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Midodrine Side Effects

In Summary

Commonly reported side effects of midodrine include: pruritus, paresthesia, dysuria, supine hypertension, and piloerection. Other side effects include: pain, abdominal pain, and chills. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to midodrine: oral tablet

In addition to its needed effects, some unwanted effects may be caused by midodrine. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking midodrine:

More common:
  • Blurred vision
  • cardiac awareness
  • headache
  • pounding in the ears
  • Fainting
  • increased dizziness
  • slow pulse

Minor Side Effects

Some of the side effects that can occur with midodrine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Burning, itching, or prickling of the scalp
  • chills
  • goosebumps
  • urinary frequency, retention, or urgency
Less common:
  • Anxiety or nervousness
  • confusion
  • dry mouth
  • flushing
  • headache or feeling of pressure in the head
  • skin rash
  • Backache
  • canker sores
  • dizziness
  • drowsiness
  • dry skin
  • leg cramps
  • pain or sensitivity of the skin to touch
  • stomach problems such as gas, heartburn, or nausea
  • trouble seeing
  • trouble with sleeping
  • weakness

For Healthcare Professionals

Applies to midodrine: oral tablet


Marked elevation of supine arterial blood pressure is potentially the most serious side effect reported with midodrine therapy. The manufacturer reports a systolic pressure of 200 mmHg in 13.4% of patients receiving midodrine 10 mg orally. Patients with a mean pretreatment systolic pressure of 170 mmHg were more prone to this effect. There is no experience of midodrine administered to patients with a pretreatment systolic pressure over 180 mmHg.

The patient may be able to control supine hypertension by avoiding a full supine position.

Symptoms of supine hypertension may included, but are not limited to, cardiac awareness, pounding in the ears, headache, and blurred vision.[Ref]

Cardiovascular side effects have frequently included supine and sitting hypertension.[Ref]

Nervous system

Nervous system side effects have frequently included paresthesia (18.3%). Confusion, abnormal thinking, nervousness, and anxiety have also been reported. Dizziness, skin hyperesthesia, insomnia, and somnolence have been reported rarely.[Ref]


Scalp pruritus is the most common form of pruritus reported by patients.[Ref]

Dermatologic side effects have frequently included piloerection (13.4%) and pruritus (12.2%). Rash has been reported in 2.4% of patients. Erythema multiforme and dry skin have been reported rarely.[Ref]


Other side effects have frequently included chills (4.9%) and pain/increase in level of pain (4.9%). Headache, feeling of pressure/fullness in the head, vasodilation/flushing of face, and dry mouth have also been reported. Leg cramps, canker sore, and backache have been reported rarely.[Ref]


Reports of dysuria have included urinary urge, urinary retention, urinary frequency, and impaired urination.[Ref]

Genitourinary side effects have frequently included dysuria (13.4%).[Ref]


Ocular side effects have rarely included visual field defect.[Ref]


Gastrointestinal side effects have rarely included pyrosis, nausea, gastrointestinal distress, and flatulence.[Ref]


Musculoskeletal side effects have rarely included asthenia.[Ref]


1. "Product Information. ProAmatine (midodrine)." Roberts Pharmaceutical Corporation, Eatontown, NJ.

Not all side effects for midodrine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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