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Amphetamine / dextroamphetamine Side Effects

Medically reviewed by Drugs.com. Last updated on Sep 9, 2023.

Applies to amphetamine / dextroamphetamine: oral capsule extended release, oral tablet.

Warning

Oral route (Capsule, Extended Release; Tablet)

Amphetamine has a high potential for abuse and misuse, which can lead to the development of a substance use disorder, including addiction. Misuse and abuse of CNS stimulants, including amphetamine, can result in overdose and death, and this risk is increased with higher doses or unapproved methods of administration, such as snorting or injection. Before prescribing amphetamines, assess each patient’s risk for abuse, misuse, and addiction. Educate patients and their families about these risks, proper storage of the drug, and proper disposal of any unused drug. Throughout amphetamine treatment, reassess each patient’s risk of abuse, misuse, and addiction and frequently monitor for signs and symptoms of abuse, misuse, and addiction..

Serious side effects

Along with its needed effects, amphetamine/dextroamphetamine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amphetamine / dextroamphetamine:

More common

Less common

Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking amphetamine / dextroamphetamine:

Symptoms of overdose

Other side effects

Some side effects of amphetamine / dextroamphetamine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Incidence not known

For Healthcare Professionals

Applies to amphetamine / dextroamphetamine: oral capsule extended release, oral tablet.

Metabolic

Very common (10% or more): Appetite loss (up to 36%), weight loss (up to 10%)

Frequency not reported: Anorexia[Ref]

Gastrointestinal

Very common (10% or more): Dry mouth (up to 35%), abdominal pain (up to 14%)

Common (1% to 10%): Nausea, vomiting, diarrhea, dyspepsia

Frequency not reported: Unpleasant taste, constipation, other GI disturbances[Ref]

Cardiovascular

Very common (10% or more): Transient blood pressure elevations (up to 35%)

Common (1% to 10%): Tachycardia, palpitation

Frequency not reported: Cardiomyopathy, myocardial infarction, Raynaud's phenomenon[Ref]

Psychiatric

Very common (10% or more): Insomnia (up to 27%), nervousness (up to 13%)

Common (1% to 10%): Emotional lability, agitation, anxiety

Frequency not reported: Psychotic episodes, irritability, euphoria, dysphoria, restlessness, depression, aggression, anger, logorrhea, dermatillomania[Ref]

Nervous system

Very common (10% or more): Headache (up to 26%)

Common (1% to 10%): Somnolence, dizziness, twitching, speech disorder (e.g., stuttering, excessive speech)

Frequency not reported: Overstimulation, paresthesia/formication, dyskinesia, tremor, exacerbation of motor/phonic tics and Tourette's syndrome[Ref]

Dermatologic

Common (1% to 10%): Photosensitivity reaction, sweating

Frequency not reported: Urticaria, rash, alopecia, serious skin rashes (e.g., Stevens-Johnson Syndrome, toxic epidermal necrolysis)[Ref]

Endocrine

Common (1% to 10%): Decreased libido, dysmenorrhea, impotence

Frequency not reported: Frequent or prolonged erections[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection[Ref]

Other

Common (1% to 10%): Fever, infection, accidental injury, asthenia/fatigue, tooth disorder (e.g., teeth clenching, tooth infection)

Frequency not reported: Sudden death, bruxism[Ref]

Respiratory

Common (1% to 10%): Dyspnea[Ref]

Hypersensitivity

Frequency not reported: Hypersensitivity reactions (e.g., angioedema, anaphylaxis)[Ref]

Ocular

Frequency not reported: Blurred vision, mydriasis[Ref]

Musculoskeletal

Postmarketing reports: Rhabdomyolysis[Ref]

Frequently asked questions

References

1. Product Information. Adderall (amphetamine-dextroamphetamine). Shire Richwood Pharmaceutical Company Inc. 2001;PROD.

2. Product Information. Adderall XR (amphetamine-dextroamphetamine). Shire Richwood Pharmaceutical Company Inc. 2001.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.