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What is the difference between narcolepsy and idiopathic hypersomnia?

Medically reviewed by Carmen Pope, BPharm. Last updated on Nov 29, 2023.

Official answer

by Drugs.com

Although narcolepsy and idiopathic hypersomnia both have excessive daytime sleepiness as a common symptom, people with idiopathic hypersomnia have no sleep-onset rapid eye movement (REM) period, naps are unrefreshing (unlike with narcolepsy) and idiopathic hypersomnia is not associated with cataplexy. Idiopathic hypersomnia can be difficult to distinguish from narcolepsy, but sleep laboratory studies can help differentiate between them.

Although amphetamines are used to treat both idiopathic hypersomnia and narcolepsy, the excessive daytime sleepiness (EDS) experienced by patients with idiopathic hypersomnia does not usually respond to stimulant treatments.

References

How is idiopathic hypersomnia differentiated from narcolepsy? Updated Sep 4, 2019. Medscape https://www.medscape.com/answers/1188433-112424/how-is-idiopathic-hypersomnia-differentiated-from-narcolepsy

Read next

Can you have narcolepsy and insomnia?

Yes, you can have narcolepsy and insomnia together. Almost 50% of people with narcolepsy also experience disturbed night-time sleep, fragmented sleep, or difficulty staying asleep at night. Sleep may be disrupted by insomnia, vivid dreaming, sleep apnea, acting out while dreaming, or periodic leg movements. Continue reading

What are the early signs of narcolepsy?

One of the earliest signs of narcolepsy is suddenly falling asleep during the daytime, even if you have had a full night’s sleep. This excessive sleepiness is like a “sleep attack” or an overwhelming sense of sleepiness that comes on quickly, and narcolepsy should be considered if a child or teen habitually falls asleep in class, or an adult finds themselves constantly dozing off at work, despite having had a full nights sleep. In between these sleep attacks, people with narcolepsy have normal levels of alertness, particularly if they are doing something that keeps their attention. Narcolepsy most commonly starts in young adults, aged 15 to 25, although it can occur at any age. Continue reading

What is the treatment for narcolepsy?

There is no cure for narcolepsy, but medications and lifestyle modifications can help manage symptoms such as excessive daytime sleepiness (EDS). Medications include: stimulants such as modafinil (Provigil) or armodafinil (Nuvigil) are usually tried first for narcolepsy because they are less addictive than older treatments such as methylphenidate (Aptensio XR, Concerta, Ritalin) or various amphetamines; solriamfetol (Sunosi), pitolisant (Wakix); selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine (Prozac, Sarafem) or serotonin and norepinephrine reuptake inhibitors (SNRIs), such as venlafaxine (Effexor XR); tricyclic antidepressants, such as protriptyline (Vivactil), imipramine (Tofranil), and clomipramine (Anafranil); and sodium oxybate (Xyrem). Continue reading

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