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Tirzepatide for Type 2 Diabetes User Reviews

Brand names: Mounjaro, Zepbound

Rating: 8.3

Tirzepatide has an average rating of 8.3 out of 10 from a total of 963 reviews for the treatment of type 2 diabetes. 77% of reviewers reported a positive experience, while 7% reported a negative experience.

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Reviews for Tirzepatide

Commonly mentioned side effects
  • Mis...
  • Taken for less than 1 month
  • September 13, 2022

"I usually don’t share reviews but felt this was warranted. I took my first 2.5 mg shot on 9/4, felt fine until 9/7 when the terrible sulfur burps started followed by sour stomach and nausea. Around 10 pm that night, I began 5 days of severe vomiting and diarrhea, which culminated yesterday at the ER getting fluids, CT scans, and IV nausea meds. I will not be taking this shot again. I have not thrown up anymore, but the diarrhea will just not stop. I can’t eat or take any of my other medication properly. Beware. When something sounds too good to be true, it usually is. I’m a past user of Byetta, Victoza, Ozempic, Trulicity, Rybelsus, Bydureon, all the pills, and about every homeopathic treatment ever made. I didn’t take this shot like a blind fool, but I have never had a side effect as terrible as this one. I’ll stick with my insulin. At least I can function like a normal human being!"

1 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • September 14, 2022

"I started with this medication for weight loss, and since I am 58 and a diabetic, my insurance covered it. It is a fantastic weight loss drug for me. Starting at 5'6, 242 lbs, I've lost 23 pounds in 12 weeks. I don't remember when I was able to lose this much weight. I've dieted my whole life and finally gave up and ballooned to 242 lbs. You have to be careful about eating greasy food and not overeating. I did vomit a few times after eating greasy food. Other than that, I'm so excited. My first goal is to get to 180 and see what happens. My feet no longer hurt when I stand all shift."

9 / 10
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  • Jav...
  • Taken for 1 to 6 months
  • January 20, 2023

"This is my 2nd time posting. Was on Trulicity in the past & now Mounjaro 5mg, 7.5mg & bumped to 12.5. Effects for me are minimal & not bad, at all. Some days the acid reflux or constipation is bad, but it's not way off the charts & is manageable. One thing I noticed, as my doctor progressed me up the ladder to higher doses of Mounjaro...the weight loss is amp'ing up. Gradually starting to lose more per week than when on lower doses. Also, on 5 mg & 7.5mg, I noticed on days 1-4, I wasn't hungry AT ALL & knew that I needed to eat; therefore, I thought of food as FUEL, not just tasty & I made better/healthier choices. Now, on 12.5mg, I find days 1-5 or 6....I'm not hungry at all & still making better food choices, because I have to make myself eat. The 'in between meals snacking' has totally GONE AWAY. This drug has been a miracle for me, as my Thyroid Hashimoto's has caused so much weight gain w/the slower metabolism & I couldn't lose any weight until Mounjaro. It's a blessing!"

10 / 10
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Frequently asked questions

  • Mik...
  • Taken for 1 to 6 months
  • September 20, 2025

"Mounjaro has been a lifesaver for me. Took 2.5 for 1 mo, then titrated up to 5 last week. Lost 12 lbs so far and BP (was 150/95 ish) and BS (161 on my last test) have dramatically reduced to the normal range. Will be going off of 1 of my BP meds next week already. Only symptom I have had so far was nocturia for the 1st week of each dose, which made me pretty tired that week. I had a huge food noise problem before, now with that reduced I can plan out and make great food choices. Going to the gym 4 times a week now and my overall outlook on life is just so much better."

10 / 10
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  • Amf...
  • Taken for 1 to 6 months
  • January 21, 2023

"I was on Mounjaro for 2 months. I had side effects of lower back pain, increased thirst, and decreased urine output. I increased my fluid intake, cut out all sugary drinks and foods. I could barely eat. I was on 5 mg. I woke on 1/16/2023 vomiting black coffee-like grounds. I went to the ER that afternoon and was admitted. After many labs and scans, I found out my liver was in shock. All liver enzymes were elevated. I am talking 1100 numbers elevated from what the normal is, 40 ish. My liver was on the way to shutting down. My body was shutting down. I also had a GI BLEED. Do not take this medication. There is not enough information!!!"

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  • cla...
  • Taken for 1 to 6 months
  • December 26, 2022

"I completed 4 weeks on 2.5 mg with zero side effects, other than the intended appetite suppression and lost 10 pounds. HOWEVER, after my second week at 5mg, I'm not sure I can continue. I've had awful nausea, vomiting, sulfur burps, and diarrhea, to the point I had to go to the ER for IV fluids and potassium. Zofran, Phenergan, Tums, and Pepto have zero effect. I can barely function, but hey, I'm down a total of 17 lbs in 6 weeks, so at least I'll look skinny for my next trip to the ER."

6 / 10
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  • Hop...
  • Taken for less than 1 month
  • July 29, 2022

"Started on 2.5 mg 3 weeks ago. I’m 5’2” and starting weight was 175.4, my highest was 180. I decided to try medication after my waist was 39 inches. After my 3rd injection, I am now 165 and lost 3 inches off my waist. This is with minimal exercise and mostly appetite suppression. Bacon and eggs that I have eaten faithfully as part of an attempt at the keto diet, I just can’t eat. Food is unappealing. I’ve struggled 2x this week to reach 1200 calories. That has never happened to me before. Side effects: indigestion, fatigue. Hoping this continues to work with minimal adverse events. I’ve been gaining/losing the same 3-5 pounds since my daughter’s birth 5 years ago. This makes sticking to a meal plan so much easier. My binge eating during “shark week” had gotten out of control. I’d like to add my kettlebell training back, hoping I get some energy back."

8 / 10
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More FAQ

  • lar...
  • Taken for 1 to 6 months
  • September 22, 2025

"Adrenaline rushes, last for a few hours, heart beating fast, anxiety, losing weight fast, appetite less. I don't like anxiety feeling. Blood sugar in the 70's-90, no other side effects. Once a week 10 mg."

9 / 10
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  • Kar...
  • Taken for 1 to 6 months
  • October 25, 2022

"I have had A1C 11 after two months of using Mounjaro, it's now 7, and I have been losing 2 or three pounds a week. A friend took a picture of me, and I actually saw the weight loss. I am 64 years old. I have had high blood sugar and pressure for over 10 years, so it's more than just nice to be normal. Thank you, Mounjaro medicine helped with both."

10 / 10
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  • My ...
  • Taken for 1 to 6 months
  • February 13, 2023

"Started 10/26. Weight 245, female. 2.5 1x, 5, 1x, 10mg, last 2 months. Current 214. Zero exercise unfortunately. I have read so many reviews and I am baffled at all these bad side effects, since mine were so minor (except constipation and tiredness day after injection). Learned early, no sugar, breads, or pasta/potato. I take no other meds, do a strict low carb and fast. I have a protein shake at noon, a meat and a LC veg for dinner (small portion always), then freeze a protein shake for two hours and it makes ice creamish. Delish! That’s all I eat daily. Hunger is now fully controllable! My A1C started at 6.7, BUT I was on low carb for 6 weeks prior to blood work so likely much higher in general. Last week's blood test showed A1C at 5.0. My ALT SGPT (liver) was high last test, and normal range this time. What did go up were my top 4 CBC numbers. Overall, this is a game changer. So grateful. I truly believe eating right is the key when on this med. Hope this helps someone."

9 / 10
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  • Ric...
  • Taken for 1 to 2 years
  • February 5, 2025

"I currently have renal failure. I needed a kidney and pancreas. I was on the list for both. I did all my workups, even a triple bypass. My doctor put me on Mounjaro because of my heart surgery and diabetes. The Mounjaro worked so well it fixed my pancreas, and now I’m just on the list for a kidney. The side effects of using it were a little diarrhea and weight loss. I was 300-plus pounds, now I am under 160. Plus, I am no longer needing insulin for my diabetes. It’s practically gone."

10 / 10
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  • Con...
  • Taken for less than 1 month
  • October 2, 2022

"Started taking 2.5 last Thursday. Day 1, no side effects, day 2, mild nausea, day 3, everything broke loose! Dizzy spells, clammy sweats, severe abdominal pains, and bloating. Ended up in ER and blood pressure was so high I was at stroke level! Readings were 220/123, 187/113, 197/116, 178/112! No issues before medication! Beware, this medication is so new there is no telling how many other side effects it can have! I pray this mess gets out of my system soon!"

1 / 10
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  • Kat...
  • Taken for 1 to 6 months
  • January 20, 2023

"I started Mounjaro to help control my blood sugar. I had tried Ozempic and Trulicity and could not tolerate the nausea, sulfur burps, and stomach issues. Mounjaro has been life-changing. No bad side effects. I’m not hungry, I don’t have cravings, I’m losing weight steadily, and sweet desserts taste too sweet. Many people say they’ve had bad side effects with it. I say try it as it may work for you. Just like I couldn’t use other meds that other people love. For me, it has been life-altering."

9 / 10
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  • Joy...
  • Taken for less than 1 month
  • September 18, 2022

"I was prescribed Mounjaro for weight loss. I took my first 2.5mg dose on Friday, 9/16. Today is Sunday, two days later, and I have yet to feel anything different. I don’t feel full, and there’s no lack of desire to eat. I feel the same as I always have. I wonder if I did the shot right. I don’t know, maybe it takes a moment to kick in. I see people saying they lost weight in the first week, I’m not sure how that’s possible if I don’t have appetite suppression. I guess time will tell."

2 / 10
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  • Car...
  • Taken for 1 to 6 months
  • October 21, 2022

"I am 6ft and started at 213lbs. Blood sugars were a little elevated and I could see they were headed in the wrong direction. I also have severe sleep apnea. I started at 7.5 and just finished my fourth week. This drug is amazing. I’m down 24 lbs in 28 days. Lost 4 lbs last week. Current weight is 189lb. Goal is 175lb. I check my blood sugar 2 or 3 times a day. My highest reading was 101 about an hour after eating. Most readings in the low 80s which is perfect. I couldn’t have asked for more from this drug. Side effects are constipation (drink lots of water) and tired the day after the shot. I’ve been slightly overweight my entire life. I hope to lose this weight and then see if the sleep apnea goes away. Life changing."

10 / 10
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  • Pen...
  • Taken for less than 1 month
  • September 23, 2022

"I started taking Mounjaro on 9/1. This resulted in the very worst month of my life. WEEK ONE - Super Nauseous, indigestion, stomach pain for 3-4 days of the first week. My appetite went from a 10 to a 2 (which was good). WEEK TWO - I had diarrhea for 3-4 days, along with sulfur belches, nausea, stomach pain. I ended up having to take sick days and go get an IV bag to recover from the dehydration. WEEK THREE - World-class nausea and vomiting. 3 days of vomiting so hard that I ruptured my esophagus. The entire month, if I was not having diarrhea, I was VERY constipated. I lost 9 lbs in one month, but I don't know if it was because I could barely eat due to the sickness. PASS!!"

2 / 10
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  • Tee...
  • Taken for 1 to 6 months
  • October 13, 2022

"I have been on 2.5 mg for 5 weeks. My starting weight was 263. I have lost 15 lbs. with no side effects. My doctor has placed me on the 5 mg dosage. Hopefully I will continue losing weight with no side effects."

10 / 10
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  • Gav...
  • Taken for 1 to 2 years
  • February 4, 2024

"I am a 6'2", 46-year-old male who started his journey at 305 lbs. My doctor prescribed me Mounjaro 10.0 in Jan. of 2023. In Dec. of 2023, I went to level 12.5. Mounjaro, along with a balanced diet and exercising 4-5 days a week, changed my life for the better. I went from a 'Living to Eat' person to an 'Eating to Live' person. Mounjaro helps me mentally and physically. After I eat, I feel fuller longer, and I don't get food cravings. It's amazing!! I went from 305 lbs to 238 lbs. That is 67 lbs in 13-14 months. I am off all insulin. I stopped snoring at night. I am participating in 5K races. Achieving goals and having fun! Team Gavin, I treat my body like a football team - Offense - gym four to five days a week, Defense - portion control, Special Teams - Mounjaro injections once a week. I don't think I could be doing this well without all three. The journey continues for me, and I hope after you read this, it begins with you. Good luck!"

10 / 10
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  • Mim...
  • Taken for 1 to 6 months
  • December 29, 2022

"I'm type 2 diabetic and was on Ozempic for quite some time and having difficulty getting my medication. My doctor changed me to Mounjaro for my diabetes thinking I would be able to get my meds. I started on the 5 mg since I had been on Ozempic. My side effects were typical slight nausea. I was trying to get my second month filled and the issues started with availability AGAIN. The 5 mg and 7.5 mg were on backorder. He increased my dose to 10 mg. I have experienced sulfur burps, but that is about it. I have not seen much weight loss, but then again I'm more concerned about my diabetes. Shame on the drug companies for dangling a medication that works to lower A1C and cholesterol and choosing to utilize it for weight loss where the insurance won't cover it. I'm not using this medication for vanity, it's for my chronic disease."

7 / 10
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  • Nim...
  • Taken for 6 months to 1 year
  • September 20, 2025

"Easy to use. Very little discomfort with the injection. Mounjaro definitely lowered my A1C after about 6 months of use at the 10mg dosage. I started at the 7.5mg level and have lost about 30 lbs. I’ve not had any noticeable side effects except decreased appetite and a little constipation. The cost is extremely high, but insurance allows me to continue use. Without insurance, I could not afford it."

8 / 10
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  • gre...
  • Taken for 6 months to 1 year
  • September 20, 2025

"I do have DM2 and have had it for years. But the reason I started Mounjaro is that I was on the cusp of being obese and needed to lose weight quickly. Between January 2, 2025, and January 24, 2025, I lost 18 pounds on Mounjaro. That's 18 pounds in three weeks and one day. And it wasn't hard to do! But after that, despite upping the dosage from 2.5 grams to 7.0 grams, it took about 5 more months to lose another 22 pounds. So in about six months, I lost exactly 40 pounds. Even though I wanted to lose at least 5 more pounds, I stopped Mounjaro because I suspected that it was the cause of my incessant diarrhea. I couldn't have lost 40 pounds in a million years without Mounjaro. Grateful."

9 / 10
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  • Joh...
  • Taken for 6 months to 1 year
  • September 20, 2025

"Helped control my numbers better than without. Some stomach pains, but nothing I couldn't handle. Lost 40 lbs in six months, but nothing in the last two months. Started on the high dose and see if it will help me get to the desired weight I'm looking for."

6 / 10
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  • Ang...
  • Taken for 1 to 6 months
  • December 6, 2022

"This is my fifth week, and I started on 2.5 mg and now on 5.0 mg. I have had only one side effect: dry mouth, but I lost 29 lbs in the first month. I weighed 243 lbs and now I am down to 214 lbs. If you don’t eat fried foods, sugar, or heavy carbs, you will do great. I don’t overeat anymore. Plus, I exercise, I walk 5 miles a day. I drink at least 64 fl oz of water. This medication is worth taking. I had no issues at all and feel great. I can’t wait to fulfill my journey. The key is to follow a plan. If you want a life change, this is it! I used the coupon, and only certain pharmacies know how to code it. I got lucky because my pharmacy worked with me."

10 / 10
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  • Nop...
  • Taken for less than 1 month
  • September 15, 2022

"Holy side effects. First, if you eat when you take it, it just sits in your stomach and you’ll be burping it for 12 hours. The headache is insane. Starts immediately. Then you are hit with 3 days of nausea, fatigue, and just overall fatigue. Just when you start to feel better, cue the insane heartburn! It took me 5 days to feel normal again. I’ll pass on this even though I lost 5 pounds the first week."

2 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • January 19, 2023

"I tried Ozempic for 9 weeks and thought I was going to die, so they switched me to Mounjaro. The 1st 2 weeks were okay, I just didn't have an appetite, but week 3 hit me just like Ozempic did. Total exhaustion. I've lost 5 lbs in a little over 3 days. I have side effects of sulfur burps, dehydration, constant nausea, falling asleep at all times, all-night vomiting, and diarrhea. I feel bruised from head to toe and have blurred vision. I'm telling people this for a warning. Read the reviews. People are constantly going to the ER because of these medications. I'm flustered because I found something that worked for my diabetes, but it is really bad for me. Since starting Ozempic up to now, I've lost almost 30 lbs... might sound great, but not when you can't function."

1 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.