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Generic Name: droxidopa (DROX i DOP a)
Brand Name: Northera

What is droxidopa?

Droxidopa works by constricting (narrowing) the blood vessels and increasing blood pressure.

Droxidopa is used to treat low blood pressure that causes severe dizziness or a light-headed feeling, like you might pass out. This medicine is for use in people with conditions of the nervous system that can cause low blood pressure (such as Parkinson's disease, multiple system atrophy, autonomic failure, and others).

Droxidopa may also be used for purposes not listed in this medication guide.

What is the most important information I should know about droxidopa?

Droxidopa can increase your blood pressure even while you are lying down. You may need to keep your head elevated during sleep to help prevent high blood pressure. Follow your doctor's instructions about how to position your body while you are lying down or sleeping.

Your blood pressure will need to be checked before and during treatment with droxidopa, or whenever your dose is changed. Check your blood pressure while you are lying down, and check it again with your head elevated.

What should I discuss with my healthcare provider before taking droxidopa?

You should not use droxidopa if you are allergic to it.

To make sure droxidopa is safe for you, tell your doctor if you have:

  • heart disease;

  • history of heart attack or stroke;

  • high blood pressure;

  • kidney disease;

  • asthma, or a history of severe allergic reaction to aspirin, especially aspirin triad syndrome; or

  • if you are allergic to yellow food dye.

FDA pregnancy category C. It is not known whether droxidopa will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

It is not known whether droxidopa passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Do not give this medication to anyone under 18 years old without medical advice.

How should I take droxidopa?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Droxidopa is usually taken 3 times per day, as follows. First dose in the morning when you wake up; second dose at mid-day; third dose in the late afternoon or at least 3 hours before you go to bed. The timing of your doses is very important in helping to maintain a healthy blood pressure while you are taking droxidopa. Follow your doctor's dosing instructions very carefully.

You may take droxidopa with or without food, but take it the same way each time.

Do not crush, chew, break, or open a droxidopa capsule. Swallow it whole.

Droxidopa can increase your blood pressure even while you are lying down or sleeping (when blood pressure is usually lowest). Long-term high blood pressure (hypertension) can lead to heart attack or stroke, which may be fatal.

Follow your doctor's instructions about the best way to position your body while you are laying down or sleeping. You may need to keep your head elevated to help prevent high blood pressure.

Your blood pressure will need to be checked before and during treatment with droxidopa, or whenever your dose is changed. Check your blood pressure while you are lying down, and check it again with your head elevated.

Your doctor will need to check your progress at regular visits if you use droxidopa for longer than 2 weeks.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose, or if your bedtime is less than 3 hours away. Do not take extra medicine to make up the missed dose.

Do not take the medicine less than 3 hours before bedtime.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking droxidopa?

Avoid taking the medicine less than 3 hours before bedtime.

Droxidopa side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe dizziness or light-headed feeling;

  • confusion, fever;

  • pain or burning when you urinate;

  • dangerously high blood pressure--severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure; or

  • severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Common side effects may include:

  • headache, dizziness;

  • nausea; or

  • tired feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Droxidopa dosing information

Usual Adult Dose for Hypotension:

Initial dose: 100 mg orally 3 times daily upon arising in the morning, at midday, and in the late afternoon at least 3 hours prior to bedtime (to reduce the potential for supine hypertension during sleep)
Titration: Titrate to symptomatic response, in increments of 100 mg 3 times daily every 24 to 48 hours.
Maximum dose: 600 mg orally 3 times daily (i.e., a maximum total daily dose of 1800 mg)

Duration of therapy: Effectiveness beyond 2 weeks of treatment has not been established.

-Supine blood pressure should be monitored prior to initiating and after increasing the dose of droxidopa.
-Droxidopa must be administered consistently, either with food or without food.
-Capsules should be swallowed whole, not chewed or crushed.

General Use: For the treatment of orthostatic dizziness, lightheadedness, or the "feeling that you are about to black out" in adult patients with symptomatic neurogenic orthostatic hypotension (NOH) caused by primary autonomic failure (Parkinson's disease, multiple system atrophy, and pure autonomic failure), dopamine beta-hydroxylase deficiency, and nondiabetic autonomic neuropathy.

What other drugs will affect droxidopa?

Other drugs may interact with droxidopa, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

  • Your pharmacist can provide more information about droxidopa.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 1.01.

Date modified: February 03, 2017
Last reviewed: March 13, 2014