Ephedrine Side Effects
For the Consumer
Applies to ephedrine: oral fixed-dose combination with guaifenesin, parenteral injection
Side effects include:
Parenteral ephedrine: Nervousness, insomnia, vertigo, headache, tachycardia, palpitation, sweating, nausea, vomiting, anorexia, vesical sphincter spasm (resulting in difficult and painful urination), urinary retention (particularly in males with prostatism).
For Healthcare Professionals
Applies to ephedrine: compounding powder, injectable solution, intravenous solution, oral capsule
The most frequently reported side effects were nausea, vomiting, and tachycardia.[Ref]
Very rare (less than 0.01%): Myocardial infarction
Frequency not reported: Tachycardia, palpitations, reactive hypertension, bradycardia, ventricular ectopics, R-R variability, pallor, angina/anginal pain, hypertension, hypotension, extrasystole, arrhythmias, vasodilation with low blood pressure, flushing, impaired circulation to extremities[Ref]
Frequency not reported: Difficult/painful urination, acute urinary retention[Ref]
Frequency not reported: Dizziness, headache, trembling, lightheadedness, tremor, sedation[Ref]
Frequency not reported: Dry nose, dry throat, shortness of breath, respiratory difficulty, dyspnea, respiratory depression[Ref]
Frequency not reported: Restlessness, addiction, nervousness, anxiety, insomnia, mood/mental changes, fear, irritability, confusion, delirium, euphoria, psychotic states, tension, hallucinations[Ref]
Frequency not reported: Fever, precordial pain, vertigo, tachyphylaxis, drug tolerance, drug dependence, weakness[Ref]
Frequency not reported: Nausea, vomiting, dry mouth, mild epigastric distress, hypersalivation[Ref]
Frequency not reported: Hyperglycemia, anorexia[Ref]
Frequency not reported: Sweating[Ref]
1. "Product Information. Akovaz (ePHEDrine)." Eclat Pharmaceuticals, Menomonee Falls,, WI.
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
3. Cerner Multum, Inc. "Australian Product Information." O 0
4. "Product Information. Ephedrine Sulfate (ephedrine)." Akorn Inc, Buffalo Grove, IL.
Not all side effects for ephedrine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
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