Tirzepatide and Nausea: What Users Say (Page 5)

• Hav...
• Taken for 1 to 6 months
• November 4, 2024

For Weight Loss (Obesity/Overweight) "I am only on 5 mg so far at 6 weeks from the start. Have lost 6-7 pounds already. Minor times of queasiness, and very infrequent. Appetite way down. So far, so good... I have pre-diabetes, insulin resistance, 2 heart conditions, and obesity (after a lifetime of being skinny but now can't lose), and my insurance STILL won't cover it! Costing me $500 a month with a copay card, which is outrageous, but I have to do this for my health and longevity."

• Ano...
• Taken for 6 months to 1 year
• May 25, 2025

For Weight Loss (Obesity/Overweight) "21, F, 5’3”. 8-24 weighed 230 lbs, have had a history of overeating due to never feeling full. Unknown medical/family history due to being adopted. As of 5/25, I weigh 185 lbs (loss of 45 lbs). Initial dose for the first month was 2.5 mg, each month increased to my current dose of 7.5 mg. Most likely will keep it at my current dose, as I’m already only able to eat one meal a day. Make sure to eat proteins, nutrients, micros, and macros for the meals you can eat, drink lots of water, and work out when able. For the past 4 months I’ve had to decrease my normal workout routine from high-impact to low-impact with mild cardio (biking, swimming). While I’ve lost weight, I can also tell I’ve been losing a lot of my muscle density—my current plan is to increase my weight-bearing exercises. The only side effects I’ve experienced are very slight nausea (mainly from the sound of the injection) and slight lightheadedness if I haven’t eaten around the time of injection."

• Ran...
• Taken for 1 to 6 months
• May 25, 2025

For Weight Loss (Obesity/Overweight) "I started on the 2.5 mg starting dose. After the second day, I was experiencing severe diarrhea, burping, nausea. These went away on Day 6. Very tolerable after then. I stayed on 2.5 for several months before going to the 5 mg dose, due to the intensity of my side effects. Started Day 1 of the 5 mg dose, and on the 3rd day after it I had tiredness, orthostatic hypotension (85/55 when standing up). At the 5th day, I am still having orthostatic hypotension - I maintained a water source. Spent 2.5 days without eating. I also vomited a couple of times during the 5 mg startup. Once this batch of side effects goes away, probably will be fine. I just think that a warning about the SEVERE side effects that make me functionally worthless should be discussed. I believe my side effects are a little more extreme than most, but folks should, at least, be informed."

• get...
• Taken for 1 to 6 months
• June 4, 2024

For Weight Loss (Obesity/Overweight) "I have been on Zepbound for almost 3 months now. I've been at 2.5 the whole time as we are struggling to get any higher doses from back order. I have lost over 20 pounds already. My first shot, my side effects weren't horrible, but I also deal with nausea daily. I also had really bad pain in my upper back, neck, and shoulders like I had whiplash, but that was gone after 48 hours and was nowhere near as bad the 2nd shot. And then nothing after that. This past week though, I've been waking up starving, like I haven't eaten in days. I normally eat dinner around 5:30ish and have a small snack around 8ish, and I haven't had this before. The only other thing I've noticed and just read it could be a side effect is my hands have been super itchy, like I'm having an allergic reaction to something, which I've been thinking that's what's going on. But overall, my side effects have been very minimal, and the benefits majorly outweigh them."

• Ano...
• May 20, 2025

For Weight Loss (Obesity/Overweight) "Side effect I’d say I’ve had is a little bit of diarrhea and nausea. I’ve been on it for over a year now. I’ve lost over 140 pounds, still have a lot more to go, but it also helps control my type two diabetes, brought my A1c down from 10.8 to 4.6. Very happy with that, but I just had to have my appendix out right away because it was just about to rupture. Never had a problem with it until recently, so a coincidence or is it the medicine? Who knows, but I do know that this medicine has been a godsend for me. I do have gastroparesis along with IBS, and I tried to take Ozempic before this, and it about killed me, so an ambulance had to come and get me on the Ozempic. I do know I’m able to handle Mounjaro a lot easier on my system. If it wasn’t for Mounjaro, I don’t know where I’d be with my health right now, trying to raise three kids under the age of 14. So thank you."

• Lad...
• Taken for 1 to 6 months
• February 14, 2023

For Type 2 Diabetes "Rx for weight loss, extreme fatigue for the first 3 days after injection (I stayed in bed). I thought it was good for controlling binge eating. However, I eventually started to get so dizzy after standing up that I had to hold the counters and walls to get around for the first few minutes after standing. I also started to notice a thickness or knot in my throat after the first 2 months. I had to stop taking it because no amount of weight loss is worse than being a cancer patient or bedbound. The weight loss was extremely slow for me too. I went from being on no meds to relying daily on heartburn medicine, Miralax, Tylenol, and ginger chews for nausea. And the price was ridiculous. I would have rather bought some cosmetic surgery. I was on it 5 months: 2.5, then 0.5, finally 7.5 mg."

• Tim...
• Taken for 1 to 6 months
• July 27, 2024

For Weight Loss (Obesity/Overweight) "Severe nausea, horrid vomiting and diarrhea after 7.5 mg dose - did okay with 2.5 and 5 mg doses - there should be more warnings with the higher doses as this was severe. Higher doses should be reviewed further for safety reasons."

• wen...
• Taken for 1 to 6 months
• March 26, 2025

For Weight Loss (Obesity/Overweight) "I have only taken it for 5 weeks. I have had a lot of nausea and acid reflux. Hopefully, they go away, but when I started, I weighed 174, and 5 weeks later, I am at 165, so it's working. Side effects seem to be decreasing, so I'll keep going for now."

• Mou...
• Taken for 1 to 6 months
• January 27, 2025

For Type 2 Diabetes "I have been on Mounjaro for 7 weeks. The first 4 weeks the dosage was 2.5, and the last 3 weeks it was 5. I love Mounjaro! It takes away my food obsessions and sugar cravings. It lets me focus on life rather than on food. I did get a few minor incidents of diarrhea and an occasional minor feeling of nausea, but they were nothing serious. Mounjaro has helped me lose 15 pounds in 7 weeks and brought my blood sugar from 220 to 120. I wish it were cheaper, but it has been worth it for me."

• Jac...
• Taken for 1 to 6 months
• May 15, 2025

For Type 2 Diabetes "2.5 and 5.0 worked fine with minimal side effects. Once I started 7.5, nausea and diarrhea took over. I’ve only taken 1 dose, and don’t plan on continuing 7.5. 5.0 lowered my blood sugar just fine."

• Jud...
• Taken for 1 to 6 months
• January 22, 2025

For Type 2 Diabetes "I started Mounjaro 8 weeks ago. I’m 69 years old with T2D and weighing 234 lbs. I now weigh 214. I start on 7.5 this weekend. I have had light nausea and light constipation, and the lovely burps, but other than that, all is good. I eat better, no hunger 24/7, and I feel so much better. No more metformin. Yay!!!!"

• del...
• Taken for 1 to 6 months
• March 17, 2025

For Weight Loss (Obesity/Overweight) "I have been on Zepbound for 6 months. I'm down 48 pounds. I ride a recumbent bike 25 minutes a day. My symptoms have been varied but mostly feel like morning sickness. Usually the 2nd day after the injection. Due to insurance, I do 3 months on each 2.5, 5, and on the 3rd week of 7.5. This one hit me worst, nauseous for 3 days now."

• del...
• Taken for 1 to 6 months
• March 17, 2025

For Weight Loss (Obesity/Overweight) "I have been on Zepbound for 6 months. I'm down 48 pounds. I ride a recumbent bike 25 minutes a day. My symptoms have been varied but mostly feel like morning sickness. Usually the 2nd day after the injection. Due to insurance, I do 3 months on each 2.5, 5, and on the 3rd week of 7.5. This one hit me worst, nauseous for 3 days now."

• kel...
• Taken for 1 to 6 months
• March 12, 2025

For Weight Loss (Obesity/Overweight) "I am a 45-year-old female starting weight 243... I just took my fifth shot a few minutes ago, and I have lost a total of 26 lb since my first shot. Food noise is completely gone, and I find myself not able to eat anything until the day before my shot. I do drink a lot of water and have no cravings for sweets like I used to. I have done moderate exercise in the evening and tried to force myself to eat some source of protein throughout the day. I also take women's one-a-day gummies and I feel fantastic! The very first shot I took, the first few days I felt horrible, like I had the flu and had been hit by a bus. Since then, no side effects except for very mild nausea, which I take promethazine to help, and it does wonders. My sleeping patterns have gotten better, and my energy has increased. It states for my age and height at 5'9, I should weigh 167. I honestly feel like I would look very sickly if I got that small, so my goal is basically just to fit in my pants from last summer, lol."

• Sha...
• Taken for 1 to 6 months
• June 13, 2023

For Weight Loss (Obesity/Overweight) "I have only lost 5 pounds in 2 months. It has severely decreased my appetite and occasionally caused nausea and stomach pain. I expected to lose more and more quickly than I have. Could not tolerate the severe nausea from Ozempic, so I switched to Mounjaro."

• KJa...
• Taken for 1 to 6 months
• December 27, 2024

For Weight Loss (Obesity/Overweight) "Fantastic! I have never felt better! Lost 14 lbs in 1 1/2 months minimal side effects a little nausea here and there. Nothing crazy, truly a miracle drug for weight loss, the bonus is inflammation in general is better, and I am hoping to get off my BP meds soon!"

• Lis...
• Taken for 1 to 6 months
• March 5, 2025

For Weight Loss (Obesity/Overweight) "My experience is a lot better than I was expecting. I'm on the 2.5 mg a week. So far, the side effects are manageable. I barely get nauseous, but the constipation is real. I really like the once-a-week dosage because I don't particularly care for needles. My weight loss is slow, mainly due to a lack of working out. I'm extremely fatigued and just want to rest. The fatigue hits me early in the morning and late in the afternoon. Stay hydrated!"

• Ano...
• Taken for 1 to 6 months
• June 21, 2025

For Type 2 Diabetes "Mounjaro has been a wonderful drug intervention for me. Since January 2025, I am down over 50 lbs., my A1C is 5.7, and my cholesterol is 105. I no longer take medication for diabetes, and I am a lot healthier and feeling so much better. My only slight side effects are: nausea, dizziness, and low appetite at times. These symptoms are intermittent and not all the time."

• Lyn...
• Taken for 1 to 6 months
• December 20, 2024

For Weight Loss (Obesity/Overweight) "I am happy with the results so far. I have lost 29 lbs in 13 weeks. My goal is 75 lb weight loss. My appetite is far less, and my cravings for sugar have much improved. I have had some constipation and 1 or 2 episodes of nausea but did not vomit. You have to drink water! I started on 2.5 mg and was increased to 5 mg. I'm worried to go to a higher dose due to potential increased side effects, as I have a history of kidney issues. However, since I started the medicine, my Hga1c is normal and lipid panel perfect."

• Dea...
• Taken for 6 months to 1 year
• February 26, 2025

For Type 2 Diabetes "I started on Mounjaro last May 2024, weighing 303 lbs. By December 2024, I lost down to 190 lbs. with my A1C at 6, and my glucose is 100, down from 286 in May 2024! Mounjaro is wonderful for me! I had nausea at first, but dosage of 15, no nausea whatsoever. I’ve had to buy all new clothes, and I love it!"

• Suf...
• Taken for 1 to 6 months
• December 31, 2022

For Type 2 Diabetes "My dose at 2.5 mg was tolerable. Minimal side effects. 5 mg more side effects with nausea, sour stomach, gas. 7.5 mg has been a disaster. Heartburn. Headaches, lethargy, tiredness, no appetite, and need to force food on myself. Low blood sugar on CGM Libre2. I can't eat enough to get myself back to 90. I keep pegging 70 because I can't eat and am sick to my stomach all the time. My sleep is interrupted, and I must lie down constantly. I feel like I want to sleep all the time. Weight has dropped from 250 to 233 lbs, but if I can't get out of bed, what's the point? I will talk to my doc about going back to 2.5 mg for the A1C control, but this drug needs work."

• Pro...
• Taken for 6 months to 1 year
• February 25, 2025

For Weight Loss (Obesity/Overweight) "I’ve been on Zepbound since 8/1/24 (305 lbs, 5’6). So far, I lost 65 lbs, I’m 45 lbs away from my goal. My current dose is 10 mg. I experience side effects within 24 hours of injection administration, ranging from nausea, vomiting, belching, diarrhea, abdominal pain, fatigue, and dizziness. The side effects last about 24-36 hours. The medication definitely decreases my appetite and cravings. My doctor stopped my BP medication as I continue losing weight and my BP readings are good. My husband has noticed that I stopped snoring, lol. My plan is to reach my weight goal and stop the medication. I have changed my relationship with food. I look at food more as fuel for my body instead of indulging and overeating. I also introduced portion control and exercise, mostly walking and swimming. My insurance covers the medication."

• 122...
• Taken for 1 to 6 months
• February 24, 2025

For Weight Loss (Obesity/Overweight) "Started Mounjaro in November 2024 and did not have any side effects, only when I was increased to 5 mg, and the nausea was bad, and I was sick a few times when I ate anything with a high/medium fat content. But I managed to get anti-sickness tablets from my GP, and I have lost 3.5 stone since starting this. I was 17 stone, and I can now go up 3 flights of stairs and not stop for breath, as before, I had to stop on the first flight. I have started to drink more water, as before I hated it. I was a fizzy drink person. I have also added more supplements to my daily intake, as before I never took supplements. The only issue I have now is sulfur burps and still nausea with the occasional trapped wind."

• bel...
• Taken for 6 months to 1 year
• May 11, 2023

For Type 2 Diabetes "A little bit of back story for the full benefit of transparency… I am a type 2 diabetic on an insulin pump, taking 2 Synjardy every morning in addition to my once-a-week injection. I was completely insulin resistant. Since starting the Mounjaro in September 2022 on the lowest dose, I have worked my way up to 10 mg. Now, a supply shortage kept me from getting my one-month supply twice in the last 7 months. When starting again, it did give me nausea and headaches, my doctor prescribed Zofran, and I took ibuprofen. When I started, I weighed 330 pounds and am currently down to 289 as of yesterday. The biggest benefit to me is that my pump has had to work less because the Mounjaro keeps my blood sugar steady at about 90. I am hoping as I continue to lose weight, I need less and less insulin, that is the doctor's goal. So while yes, there are side effects initially, they did not hang around for me, and if you can push through them, they do subside. I am 48 years old and have been diabetic since I was 23."

• Sar...
• Taken for 6 months to 1 year
• February 14, 2025

For Weight Loss (Obesity/Overweight) "When I first started taking Mounjaro, I would get very nauseated, even throw up sometimes. Then my body got used to it, and I actually lost around 25 lbs. I asked my Dr if we could up the dosage because I stopped losing weight. I went up to Mounjaro 5.0. After my first shot, I was fine, just nauseated. After my second shot of 5.0, I broke out in hives all over my body. I continued taking my shot, and on the third week, the hives got worse. I was miserable, itching with large red spots all over. The Dr then lowered my dose back to 1.5, and finally, the hives went away, but I am not losing any more weight."