Tirzepatide and Nausea: What Users Say (Page 3)

• Bla...
• Taken for 1 to 6 months
• April 2, 2025

For Weight Loss (Obesity/Overweight) "I have been struggling with my weight since I was 16. I quit smoking, had two children, entered menopause, and my weight became uncontrollable (my blood tests have always been perfect). I found the strength to start dieting a couple of times a year but hit rock bottom in March, 48 years old, 107 kgs. Depressed and unable to start -again- the keto diet (it works very well for me), I asked for help and was put on antidepressants and Mounjaro. A real game changer. I started the diet with no willpower, no bad feelings, no cravings, no need for self-control, just naturally. I got into ketosis easily and quickly. As a side effect, I have slight nausea a couple of days after the injection. No big deal, as it helps with the diet. No more food noise, I am able to think and prepare my meals without rushing, and so far, I have lost 6 kg in 14 days. I plan to continue for as long as I can and then stop and get my weight under control. We'll see."

• slp...
• Taken for 6 months to 1 year
• March 11, 2025

For Type 2 Diabetes "My endo doctor asked me to try the shot. At first, I said no. But she convinced me that we could get my A1C down. It was just under 9 at that time. I started the shot the 2nd week of October 2024. The first 2 months, it was just feeling nauseous. That was 2.5 mg. Here it is March 2025, I've lost 46 lbs. That to me is great. I had no idea about the weight loss when I started! Latest blood work, A1C is 6.4!! I now don't have to take Januvia or glipizide. Another plus! I am now on 7.5 mg. The only thing I've noticed, well, 2 things: I've developed eczema, bad. Currently waiting for my dermatology appointment. The other problem is depression. At least that is my thought, I've not had any ambition or 'get up and go,' which could be from the increase to 7.5 mg. I'm going to stick with it though. I'll stay at my current dose for a couple of months. I'm very happy with my morning finger pokes, I've been 92 to 103 every morning. Very pleased with the medication!"

• ric...
• Taken for less than 1 month
• May 26, 2024

For Weight Loss (Obesity/Overweight) "So, I took one dose, unfortunately, my doctor screwed up and started me at 15mg. I've been in the ED for 36 hours and have had the worst 3 weeks of my life. This is not a review but a caution, check your script thoroughly, make sure you're taking the right dose. I need to purge this dose from my system and then start a 2.5mg dose."

• Jus...
• Taken for less than 1 month
• December 28, 2024

For Weight Loss (Obesity/Overweight) "After my second 2.5 shot, the side effect symptoms are too much for me to handle. I’ve barely kept any food down except for a day and a half before my second shot. I can’t find a way to prevent acute nausea, and the vomiting is now making me weak. I knew there would be side effects, but for me, this medication doesn’t work for my body. I chose to discontinue the medication and will work with my doctor to see what other options may work for me. I have been unable to participate in family and home life, feeling trapped between being so sick I can’t leave my bed and spending a lot of time vomiting or feeling like I will if I try to move or drink water. I hoped this would be the tool to help me on a healthier path, and it’s not the right one for me, but I can see how it would possibly help others if they aren’t affected by side effects."

• JoD...
• Taken for less than 1 month
• September 7, 2025

For Weight Loss (Obesity/Overweight) "I started Zepbound with the expected side effects, chills, extreme fatigue, nausea, massive potty dumps. I am now down with days of horrible abdominal intestinal pain. I cannot go to the bathroom! I have stopped this med."

• Fin...
• Taken for 6 months to 1 year
• September 3, 2024

For Weight Loss (Obesity/Overweight) "I started Zepbound in March of this year, along with regular exercise and a more balanced diet. Since then, I have lost 65 lbs. For the first time in over 20 years, I am under 200 lbs. I feel great. I barely use my inhaler, my knees rarely hurt, and I can jog! My labs are all within normal limits, and I feel so much better about myself. I have very little side effects from ZB: nausea the day after I take it, intolerance to most alcoholic beverages, and I get hot after every meal. I’ll take those side effects any day if it means that I’ll continue to have my life back. I’m on the highest dose now and will continue until I reach my goal of 165. I’m 5’4'' and 44 yrs old. I’m not sure that I want to get back to my high school weight of 140 or less. Anyway, I’m not here to steer anyone, I just wanted to share how well it’s going for myself."

• Jun...
• Taken for 6 months to 1 year
• January 26, 2025

For Weight Loss (Obesity/Overweight) "I am on the lowest dose and have been on it for several months and have lost 24 lbs. I started off slowly walking 0.5 mile a day for the first week until I was able to do 3 miles a day. I had a friend walk with me, which was a good support. The last month, I have gained 3 lbs. back because of the weather, but I am back on my grind again. So far, no real side effects. When I first started, I felt a little queasy the first 24 hours."

• Ano...
• Taken for 1 to 6 months
• August 8, 2025

For Weight Loss (Obesity/Overweight) "This has changed my life! I didn’t know how I was ever going to lose weight again, and I’d given up. My weight had risen to nearly 13 stone over the last six years. I thought I was around twelve stone maximum, but I hadn’t weighed in years. I have osteoarthritis in both my knees and was finding it difficult to walk, and I'm only 5 foot two. I have now lost 2 1/2 stone after six months of taking this. The pain and inflammation in my knees have completely gone. I have hardly any side effects apart from not really wanting to eat very much and occasionally feeling a bit nauseous after the first dose when it’s been increased. I just can’t believe what an amazing drug this is. I’m just a little bit nervous about coming off it and getting my appetite back. It’s so lovely to live a life without food noise!"

• Mat...
• Taken for 6 months to 1 year
• March 18, 2025

For Weight Loss (Obesity/Overweight) "Question: Why wouldn’t you use this to get a head start on a new life? I started on Monjaro for weight loss and had to switch to Zepbound after three months (insurance). I always dieted and would stall after 20 pounds. My ultimate goal was to lose enough weight to safely run again. After a year, I had lost 80 lbs and was able to start running. I just finished a half marathon, one year after starting this journey. The side effects of it are what is advertised; some nausea, it can hit you but goes away quickly, the heartburn was less with Zepbound than Monjaro, and the decrease in using the bathroom is a godsend for anyone experiencing IBS. The injection is not bad with the auto pen. Take the leap and change your life!"

• SDG...
• Taken for less than 1 month
• September 21, 2022

For Type 2 Diabetes "I was prescribed the 2.5 dosage as a trial by my endocrinologist for pre-diabetic and weight loss on 9/15/22. I felt fine the first day, shot was given in the morning, but the next day I actually forgot to eat lunch. That is not normal for me. I wasn’t hungry. The third and fourth day I had horrible sulfur burps, nausea, fatigue. On the fourth day, I took two naps, which is not normal for me. I thought my symptoms were getting worse, but then the fifth and sixth day I felt great. I am fearful to take the next injection this week as I don’t want a repeat of the less than desirable side effects. It really wrecked my weekend. On the upside, I lost a couple of pounds the first week. That’s exciting, but at what cost?"

• Ano...
• Taken for 1 to 6 months
• July 17, 2025

For Weight Loss (Obesity/Overweight) "I have lost 20 lbs in 3 1/2 months on Zepbound taking 2.5, 5.0, and 7.5 mg so far as per plan and dosage increases. I plan to use 5 mg for maintenance dosage now that I am almost at my goal weight. It is very simple to use. I had some GERD, nausea, and adjustments to make with certain foods, but that subsided after the first few months. You definitely cannot overeat as you will not feel well. The exhaustion and body aches are what bother me the most. For the first 3 days after an injection, I am so tired that it impacts what I can get done in a day, including energy to exercise and do my job during the day. I am sleeping okay with it, but the fatigue is almost debilitating."

• Tri...
• Taken for 1 to 6 months
• September 3, 2025

For Weight Loss (Obesity/Overweight) "I have been on Zepbound for a month now, lowest dosage of 2.5 mg, and today I'm to start my second month with the next dosage up, but personally, I'm done. I've lost 7 pounds this August 2025, and though it may not seem like a lot to most people, it's quite something to those of us who have a very hard time losing weight. The thing is, how can a person be happy with the weight loss when you're miserable all the time? My first week went well, but come the second, the stomach aches/cramps and nausea are too much... every day, all day, through the night... sicker than a dog. I've heard good things about Zepbound, but the side effects are just too much for anyone to feel good about the journey it takes you on, and if the side effects only get worse with the higher dosages, then I might as well not eat at all for what little I can now, when I can. I'm 300+ pounds, and this was my last hope for any type of weight loss help. I don't recommend this product, the side effects outweigh any of the happy."

• Mar...
• Taken for 1 to 6 months
• December 28, 2024

For Type 2 Diabetes "This medication has been life-changing. Started with 2.5 mg and now at 5 mg. A bit of constipation and nausea, but nothing major. I started at 288 lbs and now at 236 lbs. I am a male, 5’11”. I hope I can get to my goal of 190 lbs in a few months. Working out, walking, and avoiding carbs is key. No fried foods or heavy carb meals, or you will pay a price. Lots of protein, lean meats, and veggies/berries. Good luck, everyone."

• 50 ...
• Taken for 1 to 6 months
• May 17, 2025

For Weight Loss (Obesity/Overweight) "I started taking Mounjaro for weight loss. I had no side effects on 2.5 mg and 5 mg. Weight loss was consistent at 1 kg per week. On 2.5 mg I still had an appetite and had no trouble eating moderately. On 5 mg I began to experience total loss of appetite. On W1 of 7.5 mg I awoke with extreme nausea, but other than that I was okay. On W2 of 7.5 mg I got very ill. I took the injection on Tuesday. By Wednesday night I vomited once. On Thursday, I started feeling nauseous with an egg-like aftertaste. By evening I was suffering from extreme diarrhea - every 20 to 30 minutes through the night. My stomach sounded full of sloshing water and gas and periodic large burps. On Friday I felt very dehydrated. I stayed in bed, sipped only water and diarrhea subsided. On Saturday I ate breakfast and a small amount of food for lunch. Saturday night diarrhea and vomiting again. It’s now Sunday and I feel weak and will not be taking 7.5 mg again. I will take a rest for a week before decreasing the dose to 5 mg to see how I go."

• roo...
• Taken for 1 to 6 months
• August 29, 2022

"Have been on Mounjaro since July 15th for obesity. I am only down 8 pounds since then. However, I have no cravings, I do not binge eat, I do not overeat. You will learn quickly to listen to your body. If you overeat, you will regret it. Your stomach hurts and you get bad heartburn. I get really nauseated the first two days after my injections. I do not feel hungry for most of the day. I listen to my body when it is hungry and I eat. If I get nauseous, and I know I haven't eaten in a while, I go eat. I have heard about this app Methreesixty, and it shows your inches lost. This is a really helpful tool if you get discouraged, because you might not see it on the scale, but you will see it in inches with this app. I started on the 2.5 and then went up to 5, but I don't think it is doing much for me as I am really hungry the last two days before my next shot. My doctor has me skipping the 7.5 and going straight to the 10 mg. It really is helping me in other ways, I did not realize I needed the help."

• Hur...
• Taken for 6 months to 1 year
• September 14, 2025

For Type 2 Diabetes "Mounjaro has been highly effective in lowering my blood sugar levels. My A1C was at 11.8% and in 4 months was down to 7.8% (doctor’s office) and at 6 months it was down to 6.6% (per GCM). I was also on daily fast-acting and slow-acting insulins, and the fast-acting has been discontinued because of progress. (I also exercise and eat very healthy.) I’m on the highest dose and I’m doing well. In the beginning, I had some nausea but hung it out and rarely experience nausea now. I have noticed a “blah” feeling and I feel tired most of the time. Those are the main things I have noticed. It has been highly beneficial for me, but I am looking forward to when I do not need it anymore."

• Cry...
• Taken for 1 to 6 months
• September 20, 2022

"My doctor prescribed Mounjaro after seeing my weight increase. First, I am a bariatric weight loss patient - 6 years out. I lost 80 lbs after my surgery and gained 30 back since. So yes, there is reason to be concerned. The month supply of 2.5 mg dose produced a 5 lb weight loss, and my appetite was suppressed somewhat. But more noticeable is the craving loss. They completely went away. I'm anxious to see how the 5 mg dose works. Some annoying side effects, but nothing drastic so far. Light nausea and diarrhea (subsides somewhat following the first few days after dosage). It took me a bit of time to get it together and start making healthy choices. I was in a very stressful work environment and chose to retire a little earlier than planned. Now, I work part-time from home now so I can take care of myself better. That's just me... I get overwhelmed and spiral. But even seeing this small amount of weight loss from the 2.5 dose has given me lots of hope and motivation!"

• MJC...
• Taken for 6 months to 1 year
• March 4, 2023

For Weight Loss (Obesity/Overweight) "Been on Mounjaro since 9/11/22. Today is 3/4/23. I have lost close to 60 lbs and went from a pant size 46 down to 40. My wife says I “lost my tire” looking at me from behind. Started at 2.5 dose. Was dizzy and unsteady in the early days. Headache and nausea till my body acclimated. Switched my shot day to Friday night so if I’m not feeling great, it’s the weekend and not impacting work. Worked up to 5.0 then 7.5. Did each for 8 weeks instead of 4 to level off the side effects. Wanted to stay at that level, but no one can get it. Took my first 10.0 shot last night. So far so good. All my levels are great. Sulfur burps if I overeat. Am also doing Herbalife shakes 2 times a day and having a sensible dinner. I still snack after dinner, but nothing crazy. Exercise 5/6 times per week. I think 7.5 should be my maintenance dose, but again, no one can get it. Will trade the mild side effects for being able to fit into my clothes."

• Mik...
• Taken for 1 to 6 months
• May 17, 2025

For Weight Loss (Obesity/Overweight) "Started with the initial 2.5 mg injections and experienced queasiness, and though my appetite remained, I got a sick feeling less than halfway through the meal. After 4 weeks, even though I was eating very little, my weight only dropped a few pounds. Then I advanced to 5 mg and my stomach was gassy and totally upset, I ate Tums constantly to control the acid indigestion. The worst part was to come, for one solid week, I was a total insomniac. I mean no sleep. This lasted a little over a week. I stopped with the injections after the first 5 mg one. It is now a month later and most of the symptoms are gone."

• mir...
• Taken for less than 1 month
• August 12, 2025

For Weight Loss (Obesity/Overweight) "On my first week I am down 9 pounds already. My problem was never overeating. I am 5'7" 295. I have always eaten healthy and exercised. Come to find out my hormones are off. This shot has balanced everything out and I feel great. Some side effects: first few days I was extremely tired, now I have a ton of energy. I am also very nauseous. Make sure you get 100 mg of protein a day to maintain muscles."

• kto...
• Taken for 1 to 6 months
• November 7, 2022

For Type 2 Diabetes "I started Mounjaro 7 weeks ago. The first shot made me so nauseous and have such bad abdominal pain that lasted for 12 hours. I almost went to the ER. I told my doctor about my experience, and she gave me Zofran and told me to continue dieting. Fast forward to this weekend - took my shot on Friday morning, then spent all day Saturday and Sunday projectile vomiting (it literally ended up about 7 feet from where I was standing), uncontrollable diarrhea, disgusting sulfur burps, horrible heartburn, and dizziness. Finally, I decided to go to the ER and got treated for dehydration. They told me to follow up with my primary doctor to talk about the best way to continue the medication. After this experience, I am NEVER taking this drug again. While I've lost 25 lbs in the past 7 weeks, I believe it's mostly because I've been afraid to eat anything. I will continue to eat healthy and cut carbs and sugars, but I won't be taking Mounjaro again."

• Dee...
• Taken for 1 to 6 months
• September 5, 2022

For Type 2 Diabetes "As of today, 9/5/2022, I have been on Mounjaro for 5 weeks. I have experienced upset stomach, nausea, weakness, and tiredness. I am on 2.5 mg. Hoping symptoms start to disappear. I am a Type 2 diabetic, and the pills didn't seem to help. I am in my 60s, so was wondering if that mattered. I'm not sure. I would like to continue the Mounjaro, but if side effects persist, I may have to try other options."

• lif...
• Taken for 1 to 2 years
• May 23, 2024

For Type 2 Diabetes "It’s been 2 years. Yes, there were challenges. Some nausea. Lot’s of constipation. Some fatigue. And mostly good aversion. I understand fully the phrase eat to live. This medication was/is a game changer for long-time diabetes sufferers. I lost 50 pounds. Got off of insulin shots. Cholesterol meds. BP meds. I am over 60 years old and feel better than I did at 40. I would rate my experience on Mounjaro on a scale from 1-10, a solid 10. Everyone’s journey is unique, based on many different factors. I would rate my journey as successful."

• Mel...
• Taken for less than 1 month
• May 22, 2023

For Weight Loss (Obesity/Overweight) "I've been a yo-yo dieter for as long as I can remember. This is by far the best thing I've tried. I lost 11 lbs in the first week, this really does work to decrease your appetite! My diet doctor gives me injections and told me to follow what is essentially a keto diet (no carbs or sugar - 8 oz of protein and as many veggies as you want), in conjunction with intermittent fasting (16 hours fasting, 8 hours allowed to eat). There is NO WAY I'd make it through 16 hours of not eating without this! I feel very slight nausea sometimes after I eat, but not enough to affect my day-to-day activities. This is a game changer if you have struggled to lose weight as I have!"

• 2go...
• Taken for 1 to 6 months
• July 16, 2025

For Weight Loss (Obesity/Overweight) "On week 5 of Zep. Goal to lose 20-25 lbs. Received a 2.5 mg 'loading' dose, I split it into 1.25 doses 3 days apart for the first 2 weeks as I tend to react strongly to meds. I had a bit of anxiety and fatigue on this dose and appetite suppression that waned by week 2, so I increased to 2.5 in one shot for weeks 3 and 4. Less anxiety/fatigue but more nausea and constipation, still manageable. I received a 5 mg dose in the mail at week 4 but had already lost 15 lbs on the 2.5 dose for 4 weeks. Week 5 - I tried the 5 mg. The next day, I was so sick to my stomach and nauseous that I struggled to eat or drink at all. I was dizzy and felt terrible, depressed, and kept getting the long bouts of hiccups. I will be at goal soon and plan to switch to metformin to maintain weight. For me, this med is miraculous, but I do not feel great on it. (For reference - I have a mental health diagnosis and pre-existing mild gastrointestinal issues, MTHFR gene variant)"