes one or two times of being nauseated or vomiting to remember to eat less. I have lost 48 lbs in exactly 7 months, and my hypertension is gone."

• Con...
• Taken for less than 1 month
• October 2, 2022

For Type 2 Diabetes "Started taking 2.5 last Thursday. Day 1, no side effects, day 2, mild nausea, day 3, everything broke loose! Dizzy spells, clammy sweats, severe abdominal pains, and bloating. Ended up in ER and blood pressure was so high I was at stroke level! Readings were 220/123, 187/113, 197/116, 178/112! No issues before medication! Beware, this medication is so new there is no telling how many other side effects it can have! I pray this mess gets out of my system soon!"

• krp...
• Taken for 1 to 6 months
• October 6, 2022

"Started taking specifically for weight loss. Starting weight on Aug 1 was 192 lbs and did the 2.5mg for a month. Weight on Aug 30 was 176 lbs! Only side effect was the WORST dry mouth - whoa! Not expecting that but it went away. It completely took away constant thoughts of eating and cravings. Weight loss was effortless. Started 5mg - 2nd week had a lot more nausea - felt like pregnancy nausea. If I was busy, I wouldn't think about it but if I thought about eating or smelled food - no thank you! It was the most intense the day after I did my shot and for the next 2 days or so. Weight after 2 months - 162.6 lbs! I'm on week 7 of 5mg and the nausea is basically gone. Weight hasn't changed for the last week."

• All...
• Taken for 1 to 6 months
• April 22, 2025

For Weight Loss (Obesity/Overweight) "My insurance won't cover Zepbound. I get it through the 'Lilly Direct Cash Pay for Zepbound vials.' I started with 2.5 mg for 1 month and lost 12 pounds. I moved up to 5 mg and lost 30 pounds in 4 months. Total loss so far, 42 pounds! Starting weight was 184, height is 5'3'. Current weight is 142. Only side effect for me is seldom nausea. Price is $504 each month, and that includes the needles, otherwise, it's $499. Now that Lilly offers the higher doses for the same price, next week I start 7.5 mg. I will update again in a month or so."

• Hap...
• Taken for 1 to 6 months
• September 25, 2022

"I started Mounjaro on July 1, 2022. I just turned 74 and was at the end of my rope with my obesity. I immediately developed a sour stomach/nausea and heartburn. But the wonderful side effect of having no appetite and not obsessing about food EVERY WAKING MOMENT was worth it. I still enjoy food, just eat less than half what I used to and no snacking. I lost 30 pounds in 2 months. I take one more injection (totally painless and easy to give) of 7.5 mg and then move up to 10 mg. My worst problem is terrible constipation. I’m working on it by using Colace, etc. but haven’t solved it completely. Since I’m on Medicare, I am paying THOUSANDS of dollars for this drug. So my savings account is decreasing but so is my weight. If I can afford it, I hope to stay on Mounjaro for one year. I still go to Weight Watchers and live by their eating plan which is very healthy."

• Kat...
• Taken for 1 to 6 months
• January 20, 2023

For Type 2 Diabetes "I started Mounjaro to help control my blood sugar. I had tried Ozempic and Trulicity and could not tolerate the nausea, sulfur burps, and stomach issues. Mounjaro has been life-changing. No bad side effects. I’m not hungry, I don’t have cravings, I’m losing weight steadily, and sweet desserts taste too sweet. Many people say they’ve had bad side effects with it. I say try it as it may work for you. Just like I couldn’t use other meds that other people love. For me, it has been life-altering."

• Kay...
• Taken for 1 to 6 months
• January 10, 2025

For Weight Loss (Obesity/Overweight) "I started taking Mounjaro 2.5 mg on September 6th, weighing in at 128 kilos. I'm now on my 7th shot of 10 mg (as I stayed on 10 mg for another month over Christmas) and I weigh 106 kilos in January. This is without changing my lifestyle of exercise or food. I eat smaller portions and don't think about food half as much as I used to. It's been great up until my 6th shot of 10 mg. I would experience mild side effects of nausea, vomiting, diarrhea, sulfur burps. These tended to be spread across the board as well though, never all at the same time, and it was manageable. However, my 6th dose I felt instantly! I was nauseous for 3 days straight, vomiting, diarrhea, sulfur burps, tired, the list is endless. I was so worn out by the nausea, I couldn't sleep, eat, or drink. I took myself to the walk-in center at the hospital where they referred me straight to A&E for having a resting heart rate of 128 bpm. I was put on an IV drip, bloods taken. I felt awful and still do! Going to go back to 7.5 mg."

• Anonymous
• Taken for 2 to 5 years
• March 26, 2025

For Weight Loss (Obesity/Overweight) "This medication saved my life! In the beginning, the nausea was very noticeable but worth every bit! I never really had a problem with my weight until after my pregnancies. I gained over 90 lbs with each of my two pregnancies. Being at over 300 lbs and only 5’1” was a miserable existence. I couldn’t breathe and was exhausted all of the time, not to mention pre-diabetic and very high blood pressure. It has definitely been a journey, but I stand by that this medication saved my life. I’ve lost 125 lbs. I still have a way to go to get to my goal, but I’m so happy to be alive to see how much better life can be! By the way, my A1C is now normal, and the hypertension has also resolved! I’m very grateful!"

• Pen...
• Taken for less than 1 month
• September 23, 2022

For Type 2 Diabetes "I started taking Mounjaro on 9/1. This resulted in the very worst month of my life. WEEK ONE - Super Nauseous, indigestion, stomach pain for 3-4 days of the first week. My appetite went from a 10 to a 2 (which was good). WEEK TWO - I had diarrhea for 3-4 days, along with sulfur belches, nausea, stomach pain. I ended up having to take sick days and go get an IV bag to recover from the dehydration. WEEK THREE - World-class nausea and vomiting. 3 days of vomiting so hard that I ruptured my esophagus. The entire month, if I was not having diarrhea, I was VERY constipated. I lost 9 lbs in one month, but I don't know if it was because I could barely eat due to the sickness. PASS!!"

• Jac...
• Taken for 1 to 6 months
• May 15, 2025

For Type 2 Diabetes "2.5 and 5.0 worked fine with minimal side effects. Once I started 7.5, nausea and diarrhea took over. I’ve only taken 1 dose, and don’t plan on continuing 7.5. 5.0 lowered my blood sugar just fine."

• Anonymous
• Taken for 1 to 6 months
• March 29, 2023

For Weight Loss (Obesity/Overweight) "I'm on month three. My doctor thinks I might be too sensitive to it and may have to stop soon. Extreme nausea, occasional vomiting, and sulfur burps followed by diarrhea, weakness, and lethargy. The pros: in three months, I've gone from 262 lbs to 239 lbs."

• Mim...
• Taken for 1 to 6 months
• December 29, 2022

For Type 2 Diabetes "I'm type 2 diabetic and was on Ozempic for quite some time and having difficulty getting my medication. My doctor changed me to Mounjaro for my diabetes thinking I would be able to get my meds. I started on the 5 mg since I had been on Ozempic. My side effects were typical slight nausea. I was trying to get my second month filled and the issues started with availability AGAIN. The 5 mg and 7.5 mg were on backorder. He increased my dose to 10 mg. I have experienced sulfur burps, but that is about it. I have not seen much weight loss, but then again I'm more concerned about my diabetes. Shame on the drug companies for dangling a medication that works to lower A1C and cholesterol and choosing to utilize it for weight loss where the insurance won't cover it. I'm not using this medication for vanity, it's for my chronic disease."

• Bla...
• Taken for 1 to 6 months
• April 2, 2025

For Weight Loss (Obesity/Overweight) "I have been struggling with my weight since I was 16. I quit smoking, had two children, entered menopause, and my weight became uncontrollable (my blood tests have always been perfect). I found the strength to start dieting a couple of times a year but hit rock bottom in March, 48 years old, 107 kgs. Depressed and unable to start -again- the keto diet (it works very well for me), I asked for help and was put on antidepressants and Mounjaro. A real game changer. I started the diet with no willpower, no bad feelings, no cravings, no need for self-control, just naturally. I got into ketosis easily and quickly. As a side effect, I have slight nausea a couple of days after the injection. No big deal, as it helps with the diet. No more food noise, I am able to think and prepare my meals without rushing, and so far, I have lost 6 kg in 14 days. I plan to continue for as long as I can and then stop and get my weight under control. We'll see."

• slp...
• Taken for 6 months to 1 year
• March 11, 2025

For Type 2 Diabetes "My endo doctor asked me to try the shot. At first, I said no. But she convinced me that we could get my A1C down. It was just under 9 at that time. I started the shot the 2nd week of October 2024. The first 2 months, it was just feeling nauseous. That was 2.5 mg. Here it is March 2025, I've lost 46 lbs. That to me is great. I had no idea about the weight loss when I started! Latest blood work, A1C is 6.4!! I now don't have to take Januvia or glipizide. Another plus! I am now on 7.5 mg. The only thing I've noticed, well, 2 things: I've developed eczema, bad. Currently waiting for my dermatology appointment. The other problem is depression. At least that is my thought, I've not had any ambition or 'get up and go,' which could be from the increase to 7.5 mg. I'm going to stick with it though. I'll stay at my current dose for a couple of months. I'm very happy with my morning finger pokes, I've been 92 to 103 every morning. Very pleased with the medication!"

• cod...
• Taken for 1 to 6 months
• February 19, 2025

For Weight Loss (Obesity/Overweight) "It's too early to say that Mounjaro has been life-changing, but it is certainly trending that way. My first week was a huge drop in water weight; I lost about 11 pounds. Weeks 2-4 it slowed a bit, and I'm down about another 5 lbs. I'll be starting the 5 mg tomorrow. 16 lbs in my first month is pretty darn good, I'd say. Very little side effects thus far: severe nausea, but it's fleeting; it sticks around for 30-60 seconds then disappears, occurring every two or three days. In terms of how I feel, the changes have been subtle but definitely noticeable. My appetite is absolutely gone for the first 48 hours after injection, then comes back gradually. By the 5th or 6th day, I'm thinking about food again on a regular basis. I do feel that I have more energy, and my willingness to do even small household tasks seems to be higher than it has in a couple of years. Everything just seems like less of a burden. I started at 441 lbs, and am hopeful I can get back to around 300 eventually."