Tirzepatide and Nausea: What Users Say (Page 3)

• Jun...
• Taken for 6 months to 1 year
• January 26, 2025

For Weight Loss (Obesity/Overweight) "I am on the lowest dose and have been on it for several months and have lost 24 lbs. I started off slowly walking 0.5 mile a day for the first week until I was able to do 3 miles a day. I had a friend walk with me, which was a good support. The last month, I have gained 3 lbs. back because of the weather, but I am back on my grind again. So far, no real side effects. When I first started, I felt a little queasy the first 24 hours."

• Jus...
• Taken for less than 1 month
• December 28, 2024

For Weight Loss (Obesity/Overweight) "After my second 2.5 shot, the side effect symptoms are too much for me to handle. I’ve barely kept any food down except for a day and a half before my second shot. I can’t find a way to prevent acute nausea, and the vomiting is now making me weak. I knew there would be side effects, but for me, this medication doesn’t work for my body. I chose to discontinue the medication and will work with my doctor to see what other options may work for me. I have been unable to participate in family and home life, feeling trapped between being so sick I can’t leave my bed and spending a lot of time vomiting or feeling like I will if I try to move or drink water. I hoped this would be the tool to help me on a healthier path, and it’s not the right one for me, but I can see how it would possibly help others if they aren’t affected by side effects."

• Fin...
• Taken for 6 months to 1 year
• September 3, 2024

For Weight Loss (Obesity/Overweight) "I started Zepbound in March of this year, along with regular exercise and a more balanced diet. Since then, I have lost 65 lbs. For the first time in over 20 years, I am under 200 lbs. I feel great. I barely use my inhaler, my knees rarely hurt, and I can jog! My labs are all within normal limits, and I feel so much better about myself. I have very little side effects from ZB: nausea the day after I take it, intolerance to most alcoholic beverages, and I get hot after every meal. I’ll take those side effects any day if it means that I’ll continue to have my life back. I’m on the highest dose now and will continue until I reach my goal of 165. I’m 5’4'' and 44 yrs old. I’m not sure that I want to get back to my high school weight of 140 or less. Anyway, I’m not here to steer anyone, I just wanted to share how well it’s going for myself."

• Mat...
• Taken for 6 months to 1 year
• March 18, 2025

For Weight Loss (Obesity/Overweight) "Question: Why wouldn’t you use this to get a head start on a new life? I started on Monjaro for weight loss and had to switch to Zepbound after three months (insurance). I always dieted and would stall after 20 pounds. My ultimate goal was to lose enough weight to safely run again. After a year, I had lost 80 lbs and was able to start running. I just finished a half marathon, one year after starting this journey. The side effects of it are what is advertised; some nausea, it can hit you but goes away quickly, the heartburn was less with Zepbound than Monjaro, and the decrease in using the bathroom is a godsend for anyone experiencing IBS. The injection is not bad with the auto pen. Take the leap and change your life!"

• Ano...
• Taken for 1 to 6 months
• June 11, 2025

For Weight Loss (Obesity/Overweight) "As soon as I began at the 2.5 dosage, I modified my diet radically to mitigate or even entirely avoid the dreaded side effects of indigestion, nausea, constipation, heartburn, and vomiting. I also embarked on a free-weight program to build muscle. Fortunately, I’ve experienced none of the unpleasant side effects. I’ve titrated up after each 4-week dosage and am now in the middle of 7.5 mg. My doctor tells me I have lost more weight than most patients have at this point. I also have chronic inflammation, which extra weight exacerbates, and I’m watching carefully to see that marker decrease. That’s the good news. Zepbound has completely changed my relationship to food. I consider myself a “foodie.” That’s now behind me. I remind myself that it’s been only 10 weeks. I’m hopeful that at some point, I will be able to enjoy more of the foods that were once such a large part of my life."

• SDG...
• Taken for less than 1 month
• September 21, 2022

For Type 2 Diabetes "I was prescribed the 2.5 dosage as a trial by my endocrinologist for pre-diabetic and weight loss on 9/15/22. I felt fine the first day, shot was given in the morning, but the next day I actually forgot to eat lunch. That is not normal for me. I wasn’t hungry. The third and fourth day I had horrible sulfur burps, nausea, fatigue. On the fourth day, I took two naps, which is not normal for me. I thought my symptoms were getting worse, but then the fifth and sixth day I felt great. I am fearful to take the next injection this week as I don’t want a repeat of the less than desirable side effects. It really wrecked my weekend. On the upside, I lost a couple of pounds the first week. That’s exciting, but at what cost?"

• roo...
• Taken for 1 to 6 months
• August 29, 2022

"Have been on Mounjaro since July 15th for obesity. I am only down 8 pounds since then. However, I have no cravings, I do not binge eat, I do not overeat. You will learn quickly to listen to your body. If you overeat, you will regret it. Your stomach hurts and you get bad heartburn. I get really nauseated the first two days after my injections. I do not feel hungry for most of the day. I listen to my body when it is hungry and I eat. If I get nauseous, and I know I haven't eaten in a while, I go eat. I have heard about this app Methreesixty, and it shows your inches lost. This is a really helpful tool if you get discouraged, because you might not see it on the scale, but you will see it in inches with this app. I started on the 2.5 and then went up to 5, but I don't think it is doing much for me as I am really hungry the last two days before my next shot. My doctor has me skipping the 7.5 and going straight to the 10 mg. It really is helping me in other ways, I did not realize I needed the help."

• MJC...
• Taken for 6 months to 1 year
• March 4, 2023

For Weight Loss (Obesity/Overweight) "Been on Mounjaro since 9/11/22. Today is 3/4/23. I have lost close to 60 lbs and went from a pant size 46 down to 40. My wife says I “lost my tire” looking at me from behind. Started at 2.5 dose. Was dizzy and unsteady in the early days. Headache and nausea till my body acclimated. Switched my shot day to Friday night so if I’m not feeling great, it’s the weekend and not impacting work. Worked up to 5.0 then 7.5. Did each for 8 weeks instead of 4 to level off the side effects. Wanted to stay at that level, but no one can get it. Took my first 10.0 shot last night. So far so good. All my levels are great. Sulfur burps if I overeat. Am also doing Herbalife shakes 2 times a day and having a sensible dinner. I still snack after dinner, but nothing crazy. Exercise 5/6 times per week. I think 7.5 should be my maintenance dose, but again, no one can get it. Will trade the mild side effects for being able to fit into my clothes."

• Cry...
• Taken for 1 to 6 months
• September 20, 2022

"My doctor prescribed Mounjaro after seeing my weight increase. First, I am a bariatric weight loss patient - 6 years out. I lost 80 lbs after my surgery and gained 30 back since. So yes, there is reason to be concerned. The month supply of 2.5 mg dose produced a 5 lb weight loss, and my appetite was suppressed somewhat. But more noticeable is the craving loss. They completely went away. I'm anxious to see how the 5 mg dose works. Some annoying side effects, but nothing drastic so far. Light nausea and diarrhea (subsides somewhat following the first few days after dosage). It took me a bit of time to get it together and start making healthy choices. I was in a very stressful work environment and chose to retire a little earlier than planned. Now, I work part-time from home now so I can take care of myself better. That's just me... I get overwhelmed and spiral. But even seeing this small amount of weight loss from the 2.5 dose has given me lots of hope and motivation!"

• kto...
• Taken for 1 to 6 months
• November 7, 2022

For Type 2 Diabetes "I started Mounjaro 7 weeks ago. The first shot made me so nauseous and have such bad abdominal pain that lasted for 12 hours. I almost went to the ER. I told my doctor about my experience, and she gave me Zofran and told me to continue dieting. Fast forward to this weekend - took my shot on Friday morning, then spent all day Saturday and Sunday projectile vomiting (it literally ended up about 7 feet from where I was standing), uncontrollable diarrhea, disgusting sulfur burps, horrible heartburn, and dizziness. Finally, I decided to go to the ER and got treated for dehydration. They told me to follow up with my primary doctor to talk about the best way to continue the medication. After this experience, I am NEVER taking this drug again. While I've lost 25 lbs in the past 7 weeks, I believe it's mostly because I've been afraid to eat anything. I will continue to eat healthy and cut carbs and sugars, but I won't be taking Mounjaro again."

• Mel...
• Taken for less than 1 month
• May 22, 2023

For Weight Loss (Obesity/Overweight) "I've been a yo-yo dieter for as long as I can remember. This is by far the best thing I've tried. I lost 11 lbs in the first week, this really does work to decrease your appetite! My diet doctor gives me injections and told me to follow what is essentially a keto diet (no carbs or sugar - 8 oz of protein and as many veggies as you want), in conjunction with intermittent fasting (16 hours fasting, 8 hours allowed to eat). There is NO WAY I'd make it through 16 hours of not eating without this! I feel very slight nausea sometimes after I eat, but not enough to affect my day-to-day activities. This is a game changer if you have struggled to lose weight as I have!"

• Dee...
• Taken for 1 to 6 months
• September 5, 2022

For Type 2 Diabetes "As of today, 9/5/2022, I have been on Mounjaro for 5 weeks. I have experienced upset stomach, nausea, weakness, and tiredness. I am on 2.5 mg. Hoping symptoms start to disappear. I am a Type 2 diabetic, and the pills didn't seem to help. I am in my 60s, so was wondering if that mattered. I'm not sure. I would like to continue the Mounjaro, but if side effects persist, I may have to try other options."

• Hed...
• Taken for 1 to 2 years
• July 15, 2025

For Weight Loss (Obesity/Overweight) "I love Zepbound as it is the only thing that has helped me lose weight easily. After reading the reviews on here, my approach has been somewhat different as I refused to give up any foods or alcohol as that isn't real life for me. I walk 4 miles a day but haven't done real cardio or weight lifting very often so that is next. I have been on it for 13 months and started at 190 and am at 152, which is less than my high school weight/5'6'' and was a college athlete, so a very muscular type build. I am ecstatic at this weight but scared to go off Zepbound as I can control my food addictions with it and don't eat 2000 calories at midnight anymore. I get full very quickly so I am eating way less than my old norm of 4000 calories a day. :-) I am at 12.5 mg and the side effects I have had are mostly fatigue and my hair breaking off. At first, I had nausea and injection site swelling, but that went away after the first month."

• dmj...
• Taken for 1 to 6 months
• May 8, 2023

For Weight Loss (Obesity/Overweight) "You do lose weight, but the waves of nausea, vomiting, severe constipation, and hypoglycemia are so unpleasant, and if you escalate and find it too much - it lasts for a whole week. Consider liraglutide daily, much easier to titrate, and if you escalate and find it too much, you can lower down and only have one day of downtime."

• lif...
• Taken for 1 to 2 years
• May 23, 2024

For Type 2 Diabetes "It’s been 2 years. Yes, there were challenges. Some nausea. Lot’s of constipation. Some fatigue. And mostly good aversion. I understand fully the phrase eat to live. This medication was/is a game changer for long-time diabetes sufferers. I lost 50 pounds. Got off of insulin shots. Cholesterol meds. BP meds. I am over 60 years old and feel better than I did at 40. I would rate my experience on Mounjaro on a scale from 1-10, a solid 10. Everyone’s journey is unique, based on many different factors. I would rate my journey as successful."

• Mik...
• Taken for 1 to 6 months
• May 17, 2025

For Weight Loss (Obesity/Overweight) "Started with the initial 2.5 mg injections and experienced queasiness, and though my appetite remained, I got a sick feeling less than halfway through the meal. After 4 weeks, even though I was eating very little, my weight only dropped a few pounds. Then I advanced to 5 mg and my stomach was gassy and totally upset, I ate Tums constantly to control the acid indigestion. The worst part was to come, for one solid week, I was a total insomniac. I mean no sleep. This lasted a little over a week. I stopped with the injections after the first 5 mg one. It is now a month later and most of the symptoms are gone."

• Gha...
• Taken for 1 to 6 months
• February 28, 2023

For Weight Loss (Obesity/Overweight) "I have slowly lost weight. I have taken it for 8 weeks and have lost 18 lbs on the 2.5 mg dose. It makes me very nauseous and causes GI upset. But overall, I think slow weight loss is probably best anyway for long term."

• Wan...
• Taken for 1 to 6 months
• May 12, 2023

For Weight Loss (Obesity/Overweight) "I’m a 58-year-old woman. When I started Mounjaro, I was at 172 lbs. I am taking 5 mg. On the first injection of 5 mg, I had hives, but the next day, with allergy medication, it went away. I had a little bit of nausea off and on every time I took an injection. The worst part about this medicine is I feel cold all the time and fatigued. The fatigue goes away after a couple of days. I just took my 4th injection of 5 mg and will move up to 7.5 mg next week. So far, all good. I did notice I got pretty hungry 2 days before it was time to take my 4th 5 mg injection, which to me said it lost its effectiveness. I did struggle with those 2 days trying not to go back to old habits. I have lost 20 lbs since starting Mounjaro, and all of my blood work is much, much better. My A1C is down 2 points!"

• Ste...
• Taken for 6 months to 1 year
• October 3, 2024

For Weight Loss (Obesity/Overweight) "I've been on the shot for 5 months now, and at first, the appetite suppression was strong, with no side effects. After I went up in dose month two, I had extreme bloating and nausea to the point where I nearly took myself to the emergency room. Since then, the side effects have gone down, and the only one I deal with regularly is heartburn. Ask your doctor for Zantac and keep it and Tums on you at all times. Thankfully, it has mostly subsided, and I'm down 80 pounds with moderate exercise in 5 months. I have basically 0 appetite most days and have grown to work with it. I'd give it a 4/5. It's not easy, but if you're serious about losing weight and taking back control of your body, do it. Make sure you work out and follow a strict diet while you're doing it to get the most out of the medication. ALSO! Go to the manufacturer Lilly's website and sign up for the savers card. Saves me $300 a month with insurance."

• Ano...
• Taken for 6 months to 1 year
• May 8, 2025

For Weight Loss (Obesity/Overweight) "I started taking Zepbound on July 1, 2024, after much research and many discussions with my primary care provider. My insurance did not cover the cost and, at that time, it was difficult to get access to some of the other weight loss drugs. I was able to get Zepbound at my local Walmart Pharmacy and decided to go for it in spite of the cost. At the beginning of my weight loss journey, I was 74 years old, 5'5" and 190 lbs. I started at the lowest dose, 2.5 mg, and began losing weight right away. The only side effect I experienced was slight nausea for a day or so after each injection. It also lowered my blood pressure and I was able to stop taking blood pressure medication. I never exceeded the 7.5 mg dose and am still using it sporadically (probably not the proper way to go about it). I was able to go from 190 lbs. down to 135 lbs. in 9 months."

• Jan...
• Taken for 1 to 6 months
• June 22, 2025

For Weight Loss (Obesity/Overweight) "I’m a 68-year-old female and have lost 50 lbs from January to June 2025. Started with 5 mg injections and now am getting 15 mg injections once per week. Minimal side effects unless I eat too much or eat unhealthy foods - and then I will have nausea and/or diarrhea. The biggest benefit has been that my blood pressure went from approximately 140/90 or so to a very consistent 110/60 or slightly above that, but hasn’t been anywhere near 140/90 since a couple of weeks after I began the injections. The cost has been a bit prohibitive, and I’m hoping that I’ll be able to transition off after I reach my goal weight loss of 75 lbs (without too much weight gain) OR that there will be a generic available and covered by Medicare. I can also breathe much better after climbing stairs and feel so much healthier and am able to play with my grandkids much more! Thanks so much!"

• Jca...
• Taken for less than 1 month
• October 7, 2022

For Type 2 Diabetes "I just took my fourth injection, and I couldn’t be more excited! I’ve lost 10 pounds in three weeks, my appetite is controlled, I feel like I’ve finally got some hope to get my health where it needs to be. My morning fasting glucose is close to 100 (always near 140), no more crazy spikes hitting 200-300. I do get very tired the day of each shot. The first three days or so of my first injection, I was so ill (sick stomach). I got some Zofran, and that helped tremendously, so I’ll expect to need that with each dose increase. Looking very forward to 5 mg next week :) Ins won’t pay for it yet, even though I’m type 2, but I’ve got a coupon for it and paid $25 a month. Thank God, or I couldn’t get it, hopefully soon it will be covered."

• Ski...
• Taken for 1 to 6 months
• March 5, 2023

For Type 2 Diabetes "In November 2022, my ACI was 7.4%, and I weighed 258 pounds at 67 years old. The wake-up call was when I renewed my life insurance, a big jump in premium due to the AC1 and weight. I was now tagged as a Type 2 Diabetic. I was referred to an endocrinologist who did extensive blood work. It was agreed to go on Mounjaro 2.5 mg. The first week I suffered some side effects such as nausea, constipation, and acid burps. Within 10 days, the symptoms subsided due to stool softeners, lots of fruit (berries), and Nexium. The first month I dropped 10 pounds with no dieting, just was not hungry at all. I had no cravings, especially for sweets like cookies, donuts, and candy-all things that I used to eat. Fast forward to March 2023, I am down to 217 pounds and 20 more to go. I am now on Mounjaro 10 mg, it's a bit strong, but the results are fantastic. My AC1 is now 5.6%, which is fantastic. The bad news is nothing fits- all new suits for the spring."

• PP6...
• Taken for less than 1 month
• November 22, 2022

For Type 2 Diabetes "Horrible experience taking this drug. I do not recommend taking this medication unless you want to die. I started taking 2.5 mg 6 days ago. Day 2 and 3 had no appetite and ate very little because the thought of food made me sick. Day 4 and 5 developed nausea, severe abdominal pain, and indigestion unrelieved by antacids. I also have lost five lbs because I am unable to eat or drink anything. I do not have any energy or feel like doing anything. Day 6 and I still feel sick. My fasting blood sugar this morning was 224 even though I am not eating or drinking hardly anything at all. It is noon, and I haven’t eaten anything because I’m afraid I will throw up. My heart rate is 120 and normally runs in the eighties. My doctor is out of the office this week for holidays. Just hoping and praying I don’t wind up in the emergency room. I will never inject this toxic stuff into my body again. I also read that it can cause thyroid cancer."

• mar...
• Taken for 1 to 6 months
• May 1, 2025

For Weight Loss (Obesity/Overweight) "I started Zepbound late January. I was generally a small person and was the same size for over 25 years. However, with menopause and COVID combination, I gained over 25 pounds and my BMI went from a 24 to a 30 in the past 4 years. Both of my parents were diabetic, therefore, my risk factors were great. Initially, I felt nauseous for a few days, but the nausea went away. I started on 2.5 mg and lost 13 pounds in the first month. Moved to 5 mg the second month. I was down 18 pounds after month 2. No side effects from the meds. I went to 7.5 for the 3rd month and am still on it. I have lost 24 pounds. I am also exercising more. I try to put in 10k steps at least 5 days a week and exercise for 30 minutes 4 days a week. I am 5'2 and started at 166 pounds. I am down to 142 now and have more energy. My A1C was 6.1 when I started and is now 5.7. My cholesterol did go up from 212 to 267, however, I attribute this to the rapid weight loss and will test again in 6 months."