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Sunosi and Insomnia: What Users Say

Insomnia: mentioned by 5 users (6.3%)

Based on user experiences from 80 Sunosi reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

irritability 8.8%
high blood pressure 7.5%
increased heart rate 7.5%
tiredness 7.5%
insomnia 6.3%
anxiety 5.0%
fatigue 5.0%
headaches 5.0%
nausea 5.0%
depression 3.8%

Reviews for Sunosi

  • Tnd...
  • Taken for 1 to 6 months
  • October 20, 2021

For Narcolepsy "I had spent months just eating enough to live. Going to the store was too much effort. Sleep, depression, not getting up or out, the world will forget you exist. My psych added Sunosi and a half dose of one of the drugs that had faded results years ago, 6 weeks ago. It was about 2 weeks before I was getting up and dressed most days. Then every day. (TBI survivor 2004) Fatigue, sleep, and on-task energy have been some of my longest battles after injury. Sunosi has helped lift me from a 6 or 8-month very deep slump. It has worked where other drugs did not. [Many of us react differently to each drug, this one works well for me.]"

8 / 10
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  • Fro...
  • Taken for 1 to 6 months
  • August 2, 2021

For Obstructive Sleep Apnea/Hypopnea Syndrome "I’ve been taking Sunosi for a month. I started at 37.5 mg and worked up to 150 mg. Sunosi has been keeping me awake during the day, but both my heart rate and BP are elevated. Insomnia is also becoming a problem. My doc lowered my dose to 75 mg, but I still have elevated heart rate and BP. I’ll probably have to stop the medication. Disappointing! I had the same problem with Nuvigil and Provigil."

2 / 10
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5 Report
  • Bob...
  • Taken for 6 months to 1 year
  • January 30, 2023

For Narcolepsy "I have chronic fatigue. We are not all the same. I get about 3 hours of awakeness and then sleep until about 8 p.m. Then by 11:00 I sleep for an hour and a half unless I take diazepam. At maximum dosage, I get 5-6 hours of sleep. What works for some will not work for others. We know the source of the problem - hypothalamic dysfunction. I go this week because the left vestibular artery is missing, which feeds oxygen and blood to the brain. For most doctors, this is all a big guess. Sunosi was my 4th medication to basically fail. But for others, it may work well."

1 / 10
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2 Report

Frequently asked questions

  • Nik...
  • Taken for 1 to 2 years
  • April 5, 2023

For Narcolepsy "I have severe narcolepsy, cataplexy, fibromyalgia, and migraine (they all feed off narcolepsy). I have had these disorders since I was a teenager, although I was only recently diagnosed properly. I have tried multiple stimulants, antidepressants, and pain medications with little to no relief of symptoms. I tried Sunosi at 75 mg for a few months before increasing to 150 mg. I have been on the larger dose for about a year before my heart rate and blood pressure raised. I ended up having multiple seizures due to a sudden severe spike in blood pressure for no reason at all. I no longer take this medication and will be trying Zyrem. The theory is that the medication stored too much adrenaline in my brain, overdosing my body and causing near-death seizures. Please monitor your blood pressure regularly, even if you feel fine. It will hit out of nowhere. Otherwise, the medication helped quite a bit with agitation, increased heart rate, and insomnia being the noticeable side effects."

1 / 10
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  • ILj...
  • Taken for less than 1 month
  • January 10, 2023

For Narcolepsy "Been dealing with symptoms of a sleep disorder for 15+ years and have now been diagnosed with narcolepsy with cataplexy along with idiopathic insomnia. After trying armodafinil and having adverse reactions, I was then subjected to try Sunosi. I had half a tablet daily for a week, then went to a full tablet after that. This medication helped me almost instantly. I had energy, I was able to think clearly, and able to process multiple things happening in my environment. It did, though, cause insomnia, I am getting roughly 4-5 hrs of sleep in a 24 hr span. Today marks day 22 of Sunosi, and the effects of the medication are reducing. I’ve been consistent with taking the medication and have no alcohol or drug use. My emotions are haywire, and I’m spouting anger outbursts. I’m overwhelmed by almost nothing. I’m trying to not get defeated or angry. I just thought I had been given an answer to a prayer, and now it’s not working. I’m hoping that my doctor will be able to provide help."

7 / 10
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2 Report

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