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User Reviews for Sunosi

Sunosi has an average rating of 4.6 out of 10 from a total of 43 ratings on Drugs.com. 27% of reviewers reported a positive effect, while 45% reported a negative effect.

Condition Avg. Rating Reviews Compare
Narcolepsy  
4.5
31 reviews 17 medications
Obstructive Sleep Apnea/Hypopnea Syndrome  
4.8
12 reviews 3 medications
Summary of Sunosi reviews 4.6 43 reviews

Reviews may be edited to correct grammar/spelling, or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published.

Reviews for Sunosi

LolaBear November 27, 2019

For Narcolepsy: “I have been diagnosed with Idiopathic Hypersomnia - a VERY close relative of narcolepsy without cataplexy. I started on Sunosi 75 mg per day. That did nothing. I only experienced relief at the full 150 mg dose. Effects start about 1 hour after I take it, shorter on an empty stomach. When I take the 150 mg dose, I am able to focus and don't feel "jittery" or agitated at all. It's a very nice medication for that reason. I find it's much more gentle than caffeine. The downside - this effect only lasts 3 hours. On the fourth hour, I start to "crash" and get very tired. I cannot resist a nap. This is counterproductive but common with every stimulant. So, my doctor is trying me out on a low 5 mg dose of the short-acting form of Adderall to "cover" me during this crash. I will report back on the combination soon. Hope this review helps someone!”

7 / 10
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DP April 10, 2021

For Narcolepsy: “I started Sunosi 2 weeks ago for Hypersomnia. This medication may be life changing. Before taking Sunosi, I was miserably dragging myself out of bed ever morning, not knowing how I would make it through the day. My daily life consisted of working, constantly yawning, craving one more minute to close my eyes, napping 3-4 hours every day after work, and sleeping all night. Then, I would sleep the entire weekend away. A terrible “existence.” Since starting Sunosi, I wake up much easier, my constant yawning has decreased by about 90%, and the best part is my daily 3-4 hours naps are disappearing! A couple days I’ve taken 2 hour naps (huge improvement), but I’ve also gone many days with NO naps!!!! I start to get tired around 8pm and head to bed almost like a normal person. I do get a slight stomach ache at times, but eating usually helps. Thank you, Sunosi for HOPE!”

9 / 10
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Tired of Being Sleepy November 13, 2020

For Obstructive Sleep Apnea/Hypopnea Syndrome: “I've been taking Sunosi 75mg for over a week now. First couple days I didn't notice any difference. Normally I am in bed 7:30 or 8pm at the very latest because I could not stay awake. I yawn all day long and just ready to drop. I can not ever get enough sleep even if its 12 or more hours. On the 3rd day of taking Sunosi I had to catch myself because I looked at the clock and it was 10:30pm. I was not ready for bed but I forced myself because I knew I would pay for it in the morning. I woke up before my alarm went off at 4am. It had been the same every day since. I still yawn occasionally during the day but I am able to stay up much later and wake up easier in the morning. Thank you Sunosi!”

9 / 10
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jw November 3, 2019

For Narcolepsy: “I got the free trial of 15 Sunosi pills. When I started using it I didn't feel any better still felt very tired. On the 2nd day of use I started getting a bad headache and I still felt really tired I also checked my blood pressure it was starting to get higher than normal and my stomach was starting to bother me. After the 3rd day stomach got worse still had bad headache and blood pressure was getting higher some slight chest pain. So after that I stopped taking it and now it's been a week since I have been off of it and no headache or stomach problems and blood pressure is down. The only thing I know is all the drugs that I have taken for narcolepsy had bad side effects and they all seem to be a bandage to fix the problem. I hate all of these meds because no one knows what damage you're doing to your body taking these meds that's why none of this stuff is good for you.”

1 / 10
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Dissatisfied · Taken for 6 months to 1 year March 3, 2020

For Narcolepsy: “I have had narcolepsy and been on Adderall or Nuvigil for 20 years. I did the 75mg To 150mg and at 12 weeks I thought my life has changed. Then at 16 weeks I come home from work more exhausted and tired than I can remember as if I’m not taking anything. I’m withdrawing from life -to sleep by 7pm Unless I throw Ritalin at it which I’ve never had until now (odd?) I’m worthless by 5. Then I’m up at 330 or 4am. Let me off the Roller coaster Ride”

3 / 10
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Mdezify · Taken for less than 1 month July 30, 2019

For Narcolepsy: “I started at 75mg at 7am. By 12:30pm I crashed and could barely stay awake. I’m now taking 75mg upon waking and 75mg two hours later. The best way I can describe it is that I’m awake but not overly motivated to do anything and I’d rather be sleeping. However, it’s the best option I have at this point because nothing else seems to work.”

7 / 10
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Sleepy Mommy · Taken for 1 to 6 months July 30, 2020

For Obstructive Sleep Apnea/Hypopnea Syndrome: “I've been taking Sunosi for around two months for OSA. I started at 75mg daily and I've been taking 150mg for about two weeks. It is probably important to note that I also take 250mg of Nuvigil and 20-60mg of adderall daily as well. I started the Sunosi with the goal of stopping the adderall. My diagnosis is severe OSA with excessive daytime sleepiness. Narcolepsy was ruled out although I experience restless legs and occasional sleep paralysis. I hold my breath in my sleep and wake up feeling like I am suffocating because I cannot force myself to breathe. I have used a CPAP regularly for more than 10 years, and the data shows that my sleep apnea is well controlled. But even so I sleep between 15 to 18 hours per day Sunosi was ineffective at 75mg. At 150mg I am awake but too fatigued to do anything. It has caused anxiety, headaches, excessive sweating, nausea, and diarrhea.”

5 / 10
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Frequently asked questions

Sael · Taken for less than 1 month September 27, 2019

For Narcolepsy: “Sunosi 75mg a day has changed my life. I’m awake and not sleepy all day - it even seems to help me wake up in the morning. I don’t get the crash I did with adderall. It’s a much more natural awake feeling. Even spending an entire day in front of a computer I didn’t get sleepy.”

10 / 10
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So tired · Taken for 1 to 6 months January 7, 2021

For Narcolepsy: “I’ve been on and off Sunosi for 6 months. I’m still tired and the side effects are not great. The extreme dry mouth and clinching my jaws are driving me crazy. Going to see if my DR can give me something else to take.”

4 / 10
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Mickey · Taken for 1 to 6 months September 11, 2020

For Narcolepsy: “I was just diagnosed May 2020 with Narcolepsy. I was given another drug that worked at first then stopped after about 2 months. So my doc prescribed Sunosi. It did not help at all. I call him and he tells me to double my daily dose, so I do. Still don't feel anything, still am exhausted, no energy! I've been having a heck of a time with my insurance not wanting to fill it then it doesn't work when I do get it finally. Disappointed.”

1 / 10
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Silverado November 15, 2019

For Narcolepsy: “I didn’t have a lot of high hopes for Sunosi, I thought it would be very similar to Nuvigil/Provigil. I tried to 75 mg we jumped up to the 150 within two days doctor even had me take an additional 75 mg to make it to 225mg, which is over the recommended dose, and I still felt absolutely nothing on any dosage. It’s labeled as a Norepinephrine, Dopamine re-uptake inhibitor or a NDRI. Which there are several already on the market but their use is for anti-depressants, however a NDRI according to all the medical research I’ve seen would take weeks to reach full effect. I don’t understand how Sunosi can possibly block reuptake of dopamine and norepinephrine within 20 to 30 minutes to achieve the affect needed. So I hope this helps somebody make sure you get free samples or get it covered by your insurance. The manufacturer also offers a discount card which makes it only $8.00. Do not pay cash for this medication until you’ve tried it.”

2 / 10
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TiredAf · Taken for 1 to 6 months October 29, 2019

For Narcolepsy: “So I’ve been taking the 150mg for about five months now, at first it seemed like it was helping me and I didn’t get the crash with the Adderall. At this point I’m not sure if I still feel that way. I still get excessively tired and I am extremely moody. I don’t have any motivation at all and I feel as though my chest is tightened around hour two and I’m almost in a daze/fog. The depression associated with the narcolepsy seems to be getting worse. I definitely think I need to change it. I was never on provigil/nuvigil since I was diagnosed right when this drug came out.”

5 / 10
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zork · Taken for 1 to 6 months April 3, 2020

For Narcolepsy: “Sunosi is very disappointed so far. Disturbing my husbands sleep more as he is having more awakenings. Not seeing much difference after taking except more irritable. Also cannot seem to stay awake for long at all during the day and when he is awake no motivation, fatigued. So far does not look like the drug for him. Better on older stimulants.”

1 / 10
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Sleepy April 24, 2021

For Obstructive Sleep Apnea/Hypopnea Syndrome: “I have OSA and use a CPAP. I also have severe RLS which is treated with oxycodone. I am constantly tired. I heard about Sunosi and asked my doctor about prescribing it for me. She first wanted to try modafinil. This did absolutely nothing and actually made me feel worse from the side effects, which I found later that oxycodone and modafinil have “major” interactions. (Not sure how my doctor or the pharmacist dropped the ball on that one). So finally my doctor agreed to try the Sunosi. Started at 75mg, felt absolutely nothing good or bad. After several days went up to 150mg, still no improvement in my sleepiness after several weeks of trying. I’m now weaning off ( as recommended by my doctor) since the medication did nothing for me, and I feel awful. I’ve been having panic attacks and my heart rate has been elevated and I also feel achy all over! Not sure if anyone else has had this experience trying to get off the medication but I feel worse than ever!”

1 / 10
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Eddie · Taken for less than 1 month November 16, 2019

For Obstructive Sleep Apnea/Hypopnea Syndrome: “First day took half of 75mg. Went home and took a nap. Woke up and took the other half, still went to bed a few hours later. Medicine had no effect on me. Got up the next morning took a whole 75mg in the morning. Felt sleepy on my way to work an hour later. Felt ok through the morning at work but when the afternoon came it all changed. I got sleepy and very agitated. I felt like I hadn’t slept in 3 days but my eyes were forced open. I felt terrible and was very angry and bothered. Tried a whole again the next morning. Here I am laying on the couch ready to take a nap 5 hours later. I feel like the medicine has no effect whatsoever other than annoying me and keeping my eyes open when my body desperately wants sleep.”

1 / 10
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Cocco · Taken for 1 to 6 months December 31, 2019

For Narcolepsy: “I was given 75 mg Sunosi for my narcolepsy. On the positive side I can tell the difference in energy, concentration, motivation and productivity and there is decreased need for a midday nap. Negative: this drug causes major heart issues. I have atrial fibrillation and I cannot take this medicine regularly as it increases my heart rate to 120 and raises my blood pressure. However, I try to take it once in a while if I have a commitment or something important to do like running errands, or needing to go somewhere. I am on Xyrem 4.5 for narcolepsy with excessive day time sleepiness which although helps me sleep about 6-7 hours it no longer helps me wake up refreshed as it did the first time I tried it. I also take Doxepin to sleep longer but it leaves me feeling too tired the next day and counter the effect of a good night sleep. I take a nap in the afternoon except on the day when I take Sunosi.”

8 / 10
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Anonymous February 6, 2020

For Narcolepsy: “I shared the experience of another person that added a review. I was so excited the second day I was on this medicine because I wasn't tired and didn't have any other side effects. Fast forward two weeks, my chest erupted in hives and I went to urgent care. They put me on a steroid pack for six days. While I don't have a rash any longer, I'm extremely itchy, have pins and needles on my face, tongue, throat, and eyes. I stopped the drug and am on another round of steroids in the morning and Zyrtec at night per my primary. I also had an increasing heart rate which made me very uncomfortable. That has generally subsided.”

2 / 10
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Sidney · Taken for less than 1 month September 30, 2019

For Narcolepsy: “I was put on 150 mg Sunosi for excessive daytime sleepiness. I took one day and I was awake, but not motivated and could not focus on anything or be productive. I have been on Provigil for many years and they said this medication was better than provigil. I hope it works for others”

1 / 10
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Anonymous August 27, 2019

For Narcolepsy: “Started with 75mg for about 5 days and then went up to 150mg. At first, the medicine seemed that it would work once I got used to the side effects and learning how to take it so that I was awake during the day but that it didn't keep me up at night - I was more awake during the day without really thinking about it. Unfortunately on about the 7th day of taking Sunosi I had a horrible "drug eruption" reaction. I went to urgent care and they put me on steroids to help with the swelling and I obviously stopped taking the drug. My face completely swelled up and developed a horrible itchy rash all over my body. It has been over ten days now and although things are getting better I still have an extremely itchy rash over most of my body. I am not allergic to any other medication and have never had a reaction like this. The other side effect I noticed during the week of taking it was lack of appetite.”

2 / 10
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Rye guy · Taken for less than 1 month March 11, 2020

For Narcolepsy: “75mg taken in morning I usually expect my medication for my narcolepsy to take effect after about 1-2 hours depending if I eat with it however at 75mg I can’t really say if I feel it working I still feel tired during the day even though I don’t fall asleep. I definitely feel I would fall asleep if I didn’t preoccupy myself like playing a game on my phone to keep myself from closing my eyes. If I did close my eyes I feel I’d be likely to fall asleep especially if I had a busy day or a bad night with little sleep.”

4 / 10
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SleepyKitty · Taken for less than 1 month October 23, 2019

For Narcolepsy: “I’ve been on 150mg of Sunosi for two days and I can barely stay awake. I was previously on modafinil, but after years of taking it, it stopped working for me. I am not impressed with Sunosi at all, and will be looking for something else until I can go back to modafinil.”

1 / 10
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Ms tired · Taken for less than 1 month September 20, 2019

For Obstructive Sleep Apnea/Hypopnea Syndrome: “Sunosi doesn’t work for me. It’s been about a week at 150mg. It makes me crash hard at the end of the day (around 4pm). At the end of the day, I’m more tired than if I didn’t take it at all. I’ve been waiting for this “miracle medication “ for a few months and I’m disappointed. Nuvigal was great but it stopped working .”

1 / 10
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OrlandoBound · Taken for less than 1 month August 9, 2021

For Obstructive Sleep Apnea/Hypopnea Syndrome: “I have used my CPAP religiously. But even after starting CPAP, I was still exhausted. After work was a nap until I had to go pick up my husband. My lunch time was a nap. Getting out of bed in the morning was considered cruel and unusual punishment. I had decided to just live with it. But then one of my doctors suggested Sunosi. I was a little skeptical, but desperate to stay awake longer. The 75 mg didn’t have much of an effect on me, but boy, the 150 mg has been life changing! I’m thinking more clearly, daytime napping is gone, and I’m able to get to sleep at a decent hour because I haven’t napped. It wonderful to feel like a normal human instead of constantly being exhausted.”

9 / 10
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AngdHan · Taken for 1 to 6 months September 25, 2021

For Narcolepsy: “I have been reading these other reviews, and other than the people with allergic reactions, I don’t feel that most of them are giving the medicine enough time to work. I have been on Sunosi for three months now, and the side effects have changed over time. Everyone knows it can take your body some time to adjust to medication. I have been diagnosed with Obstructive Sleep Apnea with excessive daytime sleepiness, but my neurologist thinks I do have Narcolepsy, too. He started me out on 75 mg, but I didn’t notice any difference and after two weeks he doubled it to 150 mg. One side effect I had at first was agitation, but I rode it out and after a while I noticed that I wasn’t feeling agitated anymore. Also the way my body reacted to the drug changed over time. At first I would crash around lunchtime and early afternoon, but wake up during the evening. Now the afternoon crash is a lot better. This is a great medication, but you’ve got to give your body time to adjust.”

9 / 10
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Katy · Taken for 6 months to 1 year August 6, 2021

For Obstructive Sleep Apnea/Hypopnea Syndrome: “I started using Sunosi about 6 months ago. I started out on 75 mg and upped the dosage to 150 mg. I know you are suppose to take it in the morning, but it does not get me through an entire day. So I started taking it around noon or 1pm and that has worked well for me. If I know I am going out for the evening, I will take another one around 5-6 pm to get me through the night until about 11pm. What I like is, not having any side effects. Unfortunately, my insurance won't pay for Sunosi so I am being forced to switch to Nuvigil which is a narcotic, so I am not happy about that. My doctor was giving me free samples (thank goodness). I would recommend Sunosi to anyone, in fact I am going to see if I qualify for their $9.00 coupon for a year because I don't want to take a narcotic.”

8 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.