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Corphedra (Intravenous)

Generic Name: ephedrine (Intravenous route)

e-FED-rin

Commonly used brand name(s)

In the U.S.

  • Akovaz
  • Corphedra

Available Dosage Forms:

  • Solution

Therapeutic Class: Vasopressor

Pharmacologic Class: Adrenergic

Chemical Class: Alkylarylamine

Uses For Corphedra

Ephedrine injection is used to treat hypotension (low blood pressure) caused by anesthesia (numbing medicines).

This medicine is to be given only by or under the direct supervision of your doctor.

Before Using Corphedra

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of ephedrine injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ephedrine injection in the elderly. However, elderly patients are more likely to have kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving this medicine.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Cyclopropane
  • Halothane
  • Isocarboxazid
  • Rasagiline
  • Selegiline

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acetyldigoxin
  • Clorgyline
  • Deslanoside
  • Digitalis
  • Digitoxin
  • Digoxin
  • Ergonovine
  • Furazolidone
  • Iobenguane I 123
  • Iproniazid
  • Methylergonovine
  • Metildigoxin
  • Midodrine
  • Nialamide
  • Oxytocin
  • Pargyline
  • Phenelzine
  • Procarbazine
  • Tranylcypromine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Heart disease or
  • Hypertension (high blood pressure) or
  • Stroke, or history of—Use with caution. May make these conditions worse.
  • Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of ephedrine

This section provides information on the proper use of a number of products that contain ephedrine. It may not be specific to Corphedra. Please read with care.

A doctor or other trained health professional will give you this medicine. This medicine is given through a needle placed in your veins.

Precautions While Using Corphedra

Your doctor will check your progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to check for unwanted effects.

Hypertension (high blood pressure) may occur after receiving this medicine. It is very important that your doctor check your blood pressure after receiving this medicine. If you notice any changes to your normal blood pressure, call your doctor right away.

Using this medicine repeatedly may cause a rapid decrease of response to the drug.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Corphedra Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Incidence not known
  • Blurred vision
  • dizziness
  • fast, pounding, or irregular heartbeat or pulse
  • headache
  • nervousness
  • pounding in the ears
  • slow or fast heartbeat

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known
  • Nausea or vomiting
  • restlessness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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