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Sodium Oxybate Dosage

Medically reviewed by Drugs.com. Last updated on Sep 5, 2023.

Applies to the following strengths: 500 mg/mL; 4.5 g; 6 g; 7.5 g; 9 g

Usual Adult Dose for Narcolepsy

Initial dose: 4.5 g orally per day, divided and given as 2 equal doses with the first dose taken at bedtime and the second dose taken between 2.5 to 4 hours later

Maintenance dose: 6 to 9 g/day
Maximum dose: 9 g/day

Comments:

Use: Treatment of cataplexy in narcolepsy and excessive daytime sleepiness (EDS) in patients with narcolepsy

Usual Adult Dose for Idiopathic Hypersomnia

2 times a night regimen:


Once a night regimen:

Comments:

Use: Treatment of idiopathic hypersomnia

Usual Pediatric Dose for Narcolepsy

7 years and older:
Less than 20 kg: Specific dosing recommendations are not available.

20 to less than 30 kg:


30 to less than 45 kg:

45 kg and greater:

Comments:

Use: Treatment of cataplexy in narcolepsy and EDS in patients with narcolepsy

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Liver dysfunction:

Dose Adjustments

Co-administration of divalproex sodium:
Patients already stabilized on this drug: The addition of divalproex sodium should be accompanied by an initial reduction in the nightly dose of this drug by at least 20%.

Patients already taking divalproex sodium:

Precautions

The US FDA requires a Risk Evaluation and Mitigation Strategy (REMS) for brand and generic versions of this drug. It includes a medication guide, elements to assure safe use, and implementation system. For additional information: www.accessdata.fda.gov/scripts/cder/rems/index.cfm

US BOXED WARNINGS:
CENTRAL NERVOUS SYSTEM (CNS) DEPRESSION:

ABUSE AND MISUSE:
RECOMMENDATION:

CONTRAINDICATIONS:

Safety and efficacy have not been established in patients younger than 7 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance:

Dialysis

Data not available

Other Comments

Administration advice:


Storage requirements:

Reconstitution/preparation techniques:

General:

Monitoring:

Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.