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droxidopa (Oral route)


Oral route(Capsule)

Monitor supine blood pressure before and during treatment with droxidopa, especially when increasing doses. Elevating the head of the bed may lessen the risk of developing supine hypertension and blood pressure should be measured in this position. If supine hypertension cannot be managed by elevating the head of the bed, reduce or discontinue droxidopa .

Commonly used brand name(s)

In the U.S.

  • Northera

Available Dosage Forms:

  • Capsule

Therapeutic Class: Vasopressor

Pharmacologic Class: Adrenergic

Uses For droxidopa

Droxidopa is used to treat neurogenic orthostatic hypotension (lightheadedness, dizziness, or fainting) caused by primary autonomic failure (eg, Parkinson's disease, multiple system atrophy, and pure autonomic failure), dopamine beta-hydroxylase deficiency, and non-diabetic autonomic neuropathy.

droxidopa is available only with your doctor's prescription.

Before Using droxidopa

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For droxidopa, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to droxidopa or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of droxidopa in the pediatric population. Safety and efficacy have not been established.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of droxidopa in the elderly.


Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking droxidopa, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using droxidopa with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Carbidopa

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of droxidopa. Make sure you tell your doctor if you have any other medical problems, especially:

  • Allergy to aspirin or
  • Asthma—droxidopa contains tartrazine, which can make these conditions worse.
  • Congestive heart failure or
  • Heart or blood vessel problems (eg, ischemic heart disease) or
  • Heart rhythm problems (eg, arrhythmia) or
  • Supine hypertension—Use with caution. May make these conditions worse.

Proper Use of droxidopa

Take droxidopa exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Take droxidopa the same way every day. This means take it at the same time and take it consistently, either with or without food.

Swallow the capsule whole. Do not crush, break, or chew it.


The dose of droxidopa will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of droxidopa. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (capsules):
    • For neurogenic orthostatic hypotension:
      • Adults—At first, 100 milligrams (mg) three times a day (taken upon waking up in the morning, at noon, and in the late afternoon at least 3 hours before bedtime). Your doctor may adjust your dose as needed. However, the dose is usually not more than 600 mg three times a day.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of droxidopa, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using droxidopa

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to check for unwanted effects caused by droxidopa. You may also need to monitor your blood pressure at home before, during, and after treatment.

droxidopa may increase your risk of having supine hypertension, which can lead to stroke or heart attack. You doctor will tell you to rest or sleep in an upper body elevated position and monitor your blood pressure. If you notice changes in your blood pressure, tell your doctor right away.

droxidopa may cause confusion, fever, and worsening of heart or blood vessel problems. Tell your doctor right away if you have these conditions.

If your condition does not improve within 2 weeks, or if it become worse, check with your doctor.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

droxidopa Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common
  • Bladder pain
  • bloody or cloudy urine
  • blurred vision
  • difficult, burning, or painful urination
  • dizziness
  • fainting
  • frequent urge to urinate
  • lower back or side pain
  • nervousness
  • pounding in the ears
  • slow or fast heartbeat

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Headache
  • nausea

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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