Tirzepatide and Nausea: What Users Say (Page 4)

• Sus...
• Taken for less than 1 month
• March 5, 2023

For Type 2 Diabetes "I have been on Ozempic 2 mg since it came out. When I couldn't get it due to shortage, I was prescribed Mounjaro 5 mg. Five days after eating my one meal a day, I intermittent fast, and I started vomiting. I spent the whole night throwing up every half hour. I figured it was a side effect and hoped I would improve. I had stomach and back pain, weakness, and was unable to eat. I was in bed until I had to get up and sit due to pain, sleeping off and on. I could only drink water. I got worse and finally, five days later, had my husband drive me to the ER. I know I should have gone sooner. I didn't take a second shot. I had a CAT scan and was told I had a bowel obstruction, and I would be admitted and there for a few days. If they couldn't resolve it through a tube down my nose, I would have surgery. Luckily, it was resolved by the nasal tube, but it was awful. My medical care pharmacist told me to try Mounjaro 2.5 mg. I was worried but did it. I didn't get nausea, but I had all these other side effects. I quit taking it."

• Sha...
• Taken for 1 to 6 months
• December 1, 2024

For Weight Loss (Obesity/Overweight) "I started using Zepbound on October 31st of this year. The beginning dosage was 2.5 mg. I started to lose 1-3 lbs. a week. The dosage was increased to 5 mg, which I started on the 4th week. Current total loss of 11.5 lbs. My provider has suggested that I increase the dose to 7.5 mg for my next refill. I do have side effects: nausea, constipation, dry mouth. My appetite has diminished, but I have to make a conscientious effort to eat. Cravings for specific foods have gone as well. I have a fear of needles, but do not feel the injections or any discomfort associated with normal 'shots.' Overall, my experience has been a good one, but it is still early."

• Ano...
• Taken for 1 to 6 months
• July 9, 2025

For Weight Loss (Obesity/Overweight) "So far the experience for me has been difficult. The weight loss is slow but pretty much steady. I’m experiencing nausea, stomach pain, and fatigue. I’m still trying to stick it out, hoping that it will subside."

• Day...
• Taken for less than 1 month
• February 2, 2025

For Weight Loss (Obesity/Overweight) "Flu-like symptoms, nausea, discomfort after eating anything. Broth has been my go-to. Very fatigued. Hoping week 2 will be better. Today is day 7. No appetite, no energy. There's not an option for maybe. One week isn’t enough time to give recommendations."

• Jea...
• Taken for 1 to 6 months
• April 13, 2025

For Weight Loss (Obesity/Overweight) "I have used Ozempic, Saxenda, and Wegovy and changed due to shortages, nausea, or not getting results. Been on Mounjaro for 1 month at 2.5. I have lost 2.8 kilos. No nausea and no desire to eat or pig out. My IBS/bloating has significantly reduced too. However, I eat small, healthy meals of protein, salads, and some fruit. I am very conscious of eating nutritious food and drinking lots of water. Mounjaro is expensive (in Australia), but it so far is the best product for me."

• Anonymous
• Taken for 1 to 6 months
• December 17, 2024

For Weight Loss (Obesity/Overweight) "I am 5'2" and 46 years old. I started Zepbound on 8/20/2024 at 166 pounds. I took the 2.5 mg dose for one month, then increased to 5 mg in Oct. and Nov. I had very mild side effects, and I steadily lost weight until last week. I have now increased to the 7.5 mg dose, and the nausea and diarrhea are pronounced. I'm down 30 pounds, but I may switch back to the 5 mg dose if the side effects don't subside."

• 8LL...
• Taken for 1 to 6 months
• June 9, 2023

For Type 2 Diabetes "Started medication in early March. One dose weekly for 6 weeks, till I quit. Severe nausea that would last for 5 days after each shot. It does eliminate your desire to eat, but I gained 11 pounds during the 6-week period. Also, I now have an irregular heartbeat and shortness of breath from this. I've been off the medication since mid-April. It is now 6/9/23, and I am still having problems, and upcoming heart tests scheduled."

• Anonymous
• Taken for less than 1 month
• November 29, 2024

For Weight Loss (Obesity/Overweight) "First dose 2.5 today, and already my appetite is none. I only ate a very small portion plate and drank nothing but water. It wasn't until I tried to have my daily cup of coffee when I felt very nauseated after only a few steps. Day 1, and I'm here to say I know it's going to work out (I'm hoping I can build my coffee/frappe tolerance back up, I LOVE my coffee)."

• Anonymous
• Taken for 1 to 6 months
• January 12, 2025

For Weight Loss (Obesity/Overweight) "I am a 49-year-old female. Started on 2.5 mg of Zepbound at 201. Lost some weight quickly and got to 191, then stopped. Second month, they bumped me to 5 mg. I only got sick once. It was nausea. I started losing again. Got down to 185. Then, for reasons I can’t explain, I gained 2 lbs despite walking and tracking food. On my 3rd shot, I was very lethargic for a whole weekend after the shot. I have no energy, and I am taking nothing else. I hope it goes away soon and I start losing again. It’s not a magic bullet. You have to track your food and exercise too (which is hard with lethargy)."

• Mrs...
• Taken for 6 months to 1 year
• October 8, 2024

For Weight Loss (Obesity/Overweight) "Zepbound made weight loss easy. I have lost 40-50 pounds on it. Very little side effects outside of a little nausea occasionally. It’s so easy to use with the prefilled injector. I am now maintaining, and my doctor is happy with my weight. I’m so excited, I haven’t been this thin in 30 years! The only downside for me is the cost. It’s quite expensive even with the coupon. I’m not sure how much longer I can keep paying at this price."

• Lin...
• Taken for 1 to 6 months
• November 10, 2024

For Type 2 Diabetes "I’ve been taking 2.5 ml for 4 weeks and had few side effects apart from zero appetite, a little nausea, and a migraine (think the migraine was due to not eating). Now, week 5, increased to 5 ml and a different story: quite a lot of nausea, diarrhea, headache, and tiredness. Also again, total lack of appetite. Fortunately, these side effects more or less calmed down 2 or 3 days after taking the dose. I’m hoping it’s a temporary thing when you take a new dose - I can live with that."

• Ant...
• Taken for less than 1 month
• September 22, 2024

For Weight Loss (Obesity/Overweight) "I started on a low dosage (0.25 mg/weekly) two weeks ago. It actually decreased the appetite without any side effects. I am exercising due to an increase in energy. I actually eat one meal a day, I only eat until I am full. I tried to eat more but got very nauseous. At the end of two weeks, I have lost 30 lbs. The exercise allows me to keep my muscle mass. It's great to be able to move more easily. One side effect I noticed also was increased focus in my thought patterns. It is a blessing for that. Multi-tasking is made simpler."

• mou...
• Taken for less than 1 month
• June 1, 2023

For Type 2 Diabetes "My husband suffered from severe nausea, mostly at night, but also from loss of appetite, constipation, and increased fatigue. He could not even get out of bed after one injection. He will not take a second dose."

• S-L...
• Taken for 1 to 6 months
• November 6, 2022

For Type 2 Diabetes "I tried to leave a review, but for some reason, it wasn't posted, so I will try again. My doctor took me off of Mounjaro recently. I developed large welts about 24 hours after I injected the 75 doses and 10. My doctor fears I am developing an allergic reaction, so I am going back to the rival insulin alternative. (I had more side effects with the Ozempic: exhaustion, extreme nausea, and constipation, but hopefully, over time, they go away this time.) Too bad, because I really wanted to stay on Mounjaro. It should be noted that I really like Mounjaro very much. Well-controlled sugar, once I was on my maintenance dose of 10. For some reason, I gained five pounds while on Mounjaro, I never lost weight, where I lost about 15 pounds on the other mentioned insulin alternative. It seems that other patients on other review sites have this welt issue too. The issue should be reported not only to the doctor, but per the request of the manufacturer, please report to them as well."

• kan...
• Taken for 1 to 6 months
• December 21, 2024

For Weight Loss (Obesity/Overweight) "I am a 55-year-old female, 5’7 starting weight 250, started Zepbound 6 weeks ago. 1st month, 2.5 — moved up to 5 2nd month. Probably the most annoying, almost immediate side effects were GERD, bloating, and constipation. However, this did improve quickly when I added more fiber, avoided high-fat, saucy foods, and ate less. I do agree with the others… that it definitely helps your “hunger-food brain.” I can skip a meal without even noticing. I fill up eating a quarter to half of what I would normally eat. I begin getting nauseated while I eat, which makes me stop eating, of course. Now that I've increased from 2.5 to 5, the nausea is a little worse, but intermittent and tolerable. Hoping this will improve once my body adjusts. Overall, still very thankful for this opportunity to try Zepbound. I'm trying to find some type of a meal plan to follow, with sufficient protein and fiber, as well as other foods or supplements to prevent muscle loss, hair loss, constipation, and fatigue."

• Gre...
• Taken for 1 to 6 months
• February 28, 2023

For Type 2 Diabetes "I have been taking Mounjaro for 13 weeks. I am currently on the 7.5 mg dose. This medicine has changed my life! My A1C went from 12.9 to 6.5 in 12 weeks. My weight dropped 27 lbs, and my relationship with food has improved 100%. Side effects: slight nausea the day after I increased the dosage, decreased appetite, occasional need for a laxative to combat constipation."

• Mrs...
• Taken for less than 1 month
• February 21, 2023

For Type 2 Diabetes "I was on 2.5 dosages for several weeks. I felt a little nauseous but was losing weight and very happy. I was not waking up in the middle of the night feeling hungry. When I went to refill my next prescription, all the pharmacy had was 12.5 mg, so I agreed to try. Huge mistake. I have severe nausea, felt like I have the flu, can't stay awake, and body aches are ridiculous. I projectile vomited what looks like coffee grounds, I have awful sulfuric burps, and can't even keep down sips of water. I've missed 2 days of work thus far and have to have someone come to my house tomorrow to give me an IV because I'm too scared to drive. Not worth it at all."

• MAW...
• Taken for 1 to 6 months
• November 11, 2022

For Type 2 Diabetes "I started out on the 2.5 for 2 months and lost 15 lbs, and my A1C dropped from 6.7 to 6.0. Mild side effect symptoms of abdominal pain and nausea. I started the 5 mg and had explosive diarrhea and uncontrollable vomiting, with abdominal and back pain. My blood pressure dropped to 88/55. I had to stop taking the Mounjaro. After 3 weeks, I am starting to feel normal again. Sorry it didn’t work for me. It did curb the appetite."

• WVN...
• Taken for 1 to 6 months
• December 27, 2022

For Type 2 Diabetes "I started on the 2.5 dose in October, my doctor felt that the weight loss would help with my joint pain and lower my A1C. From day 1, I was extremely nauseous, had no desire to eat, had sulfur burps, and had constipation. I spoke with my doctor, who encouraged me to ride it out. On week four, I was stepped up to the 5 mg dosage. The doctor called in Zofran for stomach issues. On week six, I called her and said I could no longer function. During this time, I was so fatigued and was having heart palpitations and was barely able to walk 20 feet without being totally exhausted. I chalked it up to being so nauseous and not eating. Then my legs started to burn like I had walked up a steep hill and felt so sore and bruised I could barely sit. That week, I had my follow-up appointment with my doctor. I told her about my symptoms, and she said that rhabdomyolysis is not a side effect of Mounjaro. I was never dehydrated, but my CK levels were still 440 two weeks off the medication! Eight weeks later, and no improvement!"

• Ms ...
• Taken for 6 months to 1 year
• March 11, 2025

For Weight Loss (Obesity/Overweight) "I started my Zepbound journey in August 2024. I have been on .50 the whole time. I've lost 40 lbs using this medicine, which is amazing! In February, out of nowhere, I started to get side effects after my shot: nausea and diarrhea. Thinking it was the flu, I nursed myself back. Shot day is Wednesdays. On Saturday, the diarrhea came back again. I truly am excited for my weight loss journey but am literally pooped out."

• Mom...
• Taken for 1 to 6 months
• November 19, 2024

For Weight Loss (Obesity/Overweight) "I have had great success with Zepbound, currently on 15 mg. Been on it for 6 months, 67 lbs down. Went from a size 20 pants to a 12. I have had some nausea and vomiting. It’s easy to use. I’m squeamish when it comes to shots, so for the first 2 months, my husband had to inject me. I got used to it and can now do it on my own. I feel so much better about myself and so much healthier."

• Not...
• Taken for less than 1 month
• October 23, 2022

For Type 2 Diabetes "I’m struggling to get below 154 lbs, and being 5’, that’s a lot of weight to carry, which induces back pain. Lost 20 lbs on Ozempic from the beginning of the year till June, have managed to gain back 5 lbs, which isn’t awful but still not at my goal weight. I just left the ER from getting a bolus of saline due to dehydration. I’m battling hypoglycemia. I took my first shot on Tuesday. Wednesday felt decent, but malaise was setting in. Thursday, I didn’t even realize I had not eaten all day and all night at work. Friday night, I tried to eat half of a sandwich and was completely nauseous. Tonight at work, after eating half a sandwich and a few green beans, I had terrible diarrhea and became so dizzy and nauseated I was forced to leave work, having someone else take over my patients. Just a word of advice: if you’re a busy person, this med may not be for you. I had side effects of fever, chills, nausea, diarrhea, fatigue, and muscle pain, and I was negative for flu, COVID, and strep. The doctor said to go back to Ozempic :( but I’ve lost 6 lbs already!"

• Hol...
• Taken for 1 to 6 months
• January 18, 2023

"For me, this is a miracle drug! I am perimenopausal and have gained belly fat and weight over the last two years. I started the Mounjaro 2.5 mg dose the first month and lost almost 3 pounds a week. I am sleeping better too, without the extra weight. The only side effects I have are small bouts of nausea here and there the first two days after my dose. Everyone I know taking the medication for weight loss who has had side effects has told me they are not eating properly or exercising. The recommendation was low sugar and no fried foods, so that is how I am eating. I have limited alcohol intake as well. I am now in my 6th week of the shots and was moved up to 5 mg on week five. I have the same side effects, a little bit of nausea here and there the first two days after the shot. I am now down 16 pounds. I only wanted to lose 20, so I am almost at my goal weight. My exercise consists of walking 2 miles around my neighborhood, yoga, and some pickleball. Eat well! Mounjaro is a miracle!"

• BMC...
• Taken for less than 1 month
• October 3, 2022

For Type 2 Diabetes "I'm only on my second week, but I've lost 7 pounds so far. It forces me to eat because if I don't, I feel sick, but when I eat, I get full super fast. So it's like it's forcing me to do good and not starve myself. I really like that. The first week I had slight nausea here and there and a couple of headaches. Also, a little indigestion. I do feel pretty tired. I've been eating a low-carb diet. I'm going to incorporate exercise at the end of this week. I can only imagine how much I have the potential to lose once I start exercising if I've lost 7 just by eating better. Overall, I am satisfied with this drug. I'm on the low dose right now."

• Mil...
• Taken for 1 to 6 months
• May 22, 2023

For Type 2 Diabetes "The meds did exactly what I expected. Lowered A1C, and I lost weight. The bad part is I was so sick on days 3-5 that it was awful. I couldn’t do my usual activities. No swimming for fear of losing control of bowels, and severe nausea. It worked great, but the side effects were extremely uncomfortable, I lost sleep from GERD. Disappointing for me."