Tirzepatide and Tiredness: What Users Say

• Sen...
• Taken for 1 to 6 months
• February 27, 2023

For Weight Loss (Obesity/Overweight) "I am an African American female, 58 years old, 5’8” tall, weighed an unbelievable 270 lbs on 12/30/22. I asked my doctor if I could take this medication, and now here we are, 8 weeks later. I currently weigh 244.6 lbs. I lost 16 lbs in the first 3 weeks. I was extremely shocked and a little worried. My health is a constant concern, I suffer from chronic allergies, and frequently took steroid shots to manage the problem, which brought on weight gain. I am feeling better about myself. I am honestly trying to make this a life change. As for the first day after each shot, I am exceptionally tired, and I experienced redness at the injection site once. I'm not sure why, but so far so good. No headaches, no vomiting, just slight constipation. I am attempting to make this a life change with better food selections and exercise regimens to keep me on track."

• Fem...
• Taken for less than 1 month
• September 1, 2022

"Lost 5 lbs in one week. First 2 days after injection, I am spacey & can't think clearly; just feel a little odd mentally. Also, EXTREMELY tired/run-down feeling. Otherwise, mild headache & constipation the rest of the week. Overall, would say it's worth it as I no longer binge or even eat much. Never in my life did I think I could stop obsessing over food and dieting. Maybe one day this drug could be reverse-engineered for anorexia or bulimia. Definitely took care of that awful desire and craving to eat all day and night."

• Mom...
• Taken for less than 1 month
• March 11, 2023

For Weight Loss (Obesity/Overweight) "I have been struggling on the weight loss rollercoaster for a while. Up 30 lbs, down 15 lbs, and so on and so forth. I'm taking a compound Mounjaro with B12. I have only been on 2.5 mg for less than a week and in that time, I feel GREAT! I've lost 3 lbs and don't crave midnight snacks, or snacks at all for that matter. The first couple of days I was unsure if I wanted to continue. I was exhausted, I couldn't think clearly, and had no energy. My body ached all over - no one had mentioned this, and just flat out was about to think that this was not for me. Day 3 and I felt great both physically and mentally. I hear people go up on dosage even after losing weight the first month, and unless I stall in my loss, I will continue on 2.5 mg. Remember, too much weight loss in a short amount of time isn't healthy. Slow and steady will help you keep the weight off when you stop taking this medicine (obviously with a change in your eating habits). Why put more drugs into my body than what is needed?"

• Mom...
• Taken for less than 1 month
• March 11, 2023

For Weight Loss (Obesity/Overweight) "I have been struggling on the weight loss rollercoaster for a while. Up 30 lbs, down 15 lbs, and so on and so forth. I'm taking a compound Mounjaro with B12. I have only been on 2.5 mg for less than a week and in that time, I feel GREAT! I've lost 3 lbs and don't crave midnight snacks, or snacks at all for that matter. The first couple of days I was unsure if I wanted to continue. I was exhausted, I couldn't think clearly, and had no energy. My body ached all over - no one had mentioned this, and just flat out was about to think that this was not for me. Day 3 and I felt great both physically and mentally. I hear people go up on dosage even after losing weight the first month, and unless I stall in my loss, I will continue on 2.5 mg. Remember, too much weight loss in a short amount of time isn't healthy. Slow and steady will help you keep the weight off when you stop taking this medicine (obviously with a change in your eating habits). Why put more drugs into my body than what is needed?"

• My ...
• Taken for 1 to 6 months
• February 13, 2023

For Type 2 Diabetes "Started 10/26. Weight 245, female. 2.5 1x, 5, 1x, 10mg, last 2 months. Current 214. Zero exercise unfortunately. I have read so many reviews and I am baffled at all these bad side effects, since mine were so minor (except constipation and tiredness day after injection). Learned early, no sugar, breads, or pasta/potato. I take no other meds, do a strict low carb and fast. I have a protein shake at noon, a meat and a LC veg for dinner (small portion always), then freeze a protein shake for two hours and it makes ice creamish. Delish! That’s all I eat daily. Hunger is now fully controllable! My A1C started at 6.7, BUT I was on low carb for 6 weeks prior to blood work so likely much higher in general. Last week's blood test showed A1C at 5.0. My ALT SGPT (liver) was high last test, and normal range this time. What did go up were my top 4 CBC numbers. Overall, this is a game changer. So grateful. I truly believe eating right is the key when on this med. Hope this helps someone."

• SMP...
• Taken for 6 months to 1 year
• February 5, 2025

For Weight Loss (Obesity/Overweight) "I’ve lost 43 lbs in the last 9 months. I experienced some mild hair loss (but started this in menopause, so that contributed to hair loss as well), increased heart rate, although mine was low to start, some burping, and tiredness. The worst side effect for me is the diarrhea. I have it starting about 24-48 hrs after injection. It lasts on and off for about 3 days. Overall, these side effects have been mild and manageable. The weight loss has been life-changing!!"

• Ano...
• Taken for less than 1 month
• August 30, 2025

For Type 2 Diabetes "I take Mounjaro 2.5 once a week. Have taken 4 times. Nausea and lost appetite getting worse. Lost 10 lb. My glucose was 140 and up, and a few times 180 before Mounjaro. The last 3 days I had 83, 89, and 90. I test first thing in the morning before eating. I feel bloated, nauseated, tired, no energy, and no appetite."

• Ano...
• Taken for less than 1 month
• August 30, 2025

For Type 2 Diabetes "I take Mounjaro 2.5 once a week. Have taken 4 times. Nausea and lost appetite getting worse. Lost 10 lb. My glucose was 140 and up, and a few times 180 before Mounjaro. The last 3 days I had 83, 89, and 90. I test first thing in the morning before eating. I feel bloated, nauseated, tired, no energy, and no appetite."

• Car...
• Taken for 1 to 6 months
• October 21, 2022

For Type 2 Diabetes "I am 6ft and started at 213lbs. Blood sugars were a little elevated and I could see they were headed in the wrong direction. I also have severe sleep apnea. I started at 7.5 and just finished my fourth week. This drug is amazing. I’m down 24 lbs in 28 days. Lost 4 lbs last week. Current weight is 189lb. Goal is 175lb. I check my blood sugar 2 or 3 times a day. My highest reading was 101 about an hour after eating. Most readings in the low 80s which is perfect. I couldn’t have asked for more from this drug. Side effects are constipation (drink lots of water) and tired the day after the shot. I’ve been slightly overweight my entire life. I hope to lose this weight and then see if the sleep apnea goes away. Life changing."

• Bat...
• Taken for less than 1 month
• August 29, 2025

For Type 2 Diabetes "I started Mounjaro on Sunday, the 24th of August 2025. It immediately brought my blood sugar down and did have a decreased appetite. 1st day, I was very, very tired and slept a lot. After that, I was tired but okay. The only problem I had was no bathroom for 6 days. Problem being resolved. It is a great medicine, but the cost is almost too high for me. I am 75 and on social security. Bonus: lost over 5 pounds."

• Anonymous
• Taken for 1 to 6 months
• March 29, 2023

For Weight Loss (Obesity/Overweight) "I'm on month three. My doctor thinks I might be too sensitive to it and may have to stop soon. Extreme nausea, occasional vomiting, and sulfur burps followed by diarrhea, weakness, and lethargy. The pros: in three months, I've gone from 262 lbs to 239 lbs."

• Ran...
• Taken for 1 to 6 months
• May 25, 2025

For Weight Loss (Obesity/Overweight) "I started on the 2.5 mg starting dose. After the second day, I was experiencing severe diarrhea, burping, nausea. These went away on Day 6. Very tolerable after then. I stayed on 2.5 for several months before going to the 5 mg dose, due to the intensity of my side effects. Started Day 1 of the 5 mg dose, and on the 3rd day after it I had tiredness, orthostatic hypotension (85/55 when standing up). At the 5th day, I am still having orthostatic hypotension - I maintained a water source. Spent 2.5 days without eating. I also vomited a couple of times during the 5 mg startup. Once this batch of side effects goes away, probably will be fine. I just think that a warning about the SEVERE side effects that make me functionally worthless should be discussed. I believe my side effects are a little more extreme than most, but folks should, at least, be informed."

• Sar...
• Taken for less than 1 month
• September 13, 2022

For Type 2 Diabetes "Constant nausea no matter what I eat. Muscle weakness and tired all the time. I’m feeling mentally down. Tomorrow will be my 3rd shot, and I’m seriously hoping these side effects go away so I can get type II diabetes under control. Probably losing some weight because I dread the nausea after eating so am not eating as much. The verdict is still out for me on this medicine."

• Kim...
• Taken for 1 to 6 months
• June 19, 2023

For Weight Loss (Obesity/Overweight) "I am starting my 3rd month on Mounjaro. I have been overweight/obese most of my adult life. I have lost some weight but not as much as I expected. I feel terrible - I suffer with exhaustion, constipation, indigestion, depression, and nausea. I just do not feel good. It has sucked the joy out of my life. I used to exercise much more when I was not taking Mounjaro. I don't want to do anything. I am wondering if it is worth it?"

• LML...
• Taken for 1 to 6 months
• January 21, 2025

For Weight Loss (Obesity/Overweight) "5’1”, 180 lbs, 63 yrs. old female, BMI 34%. History of cardiac disease and hypothyroidism. I’ve been taking the 2.5 mg dose for six months with virtually no worrisome side effects. I do experience unusual tiredness within 8–12 hours of each dose. Who doesn’t enjoy a good nap, yeah? I'm currently experiencing moderate hair loss, which is a concern. I consulted my PCP, who agreed we should rule out other potential causes such as a recent change in thyroid medication, nutrient deficiencies, or age before deciding the next step in my weight-loss journey with Zepbound. My current weight is 142 lbs. That’s 38 lbs (an approximate 1.5 lbs/week or 6 lbs/month) weight loss over six months. It’s just the boost I needed. According to the CDC, losing 1–2 lbs per week is a healthy weight loss goal. It’s reassuring to know that my weight loss is at a healthy pace at the lowest effective dose of Tirzepatide. Thank you, Eli Lilly, for the Zepbound coupon card ($25 co-pay)."

• SIM...
• Taken for less than 1 month
• June 12, 2023

For Weight Loss (Obesity/Overweight) "I have been on Mounjaro for 3 weeks (2.5 mg injection), and it has helped me tremendously. I started out at 333 lbs. Now I weigh 319 lbs. I feel full for longer. Just feel tired a lot, but I take vitamins and something for energy, so that has helped. I take stool softeners so I won't get constipated. I had a slight headache for a couple of days when I first started, but not bad. I don't crave snacks, caffeine, or sweets like I used to on a daily basis. If I even overeat a little, I feel miserable, so I have to watch that. Managing your portions is very important. I'm doing better with that now. It doesn't take much for me to eat and drink to be satisfied. My BP has been good. My doctor said I may be able to get off BP meds soon. I am so grateful for this new med. Can't wait to move up to the next dosage."

• The...
• Taken for less than 1 month
• May 25, 2023

For Weight Loss (Obesity/Overweight) "I took my first injection on April 20, and the second injection on April 27. On April 20, I had shortness of breath, which increased dramatically. Ended up in the hospital on April 22 for the day. Shortness of breath continued. Took another injection on April 27. That night, I looked at my calendar and realized that I had done activities without shortness of breath the week of April 17, 18, and 19 with no problem. I took an injection at about 9 am on the 20th and was short of breath by 10:30 am that day. The endocrinologist says it takes 4-6 weeks to exit the body. My symptoms did NOT improve until the 4th week, and then they have improved only slightly. I can't walk 40 ft without sitting down to catch my breath. Before the 4th week, it was 20 ft. Praying that at the end of 6 weeks, my breathing will return to normal. Also, many instances of BP under 90/57. When this happens, I am exhausted, have to drink 8-12 oz water, and lay down for at least an hour with feet elevated to get BP up to acceptable levels. No weight loss."

• Ano...
• Taken for 1 to 6 months
• July 17, 2025

For Weight Loss (Obesity/Overweight) "I have lost 20 lbs in 3 1/2 months on Zepbound taking 2.5, 5.0, and 7.5 mg so far as per plan and dosage increases. I plan to use 5 mg for maintenance dosage now that I am almost at my goal weight. It is very simple to use. I had some GERD, nausea, and adjustments to make with certain foods, but that subsided after the first few months. You definitely cannot overeat as you will not feel well. The exhaustion and body aches are what bother me the most. For the first 3 days after an injection, I am so tired that it impacts what I can get done in a day, including energy to exercise and do my job during the day. I am sleeping okay with it, but the fatigue is almost debilitating."

• Rom...
• Taken for 1 to 6 months
• December 3, 2024

For Weight Loss (Obesity/Overweight) "56 yr female, 257 lbs (20 years post gastric bypass). Started Zepbound 11/3 2.5 mg. Lost 12 lbs in the first 4 weeks. Minimal side effects until week 3-4. Felt dizzy, headaches, lethargic though likely due to not enough calories. 1st 5 mg dose yesterday and feel great so far. Absolutely no food noise or cravings since the 1st shot. No issues at all with the injection site or pain. Will stay at 5 mg as long as I can before increasing. This medication has been a life changer for me. I was hesitant due to reported side effects as I researched for over a year before I decided to move forward. My insurance denied, I appealed and got the decision overturned. Meds currently covered at 100%, thankfully. I am exercising though I have always walked. I am not a big eater to start with, the difference is I no longer crave foods. I eat because I have to, so I make better food choices. Looking forward to continuing on the path I am currently on."

• Bec...
• Taken for 1 to 6 months
• August 11, 2024

For Weight Loss (Obesity/Overweight) "I have lost over 35 lbs in 5 months. I started at the 2.5 and have worked up to the 10. Zepbound is incredibly effective at assisting with the weight loss. Greasy fatty foods definitely upset my stomach now. The first day post-shot, I am super tired and have a very mildly upset stomach, after that, it’s fine. I am freezing all the time, so for sure take a jacket wherever you go! I am not starving and do not have cravings at all. Staying hydrated seems to help with curbing the initial side effects. Initially, I found myself hardly eating just because I wasn’t hungry. I had to make a concerted effort to make myself sit down and eat. Protein and veggies made me feel a ton better and didn’t result in any digestive discomfort. It really was a trial and error. Alcohol is not your friend, even 1 or 2 drinks makes me feel awful. I ended up naturally having a cleaner diet and drinking a lot more water just to minimize the digestive side effects."

• Eli...
• Taken for 1 to 6 months
• December 30, 2024

For Weight Loss (Obesity/Overweight) "I started Zepbound at 2.5. My weight was 249 and I'm 5'2''. I've lost 34 lbs starting in July. I went up to 7.5 and was doing great. Then the third dose, all the side effects started in spades. I started vomiting, no appetite, tired all the time. I drink water all the time (and I'm a reformed soda drinker). I'm suddenly itchy all the time. The weight loss has slowed down. But I'm not giving up in order to get my knee replacement. This comment section makes me feel like I'm not alone. Thanks for listening. Oh, the one thing that could make me quit is the price is ridiculous! I'm running out of money."

• mir...
• Taken for less than 1 month
• August 12, 2025

For Weight Loss (Obesity/Overweight) "On my first week I am down 9 pounds already. My problem was never overeating. I am 5'7" 295. I have always eaten healthy and exercised. Come to find out my hormones are off. This shot has balanced everything out and I feel great. Some side effects: first few days I was extremely tired, now I have a ton of energy. I am also very nauseous. Make sure you get 100 mg of protein a day to maintain muscles."

• Dee...
• Taken for 1 to 6 months
• September 5, 2022

For Type 2 Diabetes "As of today, 9/5/2022, I have been on Mounjaro for 5 weeks. I have experienced upset stomach, nausea, weakness, and tiredness. I am on 2.5 mg. Hoping symptoms start to disappear. I am a Type 2 diabetic, and the pills didn't seem to help. I am in my 60s, so was wondering if that mattered. I'm not sure. I would like to continue the Mounjaro, but if side effects persist, I may have to try other options."

• Ano...
• Taken for 1 to 6 months
• August 9, 2025

"I was prescribed Zepbound as a minor by my PCP since a close relative had great improvement of symptoms on the drug. I had moderate/severe side effects, including severe abdominal pain, complete lack of appetite leading to hypoglycemia, exhaustion and weakness, increased stress, nausea, IBS flare-ups, and significantly increased suicidality. While my lab results showed improvement, my physical and mental well-being plummeted. I was told that side effects would subside and that they were mild, but unfortunately my side effects did not subside and were unmanageable for me. Luckily, I was able to convince my doctor that it wasn’t working after a few more months and am now off the drug."

• Anonymous
• Taken for less than 1 month
• February 13, 2025

For Obstructive Sleep Apnea/Hypopnea Syndrome "Started on Zepbound 2 weeks ago. I have only lost 2 pounds. I don’t feel like eating. At first, I was so tired, and that subsided. My biggest problem is the belching. I can’t seem to get rid of it."