Droxidopa Side Effects

Medically reviewed by Drugs.com. Last updated on Jan 25, 2025.

Applies to droxidopa: oral capsule.

Important warnings This medicine can cause some serious health issues

Oral route (capsule)

Monitor supine blood pressure before and during treatment, and more frequently when increasing doses.

Elevating the head of the bed lessens the risk of supine hypertension and blood pressure should be measured in this position.

If supine hypertension cannot be managed by elevating the head of the bed, reduce or discontinue droxidopa.

Serious side effects of droxidopa

Along with its needed effects, droxidopa may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking droxidopa:

More common side effects

• bladder pain
• bloody or cloudy urine
• blurred vision
• difficult, burning, or painful urination
• dizziness
• fainting
• frequent urge to urinate
• lower back or side pain
• nervousness
• pounding in the ears
• slow or fast heartbeat

Other side effects of droxidopa

Some side effects of droxidopa may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• headache
• nausea

For healthcare professionals

Applies to droxidopa: oral capsule.

Cardiovascular adverse events

• Common (1% to 10%): Hypertension (greater than 5%)
• Frequency not reported: Supine hypertension, exacerbation of existing heart disease, arrhythmias, and congestive heart failure^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea^[Ref]

Genitourinary

• Very common (10% or more): Urinary tract infections (15% in the elderly)^[Ref]

Musculoskeletal

• Very common (10% or more): Falls (24% in the elderly)^[Ref]

Nervous system

• Very common (10% or more): Headache (up to 15%), syncope (13% in the elderly), dizziness (up to 11%)^[Ref]

Further information

Droxidopa side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer