Daxxify Side Effects
Generic name: daxibotulinumtoxinA
Medically reviewed by Drugs.com. Last updated on Sep 28, 2023.
Note: This document contains side effect information about daxibotulinumtoxinA. Some dosage forms listed on this page may not apply to the brand name Daxxify.
Applies to daxibotulinumtoxinA: intramuscular powder for solution.
Warning
Intramuscular route (Powder for Solution)
The effects of all botulinum toxin products, including daxibotulinumtoxinA-lanm, may spread from the area of injection to produce symptoms consistent with botulinum toxin effects. These symptoms have been reported hours to weeks after injection. Swallowing and breathing difficulties can be life threatening and there have been reports of death. The risk of symptoms is probably greatest in children treated for spasticity, an unapproved use for daxibotulinumtoxinA-lanm, but symptoms can also occur in adults, particularly in those patients who have an underlying condition that would predispose them to these symptoms
Serious side effects of Daxxify
Along with its needed effects, daxibotulinumtoxinA (the active ingredient contained in Daxxify) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking daxibotulinumtoxinA:
Less common
- Drooping upper eyelids
- partial or slight paralysis of the face
Incidence not known
- Blurred vision
- change in color vision
- change in patterns and rhythms of speech
- chest pain, discomfort, or tightness
- cough
- difficulty seeing at night
- difficulty swallowing
- dizziness
- double vision
- dry eye
- eye irritation
- fainting
- fast, slow, or irregular heartbeat
- feeling of discomfort
- fever
- hives, itching, or skin rash
- hoarseness
- increased sensitivity of the eyes to sunlight
- infection from breathing foreign substance into the lungs
- joint inflammation
- loss of bladder control
- muscle aches and weakness
- nausea
- pain or discomfort in the arms, jaw, back, or neck
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- seeing double
- slurred speech
- sore throat
- sweating
- swollen lymph glands
- trouble breathing
- trouble in speaking
- voice changes
- vomiting
Other side effects of Daxxify
Some side effects of daxibotulinumtoxinA may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- headache
Incidence not known
- Redness of the skin
For Healthcare Professionals
Applies to daxibotulinumtoxinA: intramuscular powder for injection.
General
The most frequently reported side effects included injection site reactions, headache, eyelid ptosis, facial paresis, muscular weakness, and upper respiratory tract infection.[Ref]
Cardiovascular
Common (1% to 10%): Atrioventricular block (First degree)
Frequency not reported: Cardiovascular system adverse reactions[Ref]
Cardiovascular system adverse reactions included arrhythmias and myocardial infarction.[Ref]
Dermatologic
Common (1% to 10%): Erythema[Ref]
Gastrointestinal
Frequency not reported: Dysphagia[Ref]
Genitourinary
Common (1% to 10%): Urinary tract infection[Ref]
Immunologic
-Treatment emergent binding antibodies were reported to be developed against this drug and RTP004 (amino acid excipient).
-Two individuals who previously had botulinum toxin treatment tested positive for neutralizing antibodies.[Ref]
Common (1% to 10%): Anti-drug antibodies[Ref]
Local
Injection site reactions included injection site pain, injection site erythema, injection site edema, injection site bruising, injection site hematoma, injection site papule, and injection site pruritus.[Ref]
Common (1% to 10%): Injection site reactions[Ref]
Musculoskeletal
Common (1% to 10%): Muscular weakness, musculoskeletal pain, arthralgia, spinal pain[Ref]
Nervous system
Facial paresis includes facial asymmetry.[Ref]
Common (1% to 10%): Facial paresis, headache
Frequency not reported: Neuromuscular compromise[Ref]
Ocular
Ophthalmic adverse reactions included dry eye (eye irritation, photophobia, or visual changes).[Ref]
Common (1% to 10%): Eyelid ptosis
Frequency not reported: Ophthalmic adverse reactions[Ref]
Other
Spread of toxin effect included asthenia, generalized muscle weakness, diplopia, blurred vision, ptosis, dysphagia, dysphonia, dysarthria, urinary incontinence, and breathing difficulties.[Ref]
Common (1% to 10%): Edema
Frequency not reported: Spread of toxin effect[Ref]
Respiratory
Common (1% to 10%): Nasopharyngitis, upper respiratory tract infection
Frequency not reported: Breathing difficulties[Ref]
Hypersensitivity
Frequency not reported: Hypersensitivity reactions[Ref]
Hypersensitivity reactions included anaphylaxis, serum sickness, urticaria, soft tissue edema, and dyspnea.[Ref]
Frequently asked questions
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References
1. Product Information. Daxxify (daxibotulinumtoxinA). Revance Therapeutics, Inc. 2022;1.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.
