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Tirzepatide User Reviews & Ratings (Page 2)

Brand names: Mounjaro, Zepbound

Tirzepatide has an average rating of 8.6 out of 10 from a total of 1,864 reviews on Drugs.com. 81% of reviewers reported a positive experience, while 5% reported a negative experience.

Reviews for Tirzepatide

Commonly mentioned side effects
  • Anonymous
  • Taken for 1 to 6 months
  • September 14, 2022

For Type 2 Diabetes "I started with this medication for weight loss, and since I am 58 and a diabetic, my insurance covered it. It is a fantastic weight loss drug for me. Starting at 5'6, 242 lbs, I've lost 23 pounds in 12 weeks. I don't remember when I was able to lose this much weight. I've dieted my whole life and finally gave up and ballooned to 242 lbs. You have to be careful about eating greasy food and not overeating. I did vomit a few times after eating greasy food. Other than that, I'm so excited. My first goal is to get to 180 and see what happens. My feet no longer hurt when I stand all shift."

9 / 10
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  • 60y...
  • March 22, 2023

For Weight Loss (Obesity/Overweight) "I have been on Mounjaro since Jan. 2023. I have lost 20 pounds. I need to lose 20 more. Side effects: burping, stomach upset, constipation, flu-like body aches, mildly depressed feeling, and fatigue. Not every day, not every symptom every day, and not all day. It comes and goes. I will continue but do wonder how it’s gonna go long term. I’m just sick of being fat."

7 / 10
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  • cpo...
  • Taken for less than 1 month
  • December 20, 2023

For Weight Loss (Obesity/Overweight) "57 years old female, 5'7", and 200 pounds. Tried to get on Mounjaro for 13 months, but cost was $1,200-1,300. I am not diabetic. In 2022, I had normal cholesterol, and BMI was 30. When Zepbound came out, I went to three doctors. One doctor had never heard of Zepbound, acted like GLP-1 was cheating and that I needed to try more exercise and food control. One doctor said maybe I should try diet and exercise first. An Online doctor, Plushcare, agreed after blood work showed high cholesterol, high blood sugar, and other indicators heading up from the prior year. After five blood tests, each worsening, thirteen months of waiting, and spending $800 on visits, I was written a prescription for Zepbound, which cost me $550 for four 2.5 injections. My insurance will not cover the drug, even though they turned down Mounjaro because it was off-label, and Zepbound is for weight loss. Hope insurance companies will pay for Zepbound, but not today. Thanks Ely Lilly for savings card. I'll post results."

10 / 10
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Frequently asked questions

  • Jav...
  • Taken for 1 to 6 months
  • January 20, 2023

For Type 2 Diabetes "This is my 2nd time posting. Was on Trulicity in the past & now Mounjaro 5mg, 7.5mg & bumped to 12.5. Effects for me are minimal & not bad, at all. Some days the acid reflux or constipation is bad, but it's not way off the charts & is manageable. One thing I noticed, as my doctor progressed me up the ladder to higher doses of Mounjaro...the weight loss is amp'ing up. Gradually starting to lose more per week than when on lower doses. Also, on 5 mg & 7.5mg, I noticed on days 1-4, I wasn't hungry AT ALL & knew that I needed to eat; therefore, I thought of food as FUEL, not just tasty & I made better/healthier choices. Now, on 12.5mg, I find days 1-5 or 6....I'm not hungry at all & still making better food choices, because I have to make myself eat. The 'in between meals snacking' has totally GONE AWAY. This drug has been a miracle for me, as my Thyroid Hashimoto's has caused so much weight gain w/the slower metabolism & I couldn't lose any weight until Mounjaro. It's a blessing!"

10 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • February 14, 2024

For Weight Loss (Obesity/Overweight) "65, 5' 6'' inches, who weighed 305 lbs 2.5 years ago. Needless to say, I needed to lose weight for more than cosmetic reasons. I started on a medically managed weight loss plan under the direction of a great NP who is well-versed in treating obesity. My insurance won't cover weight loss drugs, so all drugs have been out of pocket. I started on Contrave while following WW and lost 60 lbs. I then went on compounded semaglutide (I know, don't do that) and lost another 40 lbs for a total of 100 lbs, again sticking with WW along with the meds. When Zepbound was approved, I switched to Zepbound using the Lilly savings card ($550/mo) and have lost another 22 lbs so far (a total of 122 lbs) (on 12.5 mg shots now). I am still following WW, and it is so much easier to stick to the food plan with the help of the weight loss drugs. I am a believer and advocate for using these drugs if you need them with a healthy nutrition plan. Mild side effects that diminish over time. Stick with it! It works!"

10 / 10
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  • A K...
  • Taken for 6 months to 1 year
  • June 13, 2023

For Weight Loss (Obesity/Overweight) "I started Mounjaro at 2.5 mg, 8 months later I am at the 7.5 mg dose but to maintain my loss I now take it twice a month. I went from 210 to 150 lbs. This is a life-changer for me. It took all my cravings for bad food away, no more chips and pizza. I eat a much healthier diet now and like many others eat much less. My heartburn problems are gone and I have a lot more energy."

10 / 10
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  • My ...
  • Taken for 6 months to 1 year
  • September 3, 2024

For Weight Loss (Obesity/Overweight) "I am 64, 5'7" and weighed 245. Started Zepbound the second week of February, and as of September 1, have lost 65 lbs and went from a 42 waist to a 34 and never walked into a gym. Had some morning sickness at first, but got over it. You have to ask yourself, is the juice worth the squeeze? And yes, it is. Do the math: that’s between 2 to 3 lbs a week. My doctor discontinued my blood pressure medication, and my gout has gone away, not to mention how great I feel and look. You owe it to yourself if you are in need of losing weight. My BMI went from 39% to 25% as well."

10 / 10
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More FAQ

  • Nic...
  • Taken for 1 to 6 months
  • January 31, 2024

For Weight Loss (Obesity/Overweight) "I love Zepbound ❣️ I started on the low dose, and now I’m on the 7.5, and I have lost over 25 lbs. There are side effects, not bad enough to make me not use it, they include nausea, cramping, and loose dark stool. I am totally disabled and can’t exercise, so this was a great way for me to get lighter on my feet. Thank you. Good luck if you’re starting."

9 / 10
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151 Report
  • cer...
  • Taken for 1 to 2 years
  • February 3, 2025

For Weight Loss (Obesity/Overweight) "Started last January at 268 pounds, 5 ft 7 in, morbidly obese, could barely walk because of breathlessness and back pain. One year later, I'm down to 159 pounds and have never been healthier. The only side effect I've had from this medication is really bad constipation, which requires a laxative a couple of times per week. This med works so well when you are in a deficit and working out, it makes you full really quickly too. Nothing ever worked for me in the past, but my whole lifestyle has changed for the better since being on this med."

10 / 10
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  • Roa...
  • Taken for 6 months to 1 year
  • October 27, 2023

For Weight Loss (Obesity/Overweight) "Thanks for your efforts in publicizing the difficulties related to weight loss and the great results thus far regarding Mounjaro. I'm 73 years old. T2D and have a history of heart attack and ongoing heart disease. Every type of diet I've tried in the past has shown great results, but at 316 lbs this year, I no longer had the discipline or physical ability to repeat any of those efforts. I started on Mounjaro, paying my own way, on March 3rd of this year. 43 weeks in, with no side effects of any type, I've lost 103 lbs. I'm eating in a far less and healthier manner as I am able, but have no strict food regimen. The same goes for exercise. This is a miracle drug, with terrific results for blood pressure (now 118/68), A1c (5.7), PSA actually decreasing (.15), and I can now walk up to 3 miles at a time compared to 1 block in March. The only prohibitive factor for most people is the cost. Cancer, heart disease, and diabetes don't cause obesity. It seems the profession has it backwards when it comes to treatment."

10 / 10
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  • Fin...
  • Taken for 6 months to 1 year
  • April 25, 2025

For Weight Loss (Obesity/Overweight) "I have struggled with weight loss for the past 10 years. Healthy diet, regular exercise used to work for me but stopped working, and my weight steadily increased. I became afraid of food and barely ate 1,200 calories a day. Still, the weight wouldn’t budge. Doctors told me it was because I wasn’t 35 anymore or I was insulin resistant. I was diagnosed with fatty liver, and my frustration was at its peak. I am now 60, and at my peak, I was 216 lbs at 5'10" and pre-diabetic. I didn’t feel good and didn’t like how I looked. I was able to get Zepbound approved with my insurance, and it has been a lifesaver! I am now 160 and feel better than I’ve felt in years! I’ve had minimal side effects, and I’m just grateful that there was finally something to help me lose weight. I have saggy skin and don’t care. My knees don’t hurt, and I feel great! I’m not afraid of food and even eat treats in small portions without fear of gaining weight."

10 / 10
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  • Fra...
  • Taken for 1 to 6 months
  • February 8, 2025

For Weight Loss (Obesity/Overweight) "I have been on the lowest dosage of Zepbound for about 3-4 months. I’ve lost 22-25 pounds. No, I haven’t increased the time spent exercising. But I am no longer hungry and stuffing junk food into my mouth. My tongue hasn’t forgotten it loves Snickers, but I am able to grab apples and be content. My nephrologist put me on it as I do have kidney disease, I was in the obese range, and I was prediabetic. It’s expensive ($400 per month), but I feel better about myself, and so it’s worth it to me. I was the fat kid in my family and have never been a thin and beautiful person. But Zepbound has given me higher self-esteem because it’s doing what it’s supposed to do… help me to shed weight in a healthy way. I do sometimes experience constipation, then a giant diarrhea round, but I feel good most of the time. I have no other side effects and have been pleased with the assistance Zepbound has given me. Thank you, Lilly Pharma!"

9 / 10
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  • ADD...
  • Taken for 6 months to 1 year
  • February 5, 2024

For Weight Loss (Obesity/Overweight) "I have lost 73 lbs in 7 months. I am not hungry, cranky, normal energy levels. I eat what I want, just greatly reduced portions and I am full. Fried & processed foods no longer taste good and I naturally migrate to healthier foods, fruits & veggies. My cholesterol numbers have plummeted and are all in the normal range, I no longer have acid reflux and I quit snoring. I've gone from size 40 waist to a size 32. XL shirts and underwear to Medium. I have not felt this good or had as much energy in 30 years."

10 / 10
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  • SdS...
  • Taken for 1 to 2 years
  • February 13, 2025

For Weight Loss (Obesity/Overweight) "I have been on Zepbound for almost a full year. I lost weight quickly: 90 pounds. I was at my goal in 6 months. I had to go back 2 doses to maintain and stop losing weight. The nausea has not stopped. It’s better than in the beginning, but I still get it every time for 1 or 2 days after a shot. The diarrhea is terrible. It has never stopped. I get it on day 2, and it is uncontrollable. It’s been almost a year, so I would think some of these side effects would have stopped, but they haven’t. I also get sulfur burps for a day or 2 after a shot. I’m at the point where I might have to stop taking it due to the side effects. I love the weight loss, and I sure don’t want to gain it back, though."

6 / 10
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  • DJT...
  • Taken for 6 months to 1 year
  • February 17, 2024

For Weight Loss (Obesity/Overweight) "I am a 76-year-old female and was prescribed Mounjaro 2.5mg beginning in July 2023 due to being prediabetic, 5'3'' and 186 lbs. After 3 months, my A1C was normal at 5.7 and all my blood work was within normal range. I had no side effects at all. As soon as Zepbound was approved and available for weight loss, I received a new prescription for Zepbound... still at the 2.5 dosage. It is now February 2024 and I am down to 136, which is my goal weight and a total weight loss of 50 pounds, or about one and a half pounds per week. My doctor said that I don't need to increase to a higher dosage unless 2.5 no longer quells my cravings. So far, the 2.5 works well for me. Now that I no longer want to lose weight, I wonder if I can reduce my weekly injection to once every two weeks. I seem to recall on the Mounjaro reviews that it is possible to do that and still avoid having cravings that could undermine my weight loss maintenance."

10 / 10
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  • Reb...
  • Taken for less than 1 month
  • November 14, 2024

For Weight Loss (Obesity/Overweight) "I was so afraid to start this medication because of all the horror stories I heard about side effects. I am on my second injection of 2.5 mg and have so far experienced absolutely no negative side effects. I lost 5 lbs the first week and have so much more energy! It has been a breeze getting my 10k steps in each day. So hoping this is the trend forward. The last several years I have been so weight loss resistant (trauma and Hashimoto's related, I'm sure). So these more positive side effects have been very inspiring :) So happy I gave this medication a try!"

10 / 10
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  • san...
  • Taken for less than 1 month
  • February 4, 2024

For Weight Loss (Obesity/Overweight) "I just started Zepbound 2.5mg two days ago and OMG, I cannot eat ANYTHING! I keep having waves of nausea that feels like I have a stomach virus! OMG people TRY THIS MEDICATION! My insurance wouldn't cover it, so I paid $1292 cash for the month's supply. I have been overweight my entire life, but THIS METHOD IS THE EASIEST WAY TO LOSE WEIGHT! I did weigh myself (after only 2 days), and I lost 8 lbs so far. Next week I am only going to take a half dose (1.25mg) because the nausea has been really awful. I am an actual patient and just wanted to share my progress... THIS MEDICATION IS TRIED AND TRUE! Good luck!"

10 / 10
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132 Report
  • LLR...
  • Taken for less than 1 month
  • January 28, 2024

For Weight Loss (Obesity/Overweight) "It works but side effects are too much for me. I started 2.5 injections and immediately felt nauseous and vomited every day. I never felt hungry or had the desire to eat. I could only eat a handful of grapes or a few bites of food, and it felt like it never digested. The constant taste of stomach acid/vomit in my mouth made me miserable. Food stayed in my stomach for over 24 hours, which was disgusting. It's like I could still taste it. The lack of any food made me feel exhausted. I missed 2 days of work. I lost 5-6 pounds in 1 week, but the side effects aren't worth it. I won't be continuing. That's a lot of money down the drain, $550 for a 1-week trial. If it weren't for the stomach not emptying and vomiting, I would keep taking it."

6 / 10
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  • Amf...
  • Taken for 1 to 6 months
  • January 21, 2023

For Type 2 Diabetes "I was on Mounjaro for 2 months. I had side effects of lower back pain, increased thirst, and decreased urine output. I increased my fluid intake, cut out all sugary drinks and foods. I could barely eat. I was on 5 mg. I woke on 1/16/2023 vomiting black coffee-like grounds. I went to the ER that afternoon and was admitted. After many labs and scans, I found out my liver was in shock. All liver enzymes were elevated. I am talking 1100 numbers elevated from what the normal is, 40 ish. My liver was on the way to shutting down. My body was shutting down. I also had a GI BLEED. Do not take this medication. There is not enough information!!!"

1 / 10
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  • ibd...
  • Taken for less than 1 month
  • January 28, 2025

For Weight Loss (Obesity/Overweight) "Started the shot on Wednesday, was kind of nervous. Ate small portions, so I wouldn't get nausea. Didn't really think it was working, didn't feel any different. It is now Monday, I have lost eight pounds. I'm never hungry, have to remember to eat, don't think about food really except fruit, it always sounds good. Absolutely no negative side effects. Started at 187, am now at 179. This is on my first shot! This stuff is amazing, looking forward to that second shot! It's expensive since state insurance doesn't cover it, and I only work part-time, but worth every cent!"

10 / 10
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  • Mom...
  • Taken for less than 1 month
  • March 11, 2023

For Weight Loss (Obesity/Overweight) "I have been struggling on the weight loss rollercoaster for a while. Up 30 lbs, down 15 lbs, and so on and so forth. I'm taking a compound Mounjaro with B12. I have only been on 2.5 mg for less than a week and in that time, I feel GREAT! I've lost 3 lbs and don't crave midnight snacks, or snacks at all for that matter. The first couple of days I was unsure if I wanted to continue. I was exhausted, I couldn't think clearly, and had no energy. My body ached all over - no one had mentioned this, and just flat out was about to think that this was not for me. Day 3 and I felt great both physically and mentally. I hear people go up on dosage even after losing weight the first month, and unless I stall in my loss, I will continue on 2.5 mg. Remember, too much weight loss in a short amount of time isn't healthy. Slow and steady will help you keep the weight off when you stop taking this medicine (obviously with a change in your eating habits). Why put more drugs into my body than what is needed?"

10 / 10
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171 Report
  • cla...
  • Taken for 1 to 6 months
  • December 26, 2022

For Type 2 Diabetes "I completed 4 weeks on 2.5 mg with zero side effects, other than the intended appetite suppression and lost 10 pounds. HOWEVER, after my second week at 5mg, I'm not sure I can continue. I've had awful nausea, vomiting, sulfur burps, and diarrhea, to the point I had to go to the ER for IV fluids and potassium. Zofran, Phenergan, Tums, and Pepto have zero effect. I can barely function, but hey, I'm down a total of 17 lbs in 6 weeks, so at least I'll look skinny for my next trip to the ER."

6 / 10
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188 Report
  • Mar...
  • Taken for 1 to 6 months
  • June 29, 2024

For Weight Loss (Obesity/Overweight) "Update on my review from May 25, 2024. I have now been on Zepbound for 16 weeks. Current dosage 10 mg. In these 16 weeks, I have lost 40 pounds, from 204 lb to 164 lb, and my waist size has gone from 40 inches to 36 inches. For context, I am 5'10' tall. Even more incredibly, my blood pressure has decreased from 195/90 to an average of 116/60 as of today. I have more energy and am running regularly 5 days per week. I am also sleeping better, which I think comes from a lessening of sleep apnea symptoms. The only remarkable side effect has been occasional constipation, which is relieved by Miralax. With not only weight loss but improvement in other health measures, I consider my Zepbound treatment to be quite successful!"

10 / 10
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  • SJ4...
  • Taken for 6 months to 1 year
  • September 12, 2023

For Weight Loss (Obesity/Overweight) "In the beginning, I couldn’t bend over to tie my shoes without having to take a break to breathe, or go through my 8-hour shift on my feet without having knee and ankle pain to the point of tears. I couldn’t wait until I was able to sit down and not get up but just to turn around and do it again. Injecting myself with very simple and easy steps to follow. I had very few side effects, only an occasional loose stool or nauseous sensation once in a while. My starting weight was 248 pounds and I am now 160 pounds. This has been a huge impact on my physical health. I'm able to walk and move throughout my day without having pain from the extra weight and stress on my joints."

10 / 10
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  • Hop...
  • Taken for less than 1 month
  • July 29, 2022

For Type 2 Diabetes "Started on 2.5 mg 3 weeks ago. I’m 5’2” and starting weight was 175.4, my highest was 180. I decided to try medication after my waist was 39 inches. After my 3rd injection, I am now 165 and lost 3 inches off my waist. This is with minimal exercise and mostly appetite suppression. Bacon and eggs that I have eaten faithfully as part of an attempt at the keto diet, I just can’t eat. Food is unappealing. I’ve struggled 2x this week to reach 1200 calories. That has never happened to me before. Side effects: indigestion, fatigue. Hoping this continues to work with minimal adverse events. I’ve been gaining/losing the same 3-5 pounds since my daughter’s birth 5 years ago. This makes sticking to a meal plan so much easier. My binge eating during “shark week” had gotten out of control. I’d like to add my kettlebell training back, hoping I get some energy back."

8 / 10
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