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Xeomin

Generic Name: incobotulinumtoxinA (IN koe BOT ue LYE num TOX in A)
Brand Names: Xeomin

Medically reviewed on Oct 1, 2018

What is Xeomin?

Xeomin (incobotulinumtoxinA, also called botulinum toxin type A), is made from the bacteria that causes botulism. Botulinum toxin blocks nerve activity in the muscles, causing a temporary reduction in muscle activity.

Xeomin injection is used to treat cervical dystonia (severe spasms in the neck muscles), or muscle stiffness in the elbows, wrists, fingers, ankles, or toes.

Xeomin is also used to treat certain eye muscle conditions caused by nerve disorders. This includes uncontrolled blinking or spasm of the eyelids, and a condition in which the eyes do not point in the same direction.

Xeomin is also used to treat chronic drooling (sialorrhea).

Xeomin is also used to temporarily lessen the appearance of facial wrinkles (sometimes called "frown lines") between the eyebrows.

Important Information

You should not receive Xeomin injection if you are allergic to botulinum toxin, or if you have an infection, swelling, or muscle weakness in the area where the medicine will be injected.

The botulinum toxin contained in this medicine can spread to other body areas beyond where it was injected. This can cause serious life-threatening side effects.

Call your doctor at once if you have a hoarse voice, drooping eyelids, vision problems, severe muscle weakness, loss of bladder control, or trouble breathing, talking, or swallowing. Some of these effects can occur up to several weeks after a Xeomin injection. Do not seek botulinum toxin injections from more than one medical professional at a time. If you switch healthcare providers, be sure to tell your new provider how long it has been since your last botulinum toxin injection.

Using Xeomin more often than prescribed will not make it more effective and may result in serious side effects.

The effects of a Xeomin injection are temporary. Your symptoms may return completely within 3 months after an injection. After repeat injections, it may take less and less time before your symptoms return, especially if your body develops antibodies to the botulinum toxin.

Before taking this medicine

To make sure Xeomin is safe for you, tell your doctor if you have ever had:

  • other botulinum toxin injections such as Botox, Dysport, or Myobloc (especially in the last 4 months);

  • amyotrophic lateral sclerosis (ALS, or "Lou Gehrig's disease");

  • myasthenia gravis;

  • Lambert-Eaton syndrome;

  • a breathing disorder such as asthma or emphysema;

  • problems with swallowing;

  • facial muscle weakness (droopy eyelids, weak forehead, trouble raising your eyebrows);

  • a change in the normal appearance of your face;

  • a seizure disorder;

  • bleeding problems;

  • heart disease; or

  • surgery (especially on your face).

Tell your doctor if you have ever had a side effect after receiving a botulinum toxin in the past.

IncobotulinumtoxinA is made from donated human plasma and may contain viruses or other infectious agents. Donated plasma is tested and treated to reduce the risk of contamination, but there is still a small possibility it could transmit disease. Ask your doctor about any possible risk.

It is not known whether Xeomin will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breast-feed while using this Xeomin. Ask your doctor about any risk.

Xeomin is not approved for use by anyone younger than 18 years old.

How is Xeomin given?

Xeomin is injected into a muscle or into a gland. A healthcare provider will give you this injection once every 12 to 16 weeks. Xeomin injections should be spaced at least 3 months apart.

Botulinum toxin injections should be given only by a trained medical professional, even when used for cosmetic purposes.

Your Xeomin injection may be given into more than one area at a time, depending on the condition being treated.

While receiving injections for eye muscle conditions, you may need to use eye drops, ointment, a special contact lens or other device to protect the surface of your eye. Follow your doctor's instructions.

It may take up to 7 days after injection before neck muscle spasm symptoms begin to improve.

The effects of a Xeomin injection are temporary. Your symptoms may return completely within 3 months. After repeat injections, it may take less and less time before your symptoms return, especially if your body develops antibodies to the botulinum toxin.

Do not seek botulinum toxin injections from more than one medical professional at a time. If you switch healthcare providers, be sure to tell your new provider how long it has been since your last botulinum toxin injection.

Using this medicine more often than prescribed will not make it more effective and may result in serious side effects.

What happens if I miss a dose?

Since botulinum toxin has a temporary effect and is given at widely spaced intervals, missing a dose is not likely to be harmful.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may not appear right away, but can include severe muscle weakness, trouble swallowing, weak or shallow breathing, or loss of movement in any part of your body.

What should I avoid while taking Xeomin?

Avoid going back to your normal physical activities too quickly after receiving an injection.

This medicine may impair your vision or depth perception. Avoid driving or hazardous activity until you know how this medicine will affect you.

Xeomin side effects

Get emergency medical help if you have signs of an allergic reaction to Xeomin: hives; wheezing, difficulty breathing; feeling like you might pass out; swelling of your face, lips, tongue, or throat.

The botulinum toxin contained in this medication can spread to other body areas beyond where it was injected. This has caused serious life-threatening side effects in some people receiving botulinum toxin injections, even for cosmetic purposes.

Call your doctor at once if you have any of these side effects (up to several hours or several weeks after you have received a Xeomin injection):

  • unusual or severe muscle weakness (especially in a body area that was not injected with the medication);

  • trouble breathing, talking, or swallowing;

  • hoarse voice, drooping eyelids;

  • blurred vision, double vision;

  • seizure;

  • vision changes, eye pain or irritation;

  • wheezing, tightness in your chest;

  • eyelid swelling, crusting or drainage from your eyes, problems with vision;

  • feeling like you might pass out; or

  • loss of strength, loss of bladder control.

Common Xeomin side effects may include:

  • dry mouth, tooth problems;

  • muscle weakness, body aches;

  • vision problems;

  • feeling short of breath;

  • trouble swallowing;

  • dry eyes, drooping eyelids;

  • headache, neck pain;

  • increased blood pressure;

  • diarrhea; or

  • cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Xeomin?

Other medicines can increase some of the side effects of Xeomin. Tell your doctor about all your other medicines, especially:

  • cold or allergy medicine;

  • muscle relaxers;

  • sleeping pills;

  • bronchodilators;

  • bladder or urinary medicines; or

  • irritable bowel medicines.

This list is not complete. Other drugs may interact with incobotulinumtoxinA, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Xeomin only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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