Midodrine Side Effects
Medically reviewed by Drugs.com. Last updated on Nov 2, 2020.
Commonly reported side effects of midodrine include: dysuria, paresthesia, pruritus, supine hypertension, and piloerection. Other side effects include: abdominal pain, pain, and chills. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to midodrine: oral tablet
Oral route (Tablet)
Can cause marked elevation of supine blood pressure and should be used only in patients whose lives are considerably impaired despite standard clinical care. Clinical benefits of midodrine hydrochloride tablets, principally improved ability to carry out activities of daily living, have not been verified.
Side effects requiring immediate medical attention
Along with its needed effects, midodrine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking midodrine:
- Blurred vision
- cardiac awareness
- pounding in the ears
- increased dizziness
- slow pulse
Side effects not requiring immediate medical attention
Some side effects of midodrine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Burning, itching, or prickling of the scalp
- urinary frequency, retention, or urgency
- Anxiety or nervousness
- dry mouth
- headache or feeling of pressure in the head
- skin rash
- canker sores
- dry skin
- leg cramps
- pain or sensitivity of the skin to touch
- stomach problems such as gas, heartburn, or nausea
- trouble seeing
- trouble with sleeping
For Healthcare Professionals
Applies to midodrine: oral tablet
The most common adverse reactions were paresthesia (includes hyperesthesia and scalp paresthesia), piloerection, dysuria (includes dysuria, increased urinary frequency, impaired urination, urinary retention, and urinary urgency), pruritus (includes scalp pruritus), and supine hypertension.[Ref]
Common (1% to 10%): Supine hypertension, flushing
Uncommon (0.1% to 1%): Reflex bradycardia
Frequency not reported: Vasodilation/flushing face[Ref]
Very common (10% or more): Paresthesia (18.3%)
Common (1% to 10%): Headache
Frequency not reported: Feeling of pressure/fullness in the head, dizziness, somnolence[Ref]
Very common (10% or more): Piloerection (13.4%), pruritus (12.2%)
Common (1% to 10%): Rash
Very common (10% or more): Dysuria (13.4%)
Frequency not reported: Impaired urination[Ref]
Common (1% to 10%): Chills, pain
Frequency not reported: Asthenia[Ref]
Frequency not reported: Confusion/thinking abnormality, nervousness/anxiety[Ref]
Rare (less than 0.1%): Abnormal hepatic function, raised liver enzymes[Ref]
Frequency not reported: Backache, leg cramps[Ref]
Frequency not reported: Visual field defect[Ref]
1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
2. "Product Information. ProAmatine (midodrine)." Roberts Pharmaceutical Corporation, Eatontown, NJ.
More about midodrine
- During Pregnancy
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- Drug class: miscellaneous cardiovascular agents
- FDA Alerts (1)
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.