Tirzepatide and Upset Stomach: What Users Say (Page 3)

• pam...
• Taken for 1 to 2 years
• October 14, 2024

Tirzepatide for Type 2 Diabetes "I have been on Mounjaro since October 2023. My A1C was at a 9 at my last appointment. Sept 18, my A1C was at a 5. As an added benefit, I have lost 60 lb. and have been able to review my journey with food, make smarter choices because I don't have the crazy urges to just EAT anything. I did have issues with my stomach the first 5 months on the medication, but I was able to adjust my eating to ease the discomfort. I avoided spicier foods, and very sweet food seemed to cause discomfort, and taking/drinking Activia probiotic dailies really helped. I also noticed I really had to pay attention to my water intake because I didn't feel thirsty and I would forget to drink water, so I set my water out at my desk to make sure I didn't get dehydrated. I did at the beginning, but as I am figuring that out, it's less of a problem. And I am able to move more as the weight comes off. I do experience more headaches now, but I believe that is because I am not always drinking the water I should be drinking."

• She...
• Taken for 1 to 6 months
• May 23, 2023

Tirzepatide for Type 2 Diabetes "I started with 2.5 mg, then increased the dosage to 5.0 mg, and then 7.5 mg without any success. Skipped 10.0 mg and then moved up to 12.5 mg, and that is when the success came! I lost 25 lbs in 3 months, and it brought down A1c from 8.0 to 7.0. I had minor side effects such as diarrhea and some stomach upset. Overall, a very positive experience."

• Hop...
• Taken for 1 to 6 months
• May 16, 2023

Tirzepatide for Type 2 Diabetes "Not long after I began taking Mounjaro, my A1C dropped from 8.1 to 6.7. Finally, something that's helping. I’ve also lost some weight, although it's been a slow process. Now I’m beginning to have stomach issues along with diarrhea. Just makes me feel sluggish. I’m on the 10.0 dose, and the doctor said I may need to drop down to a lower dose. It's very easy to use. Giving myself a shot is not a problem."

• Lar...
• Taken for 1 to 6 months
• May 1, 2023

Tirzepatide "I had high A1C levels and was borderline diabetic. During the first few weeks on 2.5 mg and 5.0 mg, I had minor stomach cramps for an hour or two per day. Those have gone away. I am now on 7.5 mg and will likely go to 10 mg. I am also doing KETO and working out. In early February, I weighed 252 lbs. This morning, I weigh 213 lbs. I feel much, much better and feel like I will be able to get to my goal weight. I hope to get off my medications for high blood pressure and A1C as I get near my goal weight."

• Kat...
• Taken for 1 to 6 months
• September 2, 2024

Tirzepatide for Type 2 Diabetes "I began my journey on April 12th, 2024. I'm currently on my second dose of 7.5. A bit more stomach issues, diarrhea, and extreme fatigue. No desire to eat whatsoever. Since I've started, I have lost a total of 50 lbs. as of 9/2/24. Yes, I'm Type 2 diabetic, but I wanted to give this medication a try to see if it would be of any help for me to lose weight. It has far exceeded my expectations! It's been a bit rough, but I'm seeing great results. I'll continue on this journey with hopes of meeting my own personal weight loss goals."

• Zen...
• Taken for 1 to 2 years
• June 8, 2024

Tirzepatide for Type 2 Diabetes "7.5 dose will cause a distinct slowing of all digestion to the point of causing violent stomach upset (especially if the person overeats). Blood glucose levels dropped significantly at both the 5.0 and 7.5 dosages. I’ve taken 4 - 10 and they have all put me to bed for 4 days. Easy to use following injection instructions."

• Jos...
• Taken for 1 to 6 months
• April 1, 2024

Tirzepatide for Type 2 Diabetes "I was skeptical to start the treatment. However, I started and I am happy with it. The first week I lost 4 pounds. After 3 months, I have lost 26 pounds. My glucose is in check and I feel great. No side effects for me, besides some stomach discomfort."

• NMG...
• Taken for 1 to 6 months
• May 21, 2023

Tirzepatide for Type 2 Diabetes "The nausea and bloated stomach I experienced during the first few days are awful. I have increased my dosage to 10 mg now, and 7.5 mg was not as severe. However, I never feel good at all. Each day is better than the previous one, but I never reach a state of feeling 'good' or 'great.' I have also developed sores in my mouth, and I'm not sure if it is related. My tongue feels as though it has been sandpapered. Additionally, constipation is simply terrible. On the positive side, I do appreciate not having constant thoughts about food. Unfortunately, I haven't lost much weight, which was one of the side effects I was hoping for. Taking the injections is easy for me. However, I really wish someone could assure me that if I continue taking this medication long-term, these unpleasant side effects will eventually go away. To alleviate the nausea, I have tried ginger hard sugar-free candies. I genuinely want this treatment to work for me, but three months of feeling unwell is taking its toll. If I had been losing weight, I would at least see some benefit. On a positive note, my A1c has decreased to 6.5. However, I hate feeling sick all the time."

• me5...
• Taken for 1 to 6 months
• April 2, 2025

Tirzepatide for Type 2 Diabetes "Had to stop taking after 7 weeks of use. Total loss of appetite, very weak. When I try to eat, cannot do it due to gagging. The smell of foods upsets my stomach. Getting scary now, haven't used Mounjaro for 2 1/2 weeks and no improvement. No energy at all, hard to function."

• Ano...
• Taken for 1 to 6 months
• April 28, 2025

Tirzepatide for Type 2 Diabetes "2 weeks in and at 2.5 mg, WOW! My blood sugar is usually 150-200 even on several other meds. I stopped all meds other than Metformin/Glipizide combo, and once on Mounjaro, now it's pretty consistent 70-80 and only 150 after meals! Very little side effects. Once in a while, I feel a little upset stomach, but not bad at all. I'll take it!"

• tri...
• Taken for 6 months to 1 year
• September 2, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "After taking this medication since February of 2025 and currently being at a 10 mg dose, I can say I got a ton of side effects and still do. I get injection site reactions I'm told to ignore because it was swelling but now is just itchy. I get constipation and the urge to go poop even when I don't have to go. Stomach aches are killer and literally leave me lying in bed unable to move. But symptoms are worst during the weekend as I take my meds on a Friday. Leading me to be unable to make plans on Saturdays or Friday evenings. I have so far lost 35 lbs over these 7 months with minimal exercise and some healthy dieting. My goal weight is 160 and I'm currently 255 down from 290 starting weight. I'm down 10% body fat. The longer I stay on my current dose, the less I feel the intensity of the symptoms, but I also still have appetite issues. As in I'll eat, and an hour later I'll be hungry again because I was unable to fill myself earlier. Or I wake up in the middle of the night to eat."

• Bel...
• Taken for 1 to 6 months
• September 20, 2024

For Weight Loss (Obesity/Overweight) "It's certainly helping the weight loss. Not quickly, but I've gone from 90 to 82 kgs from June till September. I'd already lost 4 kgs this year with healthy eating, walking, and the 'Simply' program. I'm happy with the weight loss, but at 5’4”, I still need to lose another 7 to 10 kgs. Side effects: constipation. I take a million fibergels and lactulose and still go twice a week if I'm lucky, this gives me a tummy ache too. I also felt sick and generally unwell when I first started and on some, not all, step-ups. The last step-up made me so ill I had to miss half of a family wedding. Right now, I'm slightly depressed, which I do have a history of, but it could be circumstantial. If it carries on when I'm home next week, then I might think it's the Mounjaro."

• L M...
• Taken for less than 1 month
• May 17, 2024

For Weight Loss (Obesity/Overweight) "Took my first dose on 5/10/2024, felt fine but did feel loss of appetite. By 5/14, that all changed. Woke up with terrible cramps, diarrhea, chills, and headache. So bad I had to call in to work. Now I don't know if this is what caused it but I was not watching my fat intake, busy with 2 birthdays and Mother's Day. Talked to the provider and they gave me a prescription for nausea. I felt good enough on 5/16 evening to work with one of my horses but today back at work with a gurgling stomach and belching. Can hardly eat because I'm afraid to. My dose was 2.5, provider wants me to wait a week or so and lower my dosage. I am truly afraid to take it, due to the effects I am having now. I had high hopes it would help me lose 30 lbs but not so sure anymore. Effective but not much fun to feel this terrible. Maybe just need my body to get used to it. Don't know, I may have triggered this by poor eating after the injection."

• Rus...
• Taken for 1 to 6 months
• September 6, 2024

For Weight Loss (Obesity/Overweight) "1st week @ 2.5 was okay. Nothing significant. 2nd week @ 5.5 significant change. Nausea, constipation, burning stomach put me in bed for 4 days with no appetite at all. Wife makes me protein smoothies, which seems to be the only thing I can eat/drink. Week 3 supposed to be @ 7.5. I, personally, cannot do it. I take a little more than 5.5, but I have no appetite at all! Food doesn't even look appealing, nor does it taste the same. I have looked at all comments on different platforms and do not see anyone stating this. I'm going to stay on it and regulate it myself. I've gone from 270 to 229. Looking to lose more. I've lost muscle mass but have 0 energy to exercise. Any suggestions?"

• Tho...
• Taken for 6 months to 1 year
• October 2, 2024

For Weight Loss (Obesity/Overweight) "It works absolutely amazing. I got off it for a month and then. Now I'm back on and working gangbusters. My friends say that it's bad for you. But I haven't found anything bad yet. Other than maybe a stomachache. Once in a while."

• Mar...
• Taken for less than 1 month
• September 23, 2022

"I started taking the 2.5 on 9/1 after I had begun IF on August 1. Overall, I have now lost 12 pounds over 7 weeks. My appetite is significantly reduced; my biggest concern is I’m not getting enough calories due to lack of appetite and also a restricted eating window. Since being on the medication, I have experienced constipation, diarrhea, especially on day two and three after the shot each week, general fatigue, and a generally uneasy stomach, and sometimes stomach cramps. Usually, these wear off by day five and are worse on day three and four. It is not clear to me if my weight loss is due to the fasting or the medication or both, but it does seem to be steady at 1 to 2 pounds per week as I am tracking it. I only hope that it continues to lose at this rate and does not plateau! I am ready to move up to 5 mg next week, and I’m a little nervous to experience stronger side effects. So far, I am thrilled to actually be losing weight! SW: 187. GW: 130.5’2” age 54."

• Mar...
• Taken for less than 1 month
• September 23, 2022

"I started taking the 2.5 on 9/1 after I had begun IF on August 1. Overall, I have now lost 12 pounds over 7 weeks. My appetite is significantly reduced; my biggest concern is I’m not getting enough calories due to lack of appetite and also a restricted eating window. Since being on the medication, I have experienced constipation, diarrhea, especially on day two and three after the shot each week, general fatigue, and a generally uneasy stomach, and sometimes stomach cramps. Usually, these wear off by day five and are worse on day three and four. It is not clear to me if my weight loss is due to the fasting or the medication or both, but it does seem to be steady at 1 to 2 pounds per week as I am tracking it. I only hope that it continues to lose at this rate and does not plateau! I am ready to move up to 5 mg next week, and I’m a little nervous to experience stronger side effects. So far, I am thrilled to actually be losing weight! SW: 187. GW: 130.5’2” age 54."

• Ano...
• Taken for 1 to 6 months
• June 20, 2025

Tirzepatide for Type 2 Diabetes "Fatigue like I’ve never had before. My blood sugars are not too low, so that’s not causing it. I’ve been on for 5 weeks. Very, very loose stools and stomach cramping. I’m going to change medication in three weeks when I finish my supply. I’ve lost 10 lbs, but not worth all this fatigue. By 3:00 each day, I’m done."

• 2 o...
• Taken for 1 to 6 months
• August 13, 2024

For Weight Loss (Obesity/Overweight) "Desperate to regain health as too fat to walk without breathing heavily. Effort. Visited clinic; simple decision to pick tirzepatide. Learned from clinic drug with greatest success at their clinic. Stomach, stomach, stomach! was the main issue for the first month. Gradually decreased until only upset stomach after injection-upset for the first 24 hours. Almost immediate, after the 1st injection, no hunger thoughts at all (miracle!) until the 4th week, when I felt I wanted more to eat for breakfast. When I return for the 3-month checkup in October, will request bumping up to 5 ml if hunger pangs continue. Have lost 4 lbs since 7/11/2024. Slow progress, but am happy with how hunger and food desire quieted, very successfully. Looking forward to where this takes me."

• mas...
• Taken for 1 to 6 months
• August 23, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "Lost weight in the first few weeks. Some issues with belching and diarrhea for the first several weeks, which declined over time. But then, after approximately 6 weeks, no weight loss was noted. Still eating less, so hoping that the decreased intake of calories would reduce weight. Then had COVID, so had to miss a week, stayed on original dosage, no weight loss. Then, when dosage increased after the 3rd month, symptoms returned: upset stomach and diarrhea. During the same period, slightly elevated temperature, fatigue, headaches. Lost from 240 to 218 in 4 months, so cost was $100 per pound."

• Loi...
• Taken for 1 to 6 months
• April 24, 2023

Tirzepatide for Type 2 Diabetes "I have been taking Mounjaro since December 2022, beginning with the lowest dose of 2.5 mg, and increasing to 5 mg, briefly going to 7.5 mg, and currently back at 5 mg. Anyway, I had already made huge changes to my diet and reduced my insulin, but couldn’t quite get my glucose levels where I wanted them. For the most part, it’s been great. I’m now off all other diabetic medication, including insulin, and am able to keep my blood sugars within range. I have some issues with constipation and definitely need to use a little help to keep things moving. Occasionally, I have a headache for several hours after injecting. I have gotten a little bit of a sour stomach after some meals, but not bad. I have lost a little weight, not a lot, but I’m not in a hurry to lose. I think I’d probably lose more at a higher dose. My last HbA1c was 5.3, and I would like to get it lower. I had more stomach trouble at the higher dose. I'm glad that I’m on it. An injection once a week is better than daily."

• Jan...
• Taken for 1 to 6 months
• September 12, 2024

Tirzepatide for Type 2 Diabetes "I am very happy with the weight loss (35 lbs). I generally tolerate it well. Upon each increase, side effects returned but were manageable. The benefits certainly outweighed the few side effects and brought my A1C down to 5.2. Side effects: rapid heartbeat, nausea, headache, acid reflux, belching, and stomach upset."

• Ano...
• July 7, 2025

For Weight Loss (Obesity/Overweight) "It does well in curbing my appetite. I have lost 11 lbs in less than two months’ time. I have had some constipation, but I am controlling that by taking Colace. I have also experienced some nausea and stomach discomfort."

• mmk...
• Taken for 6 months to 1 year
• November 18, 2024

For Weight Loss (Obesity/Overweight) "Works well for me, little or no side effects. I lost about 15# in about 8 months. My cholesterol dropped some points. I don't have a gallbladder, and I do have a few side effects from that. I still need to lose 15-20# to get to a healthy BMI. I started at 167 and now 150. Helps turn the food noise off and boredom snacking. I crave fruits and veggies and not junk food. I can't eat a lot of fatty foods since I don't have a gallbladder. I try to get a lot of protein, and if I eat smaller portions, I don't get heartburn and stomach problems. I try to spend 30 min working my muscles and some cardio daily. Nothing fancy, I think a good vitamin would help. I am happy with my results. You still have to work for it. It's not a magic shot! If you eat crap and too much crap, you feel worse than crap. I mean super sick for a few days like when I ate a few Krispy Kreme donuts, and it was not worth it."

• Joo...
• Taken for 1 to 6 months
• May 5, 2025

Tirzepatide for Type 2 Diabetes "When I first took it in January 2025, I did have diarrhea and stomach issues. That has all abated and I have no more issues. It has really helped me with eating smaller portions than I was doing before. I've lost 22 lbs. since January. I had an A1C done recently at 5.5, which is outstanding. For me, this has been worth taking. Next week, I will be taking the 12.5 mg dose."