Skip to Content

Zenzedi Side Effects

Generic Name: dextroamphetamine

Note: This page contains side effects data for the generic drug dextroamphetamine. It is possible that some of the dosage forms included below may not apply to the brand name Zenzedi.

For the Consumer

Applies to dextroamphetamine: oral capsule extended release, oral solution, oral tablet

As well as its needed effects, dextroamphetamine (the active ingredient contained in Zenzedi) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking dextroamphetamine, check with your doctor immediately:

Rare
  • Agitation
  • delusions
  • seeing, hearing, or feeling things that are not there
Incidence not known:
  • Blurred vision
  • chest discomfort or pain
  • difficulty breathing
  • dizziness
  • faintness
  • false or unusual sense of well-being
  • fast, pounding, or irregular heartbeat or pulse
  • headache
  • pounding in the ears
  • shakiness in the legs, arms, hands, or feet
  • swelling of the feet or lower legs
  • trembling or shaking of the hands or feet
  • troubled breathing
  • twitching, twisting, or uncontrolled repetitive movements of tongue, lips, face, arms, or legs
  • unable to sleep
  • uncontrolled vocal outbursts and/or tics (uncontrolled repeated body movements)
  • unusual tiredness or weakness

If any of the following symptoms of overdose occur while taking dextroamphetamine, get emergency help immediately:

Symptoms of overdose:
  • Change in consciousness
  • dark-colored urine
  • diarrhea
  • discouragement
  • feeling sad or empty
  • fever
  • irritability
  • lack of appetite
  • loss of consciousness
  • loss of interest or pleasure
  • mood or mental changes
  • muscle cramps or spasms
  • muscle pain or stiffness
  • nausea
  • panic state
  • physical attempt to injure
  • rapid breathing
  • seizures
  • stomach cramps
  • sweating
  • trouble concentrating
  • violent actions
  • vomiting

Minor Side Effects

Some dextroamphetamine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Incidence not known:
  • Bad, unusual, or unpleasant (after) taste
  • change in taste
  • constipation
  • decreased interest in sexual intercourse
  • dry mouth
  • hives or welts, itching, or skin rash
  • inability to have or keep an erection
  • indigestion
  • loss in sexual ability, desire, drive, or performance
  • passing of gas
  • redness of the skin
  • weight loss

For Healthcare Professionals

Applies to dextroamphetamine: oral capsule extended release, oral solution, oral tablet

Metabolic

Very common (10% or more): Decreased appetite, reduced weight gain, weight loss
Common (1% to 10%): Anorexia
Frequency not reported: Acidosis[Ref]

Psychiatric

Very common (10% or more): Insomnia, nervousness
Common (1% to 10%): Abnormal behavior, aggression/hostility, excitation, anxiety, depression, irritability
Uncommon (0.1% to 1%): Psychotic episodes/psychosis
Very rare (less than 0.01%): Suicidal behavior (including completed suicide), mania, hallucinations
Frequency not reported: Overstimulation, restlessness, euphoria, dysphoria, confusion, dependence, emotional lability, impaired cognitive test performance, altered libido, night terrors, obsessive-compulsive behavior, panic states, paranoia[Ref]

Cardiovascular

Common (1% to 10%): Arrhythmia, palpitations, tachycardia
Rare (less than 0.1%): Angina pectoris
Very rare (less than 0.01%): Cardiac arrest
Frequency not reported: Blood pressure and heart rate changes (usually elevated), cardiomyopathy, myocardial infarction, chest pain, cardiovascular collapse, Raynaud's phenomenon[Ref]

Gastrointestinal

Common (1% to 10%): Abdominal pain and cramps, nausea, vomiting, dry mouth
Frequency not reported: Ischemic colitis, unpleasant taste, diarrhea, constipation, other gastrointestinal disturbances[Ref]

Musculoskeletal

Common (1% to 10%): Arthralgia
Rare (less than 0.1%): Growth retardation
Very rare (less than 0.01%): Muscle cramps
Frequency not reported: Rhabdomyolysis[Ref]

Nervous system

Common (1% to 10%): Vertigo, dyskinesia, headache, hyperactivity
Very rare (less than 0.01%): Tourette syndrome, tics, exacerbation of pre-existing motor and phonic tics, convulsions, choreoathetoid movements, intracranial hemorrhage, cerebral vasculitis and/or occlusion, neuroleptic malignant syndrome (NMS)
Frequency not reported: Dizziness, tremor, ataxia, dysgeusia, concentration difficulties, hyperreflexia, stroke[Ref]

Dermatologic

Rare (less than 0.1%): Rash, urticaria
Very rare (less than 0.01%): Erythema multiforme, exfoliative dermatitis, fixed drug eruption
Frequency not reported: Sweating, alopecia[Ref]

Ocular

Rare (less than 0.1%): Visual accommodation difficulties, blurred vision, mydriasis[Ref]

Other

Rare (less than 0.1%): Fatigue
Frequency not reported: Hyperpyrexia, sudden death[Ref]

Hematologic

Very rare (less than 0.01%): Anemia, leukopenia, thrombocytopenia, thrombocytopenic purpura[Ref]

Hepatic

Very rare (less than 0.01%): Abnormal liver function ranging from hepatic enzyme elevations to hepatic coma[Ref]

Endocrine

Frequency not reported: Impotence, libido changes, frequent or prolonged erections[Ref]

Hypersensitivity

Frequency not reported: Hypersensitivity reactions (e.g., angioedema and anaphylaxis)[Ref]

Renal

Frequency not reported: Renal damage[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Dexedrine (dextroamphetamine)" SmithKline Beecham, Philadelphia, PA.

It is possible that some side effects of Zenzedi may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide