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Skeletal muscle relaxants

What are Skeletal muscle relaxants

Skeletal muscle relaxants (also simply called muscle relaxants) are a diverse group of medicines that have the ability to relax or reduce tension in muscle. Some (such as baclofen, methocarbamol, and tizanidine) work in the brain or spinal cord to block over-excited neuronal (nerve) pathways. Others (such as dantrolene and botulinum toxin) act directly on muscle. Cannabis extract is thought to have a dual effect.

Muscle relaxants treat two main conditions: spasticity (stiff, rigid muscles) caused by conditions such as cerebral palsy, multiple sclerosis, and stroke; or muscle spasms which are typically temporary and associated with conditions such as tension headache, low back pain, or fibromyalgia.

Only three muscle relaxants - baclofen, dantrolene, and tizanidine are FDA approved to treat general spasticity; however, six (carisoprodol, chlorzoxazone, cyclobenzaprine, metaxalone, methocarbamol, and orphenadrine) are approved to treat muscle spasm. Botulinum toxin is only approved to treat spasticity in certain muscle groups of the upper and lower limbs. Many other medications are also used to treat spasticity or muscle spasm although most are not approved for this indication.

Evidence supporting the effectiveness of skeletal muscle relaxants for muscle spasm is sparse; most trials are old and not of good quality. For this reason, skeletal muscle relaxants should only be used to treat muscle spasm if other treatments fail.

List of Skeletal muscle relaxants:

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Drug NameView by: Brand | Generic Reviews Avg. Ratings
dantrolene systemic (Pro, More...)
3 reviews
   
10
carisoprodol systemic (Pro, More...)
199 reviews
   
8.8
abobotulinumtoxinA systemic (Pro, More...)
4 reviews
   
8.0
baclofen systemic (Pro, More...)
239 reviews
   
7.2
botulinum toxin type b systemic (Pro, More...)
3 reviews
   
7.2
metaxalone systemic (Pro, More...)
100 reviews
   
7.1
tizanidine systemic (Pro, More...)
211 reviews
   
6.8
chlorzoxazone systemic (Pro, More...)
46 reviews
   
6.7
onabotulinumtoxinA systemic (Pro, More...)
229 reviews
   
6.6
orphenadrine systemic (Pro, More...)
34 reviews
   
6.6
cyclobenzaprine systemic (Pro, More...)
403 reviews
   
6.5
methocarbamol systemic (Pro, More...)
196 reviews
   
6.1
incobotulinumtoxinA systemic (Pro, More...)
1 review
   
5.0
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