Tirzepatide and Upset Stomach: What Users Say (Page 3)

• Bel...
• Taken for 1 to 6 months
• September 20, 2024

For Weight Loss (Obesity/Overweight) "It's certainly helping the weight loss. Not quickly, but I've gone from 90 to 82 kgs from June till September. I'd already lost 4 kgs this year with healthy eating, walking, and the 'Simply' program. I'm happy with the weight loss, but at 5’4”, I still need to lose another 7 to 10 kgs. Side effects: constipation. I take a million fibergels and lactulose and still go twice a week if I'm lucky, this gives me a tummy ache too. I also felt sick and generally unwell when I first started and on some, not all, step-ups. The last step-up made me so ill I had to miss half of a family wedding. Right now, I'm slightly depressed, which I do have a history of, but it could be circumstantial. If it carries on when I'm home next week, then I might think it's the Mounjaro."

• L M...
• Taken for less than 1 month
• May 17, 2024

For Weight Loss (Obesity/Overweight) "Took my first dose on 5/10/2024, felt fine but did feel loss of appetite. By 5/14, that all changed. Woke up with terrible cramps, diarrhea, chills, and headache. So bad I had to call in to work. Now I don't know if this is what caused it but I was not watching my fat intake, busy with 2 birthdays and Mother's Day. Talked to the provider and they gave me a prescription for nausea. I felt good enough on 5/16 evening to work with one of my horses but today back at work with a gurgling stomach and belching. Can hardly eat because I'm afraid to. My dose was 2.5, provider wants me to wait a week or so and lower my dosage. I am truly afraid to take it, due to the effects I am having now. I had high hopes it would help me lose 30 lbs but not so sure anymore. Effective but not much fun to feel this terrible. Maybe just need my body to get used to it. Don't know, I may have triggered this by poor eating after the injection."

• Rus...
• Taken for 1 to 6 months
• September 6, 2024

For Weight Loss (Obesity/Overweight) "1st week @ 2.5 was okay. Nothing significant. 2nd week @ 5.5 significant change. Nausea, constipation, burning stomach put me in bed for 4 days with no appetite at all. Wife makes me protein smoothies, which seems to be the only thing I can eat/drink. Week 3 supposed to be @ 7.5. I, personally, cannot do it. I take a little more than 5.5, but I have no appetite at all! Food doesn't even look appealing, nor does it taste the same. I have looked at all comments on different platforms and do not see anyone stating this. I'm going to stay on it and regulate it myself. I've gone from 270 to 229. Looking to lose more. I've lost muscle mass but have 0 energy to exercise. Any suggestions?"

• Tho...
• Taken for 6 months to 1 year
• October 2, 2024

For Weight Loss (Obesity/Overweight) "It works absolutely amazing. I got off it for a month and then. Now I'm back on and working gangbusters. My friends say that it's bad for you. But I haven't found anything bad yet. Other than maybe a stomachache. Once in a while."

• Ano...
• Taken for 1 to 6 months
• April 9, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "I have been taking medication for 16 weeks and lost 35 lbs. I have had some problems with stomach issues, but they come and go. I have had some constipation and diarrhea with the increase and the start of taking the medication. Sometimes it can be bad, but for the most part, I feel like the med is working."

• Mar...
• Taken for less than 1 month
• September 23, 2022

"I started taking the 2.5 on 9/1 after I had begun IF on August 1. Overall, I have now lost 12 pounds over 7 weeks. My appetite is significantly reduced; my biggest concern is I’m not getting enough calories due to lack of appetite and also a restricted eating window. Since being on the medication, I have experienced constipation, diarrhea, especially on day two and three after the shot each week, general fatigue, and a generally uneasy stomach, and sometimes stomach cramps. Usually, these wear off by day five and are worse on day three and four. It is not clear to me if my weight loss is due to the fasting or the medication or both, but it does seem to be steady at 1 to 2 pounds per week as I am tracking it. I only hope that it continues to lose at this rate and does not plateau! I am ready to move up to 5 mg next week, and I’m a little nervous to experience stronger side effects. So far, I am thrilled to actually be losing weight! SW: 187. GW: 130.5’2” age 54."

• Mar...
• Taken for less than 1 month
• September 23, 2022

"I started taking the 2.5 on 9/1 after I had begun IF on August 1. Overall, I have now lost 12 pounds over 7 weeks. My appetite is significantly reduced; my biggest concern is I’m not getting enough calories due to lack of appetite and also a restricted eating window. Since being on the medication, I have experienced constipation, diarrhea, especially on day two and three after the shot each week, general fatigue, and a generally uneasy stomach, and sometimes stomach cramps. Usually, these wear off by day five and are worse on day three and four. It is not clear to me if my weight loss is due to the fasting or the medication or both, but it does seem to be steady at 1 to 2 pounds per week as I am tracking it. I only hope that it continues to lose at this rate and does not plateau! I am ready to move up to 5 mg next week, and I’m a little nervous to experience stronger side effects. So far, I am thrilled to actually be losing weight! SW: 187. GW: 130.5’2” age 54."

• 2 o...
• Taken for 1 to 6 months
• August 13, 2024

For Weight Loss (Obesity/Overweight) "Desperate to regain health as too fat to walk without breathing heavily. Effort. Visited clinic; simple decision to pick tirzepatide. Learned from clinic drug with greatest success at their clinic. Stomach, stomach, stomach! was the main issue for the first month. Gradually decreased until only upset stomach after injection-upset for the first 24 hours. Almost immediate, after the 1st injection, no hunger thoughts at all (miracle!) until the 4th week, when I felt I wanted more to eat for breakfast. When I return for the 3-month checkup in October, will request bumping up to 5 ml if hunger pangs continue. Have lost 4 lbs since 7/11/2024. Slow progress, but am happy with how hunger and food desire quieted, very successfully. Looking forward to where this takes me."

• mas...
• Taken for 1 to 6 months
• August 23, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "Lost weight in the first few weeks. Some issues with belching and diarrhea for the first several weeks, which declined over time. But then, after approximately 6 weeks, no weight loss was noted. Still eating less, so hoping that the decreased intake of calories would reduce weight. Then had COVID, so had to miss a week, stayed on original dosage, no weight loss. Then, when dosage increased after the 3rd month, symptoms returned: upset stomach and diarrhea. During the same period, slightly elevated temperature, fatigue, headaches. Lost from 240 to 218 in 4 months, so cost was $100 per pound."

• Loi...
• Taken for 1 to 6 months
• April 24, 2023

Tirzepatide for Type 2 Diabetes "I have been taking Mounjaro since December 2022, beginning with the lowest dose of 2.5 mg, and increasing to 5 mg, briefly going to 7.5 mg, and currently back at 5 mg. Anyway, I had already made huge changes to my diet and reduced my insulin, but couldn’t quite get my glucose levels where I wanted them. For the most part, it’s been great. I’m now off all other diabetic medication, including insulin, and am able to keep my blood sugars within range. I have some issues with constipation and definitely need to use a little help to keep things moving. Occasionally, I have a headache for several hours after injecting. I have gotten a little bit of a sour stomach after some meals, but not bad. I have lost a little weight, not a lot, but I’m not in a hurry to lose. I think I’d probably lose more at a higher dose. My last HbA1c was 5.3, and I would like to get it lower. I had more stomach trouble at the higher dose. I'm glad that I’m on it. An injection once a week is better than daily."

• Jan...
• Taken for 1 to 6 months
• September 12, 2024

Tirzepatide for Type 2 Diabetes "I am very happy with the weight loss (35 lbs). I generally tolerate it well. Upon each increase, side effects returned but were manageable. The benefits certainly outweighed the few side effects and brought my A1C down to 5.2. Side effects: rapid heartbeat, nausea, headache, acid reflux, belching, and stomach upset."

• mmk...
• Taken for 6 months to 1 year
• November 18, 2024

For Weight Loss (Obesity/Overweight) "Works well for me, little or no side effects. I lost about 15# in about 8 months. My cholesterol dropped some points. I don't have a gallbladder, and I do have a few side effects from that. I still need to lose 15-20# to get to a healthy BMI. I started at 167 and now 150. Helps turn the food noise off and boredom snacking. I crave fruits and veggies and not junk food. I can't eat a lot of fatty foods since I don't have a gallbladder. I try to get a lot of protein, and if I eat smaller portions, I don't get heartburn and stomach problems. I try to spend 30 min working my muscles and some cardio daily. Nothing fancy, I think a good vitamin would help. I am happy with my results. You still have to work for it. It's not a magic shot! If you eat crap and too much crap, you feel worse than crap. I mean super sick for a few days like when I ate a few Krispy Kreme donuts, and it was not worth it."

• mot...
• April 13, 2023

Tirzepatide for Type 2 Diabetes "Started out at the lowest dose due to stomach issues with new meds. Things went well for 4 weeks, then bumped up to 5 mg. No major side effects, no sickness, etc. About 4 weeks in, started having hunger issues. Went to 5 mg twice a week and did great for 3 months. Weight loss was 1 to 2 lbs per week. Just now starting 15 mg once a week."

• Ano...
• Taken for 1 to 2 years
• March 28, 2025

Tirzepatide for Type 2 Diabetes "I had to control eating. I get an upset stomach and constipation, and can eat too much. I take 5 grams of insulin once a week. However, I lost 5 pounds so far."

• Ran...
• Taken for 1 to 6 months
• August 27, 2024

Tirzepatide for Type 2 Diabetes "Usually occurs 2 to 3 days after the injection, get very gassy. Belching and stomach aches. Been on it for 6 weeks now and lost about 3 lbs. I do think my blood sugar has improved while taking this."

• Bec...
• Taken for 1 to 6 months
• July 22, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "Worked brilliantly, have to eat 'clean' otherwise I get a stomach ache"

• Jun...
• Taken for 1 to 6 months
• December 28, 2024

Tirzepatide for Type 2 Diabetes "I stayed sick in my stomach and throwing up, and I have a problem with my stomach acid reflux, and it kept my stomach upset. Every time I would eat a meal, I would get sick."

• jer...
• Taken for 1 to 6 months
• June 14, 2024

Tirzepatide for Type 2 Diabetes "It helps keep blood sugar down. I have lost 13 lbs or so. My worst problem after the shot 4 days: bad stomach gas belching. It creates a bowel movement problem for me."

• me1...
• Taken for 1 to 6 months
• December 20, 2024

Tirzepatide for Type 2 Diabetes "Helped with A1c & lower sugar. Stomach upset, nausea, belching a lot. More helpful with the diabetes. Side effects not good. But helped with diabetes."

• Shr...
• Taken for less than 1 month
• March 15, 2023

Tirzepatide for Weight Loss (Obesity/Overweight) "Weight loss has been steady and slow. First 24 hours, unsettled stomach and most of the time, no interest in eating for the rest of the week."

• joh...
• Taken for 1 to 6 months
• March 29, 2023

Tirzepatide for Type 2 Diabetes "Giving me severe diarrhea with a sour stomach, gas, and burping after taking injections. Not helping low sugars after 8 weeks and no weight loss. Has not decreased appetite at all."

• Baz...
• Taken for 1 to 6 months
• September 26, 2024

Tirzepatide for Type 2 Diabetes "Diarrhea and stomach upset for 2 days after injection. Last for about 6 weeks, after that, came back after 8 weeks. No warning diarrhea, which is inconvenient."

• cis...
• Taken for 1 to 6 months
• August 12, 2024

Tirzepatide for Type 2 Diabetes "After 9 weeks, no weight loss, but A1C is now 6. Lots of stomach issues!"

• Ric...
• Taken for 1 to 6 months
• May 19, 2023

Tirzepatide for Weight Loss (Obesity/Overweight) "Currently on the third dose, I have lost 15 pounds. I have no appetite, but I am experiencing a sour stomach and diarrhea."

• Mar...
• Taken for less than 1 month
• January 18, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "Stomach hurts with mild nausea. No appetite. On 2.5 mg subq. Hoping I will feel better after more time. Just started yesterday."