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Solriamfetol

Generic Name: solriamfetol (SOL ri AM fe tol)
Brand Name: Sunosi

Medically reviewed by Drugs.com on Jul 11, 2019 – Written by Cerner Multum

What is solriamfetol?

Solriamfetol is used to treat excessive daytime sleepiness in adults with narcolepsy or in those whose sleep is disrupted by sleep apnea.

Solriamfetol will not treat sleep apnea. Keep using your CPAP machine or other device prescribed by your doctor.

Solriamfetol may also be used for purposes not listed in this medication guide.

Important Information

Do not use solriamfetol if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Before taking this medicine

If you have sleep apnea, this condition should be treated for at least 1 month before you start taking solriamfetol.

Do not use solriamfetol if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Tell your doctor if you have ever had:

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of solriamfetol on the baby.

Tell your doctor if you are breastfeeding. Tell your doctor if you notice agitation, sleep problems, decreased appetite, or decreased weight gain in the nursing baby.

Solriamfetol is not approved for use by anyone younger than 18 years old.

How should I take solriamfetol?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Solriamfetol is usually taken once daily when you wake up.

You may take solriamfetol with or without food.

You may need to swallow a solriamfetol tablet whole or split it in half. Follow your doctor's instructions very carefully.

Carefully follow your doctor's instructions about when to increase your dose. Taking more solriamfetol than prescribed will not make it more effective and may result in serious side effects.

Your blood pressure and heart rate will need to be checked often.

Solriamfetol may be habit-forming. Misuse can cause addiction, overdose, or death. Keep the medication in a place where others cannot get to it. Selling or giving away solriamfetol is against the law.

Do not change your dose or stop taking solriamfetol without your doctor's advice.

Store at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

Do not keep leftover solriamfetol. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, follow disposal instructions in the Medication Guide provided with solriamfetol.

What happens if I miss a dose?

Take the medicine as soon as you can, but only if you plan to be awake for at least 9 hours. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking solriamfetol?

Avoid taking solriamfetol within 9 hours of when you plan to go to bed, or you may have trouble sleeping.

Solriamfetol side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • racing thoughts, increased energy, decreased need for sleep, feeling agitated or irritable;

  • ongoing sleep problems;

  • fast or pounding heartbeats; or

  • severe headache, blurred vision, pounding in your neck or ears.

Common side effects may include:

  • trouble sleeping;

  • anxiety;

  • nausea, loss of appetite; or

  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Solriamfetol dosing information

Usual Adult Dose for Narcolepsy:

Initial dose: 75 mg orally once a day upon awakening
-Dose may be doubled after 3 days based on efficacy and tolerability
Maintenance dose: 75 to 150 mg orally once a day
Maximum dose: 150 mg/day

Comments:
-Doses above 150 mg/day have not been shown to increase effectiveness enough to outweigh dose-related adverse reactions.

Use: To improve wakefulness in patients with excessive daytime sleepiness associated with narcolepsy.

Usual Adult Dose for Obstructive Sleep Apnea/Hypopnea Syndrome:

Initial dose: 37.5 mg orally once a day upon awakening
-Dose may be doubled at intervals of 3 days based on efficacy and tolerability
Maintenance dose: 37.5 to 150 mg orally once a day
Maximum dose: 150 mg/day

Comments:
-This drug does not treat the underlying airway obstruction in obstructive sleep apnea (OSA).
-Prior to initiating therapy, patients should have their underlying airway obstruction treated (e.g. with continuous positive airway pressure) for at least 1 month and should continue treatment while taking this drug.
-Doses above 150 mg/day have not been shown to increase effectiveness enough to outweigh dose-related adverse reactions.

Use: To improve wakefulness in patients with excessive daytime sleepiness associated with OSA.

What other drugs will affect solriamfetol?

Other drugs may affect solriamfetol, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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