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Pronunciation: dax'-i-fye
Generic name: daxibotulinumtoxinA-lanm
Dosage form: lyophilized powder for injection
Drug class: Skeletal muscle relaxants

Medically reviewed by Melisa Puckey, BPharm. Last updated on Mar 2, 2024.

What is Daxxify?

Daxxify is a longer-lasting botox (Botulinum toxin) injection used to reduce frown lines and for the treatment of cervical dystonia in adults. Daxxify (DaxibotulinumtoxinA-lanm) injection works by relaxing the affected muscles, which can reduce frown lines (glabellar lines) or the spasming and stiffness from cervical dystonia. Daxxify lasts longer than other first-generation botulinum toxins as it is formulated with a unique stabilizer (cell-penetrating peptide).

Daxxify is an acetylcholine release inhibitor and neuromuscular blocking agent. Daxxify works by blocking the transmission of specific chemical signals from nerves, mainly signals those cause muscles to contract. It works on frown lines by temporarily relaxing the facial muscles that cause the lines, which reduces their appearance. Daxxify works to treat cervical dystonia by relaxing muscles, which relieves abnormal involuntary movements and postures. 

Daxxify became an FDA-approved medicine on September 8, 2022, for moderate to severe frown lines (glabellar lines) in adults. Then on August 11, 2023, it became FDA-approved to treat cervical dystonia in adults. Approval for cervical dystonia was based on positive results from the Phase 3 clinical program (ASPEN 1, ASPEN OLS), which showed a median length of time that it lasted for cervical dystonia was 24.0 and 20.3 weeks for each trial.

Daxxify side effects

Common Daxxify side effects 

Daxxify side effects when used for frown lines may be Headache (6%), eyelid drooping (2%), or loss of the ability to move the muscles in your face (1%).

Daxxify side effects when used for Cervical Dystonia mat include headache (9%), injection site pain (8%), injection site redness (5%), muscular weakness (5%), or upper respiratory tract infection (5%).

Serious Daxxify side effects

Also, see Warnings Section.

Heart problems. Irregular heartbeat and heart attack that have resulted in death, have happened in some people who received botulinum toxin products.

Eye problems. Dry eye, reduced blinking, and corneal problems have happened in some people who receive this medicine to treat glabellar lines. Tell your healthcare provider if you develop eye pain or irritation, sensitivity to light, or changes in your vision.

Allergic reactions. Symptoms of an allergic reaction may include itching, rash, redness, swelling, wheezing, trouble breathing, dizziness, or feeling faint. Tell your healthcare provider or get medical help right away if you have wheezing or trouble breathing or if you feel dizzy or faint.

These are not all the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Revance Therapeutics, Inc. at 1-877-373-8669.


This medicines may cause serious side effects that can be life-threatening. Call your healthcare provider or get medical help right away if you have any of these problems after treatment:

Problems swallowing, speaking, or breathing. These problems can happen hours, days, or weeks after an injection of Daxxify if the muscles that you use to breathe and swallow become weak after the injection. Death can happen as a complication if you have severe problems with swallowing or breathing after treatment.

Spread of toxin effects. In some cases, the effect of botulinum toxin may affect areas of the body away from the injection site and cause symptoms of a serious condition called botulism. The symptoms of botulism include:

These symptoms can happen hours, days, or weeks after you receive an injection.

These problems could make it unsafe for you to drive a car or do other dangerous activities.

How will I receive Daxxify?

Dosing information

Usual Adult Dose for Glabellar Lines

Dose: 0.1 mL (8 Units) by intramuscular injection into each of five sites, for a total dose of 40 Units.

Usual Adult Dose for Cervical Dystonia

Dose: 125 Units to 250 Units given intramuscularly as a divided dose among affected muscles.

Daxxify is available as 50 Units or 100 Units of sterile lyophilized powder in a single-dose vial.

Before receiving Daxxify

Before receiving this medicine, tell your healthcare provider about all of your medical conditions, including if you:


Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known if Daxxify can harm your unborn baby.


Tell your healthcare provider if you are breastfeeding or plan to breastfeed. It is not known if Daxxify passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment.

Who should not receive Daxxify?

You should not receive Daxxify if you:

What other drugs will affect Daxxify?

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Using Daxxify with certain other medicines may cause serious side effects. Do not start any new medicines until you have told your healthcare provider that you have received Daxxify in the past.

Especially tell your healthcare provider if you:

Know the medicines you take. Keep a list of your medicines with you to show your healthcare provider and pharmacist each time you get a new medicine.

What should I avoid while receiving Daxxify?

Daxxify may cause loss of strength or general muscle weakness, blurred vision, or drooping eyelids within hours to weeks of receiving this inejction. If this happens, do not drive a car, operate machinery, or do other dangerous activities.


Active ingredient: daxibotulinumtoxinA-lanm
Inactive ingredients: L-histidine, L-histidine-HCl monohydrate, polysorbate 20, RTP004 peptide, trehalose dihydrate.


Unopened vials should be stored at room temperature 20°C to 25°C (68°F to 77°F) or refrigerated at 2°C to 8° C (36°F to 46°F) in the original carton to protect from light.


Manufactured by: Revance Therapeutics, Inc. Newark, CA 94560

Popular FAQ

Daxxify (daxibotulinumtoxinA-lanm) is the first Botox alternative that is free of human albumin or animal-based components, and it was FDA-approved in September 2022. It is also the longest-lasting of all the cosmetic injectable wrinkle treatments, lasting for 6 months in most people and 9 months in some.  Continue reading

In clinical studies with Daxxify, improvements on frown (glabellar) lines were typically seen within 2 days after administration. Research has shown that Daxxify can last as long as 6 months, with some people maintaining results on frown lines for up to 9 months. Continue reading

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.