Tirzepatide and Nausea: What Users Say (Page 4)

• Lor...
• Taken for 1 to 6 months
• July 16, 2025

For Weight Loss (Obesity/Overweight) "I started on Zepbound 3 months ago. I began at 2.5 mg the first month and then went to 5 mg for 2 months. I had no side effects whatsoever. I started 7.5 mg last Sunday, and by Tuesday, I was nauseous, vomiting, and had diarrhea. It went away overnight, and now I’m fine, but not sure I want to continue with 7.5 mg due to the side effects. I have lost only 10 lbs in the 3 months I have been on it, but will have to stop taking it if these side effects continue."

• dmj...
• Taken for 1 to 6 months
• May 8, 2023

For Weight Loss (Obesity/Overweight) "You do lose weight, but the waves of nausea, vomiting, severe constipation, and hypoglycemia are so unpleasant, and if you escalate and find it too much - it lasts for a whole week. Consider liraglutide daily, much easier to titrate, and if you escalate and find it too much, you can lower down and only have one day of downtime."

• Gha...
• Taken for 1 to 6 months
• February 28, 2023

For Weight Loss (Obesity/Overweight) "I have slowly lost weight. I have taken it for 8 weeks and have lost 18 lbs on the 2.5 mg dose. It makes me very nauseous and causes GI upset. But overall, I think slow weight loss is probably best anyway for long term."

• Ms ...
• Taken for 6 months to 1 year
• March 11, 2025

For Weight Loss (Obesity/Overweight) "I started my Zepbound journey in August 2024. I have been on .50 the whole time. I've lost 40 lbs using this medicine, which is amazing! In February, out of nowhere, I started to get side effects after my shot: nausea and diarrhea. Thinking it was the flu, I nursed myself back. Shot day is Wednesdays. On Saturday, the diarrhea came back again. I truly am excited for my weight loss journey but am literally pooped out."

• Wan...
• Taken for 1 to 6 months
• May 12, 2023

For Weight Loss (Obesity/Overweight) "I’m a 58-year-old woman. When I started Mounjaro, I was at 172 lbs. I am taking 5 mg. On the first injection of 5 mg, I had hives, but the next day, with allergy medication, it went away. I had a little bit of nausea off and on every time I took an injection. The worst part about this medicine is I feel cold all the time and fatigued. The fatigue goes away after a couple of days. I just took my 4th injection of 5 mg and will move up to 7.5 mg next week. So far, all good. I did notice I got pretty hungry 2 days before it was time to take my 4th 5 mg injection, which to me said it lost its effectiveness. I did struggle with those 2 days trying not to go back to old habits. I have lost 20 lbs since starting Mounjaro, and all of my blood work is much, much better. My A1C is down 2 points!"

• PP6...
• Taken for less than 1 month
• November 22, 2022

For Type 2 Diabetes "Horrible experience taking this drug. I do not recommend taking this medication unless you want to die. I started taking 2.5 mg 6 days ago. Day 2 and 3 had no appetite and ate very little because the thought of food made me sick. Day 4 and 5 developed nausea, severe abdominal pain, and indigestion unrelieved by antacids. I also have lost five lbs because I am unable to eat or drink anything. I do not have any energy or feel like doing anything. Day 6 and I still feel sick. My fasting blood sugar this morning was 224 even though I am not eating or drinking hardly anything at all. It is noon, and I haven’t eaten anything because I’m afraid I will throw up. My heart rate is 120 and normally runs in the eighties. My doctor is out of the office this week for holidays. Just hoping and praying I don’t wind up in the emergency room. I will never inject this toxic stuff into my body again. I also read that it can cause thyroid cancer."

• Ste...
• Taken for 6 months to 1 year
• October 3, 2024

For Weight Loss (Obesity/Overweight) "I've been on the shot for 5 months now, and at first, the appetite suppression was strong, with no side effects. After I went up in dose month two, I had extreme bloating and nausea to the point where I nearly took myself to the emergency room. Since then, the side effects have gone down, and the only one I deal with regularly is heartburn. Ask your doctor for Zantac and keep it and Tums on you at all times. Thankfully, it has mostly subsided, and I'm down 80 pounds with moderate exercise in 5 months. I have basically 0 appetite most days and have grown to work with it. I'd give it a 4/5. It's not easy, but if you're serious about losing weight and taking back control of your body, do it. Make sure you work out and follow a strict diet while you're doing it to get the most out of the medication. ALSO! Go to the manufacturer Lilly's website and sign up for the savers card. Saves me $300 a month with insurance."

• Anonymous
• Taken for 1 to 6 months
• January 12, 2025

For Weight Loss (Obesity/Overweight) "I am a 49-year-old female. Started on 2.5 mg of Zepbound at 201. Lost some weight quickly and got to 191, then stopped. Second month, they bumped me to 5 mg. I only got sick once. It was nausea. I started losing again. Got down to 185. Then, for reasons I can’t explain, I gained 2 lbs despite walking and tracking food. On my 3rd shot, I was very lethargic for a whole weekend after the shot. I have no energy, and I am taking nothing else. I hope it goes away soon and I start losing again. It’s not a magic bullet. You have to track your food and exercise too (which is hard with lethargy)."

• Jca...
• Taken for less than 1 month
• October 7, 2022

For Type 2 Diabetes "I just took my fourth injection, and I couldn’t be more excited! I’ve lost 10 pounds in three weeks, my appetite is controlled, I feel like I’ve finally got some hope to get my health where it needs to be. My morning fasting glucose is close to 100 (always near 140), no more crazy spikes hitting 200-300. I do get very tired the day of each shot. The first three days or so of my first injection, I was so ill (sick stomach). I got some Zofran, and that helped tremendously, so I’ll expect to need that with each dose increase. Looking very forward to 5 mg next week :) Ins won’t pay for it yet, even though I’m type 2, but I’ve got a coupon for it and paid $25 a month. Thank God, or I couldn’t get it, hopefully soon it will be covered."

• Sus...
• Taken for less than 1 month
• March 5, 2023

For Type 2 Diabetes "I have been on Ozempic 2 mg since it came out. When I couldn't get it due to shortage, I was prescribed Mounjaro 5 mg. Five days after eating my one meal a day, I intermittent fast, and I started vomiting. I spent the whole night throwing up every half hour. I figured it was a side effect and hoped I would improve. I had stomach and back pain, weakness, and was unable to eat. I was in bed until I had to get up and sit due to pain, sleeping off and on. I could only drink water. I got worse and finally, five days later, had my husband drive me to the ER. I know I should have gone sooner. I didn't take a second shot. I had a CAT scan and was told I had a bowel obstruction, and I would be admitted and there for a few days. If they couldn't resolve it through a tube down my nose, I would have surgery. Luckily, it was resolved by the nasal tube, but it was awful. My medical care pharmacist told me to try Mounjaro 2.5 mg. I was worried but did it. I didn't get nausea, but I had all these other side effects. I quit taking it."

• Ski...
• Taken for 1 to 6 months
• March 5, 2023

For Type 2 Diabetes "In November 2022, my ACI was 7.4%, and I weighed 258 pounds at 67 years old. The wake-up call was when I renewed my life insurance, a big jump in premium due to the AC1 and weight. I was now tagged as a Type 2 Diabetic. I was referred to an endocrinologist who did extensive blood work. It was agreed to go on Mounjaro 2.5 mg. The first week I suffered some side effects such as nausea, constipation, and acid burps. Within 10 days, the symptoms subsided due to stool softeners, lots of fruit (berries), and Nexium. The first month I dropped 10 pounds with no dieting, just was not hungry at all. I had no cravings, especially for sweets like cookies, donuts, and candy-all things that I used to eat. Fast forward to March 2023, I am down to 217 pounds and 20 more to go. I am now on Mounjaro 10 mg, it's a bit strong, but the results are fantastic. My AC1 is now 5.6%, which is fantastic. The bad news is nothing fits- all new suits for the spring."

• Ms ...
• Taken for 1 to 6 months
• September 8, 2025

For Weight Loss (Obesity/Overweight) "Have been taking for the 6 weeks. I have lost some weight, but I have been so nauseous that it is hard to continue taking. I've also experienced fatigue, and it's already hard with perimenopause. So far, not a good experience, but I'm trying to stick with it to see if it gets better. I have seen it work really well for some family members, so hopefully, it will get better."

• Anonymous
• Taken for 1 to 6 months
• December 17, 2024

For Weight Loss (Obesity/Overweight) "I am 5'2" and 46 years old. I started Zepbound on 8/20/2024 at 166 pounds. I took the 2.5 mg dose for one month, then increased to 5 mg in Oct. and Nov. I had very mild side effects, and I steadily lost weight until last week. I have now increased to the 7.5 mg dose, and the nausea and diarrhea are pronounced. I'm down 30 pounds, but I may switch back to the 5 mg dose if the side effects don't subside."

• Ano...
• Taken for 1 to 6 months
• September 7, 2025

For Type 2 Diabetes "75 yo. Female I have noticed excessive facial hair growth since I started Mounjaro 3 months ago. I have experienced frequent bouts of nausea and constipation, which I control with Zofran and laxatives. Lots of fluid is important."

• Day...
• Taken for less than 1 month
• February 2, 2025

For Weight Loss (Obesity/Overweight) "Flu-like symptoms, nausea, discomfort after eating anything. Broth has been my go-to. Very fatigued. Hoping week 2 will be better. Today is day 7. No appetite, no energy. There's not an option for maybe. One week isn’t enough time to give recommendations."

• Ano...
• Taken for 1 to 6 months
• August 9, 2025

"I was prescribed Zepbound as a minor by my PCP since a close relative had great improvement of symptoms on the drug. I had moderate/severe side effects, including severe abdominal pain, complete lack of appetite leading to hypoglycemia, exhaustion and weakness, increased stress, nausea, IBS flare-ups, and significantly increased suicidality. While my lab results showed improvement, my physical and mental well-being plummeted. I was told that side effects would subside and that they were mild, but unfortunately my side effects did not subside and were unmanageable for me. Luckily, I was able to convince my doctor that it wasn’t working after a few more months and am now off the drug."

• Sha...
• Taken for 1 to 6 months
• December 1, 2024

For Weight Loss (Obesity/Overweight) "I started using Zepbound on October 31st of this year. The beginning dosage was 2.5 mg. I started to lose 1-3 lbs. a week. The dosage was increased to 5 mg, which I started on the 4th week. Current total loss of 11.5 lbs. My provider has suggested that I increase the dose to 7.5 mg for my next refill. I do have side effects: nausea, constipation, dry mouth. My appetite has diminished, but I have to make a conscientious effort to eat. Cravings for specific foods have gone as well. I have a fear of needles, but do not feel the injections or any discomfort associated with normal 'shots.' Overall, my experience has been a good one, but it is still early."

• 8LL...
• Taken for 1 to 6 months
• June 9, 2023

For Type 2 Diabetes "Started medication in early March. One dose weekly for 6 weeks, till I quit. Severe nausea that would last for 5 days after each shot. It does eliminate your desire to eat, but I gained 11 pounds during the 6-week period. Also, I now have an irregular heartbeat and shortness of breath from this. I've been off the medication since mid-April. It is now 6/9/23, and I am still having problems, and upcoming heart tests scheduled."

• S-L...
• Taken for 1 to 6 months
• November 6, 2022

For Type 2 Diabetes "I tried to leave a review, but for some reason, it wasn't posted, so I will try again. My doctor took me off of Mounjaro recently. I developed large welts about 24 hours after I injected the 75 doses and 10. My doctor fears I am developing an allergic reaction, so I am going back to the rival insulin alternative. (I had more side effects with the Ozempic: exhaustion, extreme nausea, and constipation, but hopefully, over time, they go away this time.) Too bad, because I really wanted to stay on Mounjaro. It should be noted that I really like Mounjaro very much. Well-controlled sugar, once I was on my maintenance dose of 10. For some reason, I gained five pounds while on Mounjaro, I never lost weight, where I lost about 15 pounds on the other mentioned insulin alternative. It seems that other patients on other review sites have this welt issue too. The issue should be reported not only to the doctor, but per the request of the manufacturer, please report to them as well."

• Tim...
• Taken for 1 to 6 months
• July 27, 2024

For Weight Loss (Obesity/Overweight) "Severe nausea, horrid vomiting and diarrhea after 7.5 mg dose - did okay with 2.5 and 5 mg doses - there should be more warnings with the higher doses as this was severe. Higher doses should be reviewed further for safety reasons."

• kan...
• Taken for 1 to 6 months
• December 21, 2024

For Weight Loss (Obesity/Overweight) "I am a 55-year-old female, 5’7 starting weight 250, started Zepbound 6 weeks ago. 1st month, 2.5 — moved up to 5 2nd month. Probably the most annoying, almost immediate side effects were GERD, bloating, and constipation. However, this did improve quickly when I added more fiber, avoided high-fat, saucy foods, and ate less. I do agree with the others… that it definitely helps your “hunger-food brain.” I can skip a meal without even noticing. I fill up eating a quarter to half of what I would normally eat. I begin getting nauseated while I eat, which makes me stop eating, of course. Now that I've increased from 2.5 to 5, the nausea is a little worse, but intermittent and tolerable. Hoping this will improve once my body adjusts. Overall, still very thankful for this opportunity to try Zepbound. I'm trying to find some type of a meal plan to follow, with sufficient protein and fiber, as well as other foods or supplements to prevent muscle loss, hair loss, constipation, and fatigue."

• mou...
• Taken for less than 1 month
• June 1, 2023

For Type 2 Diabetes "My husband suffered from severe nausea, mostly at night, but also from loss of appetite, constipation, and increased fatigue. He could not even get out of bed after one injection. He will not take a second dose."

• Gre...
• Taken for 1 to 6 months
• February 28, 2023

For Type 2 Diabetes "I have been taking Mounjaro for 13 weeks. I am currently on the 7.5 mg dose. This medicine has changed my life! My A1C went from 12.9 to 6.5 in 12 weeks. My weight dropped 27 lbs, and my relationship with food has improved 100%. Side effects: slight nausea the day after I increased the dosage, decreased appetite, occasional need for a laxative to combat constipation."

• Ano...
• Taken for 6 months to 1 year
• May 8, 2025

For Weight Loss (Obesity/Overweight) "I started taking Zepbound on July 1, 2024, after much research and many discussions with my primary care provider. My insurance did not cover the cost and, at that time, it was difficult to get access to some of the other weight loss drugs. I was able to get Zepbound at my local Walmart Pharmacy and decided to go for it in spite of the cost. At the beginning of my weight loss journey, I was 74 years old, 5'5" and 190 lbs. I started at the lowest dose, 2.5 mg, and began losing weight right away. The only side effect I experienced was slight nausea for a day or so after each injection. It also lowered my blood pressure and I was able to stop taking blood pressure medication. I never exceeded the 7.5 mg dose and am still using it sporadically (probably not the proper way to go about it). I was able to go from 190 lbs. down to 135 lbs. in 9 months."

• Mrs...
• Taken for less than 1 month
• February 21, 2023

For Type 2 Diabetes "I was on 2.5 dosages for several weeks. I felt a little nauseous but was losing weight and very happy. I was not waking up in the middle of the night feeling hungry. When I went to refill my next prescription, all the pharmacy had was 12.5 mg, so I agreed to try. Huge mistake. I have severe nausea, felt like I have the flu, can't stay awake, and body aches are ridiculous. I projectile vomited what looks like coffee grounds, I have awful sulfuric burps, and can't even keep down sips of water. I've missed 2 days of work thus far and have to have someone come to my house tomorrow to give me an IV because I'm too scared to drive. Not worth it at all."