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Droxidopa Dosage

Medically reviewed by Drugs.com. Last updated on Feb 19, 2024.

Applies to the following strengths: 100 mg; 200 mg; 300 mg

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Hypotension

Initial dose: 100 mg orally 3 times daily upon arising in the morning, at midday, and in the late afternoon at least 3 hours prior to bedtime (to reduce the potential for supine hypertension during sleep)
Titration: Titrate to symptomatic response, in increments of 100 mg 3 times daily every 24 to 48 hours.
Maximum dose: 600 mg orally 3 times daily (i.e., a maximum total daily dose of 1800 mg)

Duration of therapy: Effectiveness beyond 2 weeks of treatment has not been established.

Comments:


General Use: For the treatment of orthostatic dizziness, lightheadedness, or the "feeling that you are about to black out" in adult patients with symptomatic neurogenic orthostatic hypotension (NOH) caused by primary autonomic failure (Parkinson's disease, multiple system atrophy, and pure autonomic failure), dopamine beta-hydroxylase deficiency, and nondiabetic autonomic neuropathy.

Renal Dose Adjustments

Mild or moderate renal impairment (CrCl greater than 30 mL/min): No adjustment recommended
Severe renal function impairment (CrCl less than 30 mL/min): Data not available

Liver Dose Adjustments

No adjustment recommended

Precautions

US BOXED WARNINGS:


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.