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Skeletal muscle relaxants

What are Skeletal muscle relaxants

Skeletal muscle relaxants (also simply called muscle relaxants) are a diverse group of medicines that have the ability to relax or reduce tension in muscle. Some (such as baclofen, methocarbamol, and tizanidine) work in the brain or spinal cord to block over-excited neuronal (nerve) pathways. Others (such as dantrolene and botulinum toxin) act directly on muscle. Cannabis extract is thought to have a dual effect.

Muscle relaxants treat two main conditions: spasticity (stiff, rigid muscles) caused by conditions such as cerebral palsy, multiple sclerosis, and stroke; or muscle spasms which are typically temporary and associated with conditions such as tension headache, low back pain, or fibromyalgia.

Only three muscle relaxants - baclofen, dantrolene, and tizanidine are FDA approved to treat general spasticity; however, six (carisoprodol, chlorzoxazone, cyclobenzaprine, metaxalone, methocarbamol, and orphenadrine) are approved to treat muscle spasm. Botulinum toxin is only approved to treat spasticity in certain muscle groups of the upper and lower limbs. Many other medications are also used to treat spasticity or muscle spasm although most are not approved for this indication.

Evidence supporting the effectiveness of skeletal muscle relaxants for muscle spasm is sparse; most trials are old and not of good quality. For this reason, skeletal muscle relaxants should only be used to treat muscle spasm if other treatments fail.

List of Skeletal muscle relaxants:

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Drug Name DownUp( View by: Brand | Generic ) Reviews Ratings DownUp
dantrolene systemic (Pro, More...)
3 reviews
   
10
botulinum toxin type b systemic (Pro, More...)
2 reviews
   
9.3
carisoprodol systemic (Pro, More...)
195 reviews
   
8.8
abobotulinumtoxinA systemic (Pro, More...)
4 reviews
   
7.8
baclofen systemic (Pro, More...)
237 reviews
   
7.2
metaxalone systemic (Pro, More...)
99 reviews
   
7.1
tizanidine systemic (Pro, More...)
210 reviews
   
6.8
chlorzoxazone systemic (Pro, More...)
45 reviews
   
6.7
orphenadrine systemic (Pro, More...)
34 reviews
   
6.6
cyclobenzaprine systemic (Pro, More...)
393 reviews
   
6.5
onabotulinumtoxinA systemic (Pro, More...)
224 reviews
   
6.5
methocarbamol systemic (Pro, More...)
192 reviews
   
6.2
incobotulinumtoxinA systemic (Pro, More...)
1 review
   
5.0
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