Tirzepatide and Upset Stomach: What Users Say

• Fai...
• Taken for less than 1 month
• February 3, 2024

For Weight Loss (Obesity/Overweight) "Just took my third shot. I am 60 years old, female, 5'7'', and weigh 295. I lost 5 pounds by the 2nd shot. Maybe that's not terribly impressive, but I don't want to lose quickly. Here's what I think is an absolute miracle with Zepbound: NO HEAD HUNGER! For the first time (probably in my life), I don't think about food. I don't crave junk food, I get full very quickly and can only eat small amounts. I had a gastric sleeve 6 years ago (at that time was 350 pounds) and it did a rotten job. It stretched out very quickly and never got rid of the obsessive food thoughts. This Zepbound is something else. I wonder if this is how thin people eat? lol I have had a bit of stomach upset once in a while, but for the most part, I am excited to start my higher dose next week. Even if I never lose what I want to, I am so grateful for this drug because I am eating all healthy foods. Nothing less than a miracle if you ask me!"

• 60y...
• March 22, 2023

For Weight Loss (Obesity/Overweight) "I have been on Mounjaro since Jan. 2023. I have lost 20 pounds. I need to lose 20 more. Side effects: burping, stomach upset, constipation, flu-like body aches, mildly depressed feeling, and fatigue. Not every day, not every symptom every day, and not all day. It comes and goes. I will continue but do wonder how it’s gonna go long term. I’m just sick of being fat."

• Hap...
• Taken for 1 to 6 months
• September 25, 2022

"I started Mounjaro on July 1, 2022. I just turned 74 and was at the end of my rope with my obesity. I immediately developed a sour stomach/nausea and heartburn. But the wonderful side effect of having no appetite and not obsessing about food EVERY WAKING MOMENT was worth it. I still enjoy food, just eat less than half what I used to and no snacking. I lost 30 pounds in 2 months. I take one more injection (totally painless and easy to give) of 7.5 mg and then move up to 10 mg. My worst problem is terrible constipation. I’m working on it by using Colace, etc. but haven’t solved it completely. Since I’m on Medicare, I am paying THOUSANDS of dollars for this drug. So my savings account is decreasing but so is my weight. If I can afford it, I hope to stay on Mounjaro for one year. I still go to Weight Watchers and live by their eating plan which is very healthy."

• Kat...
• Taken for 1 to 6 months
• January 20, 2023

For Type 2 Diabetes "I started Mounjaro to help control my blood sugar. I had tried Ozempic and Trulicity and could not tolerate the nausea, sulfur burps, and stomach issues. Mounjaro has been life-changing. No bad side effects. I’m not hungry, I don’t have cravings, I’m losing weight steadily, and sweet desserts taste too sweet. Many people say they’ve had bad side effects with it. I say try it as it may work for you. Just like I couldn’t use other meds that other people love. For me, it has been life-altering."

• foo...
• Taken for 1 to 6 months
• July 22, 2024

For Weight Loss (Obesity/Overweight) "I've been on this medication for 6 weeks and have never felt better about my body or my day. I didn't realize I could have a day where I wasn't thinking about food from the minute I got up until I fell asleep at night. I feel free to think about other things and to not be distracted by trying to have willpower to not eat. It's a huge relief. Is this what thin people feel like? People who have never struggled with being overweight? I have always thought my weight was based on my genetics, and maybe it is-but it's also my brain that literally is addicted to food. It feels like I've been released from an addiction. I haven't noticed any side effects. I tried Ozempic before this and was very constipated and had stomach issues. I don't feel that way at all on Zepbound, my stomach is fine. I'm on 2.5, it's very easy to administer, and I feel like it really works. I hope I'm able to take it for a long time, I'm sort of afraid to go back to the brain I had before taking it."

• MTO...
• Taken for 6 months to 1 year
• May 14, 2023

For Weight Loss (Obesity/Overweight) "This medication has been a huge blessing in my life. Started at the lowest dose in August of 2022. Increased each month to the highest dose and have stayed there for 3 months now. It's May of 2023, and I have lost 80 pounds! I was pre-diabetic, depressed, and hopeless. I've had a bit of stomach upset, diarrhea, heartburn, gas... nothing terrible. But I feel so much better. My joints don't hurt hardly at all, I have more confidence to go places and talk to people and do stuff outside, and I even sleep better. I was looking into bariatric surgery before I found Mounjaro. I'm so glad I didn't have to do that."

• jos...
• Taken for 6 months to 1 year
• May 11, 2025

For Obstructive Sleep Apnea/Hypopnea Syndrome "I started Zepbound in September 2024 to treat severe sleep apnea as diagnosed through sleep studies. I have been on the drug for 8 months and lost 35 pounds, reaching a normal weight range, and my sleep apnea is about 90-95% improved. I had mild stomach discomfort in the first month or two, but nothing very concerning. I also had some itching at the injection sites periodically over the first few months. I currently have no side effects whatsoever. I gradually ramped up from the 2.5 mg/0.5 mg dose to 5.0 mg/ml to 7.5 mg/ml, which is my final dose. This medicine was an absolute game changer. Can't emphasize how much this has improved my quality of life. I had struggled with sleep apnea and using a CPAP for about 10 years, with little success before trying this. It is important to be monitored by a doctor throughout treatment, including bloodwork, including lipase to monitor for pancreatitis."

• Dor...
• Taken for 6 months to 1 year
• March 31, 2023

For Weight Loss (Obesity/Overweight) "Mounjaro has been a lifesaver for me. I am fortunate enough to not have many side effects. In the beginning, I would get gas and stomach cramping, but I have learned what foods seem to cause that and now avoid them. It is so nice to be able to get through the day with my brain not constantly telling me to eat."

• Den...
• Taken for 6 months to 1 year
• February 10, 2025

For Type 2 Diabetes "For the most part, I’ve had no problems with Mounjaro. There is one traction, however, that presents itself. If I’m eating a meal and consume more food than I realize, I get pain right below my rib cage. It feels like a real upset stomach. From now on, I’m going to be very careful about the amount of food I consume!"

• ric...
• Taken for less than 1 month
• May 26, 2024

For Weight Loss (Obesity/Overweight) "So, I took one dose, unfortunately, my doctor screwed up and started me at 15mg. I've been in the ED for 36 hours and have had the worst 3 weeks of my life. This is not a review but a caution, check your script thoroughly, make sure you're taking the right dose. I need to purge this dose from my system and then start a 2.5mg dose."

• roo...
• Taken for 1 to 6 months
• August 29, 2022

"Have been on Mounjaro since July 15th for obesity. I am only down 8 pounds since then. However, I have no cravings, I do not binge eat, I do not overeat. You will learn quickly to listen to your body. If you overeat, you will regret it. Your stomach hurts and you get bad heartburn. I get really nauseated the first two days after my injections. I do not feel hungry for most of the day. I listen to my body when it is hungry and I eat. If I get nauseous, and I know I haven't eaten in a while, I go eat. I have heard about this app Methreesixty, and it shows your inches lost. This is a really helpful tool if you get discouraged, because you might not see it on the scale, but you will see it in inches with this app. I started on the 2.5 and then went up to 5, but I don't think it is doing much for me as I am really hungry the last two days before my next shot. My doctor has me skipping the 7.5 and going straight to the 10 mg. It really is helping me in other ways, I did not realize I needed the help."

• Bec...
• Taken for 1 to 6 months
• August 11, 2024

For Weight Loss (Obesity/Overweight) "I have lost over 35 lbs in 5 months. I started at the 2.5 and have worked up to the 10. Zepbound is incredibly effective at assisting with the weight loss. Greasy fatty foods definitely upset my stomach now. The first day post-shot, I am super tired and have a very mildly upset stomach, after that, it’s fine. I am freezing all the time, so for sure take a jacket wherever you go! I am not starving and do not have cravings at all. Staying hydrated seems to help with curbing the initial side effects. Initially, I found myself hardly eating just because I wasn’t hungry. I had to make a concerted effort to make myself sit down and eat. Protein and veggies made me feel a ton better and didn’t result in any digestive discomfort. It really was a trial and error. Alcohol is not your friend, even 1 or 2 drinks makes me feel awful. I ended up naturally having a cleaner diet and drinking a lot more water just to minimize the digestive side effects."

• Dee...
• Taken for 1 to 6 months
• September 5, 2022

For Type 2 Diabetes "As of today, 9/5/2022, I have been on Mounjaro for 5 weeks. I have experienced upset stomach, nausea, weakness, and tiredness. I am on 2.5 mg. Hoping symptoms start to disappear. I am a Type 2 diabetic, and the pills didn't seem to help. I am in my 60s, so was wondering if that mattered. I'm not sure. I would like to continue the Mounjaro, but if side effects persist, I may have to try other options."

• The...
• Taken for 1 to 2 years
• December 24, 2024

For Type 2 Diabetes "I tried Wegovy and Ozempic with no results. My endocrinologist switched me to Mounjaro, and I have had fantastic success. In 18 months, I have lost 100 pounds. My A1c is normal. I’ve been off insulin for 5 months, and I feel healthier and more energetic. The only side effects I have experienced are usually the day after I’ve taken my shot, I have an upset stomach, and I am not hungry at all. Best of all, I can shop in normal sizes now instead of plus."

• 65Y...
• Taken for less than 1 month
• January 3, 2025

For Type 2 Diabetes "I have just started the smallest dosage of Mounjaro 2.5mg/5ml and just took my 3rd injection (so I am 17 days in). I have noticed a marked decrease in appetite and have dropped 6.5 lbs (which is pretty good since I started on December 17th, right before the holiday meals and treats). The only negatives have been minor stomach distress (but I had that issue prior to starting Mounjaro), and on day 16, I have had indigestion and hiccups, which I am still trying to calm down. The hiccups stopped, but the indigestion is lingering. The injections are easy and not painful. My daily finger prick to monitor my blood sugar is more noticeable, so don’t let the injections scare you away. So far, it seems to be working very well."

• Jim...
• Taken for 1 to 2 years
• March 5, 2025

For Type 2 Diabetes "I am a 67-year-old Type 2 diabetic who has been on Mounjaro for about one year, and I am pleased to report that I have dropped from 350 pounds to about 310 lbs without any other diet or lifestyle changes. My A1C dropped from 9.5 to 5.8. Mounjaro is the only medication I take for my Type 2 diabetes. I am up to 7.5 mg/0.5 liters after starting on 2.5 and then moving to 5.0. The only real side effect has been stomach cramps for an hour or so per week. It has really helped me in so many ways. A fan, thank you, Eli Lilly."

• PRe...
• Taken for less than 1 month
• February 12, 2025

For Weight Loss (Obesity/Overweight) "On week number three, I started with stomach cramps and diarrhea. The night before, I had a huge helping of Boom Chicka Pop kettle corn. While the packaging states it only uses cane sugar, I came to the conclusion that this product (perhaps in the amount eaten) suddenly didn’t agree with me while taking Zepbound. I’ve lost 5 lbs in 2 1/2 weeks. Diarrhea and cramping subsided after 36 hours."

• Anonymous
• Taken for 1 to 6 months
• February 9, 2025

For Type 2 Diabetes "Once I started taking this product, I was able to get off Metformin and insulin. My sugar was never high during the time on Mounjaro, and I lost 30 pounds and felt great! There are side effects with a few stomach issues, but they are short-lived."

• Chi...
• Taken for 6 months to 1 year
• May 27, 2023

For Weight Loss (Obesity/Overweight) "2.5 mg/wk for 8 months, went from 234 lb to 170. Had stomach cramps at first that worsened with a higher dose. The lower dose worked well enough. Have been off of it for 2 months with little change to established weight and eating habits, so far, no weight gain."

• Suf...
• Taken for 1 to 6 months
• December 31, 2022

For Type 2 Diabetes "My dose at 2.5 mg was tolerable. Minimal side effects. 5 mg more side effects with nausea, sour stomach, gas. 7.5 mg has been a disaster. Heartburn. Headaches, lethargy, tiredness, no appetite, and need to force food on myself. Low blood sugar on CGM Libre2. I can't eat enough to get myself back to 90. I keep pegging 70 because I can't eat and am sick to my stomach all the time. My sleep is interrupted, and I must lie down constantly. I feel like I want to sleep all the time. Weight has dropped from 250 to 233 lbs, but if I can't get out of bed, what's the point? I will talk to my doc about going back to 2.5 mg for the A1C control, but this drug needs work."

• Ann...
• Taken for less than 1 month
• May 31, 2023

For Type 2 Diabetes "I am starting week three. As others have stated, it changed my relationship with food. I no longer focus or have cravings for salty and sweet, carbs, beginning day 3. No urge for late-night snacking. I can't eat carbs like potatoes or bread, or I get a stomach ache. A big improvement – I was so fatigued before, I could barely make it through the day, and now I have the energy to go into the pool and do some gentle exercising. I just don't get hungry. I was able to drop pop completely for water. I don't know what is in this medicine, but it really has made a profound impact on my life. I've lost 6 pounds so far, but it feels like I've lost a couple of inches in my clothes. Highly recommend."

• Der...
• Taken for 1 to 2 years
• August 1, 2024

For Type 2 Diabetes "I started taking Mounjaro in November of 2022. I weighed in at 382 pounds at 6 feet even. Today is 8/1/2024, and I weigh in at 220 pounds. My A1C went from 7.6 to 5.4 in 8 months. I feel like a million dollars, and I had to go shopping for a whole new wardrobe, seeing as size 54 and 56 pants no longer fit; I am in 34 or 36 in waist, down from 5x shirts to 2x shirts. Jackets went from 60 R to 46 R. This medication has changed my life. I get an upset stomach in the mornings, but it usually dissipates in 2-3 hours. If this is the worst side effect, I can live with that versus not being able to walk from my front door to my parked car without being in pain or exhausted."

• Car...
• Taken for 1 to 6 months
• October 13, 2024

For Weight Loss (Obesity/Overweight) "I lost 9 pounds the first month, and apart from a slightly upset stomach and heartburn for a few days, I was fine. I moved up to 5 ml on week 5, and after a few days, I started to get cramps and then vomiting. I have had bright yellow, watery liquid diarrhea. I thought I needed an ambulance, the pain was so bad. I will not be taking 5 ml after this."

• jef...
• Taken for 1 to 6 months
• February 21, 2025

For Type 2 Diabetes "The first week I didn't see much. The second week, blood sugar was a little better. I didn't take it the second or third due to acute leg and feet swelling, which has never been a problem. Took many tests for artery blockage, every test my doctor could come up with. The swelling left as quick as it appeared. I got started back on Mounjaro, it started working with remarkable performance, with blood sugar at around 6.7 from the high 11s, but having a very upset stomach. Following week, very sick at stomach, headaches, I felt a lot worse. I may have caught a flu that has been going around. I normally do not have the flu. I don't know if it was the Mounjaro or flu, the symptoms were the same and did not have a fever. I am due to take the Mounjaro injection tomorrow. Haven't decided what to do yet."

• sve...
• Taken for 1 to 6 months
• March 1, 2023

For Weight Loss (Obesity/Overweight) "I have been taking Mounjaro for 4 months and have lost 20 lbs. I am currently taking 7.5 mg, and since I have been on this dosage, I have experienced nausea, stomach cramps, heartburn, and fatigue. I plan on lowering my dosage to maintain."