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Ephedrine Side Effects

For the Consumer

Applies to ephedrine: oral fixed-dose combination with guaifenesin, parenteral injection

Side effects include:

Parenteral ephedrine: Nervousness, insomnia, vertigo, headache, tachycardia, palpitation, sweating, nausea, vomiting, anorexia, vesical sphincter spasm (resulting in difficult and painful urination), urinary retention (particularly in males with prostatism).

For Healthcare Professionals

Applies to ephedrine: compounding powder, injectable solution, intravenous solution, oral capsule

General

The most frequently reported side effects were nausea, vomiting, and tachycardia.[Ref]

Cardiovascular

Very rare (less than 0.01%): Myocardial infarction
Frequency not reported: Tachycardia, palpitations, reactive hypertension, bradycardia, ventricular ectopics, R-R variability, pallor, angina/anginal pain, hypertension, hypotension, extrasystole, arrhythmias, vasodilation with low blood pressure, flushing, impaired circulation to extremities[Ref]

Genitourinary

Frequency not reported: Difficult/painful urination, acute urinary retention[Ref]

Nervous system

Frequency not reported: Dizziness, headache, trembling, lightheadedness, tremor, sedation[Ref]

Respiratory

Frequency not reported: Dry nose, dry throat, shortness of breath, respiratory difficulty, dyspnea, respiratory depression[Ref]

Psychiatric

Frequency not reported: Restlessness, addiction, nervousness, anxiety, insomnia, mood/mental changes, fear, irritability, confusion, delirium, euphoria, psychotic states, tension, hallucinations[Ref]

Other

Frequency not reported: Fever, precordial pain, vertigo, tachyphylaxis, drug tolerance, drug dependence, weakness[Ref]

Gastrointestinal

Frequency not reported: Nausea, vomiting, dry mouth, mild epigastric distress, hypersalivation[Ref]

Metabolic

Frequency not reported: Hyperglycemia, anorexia[Ref]

Dermatologic

Frequency not reported: Sweating[Ref]

References

1. "Product Information. Akovaz (ePHEDrine)." Eclat Pharmaceuticals, Menomonee Falls,, WI.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

4. "Product Information. Ephedrine Sulfate (ephedrine)." Akorn Inc, Buffalo Grove, IL.

Not all side effects for ephedrine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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