Tirzepatide and Stomach Pain: What Users Say

• Pen...
• Taken for less than 1 month
• September 23, 2022

Tirzepatide for Type 2 Diabetes "I started taking Mounjaro on 9/1. This resulted in the very worst month of my life. WEEK ONE - Super Nauseous, indigestion, stomach pain for 3-4 days of the first week. My appetite went from a 10 to a 2 (which was good). WEEK TWO - I had diarrhea for 3-4 days, along with sulfur belches, nausea, stomach pain. I ended up having to take sick days and go get an IV bag to recover from the dehydration. WEEK THREE - World-class nausea and vomiting. 3 days of vomiting so hard that I ruptured my esophagus. The entire month, if I was not having diarrhea, I was VERY constipated. I lost 9 lbs in one month, but I don't know if it was because I could barely eat due to the sickness. PASS!!"

• Bec...
• Taken for 1 to 6 months
• August 11, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "I have lost over 35 lbs in 5 months. I started at the 2.5 and have worked up to the 10. Zepbound is incredibly effective at assisting with the weight loss. Greasy fatty foods definitely upset my stomach now. The first day post-shot, I am super tired and have a very mildly upset stomach, after that, it’s fine. I am freezing all the time, so for sure take a jacket wherever you go! I am not starving and do not have cravings at all. Staying hydrated seems to help with curbing the initial side effects. Initially, I found myself hardly eating just because I wasn’t hungry. I had to make a concerted effort to make myself sit down and eat. Protein and veggies made me feel a ton better and didn’t result in any digestive discomfort. It really was a trial and error. Alcohol is not your friend, even 1 or 2 drinks makes me feel awful. I ended up naturally having a cleaner diet and drinking a lot more water just to minimize the digestive side effects."

• Anonymous
• Taken for 1 to 6 months
• February 16, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "My side effects are constipation, headaches, vision is foggy, insomnia, stomach pain, nervousness, dehydration, frequent urination, bumps on my labia. It is very easy to use. I have lost 14 pounds in two months. It does cut your hunger."

• Eli...
• Taken for 1 to 6 months
• January 3, 2023

Tirzepatide for Type 2 Diabetes "I have been on Mounjaro for 9 weeks. I had to jump from 5 to 10 mg last week due to shortage issues. I am having several problems with severe bloating, constipation, headache, and stomach pain. I have severe gas that keeps me up most of the night and can be a sign of impending intermittent diarrhea at times. I am always full and started pushing myself to eat as I can go all day with nothing. Now I have small welts and itching at injection sites. Total weight loss: “0.” My blood sugar is higher, especially in the morning. This drug is horrible, and I won’t put my body through it anymore. I can lose weight easier and healthier than this since it ruined my Thanksgiving, Christmas, and New Year’s Eve. I was so excited to try it and had hope. I’m thankful for all those who are benefiting from it. Good luck to all. It just wasn’t for me."

• Ano...
• Taken for 1 to 6 months
• May 1, 2025

Tirzepatide for Obstructive Sleep Apnea/Hypopnea Syndrome "I started feeling less hungry right away after the first dose. Cravings for junk food have been reduced. I feel full faster as well. I have felt a little stomach pain if I eat too late in the day (too close to bedtime) or if I eat a high-fat meal (pizza or burgers). I have lost 14 lbs so far (started at 230 lbs). Moving to 5 mg next week."

• Ano...
• Taken for 1 to 6 months
• March 29, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "I started Zepbound two months ago. When I started, I weighed 248, and this morning I weighed myself at 226. However, my stomach pain side effects are seriously starting to disrupt my life. I will not be continuing medication. It is not even worth it."

• Sus...
• Taken for less than 1 month
• March 5, 2023

Tirzepatide for Type 2 Diabetes "I have been on Ozempic 2 mg since it came out. When I couldn't get it due to shortage, I was prescribed Mounjaro 5 mg. Five days after eating my one meal a day, I intermittent fast, and I started vomiting. I spent the whole night throwing up every half hour. I figured it was a side effect and hoped I would improve. I had stomach and back pain, weakness, and was unable to eat. I was in bed until I had to get up and sit due to pain, sleeping off and on. I could only drink water. I got worse and finally, five days later, had my husband drive me to the ER. I know I should have gone sooner. I didn't take a second shot. I had a CAT scan and was told I had a bowel obstruction, and I would be admitted and there for a few days. If they couldn't resolve it through a tube down my nose, I would have surgery. Luckily, it was resolved by the nasal tube, but it was awful. My medical care pharmacist told me to try Mounjaro 2.5 mg. I was worried but did it. I didn't get nausea, but I had all these other side effects. I quit taking it."

• Ton...
• Taken for 6 months to 1 year
• February 26, 2023

Tirzepatide for Type 2 Diabetes "I started on a 2.5 mg dose for 30 days and had nothing positive or negative. The doctor increased it to 12.5 mg, and my appetite went to zero, stomach pain, throw-up, diarrhea, general nausea, and ill feeling, but did lose 15 lbs in 3 weeks, and my blood labs were near perfect. I was ready to quit until I saw this. The second month, my appetite came back slightly, and I learned to eat less and cleaner so it wouldn’t make me throw up, lost another 15 lbs, and it excited me to get back in the gym daily. Since the drug slows your digestion, it slows the bowel too, which gave me insane constipation and made sure I eat enough fiber daily. At first, the side effects are hell, but stick with it as they only lasted a month, then your body adjusts and you learn how to eat and work with it. The end results are worth it. It's been 9 months, and I have lost 35 lbs, labs are excellent, and for the first time, I have seen glucose under 100 in 30 years."

• Din...
• Taken for less than 1 month
• December 10, 2024

Tirzepatide for Type 2 Diabetes "In the two doses, my blood sugar has been lower, my appetite has diminished, and I had no side effects. At the end of the second week (Saturday), I woke up during the night with stomach pain, diarrhea, and belching. After 6 hours, I finally vomited up undigested food that had been in my stomach for over 12 hours. It looked like I had just eaten. I avoided all food until Sunday morning, eating 1/2 of a plain English muffin. I had Lipton chicken soup, a piece of Bavarian pretzel, and a few french fries (picking from my wife’s meal). Monday, I finally felt hungry and had a Whopper Jr. (not a good choice I know), and Tuesday I woke up with food sitting in my stomach and one diarrhea BM. NOTE: I have not taken dose #3, nor do I plan to. This is slowing my digestion down too much. I have never had digestive issues, and I’m not going to start now."

• peb...
• Taken for 1 to 6 months
• February 26, 2023

Tirzepatide for Type 2 Diabetes "Started this 7 weeks ago and have one more injection. The first set was at 2.5 mg from the gynecologist. Within the first week, I lost 5 pounds and by week 5 I saw a huge difference! I went from a 22 waist to a true size 18 and still shrinking. I was having trouble catching my breath before I started this. I had a couple of pains in my stomach, similar to gas pains like clockwork, the day after the injection. But it was bearable. Sometimes I get a smelly burp issue. But now I have lost 20 pounds at week 7 and feel amazing. Please do yourself a favor and take fiber daily, this medicine will get you constipated."

• Sha...
• Taken for 1 to 6 months
• June 13, 2023

Tirzepatide for Weight Loss (Obesity/Overweight) "I have only lost 5 pounds in 2 months. It has severely decreased my appetite and occasionally caused nausea and stomach pain. I expected to lose more and more quickly than I have. Could not tolerate the severe nausea from Ozempic, so I switched to Mounjaro."

• Anonymous
• Taken for less than 1 month
• January 12, 2025

Tirzepatide for Type 2 Diabetes "Mounjaro has helped me bring down my A1C. I'm only on a relatively low dose, but I am experiencing troubling side effects: stomach pain, indigestion, nausea, fatigue. I have the side effects mostly a day or two after the injection. I noticed a slight weight loss at first, but I think I gained the weight back somehow."

• Ano...
• Taken for 1 to 2 years
• April 26, 2025

Tirzepatide for Type 2 Diabetes "This is my third review. I’m 5’0”, started weight at 157. On Mounjaro one year. I’m a diabetic kidney transplant recipient, also have high blood pressure. Was on Trulicity for approximately 5 years but started having stomach pains, so was switched to Mounjaro. My A1C is now 5.8, my weight fluctuates from 109 to 111. I lost 47 lbs, 29% kids. I started on 5 mg because I had already been on Trulicity. My glucose levels started improving with the 10 mg, and weight loss started to come off more, which I started in August 2024. I’m very appreciative of Mounjaro, and for 2 months my dose is down to 7.5 mg, and glucose levels and weight are maintained with this dose. In the beginning, I had minimal side effects and currently don’t have any side effects at all. Mounjaro affects everyone differently. Mounjaro is very easy to use. I’m sure there are negative reviews, but please try it for yourself."

• AC1...
• Taken for less than 1 month
• September 23, 2024

Tirzepatide for Type 2 Diabetes "I have been a type 2 diabetic for about 15 years. Worked hard to bring my A1c down with carb reduction and exercise. I track my 24-hour average glucose twice a day when I take my medications and track that number in a spreadsheet. I use a CGM. With the very first injection, I was able to detect a noticeable drop in my glucose numbers within 5 hours of the first injection. My 24-hour average glucose reading has dropped from 140 mg/dL to 110 mg/dL partway through the 2nd injection. I have not seen my glucose readings this good in years. My current tracking spreadsheet goes back to May of 2024. The doctor suggested this drug to see if weight loss induction might occur and help me become strictly diet controlled. During the first 2 weeks, I have been able to eliminate extended-release metformin from my medications. Some mild stomach pain and belching were initially present, but those have passed."

• loj...
• Taken for 1 to 6 months
• January 18, 2025

Tirzepatide for Type 2 Diabetes "I have started with the lowest dose and have moved up to 12.5 mg/0.5 and have had a little pain in the stomach as a side effect. I started out with an A1c of 9.9 and within 2 months of Mounjaro and changing my diet, my A1c was down to 7.0 and my weight went from 221 lbs to 197, and yes I am happy with that. I have not had any other issues or side effects other than not eating so much junk food or regular food like I used to. My craving for sweets has almost disappeared. I can't wait to see my final results, my goal is to get to 185 lbs and A1c of 5.5. Good luck to you all."

• Bev...
• Taken for 1 to 6 months
• January 2, 2023

Tirzepatide for Type 2 Diabetes "I have been on Mounjaro to help lose weight for 8 weeks, 4 at 2.5 mg & 4 at 5 mg and have not lost weight, no appetite suppression at all. I can't tell I'm taking anything at all other than burping, acid reflux, and stomach pain through the night after eating."

• RBj...
• Taken for 1 to 6 months
• August 29, 2023

Tirzepatide for Weight Loss (Obesity/Overweight) "I started using Mounjaro in March 2023, with a 2.5 mg dose, for weight loss. I shifted to 5 mg after 2 weeks; I stayed with each dose for around 2-3 months. I lost 10 kg by August (6 mo.). I had a freeze in weight loss for 5 weeks, then I lost 1.8 kg in 2 weeks when I took 10 mg. In terms of side effects, I experienced them during the first weeks of every upgrade in dose; like nausea and sometimes vomiting, headache, stomach pain, constipation and diarrhea, laziness, body ache, mood change; the worst was with 10 mg. As I have urticaria, I experienced an allergy at the needle site after week 10, which resolved in 3 days every time. This week I have pelvic, vaginal, and lower abdominal pain similar to period pain, although I have been menopausal for 4 years! I am happy about the results with minimal side effects."

• Rwi...
• Taken for 1 to 6 months
• March 19, 2023

Tirzepatide for Type 2 Diabetes "My A1C and glucose levels are great. I am not on insulin. Side effects are rotten. Nausea, GERD, constipation/diarrhea, headache, stomach pain, decreased appetite every shot lessens over the week. Had this with Ozempic and Trulicity too, but not as severe. I have seen no weight loss benefit despite a decent diet and moderate exercise 3-5 times per week. Other side effects I’m not sure are related: feeling of lump in throat, slight face rash, occasional blurred vision, tingling in hands."

• Ama...
• Taken for less than 1 month
• October 28, 2022

For Weight Loss (Obesity/Overweight) "I've been on the Mounjaro shot for 2 weeks now, I'll take my 3rd shot tomorrow. My doctor prescribed this for weight loss since I have tried many other meds that haven't worked. 1st shot: Took it in my stomach (you feel it, but it does not hurt) first thing in the morning. By afternoon, I had ZERO appetite and felt nauseous. I had some stomach pain as well. Nothing I couldn't handle, but I was glad I waited until the weekend to take it. The next 2 days, I did not feel well. VERY nauseous, couldn't even think about eating ANYTHING, so I forced myself to eat some toast/saltine crackers just so I could eat something. I did call in to work on Monday because I just had stomach pains really bad. I never experienced vomiting, luckily. It took until about day 5 to get some sort of appetite back, it was very limited. 2nd shot: I took it in my thigh this time. Much better! It did cause a little pain in my leg the day of the shot and the next day. Still had no appetite. But the nausea was better this time."

• Ano...
• Taken for 6 months to 1 year
• March 29, 2025

Tirzepatide for Type 2 Diabetes "Been on Mounjaro since April 24. Started on 5 mg because I was on Trulicity, which gave me severe stomach pains. Was on 10 mg before weight loss started. I’m 5’0”, lost 46 lbs, and A1C is 5.8. I now take 7.5 mg to avoid more weight loss. Hoping this will be my maintenance dose. Had very mild side effects initially, now just a little constipated, but coffee cures that. Feel better about myself. Very happy. Wish this came out years ago. Been diabetic since 42. Was unable to control both for a long time. Now I’m 68, and Mounjaro has made a believer out of me. I tell everyone about it that will listen. It affects everyone differently, so don’t always listen to the naysayers. Try for yourself."

• Aje...
• Taken for 1 to 6 months
• August 11, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "The BEST EFFECT is that I was free from thinking about food for the first time in my long life. The downsides that I am still working with are being constipated, getting chills, and stomach pain. I have to take Miralax every day, and some days I do not feel well, and yet, it is well worth it to not be obsessed with food anymore. I am on 5 mg. I was concerned about self-injection but found that to be a non-issue. I do get a rash around the area, and my skin itches."

• hel...
• Taken for 6 months to 1 year
• November 20, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "I started taking this in March 2024. I've had some weight loss (about 30 pounds), but not as much as I anticipated. I occasionally experience nausea and stomach pain, but it's usually after a very fatty meal (avoiding those types of foods minimizes this symptom for me). When I reached the 10 ml dose, I began having an itchy, raised red area surrounding the injection site that dissipates by the end of the week. I had one shot that didn't dispense the needle until I held it up to inspect it. I am happy I started this medication because I did lose weight (and hopefully will continue to) and was able to stop taking metformin! The worst thing about taking this medication is trying to get the prescription filled. I have had more issues trying to get my refills for Zepbound than any prescriptions for opioid pain medication (which I have taken in the past post-surgery due to an allergy to acetaminophen). At first, it was supply issues. Now it's preauths and difficulty staying at a certain dose."

• sir...
• Taken for less than 1 month
• January 5, 2023

Tirzepatide for Type 2 Diabetes "I experienced some nausea, had severe stomach pains at times, vomiting, indigestion, and terrible sulfur burps. The appetite suppression is amazing, as I felt like a normal person not feeling hungry all the time. After my 2nd shot and even worse side effects, I told my doctor I noticed my eyes had jaundice, so he told me to stop taking it. It did lower my blood sugar levels, and I'm so disappointed my body couldn't tolerate this medication, as it would have helped me lose weight."

• Aut...
• Taken for 6 months to 1 year
• March 3, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "I am 45 years old and female. I have been on Zepbound for eight months. I started at 275 lbs and am now at 235 lbs. The day after I first took it, my stomach was so full it hurt, just from my normal portion sizes. Over time, the dosage has increased to 7.5. I am a little more tired than usual, but that's a small price to pay. The vast majority of side effects occur when I overeat. There's no way to know which of these I will have then: pain in my stomach, egg burps, loud flatulence, and/or diarrhea. I have been sick a lot more than usual, along with swollen lymph nodes and hoarseness, but there's no way to know if they're related or not."

• Hap...
• Taken for 1 to 6 months
• April 10, 2023

Tirzepatide for Type 2 Diabetes "Mounjaro has been wonderful in reducing my blood sugar. However, the side effects feel like sometimes they are going to be the death of me. I experience nausea, constipation, and stomach pain. But if this is how it has to be to control my sugar, I can handle it. The only real trouble I am having is being able to get it through my pharmacy as it is often out of stock due to people using it for weight loss. I think diabetics should be given the first chance to receive this medication."