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User Reviews for Midodrine

Also known as: Orvaten

Midodrine has an average rating of 6.7 out of 10 from a total of 28 ratings on 67% of those users who reviewed Midodrine reported a positive effect, while 30% reported a negative effect.

Condition Avg. Rating Reviews Compare
Postural Orthostatic Tachycardia Syndrome  Off-label
13 reviews 4 medications
8 reviews 10 medications
Dysautonomia  Off-label
7 reviews 53 medications
Summary of Midodrine reviews 6.7 28 reviews

Reviews may be moderated or edited before publication to correct grammar and spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest in the medication will not be published. As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies.

Reviews for Midodrine

Anonymous · Taken for less than 1 month January 4, 2021

For Postural Orthostatic Tachycardia Syndrome: “My 19 year old with COVID-induced POTS tried taking midodrine and the side affects were not tolerable. One issue is she was freezing cold with goose bumps all over and they were painful like a stinging feeling. She only took it for a week and then we stopped it.”

2 / 10
Nikolai · Taken for 1 to 6 months October 20, 2020

For Hypotension: “I suffer from both hypotension (70/40 on a good day) and chronic fatigue syndrome. I needed to get surgery on an unrelated issue and we were worried about my blood pressure. So my Doctor decided to try Midodrine 10 mg up to 3 times a day. Without exaggeration this saved my life. I can now not only sit up but stand without passing out, furthermore I can stay awake like then 3 hours a day. Does this give me chills and goosebumps? Yes. But my goodness, I have my life back. I'll take the goose bumps and wear a sweater.”

10 / 10
Ln2022 · Taken for 1 to 6 months October 16, 2020

For Postural Orthostatic Tachycardia Syndrome: “Not the drug for me personally. Suffered with POTS for 10+ years now starting new medicines for it. I was prescribed 10mg Midodrine to start. No improvement of POTS symptoms and was on it for about a month. No negative symptoms other than goosebumps at first but after about a month on it my blood pressure started shooting up and I felt super sick from it. I had high hopes because it helps so many people but it just wasn't for me.”

5 / 10
SusanT · Taken for 1 to 6 months December 26, 2018

For Dysautonomia: “I give it an eight because its not for everyone and because I do get side effects like irritable mood, more headaches, body pain and stomach upset but aside from that, it is a life-changing drug. I am no longer fainting 4-5 days a week. I can stand up for more than 30 seconds without fainting. I can think. I can be active for 4 or more hours per day instead of 1-2. I can drive a car without getting tired and confused. It has given me my life back after 24 years of not living!”

8 / 10
HS004 August 13, 2014

Orvaten (midodrine) for Postural Orthostatic Tachycardia Syndrome: “I take 10mg midodrine three times a day for Postural Orthostatic Tachycardia Syndrome. It has changed my life completely. I'm able to be active and do all the things I used to avoid. I go to concerts, movies on opening night, and shopping at places with long lines. I can date without worrying about whether we're going somewhere that I'll need to stand still. There are side effects - weird sensations and goosebumps mostly. The benefit far outweighs any negative effects or risks.”

9 / 10
Anonymous July 20, 2011

For Hypotension: “I have been on this medicine for thirteen years (since age 17) without issue. Taking this medicine enables me to live my life with only the occasional (rather than inevitable) fainting, dizziness and exhaustion. My doctor tried to switch me to lower doses, but my symptoms immediately kick in and make it difficult to function. Regular doses have made all the difference in my life.”

10 / 10
keezheekoni August 17, 2010

For Hypotension: “I am greatly disappointed that they are going to take Midodrine off the market. I have taken it for about 8 years with fantastic results. Without it I have syncope often, I am really researching what to do because I rely on this medicine for help with my hypotension. Tried to go off of it once, passed out in my bosses arms - that was embarrassing - got back on it and not a problem since. Even on medication my blood pressure runs 100/70....but off of Midodrine I have to work to keep at 88/60, sometimes I am less than that and syncope is definite. I WISH they would reconsider taking it off the market.”

10 / 10
lvnpeace September 29, 2009

ProAmatine (midodrine) for Dysautonomia: “This medication gave me back my life. I was passing out everywhere. People in Target hated to see me coming. I passed out in a parking lot and prayed I wouldn't be run over. I had hypotension and vaso-vagal syncope upon movement. This didn't "cure" it, but helped me so much.”

9 / 10
Liz · Taken for less than 1 month October 14, 2019

For Hypotension: “This medication raised my heart rate and it dropped my blood pressure and landed me in the emergency room for 3 days! I remember taking it and feeling the urge to pee then I have this burning sensation all over my body, then the dry mouth kicked in and the then convulsions and weak legs, then the tachycardia and faint feeling, then the panic set in, and the flushing and burning in my ears, severe pressure in my head, abdominal cramping and finally severe severe dizziness, it was the worse thing I had ever tried...! I was very upset at the way I reacted to it.”

1 / 10
Le Me! · Taken for 1 to 2 years March 9, 2014

For Dysautonomia: “I started taking Midodrine early last year and like others before me have's the best thing since sliced bread! I had to get out of the military because of bradycardia and vaso-vagal syncope and I was taking fludrocortisone at the time. The Florinef was awful, my hair was falling out, my nails were tissue paper thin (and painful), and I was still passing out every time I stood up. Midodrine has allowed me to do the things I love! I am a serious bowler (trying to go pro) and without this awesome stuff. I wouldn't be able to bowl more than one game (and very slowly) without passing out. I can also take showers STANDING UP! *GASP!!!* What a concept! It's a lovely medication! My only quabble is the tingling on my head.”

10 / 10
Ddominelli August 17, 2010

ProAmatine (midodrine) for Postural Orthostatic Tachycardia Syndrome: “ProAmatine is the best thing since sliced bread! Without ProAmatine POTS patients like me would not be able to function! The side effects are minimal and short lasting (they usually go away within the first week) and it gives people their lives back!”

10 / 10
Anonymous February 24, 2010

For Hypotension: “It significantly improved my mother's quality of life. She is a heart and renal patient and due to low blood pressure, she was always feeling dizzy and was unable to carry out simple tasks at home. She was always sitting or lying down. Since this medication was started she has improved alot without experiencing any side effects. Positive result with this medication. It should be licensed.”

8 / 10
jamernay November 6, 2010

For Dysautonomia: “After trying a few other drugs in combination, adding midodrine was what enabled me to get out of bed and sit up without fainting, dizziness and drastic hypotension. I can now stand and walk, and participate in life when before, I was bed-bound. Yes, I now have very itchy, sensitive skin and scalp; but I will gladly suffer that slight annoyance to be able to function. I am glad its a shorter acting drug, even though I have to dose in the middle of the day, because it gets out of my system before I go to bed and don't change from hypotension to hypertension.”

9 / 10
togetherthereishope October 3, 2015

ProAmatine (midodrine) for Postural Orthostatic Tachycardia Syndrome: “I have been diagnosed with Dysautonomia & Postural Orthostatic Tachacardia Syndrome and many other things but this medicine was my only option I can't take beta blockers because I need to be able to use my epi-pen and I had a bad reaction to florinef so we decided to try midodrine. It is a lifesavor! I can't go anywhere or do much of anything if I don't take it. I will pass out if I'm not on this medicine, I'm very pleased! I do have to deal with flushing and frequent headaches but it's very much worth it the cost.”

8 / 10
POTS&Dysautomia August 17, 2011

For Postural Orthostatic Tachycardia Syndrome: “Midodrine does not affect postural orthostatic tachycardia syndrome, you need a beta-blocker for that (I am on Propranolol) which keeps your heart from kickstarting the fainting reflex that POTS patients are very susceptible to. Midodrine saved my life, it allows me to literally get up off the floor and get on with life. I have been on it for 10 years, it has a very short life span so I take both medicines every 3 hours. I am able to function quite well, not super-duper, but I can do most things. If it ever is pulled off the market I will literally be going to another country.”

10 / 10
RockinSquirrel · Taken for 2 to 5 years July 20, 2020

For Postural Orthostatic Tachycardia Syndrome: “I was doing well on Midodrine for my POTS but also take propranolol and fludricortisone for it. After a few years my blood pressure got too high and my doctor had me stop the midodrine. My POTS is now running my life. I can't even walk around the house without being extremely dizzy.”

9 / 10
trihealth May 17, 2017

For Dysautonomia: “If there's a side effect to be had from a drug, I'm the type to get it but other than initially making me nauseous, this medication is not one I can go without! It has allowed me to function from debilitating dysautonomia. While I'm not 100% yet, it has helped me get my life back. Started on 2.5 mg three times a day but I am up to 15mg three times a day.”

9 / 10
POTSgrrrrl October 1, 2010

ProAmatine (midodrine) for Postural Orthostatic Tachycardia Syndrome: “Didn't seem to lower my heart rate very much, except when I tried to walk around in physical therapy class. Then it caused a severe drop in my heart rate, from about 95 in the relaxed sitting position, to below the 50s when I walked a few yards. Bradycardia is a documented side effect, and unfortunately one I suffered from. Also had lots of goosebumps, tingling scalp, chills and flushing throughout the day. I'm not totally knocking it, because I know it works for some POTS patients, but it wasn't the medicine for me.”

3 / 10
Kay22 · Taken for less than 1 month November 3, 2015

For Hypotension: “Was prescribed for fainting/low b.p. I started taking this and it made me have involuntary facial expressions and I started fainting repeatedly. Allergic reaction so I had to stop using it immediately.”

1 / 10
MarkS. February 1, 2012

For Postural Orthostatic Tachycardia Syndrome: “Goosebumps on arms, legs, chest and back; scalp tingling. Reduced my POTS episodes to one or two a month. Wish it were a once-a-day pill instead of every four hours. I take it early morning, lunch and late afternoon.”

Daisycav February 16, 2018

For Hypotension: “I was prescribed this following 18 months of fainting, exhaustion, low blood pressure.The first time I managed a month before becoming very depressed.I was so down that my family were really concerned. I stopped it but then decided to try again when completing a months cardiac monitoring that my consultant wanted (I hadn't mentioned the side effects) Again within a week or so of starting Ibegan to feel extremely low and depressed. My blood pressure had improved, normally around 85/50 but the bad far outweighed the good!”

1 / 10
potsy_kaira July 21, 2014

ProAmatine (midodrine) for Postural Orthostatic Tachycardia Syndrome: “Has definitely helped along with the Digoxin I take to keep me from feeling faint or dizzy. Has improved my quality of life quite a bit. The side effects (for me) are not bad enough to make me stop taking it.”

8 / 10
EDR · Taken for 1 to 6 months May 19, 2018

For Hypotension: “My neurologist put me on this midodrine. I couldn’t stand and walk 5 ft with out going down. I was getting ready to accept life in power chair. I have CIDP (Chronic inflammatory demyelinating polyneuropathy). I have lost 60% of the nerves in my legs due to severe neuropathy. The blood vessels do not get the signal from my brain to constrict just before I stand up so the blood drains down and I go down.”

10 / 10
canelante June 22, 2017

For Postural Orthostatic Tachycardia Syndrome: “I get seizures with allergic reactions from Mast cell activation syndrome (MCAS), but I didn't when I first took this drug in 2016. Lots of goosebumps, tingling, tight scalp, chills, shivering, and felt like a zombie, though. Became a different person- dissociated, honestly. That'd never happened to me before, was so afraid. Doctor made me try again, seized the entire time and the tingling burned so bad it felt like I was on fire. Got bradycardic within 2 hours of taking it, too. I get brady sometimes as it is (my heart rate was at 30 the other day) so this medication wasn't a good idea in the first place. Bad call on my doctor's part and bad call on mine for even listening to him.”

1 / 10
zahta32 · Taken for 1 to 6 months December 24, 2012

ProAmatine (midodrine) for Dysautonomia: “I can't stand up without it.”

10 / 10
Anonymous · Taken for less than 1 month April 20, 2016

For Postural Orthostatic Tachycardia Syndrome: “Really bad reaction with me.severe side effects with little to no results.”

1 / 10
simplivin December 20, 2009

ProAmatine (midodrine) for Postural Orthostatic Tachycardia Syndrome: “Rash, goosebumps even when hot, odd blood pressure swings, scalp tingling and other problems. Was taken off it fairly quickly.”

1 / 10
Anonymous June 8, 2017

For Dysautonomia: “Great to be able to stand-up without constantly feeling faint”

9 / 10

This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.